TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2020-1230-401

R. Noor, S. Abdullah

引用次数: 0

Prevalence and factors associated with low birth weight among neonates in Rwanda: a prospective cross-sectional study 卢旺达新生儿低出生体重的患病率和相关因素:一项前瞻性横断面研究

TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0401-0510.

N. Emmanuel, Nzayisenga Joseph, M. Connie, Habtu Michael

引用次数: 1

DUSP8 inhibits LPS-induced acute lung injury by regulating macrophage response DUSP8通过调节巨噬细胞反应抑制lps诱导的急性肺损伤

TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0531-107

Qinwen Xu, Chenxi Tang, Li He, Wen-Ling Cheng, P. Jiang, Xiaoya Wang

引用次数: 2

Implications of helminth immunomodulation on COVID-19 co-infections 寄生虫免疫调节对COVID-19合并感染的影响

TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0502-309

N. Chacón, L. Chacin-Bonilla, Italo M. Cesar

{"title":"Implications of helminth immunomodulation on COVID-19 co-infections","authors":"N. Chacón, L. Chacin-Bonilla, Italo M. Cesar","doi":"10.53388/life2021-0502-309","DOIUrl":"https://doi.org/10.53388/life2021-0502-309","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries. The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+ T cells, eosinophils, interleukin-4, interleukin-5, and interleukin-10. In the early stages of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, virus-specific Th1 cytotoxic CD8+ T cell, interleukin-6, interferon-γ, and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs, like the intestine. CD4+ and CD8+ T cells are associated with protective immunity against and during COVID-19. However, viral evasion mechanisms occur. Interference of the interferon-γ secretion, like in helminths immunomodulation, can contribute to COVID-19 severity. Immunomodulation can result in mild, moderate, or severe COVID-19 depending on which helminth is coinfecting by regulating or avoiding host cytokine and pro-inflammatory response, decreasing viral load, and affecting vaccineinduced antibody response. We discuss the implications of immunomodulation on COVID-19 caused by helminth co-infection and for public health in the context of COVID-19 vaccine use in helminth endemic zones.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Atypical double right coronary artery: a case report and literature review 非典型双右冠状动脉1例并文献复习

TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0518-204

Tuo Han, Haoyu Wu, Yanchao Hu, Yan Zhang, Congxia Wang

引用次数: 0

Combination therapy using low dose radiation, plasma exchange, and a robust antiviral may induce synergic beneficial interactions for mitigating severe COVID‐19 采用低剂量放疗、血浆置换和强效抗病毒药物的联合治疗可诱导协同有益的相互作用，以减轻严重的COVID - 19

TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0524-308

A. Jafarzadeh, S. Ali, M. Nemati, Seyed Mohammad

引用次数: 0

Tamoxifen does not deteriorate cardiac function in female alphaMHC-MerCreMer transgenic mice 他莫昔芬不损害雌性α hamhc - mercremer转基因小鼠的心功能

TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0708-111

Tuo Han, Jie Gao, M. Fatima, Yiwen Wang, Lixia Wang, Congxia Wang