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ZMYND10 downregulates cyclins B1 and D1 to arrest cell cycle by trimethylating lysine 9 on histone 3 ZMYND10下调细胞周期蛋白B1和D1，通过组蛋白3上赖氨酸9的三甲基化来阻止细胞周期
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0727-132
Longji Wu, Xiangning Zhang, Jian Wang, X. Kong, B. Zheng, Jinglin Huang, Hongbing Yu, Zhiwei He
{"title":"ZMYND10 downregulates cyclins B1 and D1 to arrest cell cycle by trimethylating lysine 9 on histone 3","authors":"Longji Wu, Xiangning Zhang, Jian Wang, X. Kong, B. Zheng, Jinglin Huang, Hongbing Yu, Zhiwei He","doi":"10.53388/life2021-0727-132","DOIUrl":"https://doi.org/10.53388/life2021-0727-132","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Increased internet addiction during COVID-19 pandemics COVID-19大流行期间网瘾增加
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0829-635
Bibek Raj
{"title":"Increased internet addiction during COVID-19 pandemics","authors":"Bibek Raj","doi":"10.53388/life2021-0829-635","DOIUrl":"https://doi.org/10.53388/life2021-0829-635","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A cross-sectional study of the relationships between ethnicity and occupational classes with mental wellbeing in the UK 英国种族和职业阶层与心理健康之间关系的横断面研究
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0111-301
Aliza Ayaz
{"title":"A cross-sectional study of the relationships between ethnicity and occupational classes with mental wellbeing in the UK","authors":"Aliza Ayaz","doi":"10.53388/life2021-0111-301","DOIUrl":"https://doi.org/10.53388/life2021-0111-301","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a new field-deployable RT-qPCR workflow for COVID-19 detection 开发新的现场可部署的COVID-19检测RT-qPCR工作流程
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0525-110
Raphael Nyaruaba, Bo Zhang, Caroline Muema, E. Muturi, Greater K., Jin Xiong, Bei Li, Z. Shí, Caroline Mwaliko, Junping Yu, Xiaohong Li, Yanan Zhang, H. Wei
{"title":"Development of a new field-deployable RT-qPCR workflow for COVID-19 detection","authors":"Raphael Nyaruaba, Bo Zhang, Caroline Muema, E. Muturi, Greater K., Jin Xiong, Bei Li, Z. Shí, Caroline Mwaliko, Junping Yu, Xiaohong Li, Yanan Zhang, H. Wei","doi":"10.53388/life2021-0525-110","DOIUrl":"https://doi.org/10.53388/life2021-0525-110","url":null,"abstract":"Background: Outbreaks of coronavirus disease 2019 (COVID-19) have been recorded in different countries across the globe. The virus is highly contagious, hence early detection, isolation, and quarantine of infected patients will play an important role in containing the viral spread. Diagnosis in a mobile lab can aid to find infected patients in time. Methods: Here, we develop a field-deployable diagnostic workflow that can reliably detect COVID-19. Instruments used in this workflow can easily fit in a mobile cabin hospital and also be installed in the community. Different steps from sample inactivation to detection were optimized to find the fastest steps and portable instruments in the detection of COVID-19. Each step was compared to that of the normal laboratory diagnosis setup. Results: From the results, our proposed workflow (80 min) was two times faster compared to that of the normal laboratory workflow (183 min) and a maximum of 32 samples could be detected at each run. Additionally, we showed that using 1% Rewocid WK-30 could inactivate the novel coronavirus directly without affecting the overall detection results. Comparison of our workflow using an in-house assay to that of a commercially acquired assay produced highly reliable results. From the 250 hospital samples tested, there was a high concordance 247/250 (98.8%) between the two assays. The in-house assay sensitivity and specificity were 116/116 (100%) and 131/134 (97.8%) compared to that of the commercial assay. Conclusion: Based on these results, we believe that our workflow is fast, reliable, adaptable and most importantly, field-deployable.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Coronary heart disease-related fatigue: risk factors, assessment and treatments 冠心病相关疲劳:危险因素、评估和治疗
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0929-334
Yaoyao Hu, Lucun Yu, Jing Zhang, F. Mao, Qing Wu, Lin Liu
{"title":"Coronary heart disease-related fatigue: risk factors, assessment and treatments","authors":"Yaoyao Hu, Lucun Yu, Jing Zhang, F. Mao, Qing Wu, Lin Liu","doi":"10.53388/life2021-0929-334","DOIUrl":"https://doi.org/10.53388/life2021-0929-334","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis of the Chikungunya virus and the host immunity response 基孔肯雅病毒的发病机制及宿主免疫反应
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-1229-301.
T. Ahmed, S. Abdullah, Rehman Tanvir, Zobayda Nahar, N. Tasnim, Chandrika Saha, R. Noor
{"title":"Pathogenesis of the Chikungunya virus and the host immunity response","authors":"T. Ahmed, S. Abdullah, Rehman Tanvir, Zobayda Nahar, N. Tasnim, Chandrika Saha, R. Noor","doi":"10.53388/life2021-1229-301.","DOIUrl":"https://doi.org/10.53388/life2021-1229-301.","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Amyloid beta peptides, tau protein acetylation and therapeutic strategies for treating Alzheimer’s disease: a review 淀粉样β肽、tau蛋白乙酰化及治疗阿尔茨海默病的策略综述
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0121-305
Sanjib Guha, Rajalakshmi Subramaniyam
{"title":"Amyloid beta peptides, tau protein acetylation and therapeutic strategies for treating Alzheimer’s disease: a review","authors":"Sanjib Guha, Rajalakshmi Subramaniyam","doi":"10.53388/life2021-0121-305","DOIUrl":"https://doi.org/10.53388/life2021-0121-305","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Changes in muscle activity in patients with primary chronic headache 原发性慢性头痛患者肌肉活动的变化
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0401-0114.
Nigora Kadyrkhodjayeva, A. Prokhorova, Saodat Ubaydullaeva
{"title":"Changes in muscle activity in patients with primary chronic headache","authors":"Nigora Kadyrkhodjayeva, A. Prokhorova, Saodat Ubaydullaeva","doi":"10.53388/life2021-0401-0114.","DOIUrl":"https://doi.org/10.53388/life2021-0401-0114.","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress of microbiome and pathogenesis of vitiligo 白癜风微生物组与发病机制的研究进展
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0403-0315.
Yi Chen, Jiayu Zhang, Su Gao, Yongrong Li, Yifei Wu
{"title":"Research progress of microbiome and pathogenesis of vitiligo","authors":"Yi Chen, Jiayu Zhang, Su Gao, Yongrong Li, Yifei Wu","doi":"10.53388/life2021-0403-0315.","DOIUrl":"https://doi.org/10.53388/life2021-0403-0315.","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Study on the medication rule of herbs for uterine bleeding in ancient Chinese medicine 古代中医治疗子宫出血的中药用药规律研究
TMR生命研究 Pub Date : 2021-01-01 DOI: 10.53388/life2021-0401-0401.
Kuo Gao, Xiaona Gao, Xinchun Xiao
{"title":"Study on the medication rule of herbs for uterine bleeding in ancient Chinese medicine","authors":"Kuo Gao, Xiaona Gao, Xinchun Xiao","doi":"10.53388/life2021-0401-0401.","DOIUrl":"https://doi.org/10.53388/life2021-0401-0401.","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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