Journal of Biological Physics最新文献

Bioconvection of a radiating and reacting nanofluid flow past a nonlinear stretchable permeable sheet in a porous medium

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2025-01-30 DOI: 10.1007/s10867-025-09669-7

Kavita Jat, Kalpna Sharma, Prasun Choudhary, Pooja Soni

{"title":"Bioconvection of a radiating and reacting nanofluid flow past a nonlinear stretchable permeable sheet in a porous medium","authors":"Kavita Jat, Kalpna Sharma, Prasun Choudhary, Pooja Soni","doi":"10.1007/s10867-025-09669-7","DOIUrl":"10.1007/s10867-025-09669-7","url":null,"abstract":"<div><p>This study evaluates the unsteady laminar flow and heat and mass transfer of a nanofluid in the appearance of gyrotactic microorganisms. In this analysis, using the Darcy–Forchheimer flow inside the vicinity of a nonlinearly stretched surface with Brownian motion and thermophoresis impacts. Similarity conversion is familiar with reduced governing models into dimensionless variables, and “bvp4c,” a MATLAB solver, is employed to find the computational outputs of this analysis. This analysis reports that the use of nanofluids provides better thermal characteristics which are helpful to enhance the heat transfer coefficient. Graphs for this analysis are created for distinct values of non-dimensionless parameters, whereas the coefficient of surface drag, heat flux, mass flux, and rate of microorganism density are all interpreted numerically and graphically. The high level of resistance provided by velocity slip and Forchheimer parameters leads to a decrease in velocity curves while an increment is seen in the temperature profile. It is also remarked that bioconvection Peclet number induces a decrement in the density distribution of motile microorganisms. In addition, it has been observed that the Nusselt number for a nonlinear stretching sheet is better as compared to a linear stretching sheet.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"51 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of stalk orientation and size of trapped bead on force–velocity relation of kinesin motor determined using single molecule optical trapping methods

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2025-01-27 DOI: 10.1007/s10867-025-09671-z

Ping Xie

{"title":"Effects of stalk orientation and size of trapped bead on force–velocity relation of kinesin motor determined using single molecule optical trapping methods","authors":"Ping Xie","doi":"10.1007/s10867-025-09671-z","DOIUrl":"10.1007/s10867-025-09671-z","url":null,"abstract":"<div><p>Conventional kinesin protein is a prototypical biological molecular motor that can step processively on microtubules towards the plus end by hydrolyzing ATP molecules, performing the biological function of intracellular transports. An important characteristic of the kinesin is the load dependence of its velocity, which is usually measured by using the single molecule optical trapping method with a large-sized bead attached to the motor stalk. Puzzlingly, even for the same kinesin, some experiments showed that the velocity is nearly independent of the forward load whereas others showed that the velocity decreases evidently with the increase in the magnitude of the forward load. Here, a theoretical explanation is provided of why different experiments give different dependencies of the velocity on the forward load. It is shown that both the stalk orientation and bead size play a critical role in the different dependencies. Additionally, the reason why the optical trapping experiments with the movable trap usually gave a sigmoid form of the velocity versus backward load whereas with the fixed trap gave a nearly linear form is also explained theoretically. The study is not only critical to the understanding of the response of the motor to the load but also provides strong insights into the coupling mechanism of the motor.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"51 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-fluid flow of blood in a curved stenotic artery under pulsating condition 弯曲狭窄动脉在搏动状态下的双流体血流

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2025-01-22 DOI: 10.1007/s10867-024-09668-0

Muhammad Shahzad Shabbir, Meriyem Hussain

引用次数: 0

Dynamics of predator-prey system with the consequences of double Allee effect in prey population 捕食者-食饵系统动态与食饵种群双狭缝效应的影响

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2025-01-20 DOI: 10.1007/s10867-025-09670-0

Chirodeep Mondal, Ritwika Mondal, Dipak Kesh, Debasis Mukherjee

{"title":"Dynamics of predator-prey system with the consequences of double Allee effect in prey population","authors":"Chirodeep Mondal, Ritwika Mondal, Dipak Kesh, Debasis Mukherjee","doi":"10.1007/s10867-025-09670-0","DOIUrl":"10.1007/s10867-025-09670-0","url":null,"abstract":"<div><p>A underlying complex dynamical behavior of double Allee effects in predator-prey system is studied in this article to understand the predator-prey relation more intensely from different aspects. We first propose a system with the Caputo sense fractional-order predator-prey system incorporating the Allee effect in prey populations to explain how the memory effect can change the different emergent states. Local stability analysis is analyzed by applying Matignon’s condition for the FDE system. Further, we consider a discrete-time system to show the influence of double Allee effects in non-overlapping generations. For discrete-time system, different bifurcations like Neimark-Sacker, flip bifurcations, irregularity in periodic oscillations, are observed. Irregularity occurs through a period-doubling cascade which is a common route to chaos in a dynamical sense. Maximum Lyapunov exponent (MLE) is shown to illustrate the irregular behaviors of discrete-time systems. The Allee effect influences system stability where the strong Allee effect enhances system stability whereas the stability is lost for the weak Allee effect. The extinction risk of populations in the presence of the Allee effect is a concerning issue. We have insight into how all populations survive along with stable extinction equilibrium. Our proposed systems exhibit different alternative states. Multiple stable attractor basins are plotted to depict the different alternative states of the FDE system as well as the discrete-time system. Initial population densities play a key role in the coexistence of all the populations otherwise there is a risk of species extinction. Besides analytical results, numerical simulation is performed to valid our analytical findings of different dynamical states like bifurcation, stability, irregularity as well as multi-stability.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"51 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142995082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of tuberculosis model with indirect environmental transmission and optimal control 带有间接环境传播和优化控制的结核病模型分析

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2024-11-27 DOI: 10.1007/s10867-024-09667-1

Xianyi Zhao, Hui Cao, Danfeng Pang

引用次数: 0

Numerical analysis of bioconvective heat transport through Casson nanofluid over a thin needle 通过薄针上的卡松纳米流体进行生物对流热传输的数值分析

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2024-11-25 DOI: 10.1007/s10867-024-09664-4

Snehalata Jena, Manoj Kumar Mishra

{"title":"Numerical analysis of bioconvective heat transport through Casson nanofluid over a thin needle","authors":"Snehalata Jena, Manoj Kumar Mishra","doi":"10.1007/s10867-024-09664-4","DOIUrl":"10.1007/s10867-024-09664-4","url":null,"abstract":"<div><p>Bioconvective flows over a thin needle hold significant importance in various fields, particularly in biomedical engineering, microfluidics, and environmental science. This paper examines the bioconvective flow properties of a copper and blood-based Casson nanofluid over a thin needle, accounting for gyrotactic microorganisms in the presence of a magnetic field. The two-phase nanofluid model is applied to formulate the flow problem. The system of non-dimensional ordinary differential equations is obtained by reducing the governing partial differential equations with the help of similarity variables. Further, the ODEs are numerically solved using the 4th-order Runge–Kutta method based Shooting technique. The similar solutions of the non-dimensional ODEs are represented graphically and the blood-based nanofluid’s velocity, temperature, concentration, and presence of microorganisms are examined with reference to the accompanying diagrams. A detailed analysis is provided for skin friction, Nusselt number, and microorganism density number. The primary outcomes reveal that the augmentation of the mixed convection parameter and buoyancy ratio parameter enhance the rate of heat transfer.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"51 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudo-trajectory inference for identifying essential regulations and molecules in cell fate decisions 通过伪轨迹推理确定细胞命运决定中的基本规则和分子。

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2024-11-14 DOI: 10.1007/s10867-024-09665-3

Xinyu He, Ruoyu Tang, Jie Lou, Ruiqi Wang

{"title":"Pseudo-trajectory inference for identifying essential regulations and molecules in cell fate decisions","authors":"Xinyu He, Ruoyu Tang, Jie Lou, Ruiqi Wang","doi":"10.1007/s10867-024-09665-3","DOIUrl":"10.1007/s10867-024-09665-3","url":null,"abstract":"<div><p>Cell fate decision is crucial in biological development and plays fundamental roles in normal development and functional maintenance of organisms. By identifying key regulatory interactions and molecules involved in these fate decisions, we can shed light on the intricate mechanisms underlying the cell fates. This understanding ultimately reveals the fundamental principles driving biological development and the origins of various diseases. In this study, we present an overarching framework which integrates pseudo-trajectory inference and differential analysis to determine critical regulatory interactions and molecules during cell fate transitions. To demonstrate feasibility and reliability of the approach, we employ the differentiation networks of hepatobiliary system and embryonic stem cells as representative model systems. By applying pseudo-trajectory inference to biological data, we aim to identify critical regulatory interactions and molecules during the cell fate transition processes. Consistent with experimental observations, the approach can allow us to infer dynamical cell fate decision processes and gain insights into the underlying mechanisms which govern cell state decisions.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"51 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stochastic model of seed dispersal with homogeneous and non-homogeneous Poisson processes under habitat reduction conditions 栖息地减少条件下种子扩散的同质和非同质泊松过程随机模型。

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2024-11-14 DOI: 10.1007/s10867-024-09666-2

Nevena Marić

引用次数: 0

Exploring the effects of simulated microgravity on esophageal cancer cells: insights into morphological, growth behavior, adhesion, and genetic damage 探索模拟微重力对食管癌细胞的影响：对形态学、生长行为、粘附和遗传损伤的认识

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2024-10-14 DOI: 10.1007/s10867-024-09663-5

Saifaldeen Altaie, Amera Alrawi, Xuexin Duan, Qater Alnada

{"title":"Exploring the effects of simulated microgravity on esophageal cancer cells: insights into morphological, growth behavior, adhesion, and genetic damage","authors":"Saifaldeen Altaie, Amera Alrawi, Xuexin Duan, Qater Alnada","doi":"10.1007/s10867-024-09663-5","DOIUrl":"10.1007/s10867-024-09663-5","url":null,"abstract":"<div><p>The exploration of microgravity has garnered substantial scholarly attention due to its potential to offer unique insights into the behavior of biological systems. This study presents a preliminary investigation into the effects of simulated microgravity on esophageal cancer cells, examining various aspects such as morphology, growth behavior, adhesion, inhibition rate, and DNA damage. To achieve this, a novel microgravity simulator named “Gravity Challenge” was utilized for its effectiveness in minimizing external influences that could compromise microgravity conditions. The international cell line SK-GT-4 was utilized as the focal point of this investigation. Results revealed noticeable alterations in the growth behavior of cancer cells following exposure to simulated microgravity for 24 h, characterized by a loss of adhesion properties compared to control cells. Concurrently, cell viability exhibited a decline, as evidenced by cytotoxicity testing. Furthermore, the comet assay test demonstrated that cells subjected to microgravity simulation experienced a higher incidence of DNA damage compared to their control counterparts. In conclusion, this comprehensive examination of the impact of simulated microgravity on esophageal cancer cells extends beyond morphological changes, delving into genetic implications through observed DNA damage. The diminished vitality of cells under microgravity conditions underscores the multifaceted effects on cellular behavior in response to environmental variations. These findings represent a significant step towards understanding the dynamics of cancer cells, laying the groundwork for future research aimed at identifying potential therapeutic strategies for this disease.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"50 3-4","pages":"351 - 366"},"PeriodicalIF":1.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A possible origin of the inverted vertebrate retina revealed by physical modeling 通过物理建模揭示脊椎动物倒置视网膜的可能起源

IF 1.8 4区生物学

Journal of Biological Physics Pub Date : 2024-08-03 DOI: 10.1007/s10867-024-09662-6

Jan M. M. Oomens

{"title":"A possible origin of the inverted vertebrate retina revealed by physical modeling","authors":"Jan M. M. Oomens","doi":"10.1007/s10867-024-09662-6","DOIUrl":"10.1007/s10867-024-09662-6","url":null,"abstract":"<div><p>The evolutionary origin of the inverted retina in the vertebrate eye is unknown. This paper explores a hypothetical evolutionary scenario that explains the unique orientation of the photoreceptors in the vertebrate retina. The proposed scenario follows the scientific accepted scenario for eye evolution and gradually builds up towards an eye prototype by considering light direction detection and increase in achievable spatial resolution as the driving forces. It suggests that eye retinas developed along two different morphological processes, an evagination process that results in the inverted retina in vertebrate eyes and an invagination process that results in a verted retina in cephalopod eyes. The development of the inverted vertebrate retina and eye prototype morphology is strongly substantiated by physics of vision. The proposed evolutionary sequence for vertebrate eye development is simple and has the full potential to explain the origin of the inverted retina and leads to an eye prototype enabling visual detection and orientation. It allows the emergence of eye structures like, extraocular muscles, tapetum lucidum, biconvex lens, cornea, and pupil. This study supports the suggestion that a primitive inverted retina in the predecessor of vertebrates is of ectodermal origin and available before neurulation occurred.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"50 3-4","pages":"327 - 349"},"PeriodicalIF":1.8,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10867-024-09662-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0