Journal of Biological Physics最新文献

Estradiol alters actin and protrusion dynamics in endometriotic epithelial cells 雌二醇改变子宫内膜异位症上皮细胞的肌动蛋白和突起动力学。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-05-02 DOI: 10.1007/s10867-026-09712-1

Shohini Banerjee, Corey Herr, Wolfgang Losert, Kimberly M. Stroka

{"title":"Estradiol alters actin and protrusion dynamics in endometriotic epithelial cells","authors":"Shohini Banerjee, Corey Herr, Wolfgang Losert, Kimberly M. Stroka","doi":"10.1007/s10867-026-09712-1","DOIUrl":"10.1007/s10867-026-09712-1","url":null,"abstract":"<div><p>Estradiol (E2), a sex steroid hormone molecule, plays a key role in regulating the actin and shape dynamics of cells in a multitude of normal and pathophysiological conditions. While cytoskeletal rearrangements, membrane dynamics, and cellular protrusions are intimately involved in cell motility and invasiveness, little is known about the impact of E2 on these processes in estrogen-dependent epithelial cells. In this study, we quantified the impact of E2 on epithelial cell shape and actin dynamics. 12Z human endometriotic epithelial cells were transfected with LifeAct-GFP and observed with lattice lightsheet microscopy, a new imaging technique fast enough to capture 3D dynamics on second timescales. E2, when applied for 24 h, significantly decreased cell circularity, solidity, and rate of change of circularity, indicating a transition to a more elongated and less variable morphology. 24-h E2 treatment also induced the formation of large membrane protrusions reminiscent of invadopodia and led to a more disordered flow of actin within those protrusions. However, these effects were not seen after 15 min of E2 treatment, suggesting that longer-term signaling is required to drive these structural changes. Together, these results suggest that E2 modulates actin polymerization and membrane protrusion dynamics in endometriotic epithelial cells and may prime them for cell invasion. This work highlights a role for hormonal signaling in mediating cytoskeletal plasticity and migratory cell phenotypes.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10867-026-09712-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the hen egg size on its fracture point measuring the eggshell deformation 鸡蛋尺寸对其断裂点的影响，测量蛋壳变形。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-04-16 DOI: 10.1007/s10867-026-09711-2

Brenda Mireya Guzman Valdivia, Manuel Humberto De La Torre Ibarra

{"title":"Impact of the hen egg size on its fracture point measuring the eggshell deformation","authors":"Brenda Mireya Guzman Valdivia, Manuel Humberto De La Torre Ibarra","doi":"10.1007/s10867-026-09711-2","DOIUrl":"10.1007/s10867-026-09711-2","url":null,"abstract":"<div><p>A digital holographic interferometer is used to measure surface deformation and fracture points in hen eggs under mechanical compression. All samples were subjected to a constant compression load until they fractured. Three different tests are performed to analyze the eggs’ mechanical response. In the first test, the egg is vertically oriented, and so the applied load; meanwhile, for the second test, the egg is horizontally oriented with the load applied vertically. The third test keeps the egg horizontal, but on this occasion, the applied load is also horizontal. As the mechanical load is applied, a camera records full-field holograms that retrieve the entire surface deformation of each egg. The influence of the egg’s orientation and the load direction modifies the eggshell surface deformation and fracture pattern. In general, fracture propagation is aligned with the load direction. From the results, samples compressed along the length of the egg show fractures, but remained in one piece. A different behavior is observed when the load is applied at the egg’s width, which separates the eggshell into two semispheres, allowing the egg’s content to drain out. A multivariate analysis was used to integrate the egg dimensions with the resulting optical data, showing a strong relationship between egg size and the fracture point. Larger eggs tend to exhibit more extensive fractures, while smaller and medium-sized eggs showed minor damage. Even though some of this information is empirically known, this is the first time it has been proven by a full imaging inspection showing eggshell deformation and cracks across eggs, independent of egg size. The latter is an advantage as there is no need to limit the study to particular dimensions to measure the exact moment of the fracture, its position, and distribution.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational and umbrella sampling analysis of HER2 D769H and D769Y variants: mutation-specific structural alterations and drug interactions in breast cancer HER2 D769H和D769Y变异的计算和总体抽样分析：乳腺癌中突变特异性结构改变和药物相互作用

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-04-11 DOI: 10.1007/s10867-026-09709-w

Tamizhini Loganathan, George Priya C. Doss

{"title":"Computational and umbrella sampling analysis of HER2 D769H and D769Y variants: mutation-specific structural alterations and drug interactions in breast cancer","authors":"Tamizhini Loganathan, George Priya C. Doss","doi":"10.1007/s10867-026-09709-w","DOIUrl":"10.1007/s10867-026-09709-w","url":null,"abstract":"<div><p>HER2 plays a crucial role in breast cancer (BC) progression, with the D769H and D769Y mutations significantly influencing its structural integrity, drug-binding dynamics, and therapeutic response. This study employs molecular docking and molecular dynamics simulations (MDS), with trajectories propagated for 1000 ns, to examine their distinct effects. Root mean square deviation (RMSD) analysis indicates increased conformational deviations in mutant structures, signifying heightened instability, while root mean square fluctuation (RMSF) reveals enhanced flexibility near the mutation site. Solvent accessible surface area (SASA) calculations highlight changes in solvent exposure, directly affecting ligand accessibility, while radius of gyration (Rg) assessments suggest structural loosening or tightening in response to mutation-induced alterations. Binding free energy calculations using MM-PBSA indicate variability in drug affinity, with mutations disrupting hydrogen-bonding networks and altering ligand stability. Principal Component Analysis (PCA) delineates distinct motion trajectories in mutant proteins, revealing shifts in conformational behavior. Umbrella sampling simulations indicate that while the wild-type HER2-drug complex requires 150 ps to reach equilibrium, the D769H mutant stabilizes within 100 ps, suggesting diminished drug retention. Conversely, the D769Y mutation enhances ligand binding, surpassing wild-type interaction strength. These findings elucidate mutation-specific effects on HER2 structural dynamics and drug interactions, underscoring the need for mutation-tailored therapeutic strategies to mitigate the impact of these variants.\u0000</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating motion patterns in sperm cell motion with dynamic mode decomposition 用动态模式分解阐明精子运动模式。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-03-27 DOI: 10.1007/s10867-026-09710-3

Petr Šimánek, Jakub Hořenín, Islam S. M. Khalil, Veronika Magdanz, Anke Klingner, Alexander Kovalenko

{"title":"Elucidating motion patterns in sperm cell motion with dynamic mode decomposition","authors":"Petr Šimánek, Jakub Hořenín, Islam S. M. Khalil, Veronika Magdanz, Anke Klingner, Alexander Kovalenko","doi":"10.1007/s10867-026-09710-3","DOIUrl":"10.1007/s10867-026-09710-3","url":null,"abstract":"<div><p>The study employs dynamic mode decomposition (DMD) to elucidate the underlying mechanisms contributing to the enhanced motility observed in sperm bundles, primarily focusing on the role of flagellar synchronization. The decomposition reveals that synchronized flagellar movements might be a key factor enabling sperm cells to attain higher velocities when connected in bundles. Through DMD, periodical characteristics of individual periodical motion patterns, such as frequency, amplitude, and modal growth/decay rates (from DMD eigenvalues), are characterized, elucidating main parameters of the dynamic behavior of these biological systems, such as dominant frequencies of periodical motion, as well as amplitudes and velocities. The implications of this research extend beyond understanding sperm bundle dynamics, as the methodology is adaptable for identifying healthy sperm cells based on their motility patterns. Additionally, the approach holds potential for broader applications in studying other flagellar-driven microorganisms, providing a valuable tool for comparative analysis across various species.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10867-026-09710-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico ADMET profiling and DNA interaction study of xanthoxylin: assessment of pBR322 DNA protection against oxidative damage xanthoxylin的ADMET分析和DNA相互作用研究：pBR322 DNA抗氧化损伤的评估。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-03-23 DOI: 10.1007/s10867-026-09708-x

Mohd Abuzar Afaq, Mohammad Tabish

引用次数: 0

Quantum mechanical justification for induced fit model conformational changes in allosteric enzymes based on the quantum perturbation theory and Davydov’s soliton theory 基于量子微扰理论和Davydov孤子理论的变构酶诱导拟合模型构象变化的量子力学论证。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-03-21 DOI: 10.1007/s10867-026-09707-y

Farzam Faeznia

{"title":"Quantum mechanical justification for induced fit model conformational changes in allosteric enzymes based on the quantum perturbation theory and Davydov’s soliton theory","authors":"Farzam Faeznia","doi":"10.1007/s10867-026-09707-y","DOIUrl":"10.1007/s10867-026-09707-y","url":null,"abstract":"<div><p>We develop a refined quantum framework for the induced-fit model of allosteric enzymes incorporating vibrational exciton (Davydov’s soliton) dynamics and open-system perturbation theory. Using realistic biochemical parameters, we numerically evaluate the excitation conditions and find that under normal assumptions the quantum excitation energy remains orders of magnitude below the threshold needed to drive a stable soliton. This implies that classical Davydov conditions alone are insufficient for enzyme catalysis on sub-nanosecond timescales. To address this, we identify additional factors – multi-state energy accumulation and strong quantum-coherent processes – that could plausibly enhance the effect. We discuss model limitations (e.g., idealized 1D protein chain, neglect of dissipation) and the validity of our assumptions. By modeling allosteric enzymes as quantum multi-particle systems, we represent substrate-induced structural changes as Hamiltonian deformations and calculate transition probabilities and interaction energies that correlate with enzymatic accuracy or error. While Davydov’s soliton offers an appealing formalism, our calculations indicate they are insufficient under naïve parameter choices. Under standard parameters, this mechanism alone is not sufficient and requires auxiliary mechanisms. We present conditions (e.g., multi-state accumulation, enhanced coupling) under which solitonic behaviour might emerge, and propose experiments/simulations to validate these scenarios. This work bridges biophysical mechanisms with quantum mechanics, offering a novel perspective on enzymatic function at the quantum level. Finally, we situate our model within the broader context of <i>macro</i>-quantum effects (quantum coherence, tunneling, superradiance) known in biology, arguing that while Davydov’s soliton remains speculative, related quantum phenomena (e.g., proton tunneling) are well-supported in enzymatic systems.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stiff for the stride and soft for the glide: dual role of cytoskeleton in stiffness dynamics of breast cancer cell lines—a meta-analysis 硬为跨步，软为滑行：细胞骨架在乳腺癌细胞系的刚度动力学中的双重作用-一项荟萃分析。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-02-23 DOI: 10.1007/s10867-026-09705-0

Anusri Ambali, Koolipoyil Abdulkareem Rishad, Thuluvath Linshina, Sindhu Kondath

{"title":"Stiff for the stride and soft for the glide: dual role of cytoskeleton in stiffness dynamics of breast cancer cell lines—a meta-analysis","authors":"Anusri Ambali, Koolipoyil Abdulkareem Rishad, Thuluvath Linshina, Sindhu Kondath","doi":"10.1007/s10867-026-09705-0","DOIUrl":"10.1007/s10867-026-09705-0","url":null,"abstract":"<div><p>Estimation of cell stiffness has assumed significance as their difference in cancer and normal cells is being exploited for diagnostic and therapeutic purposes. However, the cell stiffness values reported (in terms of elastic modulus (E)) are largely varied even within the same cell line, hindering their exploitation. The current study aims to dissect and understand the various parameters resulting in these differences. Based on the analysis of E values reported from 1992 to 2025, it is found that the stiffness of breast cancer cell lines decreases in the order MCF-10A > MCF-7 > MDA-MB-231. The effect of anti-cancer strategies on cell stiffness reveals the important role played by the remodeling of the cytoskeleton. The dual role played by the cytoskeleton in maintaining the required stiffness and deformability in cancer cells based on biological conditions is consistently observed through the analyzed studies. The forest plots synthesized propose that although increasing and decreasing the stiffness of cancer cells is a treatment strategy, more studies focus on decreasing the stiffness of cancer cells to limit metastasis. The trend of variation in cell stiffness urges us to hypothesize the existence of a threshold range for mean stiffness values in cancer cells. The insights obtained can serve as a framework for studies related to the stiffness of breast cancer cells and aid researchers in making meaningful assessments of the obtained E values—a criterion emerging as a major player in cancer diagnosis.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of osmosis, screening charges, and electrical neutrality of nanopores on object translocation 渗透、筛选电荷和纳米孔电中性对物体易位的影响。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-02-21 DOI: 10.1007/s10867-026-09704-1

Mladen I. Glavinović

{"title":"Influence of osmosis, screening charges, and electrical neutrality of nanopores on object translocation","authors":"Mladen I. Glavinović","doi":"10.1007/s10867-026-09704-1","DOIUrl":"10.1007/s10867-026-09704-1","url":null,"abstract":"<div><p>It has been known for a long time that osmosis transfers water from low to high salt concentrations, but few simulation studies have been conducted in confined spaces. This study evaluated the osmotic axial pressure at charged disk surfaces within charged cylindrical nanopores, how osmosis influences other axial pressures, and what controls it. The screening charges on the disk surfaces determine the osmotic axial pressures and critically influence the other axial pressures. External factors (electric field and ion concentrations) and internal (disk and pore wall charges) control the screening charges. The external electric field influenced the Coulomb and dielectric axial pressures more by altering the disk screening charges than by acting directly on the fixed charges. In contrast, the pore wall fixed charges influenced the Coulomb and dielectric axial pressures exclusively by altering the disk screening charges, and their influence extended into the pore center (i.e., well beyond the length of the pore wall diffuse double layer). Both pressures increased near the pore center, especially for larger disks, indicating greater screening charge accumulation around larger disks. The axial osmotic pressure was constant along the disk surface, almost to the tip, and was disk size-independent, owing to the radially constant and disk size-independent screening charges at the disk surfaces. Finally, the axial osmotic pressure at the disk surfaces (with dielectric and fluidic pressures) typically counter-balanced the Coulomb pressure that drives the disk translocation through the nanopore, reducing its speed. The disk translocation direction may reverse at low external ion concentrations.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146775907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2D modeling of micropost-induced flow fields and biofilm adhesion mechanisms: a CA-FEM approach for flow-biofilm interactions in microfluidic channels 微柱诱导流场和生物膜粘附机制的二维建模：微流体通道中流动-生物膜相互作用的CA-FEM方法。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-02-13 DOI: 10.1007/s10867-026-09706-z

Zhiqian Ma, Zheng Zhang, Yangyang Tang, Jiahao Cui, Xiaoling Wang

{"title":"2D modeling of micropost-induced flow fields and biofilm adhesion mechanisms: a CA-FEM approach for flow-biofilm interactions in microfluidic channels","authors":"Zhiqian Ma, Zheng Zhang, Yangyang Tang, Jiahao Cui, Xiaoling Wang","doi":"10.1007/s10867-026-09706-z","DOIUrl":"10.1007/s10867-026-09706-z","url":null,"abstract":"<div><p>Biofilms are widely present in any environment with water and a substrate, posing microbial contamination risks to flow pipelines. This study established a bacterial biofilm flow growth model based on the experimental phenomena of <i>Bacillus subtilis</i> biofilm in microfluidic channels, combining the principles of cellular automata with the finite element method. In the model, the hydrodynamic model was developed using the COMSOL platform to analyze the flow field distribution characteristics induced by micropost. A cellular automata model was developed in MATLAB, innovatively incorporating a flow direction weight algorithm and a filamentous growth mode. The study focused on the attachment behavior of biofilms in microfluidic channels, and simulations of biofilm growth in microfluidic channels with different micropost structures were conducted. The model successfully reproduced key experimental phenomena, such as the attachment and growth of filamentous structures and the aggregation of streamer-like biofilms. By combining real-time flow field analysis with the model, the attachment and growth mechanism of biofilm in the micropillar-flow system was revealed. The spatial arrangement of microposts affects the flow paths of free bacteria by altering streamline distribution. The secondary flow induced by the micropillars promotes bacterial attachment, and its spatial distribution characteristics determine the initial attachment sites of bacteria. This study provides a reference for preventing biofilm formation in flow pipelines and reducing the risk of microbial contamination in similar devices.</p></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electric fields promote exosome secretion and facilitate wound healing in HaCaT cells 电场促进HaCaT细胞外泌体分泌，促进伤口愈合。

IF 2.2 4区生物学

Journal of Biological Physics Pub Date : 2026-02-09 DOI: 10.1007/s10867-025-09700-x

Jiacheng Jiang, Xiaoli Guo, Xue Chen, Sanjun Zhao

{"title":"Electric fields promote exosome secretion and facilitate wound healing in HaCaT cells","authors":"Jiacheng Jiang, Xiaoli Guo, Xue Chen, Sanjun Zhao","doi":"10.1007/s10867-025-09700-x","DOIUrl":"10.1007/s10867-025-09700-x","url":null,"abstract":"<div><p>Exosomes released by epithelial keratinocytes and dermal fibroblasts significantly accelerate wound healing. Moreover, endogenous electric fields (EFs) were demonstrated to promote wound healing by directing the migration of epidermal cells toward the wound center, it is currently unclear whether EFs may facilitate wound healing by regulating the secretion of exosomes in these cells. In this study, we demonstrated that physiological-intensity EFs significantly enhanced exosome secretion from HaCaT cells, with the total protein content of the exosomes increased by approximately 1.5 times higher than that of the control group. Additionally, the exosomes derived from EF-stimulated HaCaT cells accelerated the wound healing rate of HaCaT and HSF cells, and the wound closure rate increased by approximately 20%. Mechanistically, we identified that EFs regulated exosome secretion by influencing the expression of exosome-related proteins—including ALIX and TSG101. Overall, our research results indicate that the electric field is an effective regulatory factor for enhancing exosome secretion and establish a novel high-exosome-producing strategy based on bioelectrics. This may lay the foundation for the translational application of exosomes in wound healing and other fields.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":612,"journal":{"name":"Journal of Biological Physics","volume":"52 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0