中华儿科杂志最新文献

{"title":"[Risk factors for mucus plug formation in pediatric adenovirus pneumonia and construction of a predictive model].","authors":"B Huang, Y F Wang, Y X Zou","doi":"10.3760/cma.j.cn112140-20250722-00673","DOIUrl":"https://doi.org/10.3760/cma.j.cn112140-20250722-00673","url":null,"abstract":"<p><p><b>Objective:</b> To identify risk factors for mucus plug formation and to construct a nomogram-based predictive model in children with adenovirus pneumonia. <b>Methods:</b> In this retrospective cohort study, 149 pediatric patients diagnosed with adenovirus pneumonia were included. All patients underwent bronchoscopy at the Department of Respiratory Tianjin Children's Hospital Machang District, between January and December 2024. Their demographic characteristics, clinical manifestations, laboratory findings, imaging features, and treatment details were analyzed.The information of patients were collected about clinical manifestations, laboratory findings, imaging features, and treatment information. Patients were divided into a mucus plug group and a non-mucus plug group based on bronchoscopic findings. Independent risk factors were determined using multivariable Logistic regression. And a predictive nomogram was subsequently developed. Model performance was evaluated using the area under the receiver operating characteristic curve and the Hosmer-Lemeshow goodness-of-fit test. <b>Results:</b> Of the 149 enrolled patients (84 boys, 65 girls), 49 cases were classified into the mucus plug group and 100 cases into the non-mucus plug group. Compared with their counterparts, children in the mucus plug group were older on admission (<i>P</i><0.05), more likely to have a recent history of lower respiratory tract infection, and exhibited a higher prevalence of consolidation or bronchiolitis patterns on chest imaging (all <i>P</i><0.05), while preoperative corticosteroid use was less frequent (<i>P</i><0.05). Multivariable Logistic regression identified age on admission (<i>OR</i>=1.14, 95%<i>CI</i> 1.01-1.29, <i>P</i>=0.031), lower respiratory tract infection (<i>OR</i>=5.23, 95%<i>CI</i> 2.15-13.56, <i>P</i><0.001), radiographic consolidation (<i>OR</i>=2.64, 95%<i>CI</i> 1.10-6.61, <i>P</i>=0.032), and bronchiolitis pattern (<i>OR</i>=2.39, 95%<i>CI</i> 1.04-5.60, <i>P</i>=0.042) as independent risk factors, whereas pre-bronchoscopy corticosteroid use was a protective factor (<i>OR</i>=0.26, 95%<i>CI</i> 0.10-0.63, <i>P</i>=0.004). The nomogram predictive model demonstrated strong discriminative ability (area under the curve=0.83) and good calibration (Hosmer-Lemeshow <i>P</i>=0.358). <b>Conclusions:</b> The independent risk factors for mucus plug formation include older age, a recent history of lower respiratory tract infection, and chest imaging features of consolidation or bronchiolitis in pediatric adenovirus pneumonia. Pre-bronchoscopy corticosteroid therapy is a protective effect. The developed nomogram demonstrates favorable predictive performance and may facilitate early identification and timely intervention.</p>","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 11","pages":"1212-1217"},"PeriodicalIF":0.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of Rabson-Mendenhall syndrome treated with empagliflozin combined with metformin].","authors":"J L Wang, C Z Xu, J L Wang, X Y Liang, W Wu, K Huang, G P Dong","doi":"10.3760/cma.j.cn112140-20250319-00223","DOIUrl":"10.3760/cma.j.cn112140-20250319-00223","url":null,"abstract":"","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1144-1146"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and genetic characteristics analysis of 18 children with infantile epileptic spasms syndrome associated with mitochondrial gene variants].","authors":"T H Wu, R Li, Z Pan, Z W Zhang, J Peng","doi":"10.3760/cma.j.cn112140-20250706-00587","DOIUrl":"10.3760/cma.j.cn112140-20250706-00587","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the clinical characteristics, genetic features and prognosis of infantile epileptic spasms syndrome (IESS) associated with mitochondrial gene variants. <b>Methods:</b> A case-series study was conducted, including 18 children diagnosed with mitochondrial gene variant-associated IESS at the Department of Pediatrics, Xiangya Hospital of Central South University from June 2016 to June 2025. General data, clinical manifestations, laboratory findings and treatment outcomes were systematically analyzed. <b>Results:</b> Among the 18 children, 11 were boys, 7 were girls, the age of seizure onset was 6 (3, 9) months. Elevated lactate level was found in 7 children. Neuroimaging of magnetic resonance imaging revealed cerebral atrophy in 10 cases, and basal ganglia, thalamic, or midbrain lesions in 3 cases. Genetic testing identified 12 pathogenic genes, including mitochondrial protein synthesis-related genes: AFG3L2 (4 cases), PARS2 (3 cases), RARS2 (1 case), MIPEP (1 case), and PTCD3 (1 case); respiratory chain enzyme complex-related genes: FOXRED1 (2 cases), NDUFS7 (1 case), MT-ND1 (1 case), and MT-ATP6 (1 case); and other mitochondrial-related genes: POLG (1 case), COQ4 (1 case), and PDHA1 (1 case). ACTH or prednisone therapy was administered in 14 children, with 5 achieving spasm control for ≥28 d spasm freedom and resolution of hypsarrhythmia on electroencephalogram. Ketogenic diet therapy was used in 4 children, and effective in 1 case with the PDHA1 gene variant. Fourteen patients exhibited drug-resistant epilepsy requiring ≥2 antiseizure medications. At a follow-up of 3.0 (1.5, 4.3) years, 3 children died. Among 12 children ≥3 years of age, modified Rankin scale (mRS) scores demonstrated 1 case with favorable outcomes (mRS ≤2 score) and 11 with poor outcomes (mRS >2 score). <b>Conclusion</b>s Mitochondrial gene variants in IESS mainly involve mitochondrial respiratory chain enzyme complexes and protein synthesis pathways, typically manifesting as drug-resistant epilepsy with poor prognosis. Elevated lactate levels combined with cerebral atrophy or basal ganglia lesions may aid diagnosis.</p>","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1097-1102"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics analysis of mitochondrial short-chain enoyl-CoA hydratase 1 deficiency with ECHS1 gene c.489G>A compound heterozygous variants].","authors":"Y Liu, T Y Li, J L Wang, C L Xu, M H Song, M T Xu, Z M Liu, F Fang","doi":"10.3760/cma.j.cn112140-20250718-00662","DOIUrl":"10.3760/cma.j.cn112140-20250718-00662","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To summarize the clinical characteristics of children with mitochondrial short-chain enoyl-CoA hydratase-1 deficiency (ECHS1D) caused by c.489G&gt;A (p.Pro163=) compound heterozygous variants in the ECHS1 gene, and to explore genotype-phenotype correlations. &lt;b&gt;Methods:&lt;/b&gt; A case series study was performed to analyze clinical, biochemical, metabolic, imaging, genetic, treatment and follow-up outcomes of 24 children with ECHS1 gene c.489G&gt;A(p.Pro163=) variant, who were diagnosed in the Department of Neurology, Beijing Children's Hospital from July 2010 to June 2024. Disease severity was assessed using the Newcastle Paediatric Mitochondrial Disease Scale, and Fisher exact test was applied to compare the improvement rate between valine-restricted and non-restricted groups. &lt;b&gt;Results:&lt;/b&gt; These 24 children were all diagnosed after 2022, with a disease duration of 3.35 (1.25, 6.52) years at diagnosis. A total of 8 children initially had negative genetic results, and were finally confirmed by abnormal splicing of ECHS1 gene via skin fibroblast RNA sequencing, with the longest diagnostic time of 14 years. All 24 children presented with Leigh syndrome, including 11 boys and 13 girls, with an onset age of 1.46 (0.96, 2.79) years; 16 children (67%) were mild cases. Common initial symptoms included developmental delay (9 cases) and paroxysmal dystonia (9 cases), followed by developmental regression (3 cases), nystagmus (2 cases), and epilepsy (1 case). Main manifestations were dystonia (18 cases), developmental regression (14 cases), nystagmus (12 cases), developmental delay (11 cases), ataxia (10 cases), vision loss (9 cases), seizures (2 cases), and hearing impairment (1 case). Among 22 children who underwent blood and urine metabolic screening, 21 children (95%) had elevated urinary 2, 3-dihydroxy-2-methylbutyric acid and 19 children (86%) had elevated urinary S-(2-hydroxypropyl) cysteamine. All 24 children had symmetric abnormal signals in bilateral globus pallidus on cranial magnetic resonance imaging, 10 children had isolated globus pallidus involvement, and other common involved sites included caudate nucleus and brainstem (9 cases each), putamen (7 cases), and cerebral white matter (5 cases). At last follow-up, all 24 children survived, with a follow-up duration of 5.40 (2.75, 8.02) years and a maximum age of 17.8 years; 17 children (71%) had varying degrees of clinical improvement. There was no statistical difference in the improvement rate between children with or without valine-restricted diet (12/14 &lt;i&gt;vs.&lt;/i&gt; 5/8,&lt;i&gt;P&lt;/i&gt;=0.309). A total of 18 pathogenic variants in the ECHS1 gene were identified among 24 children, 13 of which were distributed in exons 7 and 8; those carrying c.308T&gt;C, c.523G&gt;A, c.796A&gt;G, and c.832G&gt;A variants were mostly severe cases. &lt;b&gt;Conclusions:&lt;/b&gt; Children carrying ECHS1 gene c.489G&gt;A(p.Pro163=) compound heterozygous variants face significant diagnostic delay. Clinical awareness of this synonymous","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1085-1091"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the application of intravenous immunoglobulin in children with autoimmune neurological disorders (2025)].","authors":"","doi":"10.3760/cma.j.cn112140-20250704-00580","DOIUrl":"10.3760/cma.j.cn112140-20250704-00580","url":null,"abstract":"","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1048-1057"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical analysis of anti-GT1a antibody-positive Guillain-Barré syndrome in 25 children].","authors":"D Chen, C Hou, H X Zhu, J Yu, Y N Zhang, K L Zheng, Y Y Gao, X J Li","doi":"10.3760/cma.j.cn112140-20250716-00640","DOIUrl":"10.3760/cma.j.cn112140-20250716-00640","url":null,"abstract":"<p><p><b>Objective:</b> To summarize the clinical characteristics, treatment, and prognosis of children with anti-GT1a antibody-positive Guillain-Barré syndrome (GBS). <b>Methods:</b> A case series study was conducted, including 25 children diagnosed with serum anti-GT1a antibody-positive GBS at Guangzhou Women and Children's Medical Center from March 2019 to December 2024. Clinical data, treatment protocols, and follow-up outcomes were analyzed. Mann Whitney <i>U</i> test was used to compare the changes in Hughes functional grading scale (HFGS). <b>Results:</b> A total of 25 children included 12 boys and 13 girls, and the age at first onset was (71±8) months. There were 16 children (64%) had preceding infections, and of which 13 children had predominantly respiratory tract infections. At disease peak, neurological manifestations included limb weakness (21 cases (84%)), bulbar palsy (13 cases (52%)), drowsiness (7 cases (28%)), limb pain (9 cases (36%)), ataxia (6 cases (24%)), respiratory muscle paralysis (5 cases (20%)), ophthalmoplegia (5 cases (20%)), and unilateral facial nerve palsy (4 cases (16%)). Cerebrospinal fluid analysis in 23 children revealed albuminocytological dissociation in 18 children. All 25 children underwent whole-spine magnetic resonance imaging (MRI), demonstrated spinal nerve root enhancement in 18 children, with leptomeningeal enhancement combined with spinal nerve root enhancement in 1 child. Electromyography in 16 children showed 15 children abnormality, of which demyelinating lesions in 8 children, mixed demyelinating-axonal changes in 4 children, and pure axonal involvement in 3 children. Intravenous immunoglobulin (IVIG) was administered to 21 cases (84%), of which 3 children required mechanical ventilation and blood purification (plasma exchange in 2 children and immunoadsorption in 1 child) due to disease progression. Four children (16%) received intravenous methylprednisolone (IVMP) instead of IVIG, with 1 child requiring ventilatory support due to respiratory muscle paralysis, and the tracheal tube was removed after continued sequential IVMP treatment. The hospitalization duration of 25 children was (23±3) d. At discharge, HFGS was 1.6 (0.6, 2.7) score. At a follow-up of 12 (4, 18) months, HFGS was 0.1 (0.0, 0.5) score, and higher than that at discharge (<i>Z</i>=4.38, <i>P</i><0.05). Two children relapsed but achieved remission after IVIG retreatment with no recurrence during 1-year follow-up. <b>Conclusions:</b> Anti-GT1a antibody-positive GBS in children predominantly presents with limb weakness and bulbar palsy, occasionally complicated by respiratory failure in the acute phase. Demyelinating neuropathy and spinal nerve root enhancement on MRI are characteristic. IVIG therapy yields favorable outcomes, with low residual disability. Relapses are rare but manageable with re-treatment.</p>","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1092-1096"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical observation of enteral nutrition support in pediatric patients after heart transplantation].","authors":"C E Liu, Z Zhao, A H Liu, Y H Chen, Y Hao, X H Yuan, Y Ma, J D Li, C Wu, Y J Zhu, G X Zhou, Z C Feng, X Y Hong","doi":"10.3760/cma.j.cn112140-20250516-00421","DOIUrl":"10.3760/cma.j.cn112140-20250516-00421","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the safety and clinical efficacy of enteral nutrition (EN) initiated within 24 h after heart transplantation in pediatric patients. <b>Methods:</b> A retrospective cohort study was conducted. Clinical data from 16 pediatric heart transplant recipients at the Seventh Medical Center of the Chinese People's Liberation Army General Hospital between October 2022 and October 2024 were collected, including demographics, anthropometric measurements, biochemical markers, cytokine levels, and clinical outcomes. Based on the timing of EN initiation, the patients were divided into EN-initiated within 24 h and EN-initiated after 24 h 2 groups. Demographic data, preoperative extracorporeal membrane oxygenation (ECMO) support, physical examination indicators, laboratory parameters, and cytokine levels were compared between groups using independent samples <i>t</i>-test, Mann-Whitney <i>U</i> test, Fisher's exact probability test. <b>Results:</b> The cohort comprised 16 patients (10 males and 6 females) with an age of (12.5±1.9) years. The EN-initiated within 24 h group comprised 6 cases, and the EN-initiated after 24 h group comprised 10 cases. No significant difference was observed between the two groups in age, preoperative body mass index Z-score, preoperative ECMO support, physical examination indicators, laboratory parameters (total protein, albumin, hemoglobin), or cytokine levels (all <i>P</i>>0.05). Compared to the EN-initiated after 24 h group, the EN-initiated within 24 h group exhibited a shorter intensive care unit stay (<i>t</i>=2.65,<i>P</i><0.05) and shorter mechanical ventilation duration (<i>t</i>=2.23,<i>P</i><0.05) than EN-initiated after 24 h group. Total hospitalization length had no significant difference (<i>P</i>>0.05). At 72 h post-transplant, the EN-initiated within 24 h group had a lower interleukin-12 P70 (<i>t</i>=2.46, <i>P</i><0.05) and interferon-γ levels (<i>t</i>=2.55, <i>P</i><0.05) than EN-initiated after 24 h group. Prior to discharge, the EN-initiated within 24 h group has a lower mean skinfold thickness (<i>t</i>=2.49, <i>P</i><0.05) and lower mid-upper arm circumference (<i>t</i>=2.36, <i>P</i><0.05) compared with the EN-initiated after 24 h group. <b>Conclusions:</b> Initiating EN within 24 h postoperatively is safe and feasible in pediatric heart transplant recipients. Early EN may shorten the length of intensive care unit stay and mechanical ventilation while attenuating postoperative release of inflammatory cytokine.</p>","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1126-1130"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical application and diagnostic value of 3 detection methods for acute pharyngitis of group A <i>Streptococcus</i> in outpatient children].","authors":"Y N Li, C F Gao, T M Chen, M Y Guo, X Y Li, K H Yao, W H Zhang, Y C Li, G Liu","doi":"10.3760/cma.j.cn112140-20250619-00531","DOIUrl":"10.3760/cma.j.cn112140-20250619-00531","url":null,"abstract":"<p><p><b>Objective:</b> Using bacterial culture as the gold standard, to evaluate the agreement of rapid antigen detection test (RADT) and rapid nucleic acid test (RNAT) in diagnosing group A <i>Streptococcus</i> (GAS) pharyngitis in pediatric outpatients, and assess their potential clinical utility. <b>Methods:</b> This cross-sectional study prospectively collected throat swab specimens and clinical data of 338 children diagnosed with acute pharyngitis at the Department of Outpatient Beijing Children's Hospital, Capital Medical University, between July 2023 and February 2024. The specimens were tested for GAS bacterial culture, RADT and RNAT. Using bacterial culture results as the reference standard, Kappa consistency analysis was performed to assess the diagnostic concordance between RADT and RNAT. Chi-square test was used to compare clinical characteristics between cases diagnosed by different methods. <b>Results:</b> In the 338 children diagnosed with pharyngitis, 195 were male and 143 were female, with an age at the visit of 7.4 (5.9, 7.4) years. The positivive rates for GAS detection were 25.7% (87/338) by bacterial culture, 20.7% (70/338) by RADT, and 41.7% (141/338) by RNAT. In terms of diagnostic performance, RADT exhibited a higher specificity (96.8% (243/251)) and better agreement with bacterial culture results (<i>κ</i>=0.73), whereas RNAT showed greater sensitivity (95.4% (83/87)) but lower specificity (76.9% (193/251)) and moderate agreement (<i>κ</i>=0.61). Among the 87 children with positive bacterial culture for GAS, 56 were male and 31 were female, with an age at visit of 7.3 (6.2, 8.8) years. Clinically, body temperature predominantly ranged from 38.1 to 39.0 ℃ in 48 cases (55.2%), and common accompanying symptoms included sore throat 62 cases (71.3%), cough 33 cases (37.9%), and cervical lymphadenopathy or tenderness 16 cases (18.4%). On physical examination, tonsillar enlargement was present in 73 cases (83.9%) and exudate in 37 cases (42.5%). The McIsaac score was most frequently 4 points, observed in 37 cases (42.5%). Laboratory tests showed a peripheral white blood cell (WBC) count of 14.5 (12.3, 18.7)×10⁹/L and C-reactive protein (CRP) concentration of 22.0 (10.1, 41.4) mg/L. There were no statistically significant differences in the proportion of fever, sore throat, cough, tender cervical lymphadenopathy, tonsillar exudates, or tonsillar enlargement, nor in WBC count or CRP, among children who tested positive by RADT, RNAT, or bacterial culture (all <i>P</i>>0.05). <b>Conclusions:</b> Compared with bacterial culture,the RADT demonstrates higher specificity, while the RNAT exhibits greater sensitivity. Both methods show good concordance with culture results and may serve as effective adjunctive tools for the early screening of GAS pharyngitis.</p>","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1103-1109"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The predictive value of very low frequency power for the efficacy of vitamin D treatment in children with postural orthostatic tachycardia syndrome].","authors":"T Dong, J Wang, W X Wu, Y Wang, S M Niu, X J Yan, L Min, H T Meng, X Y Dong","doi":"10.3760/cma.j.cn112140-20241114-00831","DOIUrl":"10.3760/cma.j.cn112140-20241114-00831","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the predictive value of very low frequency (VLF) for the efficacy of vitamin D treatment in children with postural orthostatic tachycardia syndrome (POTS). &lt;b&gt;Methods:&lt;/b&gt; A retrospective case-control study was conducted. A total of 65 POTS children from the Department of Pediatrics of the Second Hospital of Lanzhou University from November 2023 to May 2024 were selected as the research subjects, while 102 healthy children from the same period were selected as the control group. The 25 (OH) D levels between POTS children and healthy children were compared. The frequency of eight main symptoms, including palpitations, headache, cold sweat, blurred vision, chest tightness, dizziness, fainting, and digestive discomfort in the POTS group were analyzed, the symptom scores of the orthostatic intolerance were calculated, and the parameters related to short-range heart rate variability (HRV) during the upright test, head-up tilt test (HUTT) were collected. The correlation between 25 (OH) D levels and symptom scores of orthostatic intolerance symptoms and HRV parameters in children with POTS were analyzed by Pearson correlation analysis. The total symptom scores of children with POTS were compared for 3 months before treatment and 2 months after treatment with vitamin D 800 U/d. The difference in score before and after treatment was ≥2 as responsive group, and the score difference before and after treatment was &lt;2 as non-responsive group. The demographic characteristics including age, gender, height, weight, body mass index, as well as HRV parameters such as the standard deviation of nn intervals (SDNN), the standard deviation of the average NN intervals (SDANN), the root mean square of successive differences (rMSSD), low-frequency (LF), high-frequency (HF), very-low-frequency (VLF) were compared between the responsive group and non-responsive group. Multivariate Logistic regression was analyzed to screen independent influencing factors of vitamin D treatment efficacy for POTS. The marker molecules related to the efficacy of vitamin D treatment in children with POTS were analyzed through receiver operating characteristic (ROC) curve. &lt;b&gt;Results:&lt;/b&gt; A total of 167 children were included in this study. There were 65 children in the POTS group, 38 males and 27 females, with the age of (10.6±2.2) years. There were 102 healthy children in the control group, 53 males and 49 females, with the age of (11.2±1.8) years.There was no statistically significant difference in gender and age between the two groups (both &lt;i&gt;P&lt;/i&gt;&gt;0.05). The serum 25 (OH) D level in children in the POTS group was (37±18)nmol/L, lower than that in the control group (61±17)nmol/L (&lt;i&gt;P&lt;/i&gt;&lt;0.05).Pearson correlation analysis showed that serum 25(OH)D was positively correlated with VLF, SDNN and HF (&lt;i&gt;r&lt;/i&gt;=0.43, 0.65, 0.36, respectively, all &lt;i&gt;P&lt;/i&gt;&lt;0.05). Among the POTS children, there were 48 cases in responsive group and 17 cases in non-responsive grou","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1115-1120"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the involvement of probiotics in the neurodevelopment of preterm infants by regulating the microbiome-gut-brain axis].","authors":"X Y Zhao, M Y Liu, K H Lin, Y X Xiao, Y Xing","doi":"10.3760/cma.j.cn112140-20250603-00471","DOIUrl":"10.3760/cma.j.cn112140-20250603-00471","url":null,"abstract":"","PeriodicalId":60813,"journal":{"name":"中华儿科杂志","volume":"63 10","pages":"1152-1155"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}