生物物理学报:英文版最新文献_第9页

The prototypes of nanozyme-based nanorobots 基于纳米酶的纳米机器人原型

生物物理学报:英文版 Pub Date : 2020-11-20 DOI: 10.1007/s41048-020-00125-8

Jiaying Xie, Yiliang Jin, Kelong Fan, Xiyun Yan

引用次数: 6

Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy. 刺激反应高分子纳米材料用于类风湿关节炎治疗。

生物物理学报:英文版 Pub Date : 2020-10-31 DOI: 10.1007/s41048-020-00117-8

Yingsi Xie, Ruslan G Tuguntaev, Cong Mao, Haoting Chen, Ying Tao, Shixiang Wang, Bin Yang, Weisheng Guo

{"title":"Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy.","authors":"Yingsi Xie, Ruslan G Tuguntaev, Cong Mao, Haoting Chen, Ying Tao, Shixiang Wang, Bin Yang, Weisheng Guo","doi":"10.1007/s41048-020-00117-8","DOIUrl":"https://doi.org/10.1007/s41048-020-00117-8","url":null,"abstract":"Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41048-020-00117-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

An efficient autometallography approach to localize lead at ultra-structural levels of cultured cells. 一种有效的自动金相法在培养细胞的超结构水平定位铅。

生物物理学报:英文版 Pub Date : 2020-10-31 DOI: 10.1007/s41048-020-00116-9

Han Song, Gang Zheng, Xue-Feng Shen, Zai-Hua Zhao, Yang Liu, Yang Liu, Ying-Ying Liu, Jun-Jun Kang, Jing-Yuan Chen, Wen-Jing Luo

{"title":"An efficient autometallography approach to localize lead at ultra-structural levels of cultured cells.","authors":"Han Song, Gang Zheng, Xue-Feng Shen, Zai-Hua Zhao, Yang Liu, Yang Liu, Ying-Ying Liu, Jun-Jun Kang, Jing-Yuan Chen, Wen-Jing Luo","doi":"10.1007/s41048-020-00116-9","DOIUrl":"https://doi.org/10.1007/s41048-020-00116-9","url":null,"abstract":"Understanding the precise intracellular localization of lead (Pb) is a key in deciphering processes in Pb-induced toxicology. However, it is a great challenge to trace Pb in vitro, especially in cultured cells. We aimed to find an innovative and efficient approach to investigate distribution of Pb in cells and to validate it through determining the subcellular Pb content. We identified its ultra-structural distribution with autometallography under electron microscopy in a choroidal epithelial Z310 cell line. Electron microscopy in combination with energy-dispersive X-ray spectroscope (EDS) was employed to provide further evidence of Pb location. In addition, Pb content was determined in the cytosol, membrane/organelle, nucleus and cytoskeleton fractions with atomic absorption spectroscopy. Pb was found predominantly inside the nuclear membranes and some was distributed in the cytoplasm under low-concentration exposure. Nuclear existence of Pb was verified by EDS under electron microscopy. Once standardized for protein content, Pb percentage in the nucleus fraction reached the highest level (76%). Our results indicate that Pb is accumulated mainly in the nucleus of choroid plexus. This method is sensitive and precise in providing optimal means to study the ultra-structural localization of Pb for in vitro models. In addition, it offers the possibility of localization of other metals in cultured cells. Some procedures may also be adopted to detect target proteins via immunoreactions.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41048-020-00116-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct structural evidence supporting a revolving mechanism in DNA packaging motors. 支持DNA包装马达旋转机制的直接结构证据。

生物物理学报:英文版 Pub Date : 2020-10-31 DOI: 10.1007/s41048-020-00115-w

Yao-Gen Shu, Xiaolin Cheng

引用次数: 1

Biofriendly micro/nanomotors operating on biocatalysis: from natural to biological environments. 基于生物催化的生物友好微/纳米马达:从自然环境到生物环境。

生物物理学报:英文版 Pub Date : 2020-10-31 DOI: 10.1007/s41048-020-00119-6

Ziyi Guo, Jian Liu, Da-Wei Wang, Jiangtao Xu, Kang Liang

{"title":"Biofriendly micro/nanomotors operating on biocatalysis: from natural to biological environments.","authors":"Ziyi Guo, Jian Liu, Da-Wei Wang, Jiangtao Xu, Kang Liang","doi":"10.1007/s41048-020-00119-6","DOIUrl":"https://doi.org/10.1007/s41048-020-00119-6","url":null,"abstract":"Micro/nanomotors (MNMs) are tiny motorized objects that can autonomously navigate in complex fluidic environments under the influence of an appropriate source of energy. Internal energy driven MNMs are composed of certain reactive materials that are capable of converting chemical energy from the surroundings into kinetic energy. Recent advances in smart nanomaterials design and processing have endowed the internal energy driven MNMs with different geometrical designs and various mechanisms of locomotion, with remarkable travelling speed in diverse environments ranging from environmental water to complex body fluids. Among the different design principals, MNM systems that operate from biocatalysis possess biofriendly components, efficient energy conversion, and mild working condition, exhibiting a potential of stepping out of the proof-of-concept phase for addressing many real-life environmental and biotechnological challenges. The biofriendliness of MNMs should not only be considered for in vivo drug delivery but also for environmental remediation and chemical sensing that only environmentally friendly intermediates and degraded products are generated. This review aims to provide an overview of the recent advances in biofriendly MNM design using biocatalysis as the predominant driving force, towards practical applications in biotechnology and environmental technology.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s41048-020-00119-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Recent endeavors on molecular imaging for mapping metals in biology. 分子成像在金属分子生物学定位中的研究进展。

生物物理学报:英文版 Pub Date : 2020-10-31 DOI: 10.1007/s41048-020-00118-7

Jing Gao, Yuncong Chen, Zijian Guo, Weijiang He

引用次数: 5

Measurement of viscoelastic properties of injured mouse brain after controlled cortical impact 控制性皮质冲击后损伤小鼠脑粘弹性的测定

生物物理学报:英文版 Pub Date : 2020-08-01 DOI: 10.1007/s41048-020-00110-1

Yu Chen, Suhao Qiu, Cheng Wang, Xiaowei Li, Yaohui Tang, Yuan Feng

引用次数: 8

“At last in” the physiological roles of the tubular ER network “最后在”管状内质网的生理作用

生物物理学报:英文版 Pub Date : 2020-08-01 DOI: 10.1007/s41048-020-00113-y

Li Lü, L. Niu, Junjie Hu