生物物理学报:英文版 Pub Date : 2023-06-30 DOI: 10.52601/bpr.2023.220018

Qi Long, Yanshuang Zhou, Jingyi Guo, Hao Wu, Xingguo Liu

引用次数: 1

Synergistic glycolysis disturbance for cancer therapy by a MOF-based nanospoiler. 基于mof的纳米扰流剂治疗肿瘤的协同糖酵解干扰。

生物物理学报:英文版 Pub Date : 2023-06-30 DOI: 10.52601/bpr.2023.230003

Xuemei Zeng, Yihang Ruan, Lun Wang, Jinpeng Deng, Shuangqian Yan

{"title":"Synergistic glycolysis disturbance for cancer therapy by a MOF-based nanospoiler.","authors":"Xuemei Zeng, Yihang Ruan, Lun Wang, Jinpeng Deng, Shuangqian Yan","doi":"10.52601/bpr.2023.230003","DOIUrl":"10.52601/bpr.2023.230003","url":null,"abstract":"Increased glycolysis for promoting adenosine triphosphate (ATP) generation is one of the hallmarks of cancer. Although reducing glucose intake or depriving cellular glucose can delay the growth of tumors to some extent, their therapeutic efficacy is a highly needed improvement for clinical translation. Herein, we found that mannose synergistic with glucose oxidase (GOx) can induce cell death by ATP inhibition, autophagy activation, and apoptosis protein upgradation. By using biodegradable zeolitic imidazolate frameworks (ZIF-8) as a nanocarrier (denoted as ZIF-8/M&G), the mannose and GOx can accumulate at the tumor site while having no obvious long-term toxicity. At the tumor site, GOx inhibits glycolysis by converting glucose and oxygen to H 2O 2 and gluconic acid, realizing oxidation therapy and expediting the degradation of the pH-responsive ZIF-8 nanoparticles, respectively. Simultaneously, mannose disturbs sugar metabolism and reduces oxygen consumption, which in turn promotes the GOx oxidation process. The concerted glycolysis inhibition through interactions between mannose and GOx endows ZIF-8/M&G nanospolier with excellent therapeutic efficacy both in vitro and in vivo. Synergistic glycolysis disturbance by the designed nanospoiler in this work proposes a versatile approach for metabolism disturbance to tumor treatment.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":"1 1","pages":"134-145"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

M6A RNA methylation modification and tumor immune microenvironment in lung adenocarcinoma. 肺腺癌中M6A RNA甲基化修饰与肿瘤免疫微环境的关系

生物物理学报:英文版 Pub Date : 2023-06-30 DOI: 10.52601/bpr.2023.220020

Shujuan Li, Qianzhong Li, Luqiang Zhang, Yechen Qi, Hui Bai

{"title":"M6A RNA methylation modification and tumor immune microenvironment in lung adenocarcinoma.","authors":"Shujuan Li, Qianzhong Li, Luqiang Zhang, Yechen Qi, Hui Bai","doi":"10.52601/bpr.2023.220020","DOIUrl":"10.52601/bpr.2023.220020","url":null,"abstract":"Lung adenocarcinoma is one of the deadliest tumors. Studies have shown that N6-methyladenosine RNA methylation regulators, as a dynamic chemical modification, affect the occurrence and development of lung adenocarcinoma. To investigate the relationship between mutations and expression levels of m6A regulators in lung adenocarcinoma, we investigated the mutations and expression levels of 38 m6A regulators. We found that mutations in m6A regulatory factors did not affect the changes in expression levels, and 19 differentially expressed genes were identified. All tumor samples were classified into two subtypes based on the expression levels of 19 differentially expressed m6A-regulated genes. Survival analysis showed significant differences in survival between the two subtypes. To explore the relationship between immune cell infiltration and survival in both subtypes, we calculated the infiltration of 23 immune cells in both subtypes, and we found that the subtype with high immune cell infiltration had better survival. We found that subtypes with low tumor purity and high stromal and immune scores had better survival. The m6A-related immune genes were identified by taking the intersection of differentially expressed genes and immune genes in the two isoforms and calculating the Pearson correlation coefficients between the intersecting immune genes and the differentially expressed m6A-regulated genes. Finally, a prognostic model associated with m6A and associated with immunity was developed using prognostic genes screened from m6A-associated immune genes. The predictive power of the model was evaluated and our model was able to achieve good prediction.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":"1 1","pages":"146-158"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70713013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GNA12 regulates C5a-induced migration by downregulating C5aR1-PLCβ2-PI3K-AKT-ERK1/2 signaling. GNA12通过下调c5ar1 - plc - β2- pi3k - akt - erk1 /2信号通路调控c5a诱导的迁移。

生物物理学报:英文版 Pub Date : 2023-02-28 DOI: 10.52601/bpr.2023.230001

Haonan Yu, Zhihua Liu

引用次数: 0

(Tn5-)FISH-based imaging in the era of 3D/spatial genomics. (Tn5-) 3D/空间基因组学时代基于fish的成像。

生物物理学报:英文版 Pub Date : 2023-02-28 DOI: 10.52601/bpr.2023.220025

Liheng Yang, Yan Yan, JunLin Li, Cheng Zhou, Jinlan Jin, Tongmei Zhang, Haokaifeng Wu, Xingang Li, Wei Wang, Li Yuan, Xu Zhang, Juntao Gao

{"title":"(Tn5-)FISH-based imaging in the era of 3D/spatial genomics.","authors":"Liheng Yang, Yan Yan, JunLin Li, Cheng Zhou, Jinlan Jin, Tongmei Zhang, Haokaifeng Wu, Xingang Li, Wei Wang, Li Yuan, Xu Zhang, Juntao Gao","doi":"10.52601/bpr.2023.220025","DOIUrl":"https://doi.org/10.52601/bpr.2023.220025","url":null,"abstract":"3D genomics mainly focuses on the 3D position of single genes at the cell level, while spatial genomics focuses more on the tissue level. In this exciting new era of 3D/spatial genomics, half-century old FISH and its derivative methods, including Tn5-FISH, play important roles. In this review, we introduce the Tn5-FISH we developed recently, and present six different applications published by our collaborators and us, based on (Tn5-)FISH, which can be either general BAC clone-based FISH or Tn5-FISH. In these interesting cases, (Tn5-)FISH demonstrated its vigorous ability of targeting sub-chromosomal structures across different diseases and cell lines (leukemia, mESCs (mouse embryonic stem cells), and differentiation cell lines). Serving as an effective tool to image genomic structures at the kilobase level, Tn5-FISH holds great potential to detect chromosomal structures in a high-throughput manner, thus bringing the dawn for new discoveries in the great era of 3D/spatial genomics.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":"9 1","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9866251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant activity of the thioredoxin system. 硫氧还蛋白系统的抗氧化活性。

生物物理学报:英文版 Pub Date : 2023-02-28 DOI: 10.52601/bpr.2023.230002

Zihua Liu

引用次数: 1

The risk model construction of the genes regulated by H3K36me3 and H3K79me2 in breast cancer. H3K36me3和H3K79me2调控基因在乳腺癌中的风险模型构建。

生物物理学报:英文版 Pub Date : 2023-02-28 DOI: 10.52601/bpr.2023.220022

Ling-Yu Wang, Lu-Qiang Zhang, Qian-Zhong Li, Hui Bai

{"title":"The risk model construction of the genes regulated by H3K36me3 and H3K79me2 in breast cancer.","authors":"Ling-Yu Wang, Lu-Qiang Zhang, Qian-Zhong Li, Hui Bai","doi":"10.52601/bpr.2023.220022","DOIUrl":"https://doi.org/10.52601/bpr.2023.220022","url":null,"abstract":"Abnormal histone modifications (HMs) can promote the occurrence of breast cancer. To elucidate the relationship between HMs and gene expression, we analyzed HM binding patterns and calculated their signal changes between breast tumor cells and normal cells. On this basis, the influences of HM signal changes on the expression changes of breast cancer-related genes were estimated by three different methods. The results showed that H3K79me2 and H3K36me3 may contribute more to gene expression changes. Subsequently, 2109 genes with differential H3K79me2 or H3K36me3 levels during cancerogenesis were identified by the Shannon entropy and submitted to perform functional enrichment analyses. Enrichment analyses displayed that these genes were involved in pathways in cancer, human papillomavirus infection, and viral carcinogenesis. Univariate Cox, LASSO, and multivariate Cox regression analyses were then adopted, and nine potential breast cancer-related driver genes were extracted from the genes with differential H3K79me2/H3K36me3 levels in the TCGA cohort. To facilitate the application, the expression levels of nine driver genes were transformed into a risk score model, and its robustness was tested via time-dependent receiver operating characteristic curves in the TCGA dataset and an independent GEO dataset. At last, the distribution levels of H3K79me2 and H3K36me3 in the nine driver genes were reanalyzed in the two cell lines and the regions with significant signal changes were located.","PeriodicalId":59621,"journal":{"name":"生物物理学报:英文版","volume":"9 1","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9807813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep condolences to Professor Fuyu Yang 向杨福玉教授表示深切哀悼

生物物理学报:英文版 Pub Date : 2023-02-28 DOI: 10.52601/bpr.2023.230901

Editorial Office of Pharmacological Reports

引用次数: 0

Measurement of ATGL activity using adiposomes. 使用脂肪体测量ATGL活性。

生物物理学报:英文版 Pub Date : 2023-02-28 DOI: 10.52601/bpr.2023.220016

Xuejing Ma, Zelun Zhi, Shuyan Zhang, Pingsheng Liu

引用次数: 0

Deep condolences to Professor Fuyu Yang 向杨福玉教授表示深切哀悼

生物物理学报:英文版 Pub Date : 2023-01-01 DOI: 10.52601/bpr.2022.230901

Editorial Board of Biophysics Reports

引用次数: 0

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