国际放射医学核医学杂志最新文献

{"title":"Application of lead screen in PET-enhanced CT scanning and radiation analysis on operator","authors":"Z. Meng, Chen Shirong, Cheng Zhuzhong, Xiao Dingqiong, Lu Hao, Jiang Xiao, Wang Xiaoxiong","doi":"10.3760/CMA.J.ISSN.1673-4114.2017.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4114.2017.01.006","url":null,"abstract":"Objective \u0000To analyze the dose and the duration that medical staff can take during operation with or without lead screen protection in PET-enhanced CT and to evaluate the practical application value of lead screen on radioprotection. \u0000 \u0000 \u0000Methods \u0000According to a certain set of conditions, 40 patients were selected, and randomly and equally divided into experimental group (with lead screen protection) and control group (without lead screen protection) . A personal meter was used to measure personal radiation rate and cumulative dose equivalent. The time required for the operator was recorded. The analysis of these statistics adopted t-text by SPSS17.0 and conclusion on the radiation dose and operation convenience was drawn. \u0000 \u0000 \u0000Results \u0000The average dose equivalent rate and the median dose equivalent rate of the operator group was remarkably less than that of the control group (t=3.390, 3.392, both P<0.05) . On the average cumulative dose equivalent and the median cumulative dose equivalent, the value for the experimental group was also less than that for the control group (t=1.182, 1.182, both P<0.05) . The more the operator used the lead screen, the shorter the time could take. So the time the experimental group took was decreased with the increasing proficiency, and the time was closed to the control group. \u0000 \u0000 \u0000Conclusions \u0000When using lead screen, the radiation equivalent rate of operation personnel was low. The cumulative dose equivalent decreased, and all such changes were due to the time used in the operation. Lead screen exhibited its practical application value on radioprotection. \u0000 \u0000 \u0000Key words: \u0000Positron-emission tomography; Tomography, X-ray computed; Radiation dosage; Radiation protection","PeriodicalId":59545,"journal":{"name":"国际放射医学核医学杂志","volume":"41 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2017-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44652426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of dynamic contrast-enhanced magnetic resonance imaging in early-phase clinical trials of antivascular medicine for malignant tumors","authors":"Lin Xiaoyang, T. Ye","doi":"10.3760/CMA.J.ISSN.1673-4114.2014.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4114.2014.05.008","url":null,"abstract":"The development and research of antivascular medicine has already exerted challenges for traditional clinical trials and its evaluation system. Dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI）, as an uninvasive method to visualize and assess vascular structure and function, has been gradually utilized in clinical trials of antivascular medicine and improving stepwise with a view to further detecting angiogenesis of tumor and effects of medicine. This review will articulate on defects of traditional evaluation system in clinical trials of antivascular medicine, technological characteristics of DCE-MRI as well as pros and cons of its application in clinical trials. The detailed utilization of DCE-MRI in some early phase clinical trials during recent years will also be orchestrated in this review. \u0000 \u0000Key words: \u0000Magnetic resonance imaging; Dynamic contrast-enhanced; Tumors; Antivasculra therapy; Drug evaluation","PeriodicalId":59545,"journal":{"name":"国际放射医学核医学杂志","volume":"38 1","pages":"309-314"},"PeriodicalIF":0.0,"publicationDate":"2014-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70099063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum FPSA/TPSA and hormone determination combinded with nuclide bone imaging in diagnosis of prostate carcinoma and its recidivation and metastasis","authors":"Hu Chenggang, Chen Xiaoyan, Ma Chun-qing, Wang Junhong, Su Li, Deng Yan, Niu Wenqiang","doi":"10.3760/CMA.J.ISSN.1673-4114.2010.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4114.2010.06.005","url":null,"abstract":"Objective To evaluate the clinical value of free prostate antigen (FPSA) , total prostate specific antigen (TPSA) , FPSA / TPSA and serum hormones (PRL, FSH, LH, Prog, T, E2) combined with ECT bone imaging in patients with prostate carcinoma. Methods 44 healthy males, 75 patients of benign prostate disease (including 41 of benign prostatic hyperplasia (BPH) and 25 of HBP with acute urinary retention (BPH + AUR) surgery, 9 of acute prostatitis) , and 48 patients with prostate carcinoma were enrolled in this study. Their Gonadal hormones and TPSA, FPSA, FPSA / TPSA were measured. Results ①The level of TPSA and FPSA in patients with prostate carcinoma or benign prostate disease were significantly higher than in healthy control (t1=11.42, t2=12.01, P 0.05); ④he FSH and LH of gonadal hormones in patients with prostate carcinoma were obviously higher than in patients with benign prostate diseases and healthy control.鈶?Except patients having operation total correction, the gonadal hormones and FSH/LH, T in patients with prostate carcinoma having different treatment programs all had variances before and after therapy; ⑤TPSA and FPSA in patients with prostate carcinoma having bone metastasis were much higher than those without bone metastasis (t/TPSA=5.38, t/fpsA=4.26, P 0.05). Conclusion here was great clinlical value of the determination of TPSA and FPSA in diagnosis of prostate carcinoma, identification of prostate carcinoma and benign prostate disease and in judgment of bone metastasis. The ratio of FPSA /TPSA <0.16 is a proper prediction index for diagnosis of prostate carcinoma, FPSA /TPSA might be <0.16 in healthy ones and patients with acute prostatitis or BPH ; but when FPSA / TPSA <0.16, the risk of prostate cancer would increase; Gonadal hormones is useful biomarkers in diagnosis and treatment in patients with prostate carcinoma. \u0000 \u0000Key words: \u0000Prostatic neoplasms; Prostate specific antigen Gonadal hormones; Techmetium Tc 99m Medronate","PeriodicalId":59545,"journal":{"name":"国际放射医学核医学杂志","volume":"34 1","pages":"337-343"},"PeriodicalIF":0.0,"publicationDate":"2010-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70099054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical value of 99 Tc m -N-NOET exercise and delayed myocardial perfusion imaging in patients with hypertension","authors":"Wei Hua, L. Sijin, L. Jianzhong, Wu Zhifang, Liu Haiyan, Hu Guang, Wang Jin, Li Qing","doi":"10.3760/CMA.J.ISSN.1673-4114.2010.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4114.2010.01.006","url":null,"abstract":"Objective To investigate clinical significance of the 99Tcm-bis (N-ethoxy-N-ethyl-dithiocarbamato) nitridotechnetium(99Tcm-N-NOET) exercise and delayed myocardial perfusion imaging (MPI) in hypertensive patients. Methods Sixty patients with hypertension and 19 normal subjects were carried out 99Tcm-N-NOET exercise and delayed MPI, and analyzed the results of MPI, exercise electrocardiography (ECG), cardiac function parameters end-diastolic volume(EDV), end-systolic volume(ESV), left ventricular ejection fraction(LVEF), △ LVEF (LV EF exercis-LVEF delay) and coronary angiography(CAG). Results ① Sixty patients with hypertension, 22 cases(36.7%)of exercise ECG were abnormal, 16 cases (26.7%)were the chest tightness in exercise, 13 cases (21.7%) were blood pressure excessive reaction in exercise; control group, 2 cases (10.5%) of exercise ECG were abnormal, 1 case (5.3%, 1/19) was chest tightness in exercise,no per-son was blood pressure response in excessive. ②The positive rate of myocardial perfusion in hyper tensive group was significantly higher than the control group (31.75％ vs.5.30％, P 0.05), △ LVEF 0.05). The sensitivity,specificity and accuracy of 99Tcm-N-NOET MPI were 72.7％, 87.5％ and 78.9％. Conclusions ①99Tcm-N-NOET exercise and delayed MPI can diagnose whether hypertension patients with myocardial ischemia or not. ② △ LVEF of hypertensive patients reduced, △ LVEF is lower in hypertensive patients of MPI-positive. \u0000 \u0000Key words: \u0000Hypertension; Myocardial perfusion imaging; 99Tcm-bis(N-ethoxy-N-ethyl-dithiocarbamato)nitridotechnetium","PeriodicalId":59545,"journal":{"name":"国际放射医学核医学杂志","volume":"34 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2010-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70099019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal transduction pathway mediated by integrin and tumor radiosensitivity","authors":"J. Yizun","doi":"10.3760/CMA.J.ISSN.1673-4114.2006.04.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4114.2006.04.015","url":null,"abstract":"Integrins are a group of significant cell adhesion molecules and participate in the regulation of critical functions through cellular signal trusduction, including cell adhesion, migration, proliferation, differentiation, and so on. The integrin-mediated signaling, meanwhile, may activate a variety of protein kinases after ionizing radiation, and then form different intracellular signal pathways in order to regulate the expression of gene. As consequence, these signal pathways induce the reduction of the radiosensitivity of tumor cells for survival event. To understand integrin-mediated signal trasduciton, therefore, has the vital influence on the study of radiosensitizer and radiotherapy.","PeriodicalId":59545,"journal":{"name":"国际放射医学核医学杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70099013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}