Wei Hua, L. Sijin, L. Jianzhong, Wu Zhifang, Liu Haiyan, Hu Guang, Wang Jin, Li Qing
{"title":"The clinical value of 99 Tc m -N-NOET exercise and delayed myocardial perfusion imaging in patients with hypertension","authors":"Wei Hua, L. Sijin, L. Jianzhong, Wu Zhifang, Liu Haiyan, Hu Guang, Wang Jin, Li Qing","doi":"10.3760/CMA.J.ISSN.1673-4114.2010.01.006","DOIUrl":null,"url":null,"abstract":"Objective To investigate clinical significance of the 99Tcm-bis (N-ethoxy-N-ethyl-dithiocarbamato) nitridotechnetium(99Tcm-N-NOET) exercise and delayed myocardial perfusion imaging (MPI) in hypertensive patients. Methods Sixty patients with hypertension and 19 normal subjects were carried out 99Tcm-N-NOET exercise and delayed MPI, and analyzed the results of MPI, exercise electrocardiography (ECG), cardiac function parameters end-diastolic volume(EDV), end-systolic volume(ESV), left ventricular ejection fraction(LVEF), △ LVEF (LV EF exercis-LVEF delay) and coronary angiography(CAG). Results ① Sixty patients with hypertension, 22 cases(36.7%)of exercise ECG were abnormal, 16 cases (26.7%)were the chest tightness in exercise, 13 cases (21.7%) were blood pressure excessive reaction in exercise; control group, 2 cases (10.5%) of exercise ECG were abnormal, 1 case (5.3%, 1/19) was chest tightness in exercise,no per-son was blood pressure response in excessive. ②The positive rate of myocardial perfusion in hyper tensive group was significantly higher than the control group (31.75% vs.5.30%, P 0.05), △ LVEF 0.05). The sensitivity,specificity and accuracy of 99Tcm-N-NOET MPI were 72.7%, 87.5% and 78.9%. Conclusions ①99Tcm-N-NOET exercise and delayed MPI can diagnose whether hypertension patients with myocardial ischemia or not. ② △ LVEF of hypertensive patients reduced, △ LVEF is lower in hypertensive patients of MPI-positive. \n \nKey words: \nHypertension; Myocardial perfusion imaging; 99Tcm-bis(N-ethoxy-N-ethyl-dithiocarbamato)nitridotechnetium","PeriodicalId":59545,"journal":{"name":"国际放射医学核医学杂志","volume":"34 1","pages":"23-26"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际放射医学核医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4114.2010.01.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Objective To investigate clinical significance of the 99Tcm-bis (N-ethoxy-N-ethyl-dithiocarbamato) nitridotechnetium(99Tcm-N-NOET) exercise and delayed myocardial perfusion imaging (MPI) in hypertensive patients. Methods Sixty patients with hypertension and 19 normal subjects were carried out 99Tcm-N-NOET exercise and delayed MPI, and analyzed the results of MPI, exercise electrocardiography (ECG), cardiac function parameters end-diastolic volume(EDV), end-systolic volume(ESV), left ventricular ejection fraction(LVEF), △ LVEF (LV EF exercis-LVEF delay) and coronary angiography(CAG). Results ① Sixty patients with hypertension, 22 cases(36.7%)of exercise ECG were abnormal, 16 cases (26.7%)were the chest tightness in exercise, 13 cases (21.7%) were blood pressure excessive reaction in exercise; control group, 2 cases (10.5%) of exercise ECG were abnormal, 1 case (5.3%, 1/19) was chest tightness in exercise,no per-son was blood pressure response in excessive. ②The positive rate of myocardial perfusion in hyper tensive group was significantly higher than the control group (31.75% vs.5.30%, P 0.05), △ LVEF 0.05). The sensitivity,specificity and accuracy of 99Tcm-N-NOET MPI were 72.7%, 87.5% and 78.9%. Conclusions ①99Tcm-N-NOET exercise and delayed MPI can diagnose whether hypertension patients with myocardial ischemia or not. ② △ LVEF of hypertensive patients reduced, △ LVEF is lower in hypertensive patients of MPI-positive.
Key words:
Hypertension; Myocardial perfusion imaging; 99Tcm-bis(N-ethoxy-N-ethyl-dithiocarbamato)nitridotechnetium
目的探讨99tcm -二(n -乙氧基- n -乙基-二硫代氨基甲氧基)氮锝(99Tcm-N-NOET)运动与高血压患者延迟心肌灌注显像(MPI)的临床意义。方法对60例高血压患者和19例正常人进行99cm - n - noet运动和延迟MPI,分析MPI、运动心电图(ECG)、心功能参数舒张末容积(EDV)、收缩末容积(ESV)、左室射血分数(LVEF)、△LVEF (LVEF运动-LVEF延迟)和冠状动脉造影(CAG)结果。结果①60例高血压患者中,运动心电图异常22例(36.7%),运动时胸闷16例(26.7%),运动时血压过度反应13例(21.7%);对照组2例(10.5%)运动心电图异常,1例(5.3%,1/19)运动时胸闷,无一例血压过高反应。②高血压组心肌灌注阳性率显著高于对照组(31.75% vs 5.30%, P < 0.05),△LVEF < 0.05)。99Tcm-N-NOET MPI的敏感性、特异性和准确性分别为72.7%、87.5%和78.9%。结论①99Tcm-N-NOET运动和延迟MPI可诊断高血压患者是否心肌缺血。②高血压患者LVEF降低,mpi阳性高血压患者LVEF较低。关键词:高血压;心肌灌注显像;99年tcm-bis nitridotechnetium (N-ethoxy-N-ethyl-dithiocarbamato)