The application of dynamic contrast-enhanced magnetic resonance imaging in early-phase clinical trials of antivascular medicine for malignant tumors

Abstract

The development and research of antivascular medicine has already exerted challenges for traditional clinical trials and its evaluation system. Dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI）, as an uninvasive method to visualize and assess vascular structure and function, has been gradually utilized in clinical trials of antivascular medicine and improving stepwise with a view to further detecting angiogenesis of tumor and effects of medicine. This review will articulate on defects of traditional evaluation system in clinical trials of antivascular medicine, technological characteristics of DCE-MRI as well as pros and cons of its application in clinical trials. The detailed utilization of DCE-MRI in some early phase clinical trials during recent years will also be orchestrated in this review. Key words: Magnetic resonance imaging; Dynamic contrast-enhanced; Tumors; Antivasculra therapy; Drug evaluation