生物化学进展(英文)最新文献_第7页

The Pharmacological Effects of Triterpenoids from Ganoderma lucidum and the Regulation of Its Biosynthesis 灵芝三萜类化合物的药理作用及其生物合成调控

生物化学进展(英文) Pub Date : 2020-04-23 DOI: 10.4236/abc.2020.102005

Si-yue Chen

引用次数: 6

Syntheses of Coordination Compounds of (±)-2-Amino-3-(4-Hydroxyphenyl)Propionic Acid, Mixed Ligand Complexes and Their Biological Activities (±)-2-氨基-3-(4-羟基苯基)丙酸配位化合物、混合配体配合物的合成及其生物活性

生物化学进展(英文) Pub Date : 2020-03-18 DOI: 10.4236/abc.2020.102003

T. Aiyelabola, E. Akinkunmi, Raphael Akinade

{"title":"Syntheses of Coordination Compounds of (±)-2-Amino-3-(4-Hydroxyphenyl)Propionic Acid, Mixed Ligand Complexes and Their Biological Activities","authors":"T. Aiyelabola, E. Akinkunmi, Raphael Akinade","doi":"10.4236/abc.2020.102003","DOIUrl":"https://doi.org/10.4236/abc.2020.102003","url":null,"abstract":"Coordination compounds of \u0000(±)-2-amino-3-(4-hydroxyphenyl) propionic acid and \u0000their mixed ligand complexes with 1,10-phenantroline were synthesized, characterized using electronic and \u0000infrared spectral analyses and magnetic susceptibility. The compounds were \u0000evaluated for antimicrobial and antioxidant activities. Four different assays \u0000were applied for evaluating antioxidant capacity of the compounds. The results \u0000obtained indicated a diametric square planar geometry for both cobalt (±)-2-amino-3-(4-hydroxyphenyl) propionic \u0000acid complex and its mixed ligand \u0000complex. It was suggested that for the binary cobalt(II) complex, the phenolic \u0000substituent coordinated with neighbouring \u0000central metal ions. However, for the ternary cobalt(II) complex it was suggested it was deprotonated. Octahedral geometry was \u0000proposed for both copper complexes. Square planar geometry was indicated for the nickel (±)-2-amino-3-(4-hydroxyphenyl) propionic acid complex and a mixture of \u0000square planar and octahedral geometry for the nickel mixed ligand complex. The \u0000cobalt mixed ligand complex elicited the highest activity for all the \u0000antioxidant assays. In most cases the binary complexes exhibited better antimicrobial activities relative \u0000to their ternary counterparts.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45924850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Physico-Chemical Evaluation and Hematological Responses in Clarias gariepinus (Burchell 1822) Juveniles Exposed to Adenium obesum Stem Bark Acute Bioassay 接触腺茎皮的Clarias gariepinus (Burchell 1822)幼体的理化评价和血液学反应

生物化学进展(英文) Pub Date : 2020-03-18 DOI: 10.4236/abc.2020.102004

B. O. Muyiwa, N. S. Emmanuel, F. M. Yahuza, M. Aliyu, C. Inegbenosun, I. Musah

引用次数: 0

Nanolarvicidal Effect of Green Synthesized Ag-Co Bimetallic Nanoparticles on Culex quinquefasciatus Mosquito 绿色合成银钴双金属纳米颗粒对致倦库蚊的纳米杀蚊效果

生物化学进展(英文) Pub Date : 2020-02-05 DOI: 10.4236/abc.2020.101002

Wilson Lamayi Danbature, Zaccheus Shehu, Mela Yoro, M. M. Adam

{"title":"Nanolarvicidal Effect of Green Synthesized Ag-Co Bimetallic Nanoparticles on Culex quinquefasciatus Mosquito","authors":"Wilson Lamayi Danbature, Zaccheus Shehu, Mela Yoro, M. M. Adam","doi":"10.4236/abc.2020.101002","DOIUrl":"https://doi.org/10.4236/abc.2020.101002","url":null,"abstract":"Synthesis of bimetallic nanoparticles has \u0000employed many applications especially as larvicidal agents, these bimetallic \u0000nanoparticles therefore need to be produced via a cost-effective and eco-friendly route. Here, green \u0000synthesis of Ag-Co hybrid nanoparticles obtained from aqueous root extract of \u0000palmyra palm was reported. The hybrid nanoparticles formation was noticed by a \u0000colour change from light pink to light brown and further studied using UV-Vis and FT-IR spectrophotometers. The maximum \u0000absorption wavelength, λmax as determined by the UV-Visible \u0000Spectrophotometer was found to be 420 nm. The FT-IR showed the \u0000formation and stabilization of the BMNPs. The nanolarvicidal potency was \u0000evaluated by the application of varying concentration ranging from 5 to 50 mg/L against first to fourth instars of larvae \u0000and recording the percentage mortality after 24 hours. Probit analysis showed \u0000the LC50 and LC90 for 1st instar to be 5.237 mg/L and 49.240 mg/L, 9.310 mg/L and 94.969 mg/L for 2nd instar, 13.626 mg/L and 105.542 mg/L for 3rd/4th instars \u0000respectively. This result therefore suggests that the nanoparticles can be used \u0000as potential control for larval population growth.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42639316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

DFT-Based Prediction of Bioconcentration Factors of Polychlorinated Biphenyls in Fish Species Using Molecular Descriptors 基于DFT的分子描述符预测鱼类中多氯联苯的生物富集因子

生物化学进展(英文) Pub Date : 2020-02-05 DOI: 10.4236/abc.2020.101001

A. Soni, Pratibha Singh, V. K. Sahu

{"title":"DFT-Based Prediction of Bioconcentration Factors of Polychlorinated Biphenyls in Fish Species Using Molecular Descriptors","authors":"A. Soni, Pratibha Singh, V. K. Sahu","doi":"10.4236/abc.2020.101001","DOIUrl":"https://doi.org/10.4236/abc.2020.101001","url":null,"abstract":"Experimental determination of BCFs is expensive and demanding if \u0000performed correctly. Because of this, measuring the BCFs of many thousands of \u0000chemical substances that are potential regulatory interest is simply not \u0000possible. Hence, prediction of BCFs of the PCBs based on QSAR were made time to time to \u0000increase the probability of success and reduce the time and cost in exploring \u0000the toxicological and ecological characteristics of molecules. DFT methods are, \u0000in general, capable of generating a variety of isolated molecular descriptors \u0000as well as local reactivity descriptors quite accurately. In this work, \u0000prediction of BCFs of the fifty seven PCBs based on quantum chemical \u0000descriptors derived from DFT method using the B88-PW91 GGA energy function with \u0000the DZVP basis set have been made. The study concluded that dipole moment and ionization \u0000potential are reliable descriptors for correlation of bioconcentration factors \u0000of polychlorinated biphenyls with their electronic \u0000structures. The resulted QSAR model (r2 = 0.9139, \u0000 = 0.8986, k = 2, SE = \u00000.2668) can be useful for predicting the BCFs of compounds prior to their \u0000synthesis.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41984233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Sonication Processing on the Behavior of the Synthesis Human Serum Albumin-SPIONs Loaded PLGA Nanoparticles 超声处理对合成人血清白蛋白SPION负载PLGA纳米粒子行为的影响

生物化学进展(英文) Pub Date : 2019-11-28 DOI: 10.4236/abc.2019.96014

S. Vidawati, S. Barbosa, P. Taboada, V. Mosquera

引用次数: 0

Enzymatic Hydrolysis of Hairtail Surimi in an Ultra-High Pressure Bioreactor 在超高压生物反应器中酶解带鱼鱼糜

生物化学进展(英文) Pub Date : 2019-11-28 DOI: 10.4236/abc.2019.96015

Deqing Yang, Rong Liu, Yongsheng Wang, Minrui Ou, Junjie Gu

引用次数: 0

Physicochemical Characteristics of Mauritia arabica Shell with High Temperature Calcination 毛里求斯阿拉比卡咖啡豆壳高温煅烧的理化特性研究

生物化学进展(英文) Pub Date : 2019-10-29 DOI: 10.4236/abc.2019.95012

Di Zhang, Jiaxin Yao, Ying-li Wang

{"title":"Physicochemical Characteristics of Mauritia arabica Shell with High Temperature Calcination","authors":"Di Zhang, Jiaxin Yao, Ying-li Wang","doi":"10.4236/abc.2019.95012","DOIUrl":"https://doi.org/10.4236/abc.2019.95012","url":null,"abstract":"Mauritia arabica shell (MAS), is widely applied as a Chinese tradition medicine after thermal decomposition. However, it is still uncertain how the thermal decomposition process affects the physicochemical properties of MAS. Moreover, the influences of these properties on the bioavailability have not been well understood. In this investigation, a temperature-programmed pyrolysis process is applied to calcine MAS to achieve the desired MAS with different physicochemical properties. The results showed that a weight loss of 43.27% - 44.73% was detected after MAS was calcined at 900°C, which was mainly attributed to the decomposition of protein, the phase transition of calcium carbonate from aragonite to calcite, and the decomposition of calcium carbonate. The activation energy in the heating duration was calculated by applying the Kissinger-Akahira-Sunose model (KAS), which was 58.13 kJ/mol for crystalline transformation and 181.27 kJ/mol for decomposition. Besides,according to the analyses from Fourier transform infrared (FTIR) and X-ray powder diffraction (XRD) tests, the crystalline of calcium carbonate in MAS was aragonite. These results provide beneficial temperature parameters for the pretreatments of MAS for pharmaceutical usages.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48334213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chemical Characterization and Cytotoxic Activity of Antarctic Macroalgae Extracts against Colorectal Cancer 南极大型海藻提取物对癌症大肠癌的化学性质和细胞毒性活性

生物化学进展(英文) Pub Date : 2019-10-28 DOI: 10.4236/abc.2019.95013

R. Frassini, Yeslei Paulino da Silva, S. Moura, Leonardo Zambotti Villela, A. P. Martins, P. Colepicolo, M. Fujii, N. Yokoya, C. Pereira, Vagner Reinaldo Zingalli Bueno Pereira, J. P. Henriques, M. Roesch-Ely

{"title":"Chemical Characterization and Cytotoxic Activity of Antarctic Macroalgae Extracts against Colorectal Cancer","authors":"R. Frassini, Yeslei Paulino da Silva, S. Moura, Leonardo Zambotti Villela, A. P. Martins, P. Colepicolo, M. Fujii, N. Yokoya, C. Pereira, Vagner Reinaldo Zingalli Bueno Pereira, J. P. Henriques, M. Roesch-Ely","doi":"10.4236/abc.2019.95013","DOIUrl":"https://doi.org/10.4236/abc.2019.95013","url":null,"abstract":"Background/Aim: \u0000Antarctic seaweeds are considered a promising source of compounds with \u0000anticancer activity. Colorectal cancer (CRC) is one of the most incident \u0000cancers with high mortality rates worldwide. This work aimed to characterize \u0000chemically extracts of the Antarctic macroalgae Iridaea cordata, Cystosphaera jacquinotii and Desmarestia anceps and to evaluate the cytotoxic \u0000effects against human colon cancer HCT 116 cell line. Materials and Methods: \u0000The extracts were obtained by depletion using an ultrasound probe and were identified by High-Performance Liquid Chromatography (HPLC) and Gas Chromatography \u0000coupled with Mass Spectrometry (GC-MS). Cell viability was determined by MTT \u0000assay. Results: Hexanic and chloroform extracts of the I. cordata and the hexanic, \u0000chloroform and methanolic extracts of D. anceps were able to inhibit growth of \u0000colorectal cancer cells in the three different incubation times (24, 48 and 72 h). \u0000Through GC analysis, 01 compounds were identified in the hexane extract and 02 \u0000compounds in the chloroform extract of the algae I. cordata. The hexane extract of D. anceps macroalgae presented 5 \u0000compounds, chloroform extract 10 and methanolic extract 3 respectively, with special highlight to fucosterol. Carotenoid \u0000analysis by HPLC identified β-carotene \u0000in all species, while zeaxanthin was present in the spectrum of I. cordata and C. jacquinotii. Fucoxanthin and violaxanthin were confirmed in the \u0000brown seaweeds C. jacquinotii and D. anceps. \u0000Conclusion: Extracts of macroalgae I. Cordata and D. anceps may be a source \u0000of therapeutic agents against CRC.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42805953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anthocleistenolide B, a New Secoiridoid from Anthocleista liebrechtsiana De Wild & T. Durand Anthocleeista liebrechtsiana De Wild和T.Durand中新的二环烯醚萜类化合物Anthocleisetenolide B

生物化学进展(英文) Pub Date : 2019-07-19 DOI: 10.4236/ABC.2019.94010

F. Ngouafong, R. Tchuenguem, J. Kühlborn, B. T. Tchegnitegni, B. Ponou, R. Teponno, J. Dzoyem, T. Opatz, L. Tapondjou

引用次数: 0