Anthocleistenolide B, a New Secoiridoid from Anthocleista liebrechtsiana De Wild & T. Durand

生物化学进展(英文) Pub Date : 2019-07-19 DOI:10.4236/ABC.2019.94010

F. Ngouafong, R. Tchuenguem, J. Kühlborn, B. T. Tchegnitegni, B. Ponou, R. Teponno, J. Dzoyem, T. Opatz, L. Tapondjou

{"title":"Anthocleistenolide B, a New Secoiridoid from Anthocleista liebrechtsiana De Wild & T. Durand","authors":"F. Ngouafong, R. Tchuenguem, J. Kühlborn, B. T. Tchegnitegni, B. Ponou, R. Teponno, J. Dzoyem, T. Opatz, L. Tapondjou","doi":"10.4236/ABC.2019.94010","DOIUrl":null,"url":null,"abstract":"Drug resistance due to the extensive abuse and over-use of antibiotics has become an increasingly serious problem and researchers started to use plants as an alternative source of new antibiotics. The aim of the present study was to assess the antimicrobial properties of secondary metabolites isolated from A. liebrechtsiana. A new secoiridoid derivative, anthocleistenolide B (1), along with three known compounds, the monoterpene diol, djalonenol (2), the xanthone O-glycoside, decussatin 1-O-β-D-glucopyranoside and the fatty acid, dotriacontanoic acid (4) was isolated from the leaves and bark of this plant. Their structures were elucidated by extensive analysis of spectroscopic (1D and 2D NMR) and mass spectrometric data. The isolated compounds were screened for their antimicrobial properties against five strains of bacteria (two gram positive: Staphylococcus aureus 29213, Enterococcus faecalis ATCC 25922 and three gram negative: Escherichia coli ATCC51299, Proteus mirabilis (isolate), and Pseudomonas aeruginosa QC76110), but all were inactive.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生物化学进展(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/ABC.2019.94010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Drug resistance due to the extensive abuse and over-use of antibiotics has become an increasingly serious problem and researchers started to use plants as an alternative source of new antibiotics. The aim of the present study was to assess the antimicrobial properties of secondary metabolites isolated from A. liebrechtsiana. A new secoiridoid derivative, anthocleistenolide B (1), along with three known compounds, the monoterpene diol, djalonenol (2), the xanthone O-glycoside, decussatin 1-O-β-D-glucopyranoside and the fatty acid, dotriacontanoic acid (4) was isolated from the leaves and bark of this plant. Their structures were elucidated by extensive analysis of spectroscopic (1D and 2D NMR) and mass spectrometric data. The isolated compounds were screened for their antimicrobial properties against five strains of bacteria (two gram positive: Staphylococcus aureus 29213, Enterococcus faecalis ATCC 25922 and three gram negative: Escherichia coli ATCC51299, Proteus mirabilis (isolate), and Pseudomonas aeruginosa QC76110), but all were inactive.

查看原文本刊更多论文

Anthocleeista liebrechtsiana De Wild和T.Durand中新的二环烯醚萜类化合物Anthocleisetenolide B

抗生素的广泛滥用和过度使用导致的耐药性已成为一个日益严重的问题，研究人员开始将植物作为新抗生素的替代来源。本研究的目的是评估从A.liebrechtsiana中分离的次级代谢产物的抗菌特性。从该植物的叶片和树皮中分离到一种新的异萜衍生物，花青素B（1），以及三种已知的化合物，单萜二醇，djalonol（2），黄酮O-糖苷，decussatin 1-O-β-D-吡喃葡糖苷和脂肪酸，dotriacontanoic acid（4）。通过对光谱（1D和2D NMR）和质谱数据的广泛分析，阐明了它们的结构。分离的化合物对五种细菌菌株（两克阳性：金黄色葡萄球菌29213、粪肠球菌ATCC 25922和三克阴性：大肠杆菌ATCC51299、奇异变形杆菌（分离物）和铜绿假单胞菌QC76110）的抗菌性能进行了筛选，但均无活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

生物化学进展(英文)

自引率

0.00%

发文量

251