生物化学进展(英文)最新文献_第2页

A Study of Radiation-Induced Instability for the Gene Locus Associated with Intellectual Disorders or Developmental Delays 与智力障碍或发育迟缓相关的基因位点的辐射诱导不稳定性研究

生物化学进展(英文) Pub Date : 2023-01-01 DOI: 10.4236/abc.2023.134010

A. Chant, Ahmad Chaudary, Christina M. Kraemer-Chant

引用次数: 0

Investigation of Novel Nanoplatforms for Delivery of an Anticataract Drug in Whole Lens Cultures 新型纳米平台在全晶状体培养中递送抗白内障药物的研究

生物化学进展(英文) Pub Date : 2022-11-01 DOI: 10.4236/abc.2022.125015

A. Pfaff, Anna V. Chernatynskaya, N. Ercal

引用次数: 0

A New Fluorescent Chemosensor for Selective and Sensitive Detection of Mn²⁺ in Acidic Medium 一种用于酸性介质中Mn2+选择性敏感检测的新型荧光化学传感器

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.125014

A. Umit

引用次数: 1

Effects of Inoculum Size of Afifella marina in the Bioprocessing of Sargassum spp. Meal 马尾藻菌接种量对马尾藻饲料生物加工的影响

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.126016

Sujjat Al Azad, Mohammad Tamrin Mohamad Lal

引用次数: 0

Antarctic Macroalgae Palmaria decipiens (Rhodophyta, Palmariales) Extracts Present Antioxidant and Antitumor Activity against Colorectal Cancer 南极巨藻Palmaria decipiens (Rhodophyta, Palmariales)提取物具有抗氧化和抗肿瘤活性

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.126022

Marina Della Giustina, R. Frassini, S. Moura, F. J. Scariot, S. Echeverrigaray, Vanessa Sayuri Osaki, Franciane M. Pellizari, P. Colepicolo, J. P. Henriques, Janaina da Silva Crespo, M. Roesch-Ely

引用次数: 0

Pharmacokinetic Study and Toxicity of Leukovir: A New Combined Drug for the Treatment of Multiple Sclerosis 治疗多发性硬化症的新联合药物Leukovir的药代动力学研究及毒性

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.121001

E. Kalinichenko, I. V. Ponteleeva, M. Golubeva

{"title":"Pharmacokinetic Study and Toxicity of Leukovir: A New Combined Drug for the Treatment of Multiple Sclerosis","authors":"E. Kalinichenko, I. V. Ponteleeva, M. Golubeva","doi":"10.4236/abc.2022.121001","DOIUrl":"https://doi.org/10.4236/abc.2022.121001","url":null,"abstract":"Leukovir, an enteric-coated tablet, is the original drug product for internal use. The well-known nucleosides cladribine and ribavirin are the active ingredients of the drug product leukovir. Pharmacokinetic parameters of the drug product for the internal use of leukovir active ingredients have been es-tablished. The cladribine half-absorption period was t 1/2a = 49.5 h, C 0 = 276.4 μg/ml, C max = 6.0 μg/ml. Distribution and accumulation parameters (V d , V ss and AUC) have indicated that the drug distribution between the blood cells and blood plasma takes place in the same way, irrespective of the dosage form. Cladribine half-life period is t 1/2e = 0.62 hours. The molecule total clearance and average lifetime in the body in the case of subcutaneous drug administration are approximately the same. Ribavirin is characterized by a half-absorption period of t 1/2a = 0.71 h, C 0 = 115.6 μg/ml and C max = 75.5 μg/ml. Ribavirin total volume of distribution (V d = 1.3 l/kg) and stationary volume of distribution (V ss = 1.64 l/kg) were practically similar to leukovir when administered subcutaneously. The AUC value = 504.2 μg h/ml, which is 2.5 times less than that in the case of drug form administration. Leukovir was regarded as slightly toxic in an acute toxicity study. The risk of cumulation for this drug product is low.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Liquid Efficiency on Wood Dissolution and Polysaccharide Identification 离子液体对木材溶解及多糖鉴定的效率

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.126021

I. Plazanet, Christelle Gady, S. Lhernould, R. Zerrouki, D. Montplaisir, G. Costa

引用次数: 0

Aqueous Extract of Erythrina senegalensis Exhibits Dose-Dependent Hepatoprotective Activity on Paracetamol-Induced Liver Damage in Wistar Rats 塞内加尔赤藓水提物对扑热息痛致Wistar大鼠肝损伤的保护作用呈剂量依赖性

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.122005

P. Igeh, Elkanah Ishaku, J. G. Nangbes, S. Choji, F. O. Okonkwo

{"title":"Aqueous Extract of <i>Erythrina senegalensis</i> Exhibits Dose-Dependent Hepatoprotective Activity on Paracetamol-Induced Liver Damage in Wistar Rats","authors":"P. Igeh, Elkanah Ishaku, J. G. Nangbes, S. Choji, F. O. Okonkwo","doi":"10.4236/abc.2022.122005","DOIUrl":"https://doi.org/10.4236/abc.2022.122005","url":null,"abstract":"Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to authenticate its use in the treatment of liver ailments. This research is aimed at assessing the hepatoprotective effects of Erythrina senegalensis against paracetamol-induced (PCM-induced) hepatotoxicity in wistar albino rats. This was evaluated by es-timating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) as compared with the control group. The extract was concentrated and then desired concentrations of extracts were made by dissolving in normal saline. Four different doses of aqueous extracts Erythrina senegalensis (200, 300, 400 and 500 mg/kg) were administered orally for 6 consecutive days after the 72 hrs administration of paracetamol (1500 mg/kg) per body weight. Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Administration of the extracts showed significant (p < 0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT, AST and ALP. These data revealed that Erythrina senegalensis aqueous extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormalities of Serum Protein Fractions in Hemodialysis Patients with Chronic Renal Failure at Ouagadougou, Burkina Faso 瓦加杜古，布基纳法索慢性肾衰竭血液透析患者血清蛋白含量异常

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.126017

A. Kouraogo, F. Soudre, A. Kiba, R. Karfo, O. Da, E. Zongo, E. Kabré, J. Sakandé

引用次数: 0

The Positive Effects of Proprietary Undenatured B-Glucans on Growing Pigs 专有未变性b -葡聚糖对生长猪的积极影响

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.126020

B. Kristiansen, R. Amen

引用次数: 0