病理学期刊(英文)最新文献

{"title":"A Case of Struma Ovarii Diagnosed by Cytology during Laparoscopic Surgery","authors":"K. Niwa, M. Takenaka, T. Ishihara, S. Mori, Keigo Kuwabara, S. Murase, Y. Yamaguchi, Takuji Tanaka","doi":"10.4236/OJPATHOLOGY.2019.91001","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2019.91001","url":null,"abstract":"We report a case of pure struma ovarii tumor diagnosed by cytology during laparoscopic surgery. The patient was a 34-year-old Japanese woman, gravida 1, para 1, who had the left adnexal mass, and was pre-operatively diagnosed as left ovarian endometriotic cyst or mature cystic teratoma by magnetic resonance imaging findings. She underwent laparoscopy, and the content of the left ovarian cystic tumor was found to be yellow gelatinous material, suggesting mature cystic teratoma. The imprint cytology of the tumor showed benign glandular pattern, suggesting struma ovarii. Histopathological findings led us to the diagnosis of pure struma ovarii with positive reactions for thyroglobulin and thyroid transcription factor-1. No metastases or disseminated lesions were detected. The patient has no recurrent signs 7 months after the operation.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70494408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Papillary Renal Cell Carcinoma Seeding along a Percutaneous Biopsy Tract","authors":"C. Busset, S. Vijgen, B. Lhermitte, Pu Yan","doi":"10.4236/ojpathology.2018.84016","DOIUrl":"https://doi.org/10.4236/ojpathology.2018.84016","url":null,"abstract":"We report a rare case of a papillary renal cell carcinoma seeding along a percutaneous biopsy tract detected at the time of partial nephrectomy in a 51-year-old man with a 3.5 cm renal mass discovered on computed tomography scan (CT scan). Although renal percutaneous biopsy is now considered as an accurate and safe technique to provide valuable diagnostic information for indeterminate renal lesions, some inherent risks have been reported to associate with this procedure. One of the risks is tumor needle tract seeding, which is a very rare complication of renal percutaneous biopsy. Our well-documented case report could provide some useful information to evaluate the prognosis of patients with tumor seeding along a percutaneous biopsy tract.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"139-146"},"PeriodicalIF":0.0,"publicationDate":"2018-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47415862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomo-Clinical Case: Coexistence of Tuberculosis with Axillary Lymph Node Metastasis in Breast Carcinoma","authors":"A. Ouédraogo, H. A. Bambara, F. Ido, W. N. Ramdé, Rimwaogdo Jeremie Sawadogo, I. Savadogo, S. Ouattara, Hassami Barry, A. Sanou-Lamien, O. Lompo","doi":"10.4236/OJPATHOLOGY.2018.84015","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.84015","url":null,"abstract":"Introduction: The coexistence of tuberculosis with axillary lymph node metastasis in breast carcinoma is uncommon. Observation: We report a case of a patient aged 59 years presenting a painless nodule in the right breast for one year. The scan and mammography revealed a long-axis node of 3 × 2 × 1 cm in the upper outer quadrant of the right breast ranked stage IV by the American College of Radiology (ACR), associated with a set of axillary lymph nodes and the largest one measuring 15 × 15 × 20 millimeters (mm). The breast biopsy helped diagnose a Scarff Bloom Richardson (SBR) grade II non-specific invasive carcinoma, modified by Ellis and Elston. A right mastectomy associated with a lymph node dissection was performed. We noticed a not well defined and whitish 5 mm tumor mass associated with 16 lymph nodes removed. The histological examination confirmed the diagnosis of SBR grade II non-specific invasive carcinoma with invasion of 7 lymph nodes (N+ = 7/16). In 3 metastatic lymph nodes, there were epithelioid and gigantocellular granulomas with full central necrosis. The Ziehl Neelsen staining had highlighted acid-fast bacilli. The tumor was oestrogen and progesteron receptor, without an overexpression of the oncoprotein human epidermal growth factor receptor 2 (HER2), which corresponds to a 0 score and the Ki 67 proliferation index assessed at 10%. The patient was given an anti-tuberculosis treatment combining Rifampicin (H), Isoniazid (I), Pyrazinamid (Z), Ethambutol (E) over 2 months and secondly a combination of Rifampicin and Isoniazid over 4 months (2RHZE/4 RH). The anti-tumor chemotherapy used a protocol combining 3 FAC60+ 3 Docetaxel (F = Fluorouracil®; A = Adriblastin®, C = Cyclophosphamid). Conclusion: This coexistence is uncommon, of incidental discovery and necessitates a multidisciplinary care.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2018-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43508229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxico-Pathological Studies of Foeniculum vulgare Plant in Mice","authors":"F. Al-hizab, Y. Hussein, M. Hasseeb, S. Barakat, M. Moqbel","doi":"10.4236/ojpathology.2018.84014","DOIUrl":"https://doi.org/10.4236/ojpathology.2018.84014","url":null,"abstract":"Background and objective: Foeniculum vulgare-Mill (Umlliferae), is widely used in the Arabian Peninsula for treating various human and animal diseases. There is need to insure the safety of this plant as a remedy that could be used for a long time. This study aimed to determine the LD50 of the aerial parts of Foeniculum vulgare in mice, as well as to investigate its toxic pathological effects. Methodology: A total of eighty (80) albino mice of both sexes, weighing 25 - 30 g, were used in the present study. Ten (10) mice were used for the determination of LD50 of Foeniculum vulgare in mice. Fifty (50) mice were used in the acute toxicity, and twenty (20) mice were used to study the subacute toxicity of the aerial parts of Foeniculum vulgare juice. Results: the present results revealed that the LD50 of Foeniculum vulgare juice in mice was 9.772 mg/kg/body weight (BW). On the other hand, mice received 0.9 mg/kg/BW of Foeniculum vulgare juice intraperitoneally showed slightly closed eyes intermittent convulsions itching of the nose and increased respiratory rate and abdominal movements. Histopathological examination of the liver showed hepatocytic degeneration and necrosis, congestion with perivascular mononuclear cell infiltrations and peribiliary mononuclear cell aggregations. Whereas the spleen of mice showed depletion of lymphocytes and mononuclear as well as multinuclear cells. The duodenum showed sub-epithelial congested blood vessels, numerous areas of lymphocytic infiltrations and vascular and hydropic degeneration of epithelial cells lining the duodenal Brunner’s glands. Moreover, the kidney showed degenerated tubular epithelial cells, congestion with excess of mononuclear cells, necrotic and desquamated epithelial cells of the proximal convoluted tubules. The lung of mice showed congestion, emphysema with variable degrees of mononuclear cell infiltrations and peribronchial congested blood capillaries and mononuclear cell infiltration. Conclusion: It could be concluded that Foeniculum vulgare juice is toxic to mice when administered in a dose of 9.772 mg/kg/BW. However, the recommended dose for treatment could be less than 0.98 ml/kg BW. (1/10 of the LD50) of Foeniculum vulgare juice.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"123-131"},"PeriodicalIF":0.0,"publicationDate":"2018-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48212065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Combined; Cox-2, Cyclin D1 and P21 Expression in Colorectal Cancer (CRC) Patients: An Immunohistochemical Study","authors":"A. Salem, M. Elfeky, Nashwa Nawar, A. Alattar, O. Elekiabi, Mostafa. M. Elaidy","doi":"10.4236/OJPATHOLOGY.2018.83013","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.83013","url":null,"abstract":"Background: Cyclooxygenase (COX) is a rate limiting enzyme in synthesis of prostanoids pathway and it has 2 isoforms (COX-1 and COX-2). It has many biological roles in inflammation and oncogenesis. Cox-2 was incriminated in performing disturbances in the cell cycle control in CRC, but its role of in CRC needs clarification of the mechanisms by which Cox-2 might affect the process of colorectal carcinogenesis. Cyclin D1 is an oncogene that regulates G1 phase progression to S phase of the cell cycle. Its stimulatory role on cell cycle is antagonized by Cyclin D1-dependent kinase (CDK) inhibitors like p21. P21 plays an essential role in cell cycle regulation; it may have a pro-apoptotic or an antiapoptotic role in cancer. P21 was found to have many roles in cancer; invasion metastases, cellular senescence and stem cells aging. The roles of combined expression of Cox-2, Cyclin D1 and P21 in CRC tissues and their role of prognosis and patients survival are not sufficiently clarified. Aim of the Study: To evaluate tissue expression of Cox-2, Cyclin D1 and P21 in CRC and to correlate such expression with pathological parameters, clinical and prognostic data of the patients. Methods: Cox-2, Cyclin D1 and P21 are evaluated in colon cancer tissues. Correlations between their level of expressions pathological parameters, clinical and prognostic data of patients were analyzed. Results: Cox-2, Cyclin D1 over-expression was associated with higher grade, higher incidence of occurrence of lymph node & distant metastasis and advanced stage (P = 0.000). Cox-2 was related to higher tumor recurrence rate (P = 0.04) and decreased overall patients survival rate (p = 0.002). (r correlation coefficient = +0.987). Conclusion: Cox-2 and Cyclin D1 are markers of poor prognosis colon cancer patients.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"106-121"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43745502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Fallopian Tube Adenocarcinoma Discovered with the Vaginal Cytology: A Case Report with Pathological and Immunohistochemical Investigation","authors":"T. Honda, Yuka Hiraku, R. Aoki, K. Niwa, N. Watanabe, Takuji Tanaka","doi":"10.4236/OJPATHOLOGY.2018.83010","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.83010","url":null,"abstract":"Background: Primary fallopian tube cancer is an extremely rare gynecological malignancy. Aim: To discuss, through a case report, the diagnostic process by means of cytology immunohistochemistry. Case Presentation: A 47-year-old Japanese woman, who also had lung cancer, presented with enlarged para-aortic lymph node without any symptoms. Based on the vaginal cytology report suggestive of gynecologic malignant tumor (possibly fallopian tube adenocarcinoma), primary surgery comprised of total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Histopathology and immunohistochemistry examinations revealed primary fallopian tube carcinoma with metastasis of para-aortic lymph node. She is free from recurrence and metastases 9 months after the surgery and chemotherapy. Conclusion: Although primary fallopian tube cancer is a rare gynecologic malignancy, vaginal cytology may be useful for detecting fallopian tube carcinoma.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"85-93"},"PeriodicalIF":0.0,"publicationDate":"2018-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49641936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant Melanocytic Matricoma and Criteria for Malignancy","authors":"C. Nielson, V. Vincek","doi":"10.4236/OJPATHOLOGY.2018.83011","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.83011","url":null,"abstract":"Melanocytic matricoma is a very rare adnexal tumor that recapitulates the anagen hair follicle bulb. Few cases of malignant melanocytic matricoma have been reported, thus criteria for malignant potential have not been previously reviewed. We report a case of an 81 year old male that was originally diagnosed as atypical melanocytic matricoma. The site was re-excised with a small focus of residual tumor, but all margins were negative. The re-excision site healed without complication. However, two years after the original biopsy, a new 8 mm firm nodule appeared at the re-excision site, which was subsequently diagnosed as malignant melanocytic matricoma (MMM). In the following paper we will report a new case of MMM and review potential criteria that could be used in the future to establish malignant potential.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"94-100"},"PeriodicalIF":0.0,"publicationDate":"2018-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44530609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorating Effect of Cucumis sativus (Cucumbers) against Arsenic Induced Toxicity in Mice","authors":"N. Fatima, N. Fatmi, M. Shahzada, Shivdhar Sharma, Ranjit Kumar, M. Ali, Arun Kumar","doi":"10.4236/OJPATHOLOGY.2018.83009","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.83009","url":null,"abstract":"In the entire world, about 200 million populations are exposed to arsenic poisoning in groundwater. Arsenic is a very poisonous metalloid and has three allotropic forms. The toxic inorganic arsenic is converted and utilized metabolically into organic form. It is primarily eliminated out from the human body through metabolic wastes like urine and is also deposited in the hair, nails and skin of the affected ones. Arsenic is known to be a carcinogen as Carcinogen category 1 in the forms of arsenic trioxide, arsenic pentoxide, arsenous acids, arsenic acid and their salts. The arsenic also affects the epidermal system, the nervous system and the vascular system of humans. In the present investigation for toxicological evaluation of arsenic Liver Function Tests & Kidney Function Tests have been considered. It is presumed that medicinal plants have significance in the present day in view of the lethal diseases like AIDS, cancer, hepatitis, nephritis sterility too for which no effective drugs are found till today in modern system of medicine. Medicinal plant based drugs generally have no side effects or the least side effect. Thus to evaluate an ameliorating effect, if any, to mitigate the arsenic toxicity in mice, for which Cucumis sativus (cucumbers) has been taken as curative measure. Sodium arsenite at the dose of 3 mg/kg body weight was administered for 4 weeks followed by the administration of Cucumis sativus (cucumbers) for 4 and 6 weeks at dose of 500 mg/kg body weight. Their biochemical levels like liver and kidney function tests were assayed and were found with elevated levels. But, after administration of aqueous extract of Cucumis sativus (cucumbers), there was significant amelioration in the biochemical levels. The protective effect of Cucumis sativus (cucumbers) was shown in the form of normalization of enzymatic and non-enzymatic activities represented by normalization of liver and kidney functions.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"78-84"},"PeriodicalIF":0.0,"publicationDate":"2018-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44940448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Serous Tubal Intraepithelial Carcinoma Diagnosed by Cytology during the Operation","authors":"K. Niwa, T. Ishihara, Y. Ueda, M. Takenaka, T. Shiga, S. Mori, Keigo Kuwabara, Y. Yamaguchi, Takuji Tanaka","doi":"10.4236/OJPATHOLOGY.2018.83008","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.83008","url":null,"abstract":"We experienced a case of serous tubal intraepithelial carcinoma (STIC), which is the earliest morphologically recognizable precursor of pelvic high grade serous carcinoma, diagnosed by cytology during the operation. A 48-year-old Japanese woman visited to our department because of abnormal cytological result and the left adnexal mass on female cancer screening. Pre-operatively, she was diagnosed as cervical intraepithelial neoplasia (CIN) 3, adenomyosis, and the left adnexal cystic lesion with papillary growth. At laparotomy, the left adnexal tumor turned out to be cystic fallopian tube with small papillary growth on the inner surface, but abnormal findings were not present on bilateral ovaries. The cytology of the imprint smears from the papillary projection and ascitic fluid showed positive, suggesting serous adenocarcinoma. Histopathological examination of the lesion revealed the left fallopian tube lesion was STIC with immunohistochemically positive reactivity against p53. No metastases including disseminated lesions were noted. The patient received four courses of systemic chemotherapy, and had no recurrent signs 10 months after the operation.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2018-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43031471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucosal Schwann Cell Hamartoma—Colonic Lesion Susceptible to an Interesting Differential Diagnosis","authors":"J. Ortiz, L. Chinchilla, E. Muñoz, Ludeña","doi":"10.4236/OJPATHOLOGY.2018.83012","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2018.83012","url":null,"abstract":"We present a mucosal Schwann cell hamartoma that was observed in a 63-year-old woman with no personal or family history of interest who underwent a screening colonoscopy for early detection of colon cancer. During colonoscopy, a small polyp with a maximum diameter of 0.8 cm was detected at the rectosigmoid level. Histologically, a benign lesion of neuroid aspect was observed, consisting of multiple spindle cell fascicles that was positive for S-100 and negative for enolase, synaptophysin, CD34, CD117, actin, desmin, Dog1, EMA, and neurofilaments. These findings, supported by the family and personal history of the patient, allowed us to make a diagnosis, discarding other entities.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"08 1","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2018-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43020020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}