生物设计研究(英文)Pub Date : 2020-04-25eCollection Date: 2020-01-01DOI: 10.34133/2020/9429650
Paul E Abraham, Jessy L Labbé, Amber A McBride
{"title":"Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering.","authors":"Paul E Abraham, Jessy L Labbé, Amber A McBride","doi":"10.34133/2020/9429650","DOIUrl":"10.34133/2020/9429650","url":null,"abstract":"<p><p>In the last decade, the unprecedented simplicity and flexibility of the CRISPR-Cas system has made it the dominant transformative tool in gene and genome editing. However, this democratized technology is both a boon and a bane, for which we have yet to understand the full potential to investigate and rewrite genomes (also named \"genome biodesign\"). Rapid CRISPR advances in a range of applications in basic research, agriculture, and clinical applications pose new risks and raise several biosecurity concerns. In such a fast-moving field of research, we emphasize the importance of properly communicating the quality and accuracy of results and recommend new reporting requirements for results derived from next-generation genome engineering.</p>","PeriodicalId":56832,"journal":{"name":"生物设计研究(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物设计研究(英文)Pub Date : 2019-11-24eCollection Date: 2019-01-01DOI: 10.34133/2019/9680853
Xiaohan Yang, Lei S Qi, Alfonso Jaramillo, Zong-Ming Max Cheng
{"title":"Biodesign Research to Advance the Principles and Applications of Biosystems Design.","authors":"Xiaohan Yang, Lei S Qi, Alfonso Jaramillo, Zong-Ming Max Cheng","doi":"10.34133/2019/9680853","DOIUrl":"10.34133/2019/9680853","url":null,"abstract":"Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA Department of Bioengineering, Stanford University, Stanford, CA 94305, USA Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA Warwick Integrative Synthetic Biology Centre (WISB) and School of Life Sciences, University of Warwick, CV4 7AL Coventry, UK ISSB, CNRS, Univ Evry, CEA, Université Paris-Saclay, 91025 Evry, France Institute for Integrative Systems Biology (I2SysBio), University of Valencia-CSIC, 46980 Paterna, Spain Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA Nanjing Agricultural University, Nanjing, Jiangsu Province, China","PeriodicalId":56832,"journal":{"name":"生物设计研究(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}