Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering.

Q2 Agricultural and Biological Sciences
生物设计研究(英文) Pub Date : 2020-04-25 eCollection Date: 2020-01-01 DOI:10.34133/2020/9429650
Paul E Abraham, Jessy L Labbé, Amber A McBride
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引用次数: 3

Abstract

In the last decade, the unprecedented simplicity and flexibility of the CRISPR-Cas system has made it the dominant transformative tool in gene and genome editing. However, this democratized technology is both a boon and a bane, for which we have yet to understand the full potential to investigate and rewrite genomes (also named "genome biodesign"). Rapid CRISPR advances in a range of applications in basic research, agriculture, and clinical applications pose new risks and raise several biosecurity concerns. In such a fast-moving field of research, we emphasize the importance of properly communicating the quality and accuracy of results and recommend new reporting requirements for results derived from next-generation genome engineering.

推进我们如何从生物设计中学习,以降低下一代基因组工程的风险。
在过去的十年里,CRISPR-Cas系统前所未有的简单性和灵活性使其成为基因和基因组编辑的主要变革工具。然而,这种民主化的技术既是一种恩惠,也是一种祸害,为此,我们还没有充分了解研究和重写基因组(也称为“基因组生物设计”)的潜力。CRISPR在基础研究、农业和临床应用的一系列应用中的快速进展带来了新的风险,并引发了一些生物安全问题。在这样一个快速发展的研究领域,我们强调正确沟通结果质量和准确性的重要性,并建议对下一代基因组工程得出的结果提出新的报告要求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
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审稿时长
12 weeks
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