Alcohol research : current reviews最新文献

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The World Health Organization's global monitoring system on alcohol and health. 世界卫生组织的全球酒精和健康监测系统。
Alcohol research : current reviews Pub Date : 2013-01-01
Vladimir Poznyak, Alexandra Fleischmann, Dag Rekve, Margaret Rylett, Jürgen Rehm, Gerhard Gmel
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引用次数: 0
Alcohol and mortality: Global alcohol-attributable deaths from cancer, liver cirrhosis, and injury in 2010. 酒精与死亡率:2010年癌症、肝硬化和损伤导致的全球酒精相关死亡。
Alcohol research : current reviews Pub Date : 2013-01-01
Jürgen Rehm, Kevin D Shield
{"title":"Alcohol and mortality: Global alcohol-attributable deaths from cancer, liver cirrhosis, and injury in 2010.","authors":"Jürgen Rehm, Kevin D Shield","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alcohol consumption has long been recognized as a risk factor for mortality. By combining data on alcohol per capita consumption, alcohol-drinking status and alcohol-drinking patterns, risk relationships, and mortality, the Comparative Risk Assessment Study estimated alcohol-attributable mortality for 1990 and 2010. Alcohol-attributable cancer, liver cirrhosis, and injury were responsible for the majority of the burden of alcohol-attributable mortality in 1990 and 2010. In 2010, alcohol-attributable cancer, liver cirrhosis, and injury caused 1,500,000 deaths (319,500 deaths among women and 1,180,500 deaths among men) and 51,898,400 potential years of life lost (PYLL) (9,214,300 PYLL among women and 42,684,100 PYLL among men). This represents 2.8 percent (1.3 percent for women and 4.1 percent for men) of all deaths and 3.0 percent (1.3 percent for women and 4.3 percent for men) of all PYLL in 2010. The absolute mortality burden of alcohol-attributable cancer, liver cirrhosis, and injury increased from 1990 to 2010 for both genders. In addition, the rates of deaths and PYLL per 100,000 people from alcohol-attributable cancer, liver cirrhosis, and injury increased from 1990 to 2010 (with the exception of liver cirrhosis rates for women). Results of this paper indicate that alcohol is a significant and increasing risk factor for the global burden of mortality.</p>","PeriodicalId":56367,"journal":{"name":"Alcohol research : current reviews","volume":"35 2","pages":"174-83"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic control of gene expression in the alcoholic brain. 酒精脑中基因表达的表观遗传控制。
Alcohol research : current reviews Pub Date : 2013-01-01
Igor Ponomarev
{"title":"Epigenetic control of gene expression in the alcoholic brain.","authors":"Igor Ponomarev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic alcohol exposure causes widespread changes in brain gene expression in humans and animal models. Many of these contribute to cellular adaptations that ultimately lead to behavioral tolerance and alcohol dependence. There is an emerging appreciation for the role of epigenetic processes in alcohol-induced changes in brain gene expression and behavior. For example, chronic alcohol exposure produces changes in DNA and histone methylation, histone acetylation, and microRNA expression that affect expression of multiple genes in various types of brain cells (i.e., neurons and glia) and contribute to brain pathology and brain plasticity associated with alcohol abuse and dependence. Drugs targeting the epigenetic \"master regulators\" are emerging as potential therapeutics for neurodegenerative disorders and drug addiction.</p>","PeriodicalId":56367,"journal":{"name":"Alcohol research : current reviews","volume":"35 1","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31933597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and predictors of adolescent alcohol use and binge drinking in the United States. 美国青少年饮酒和酗酒的患病率和预测因素。
Alcohol research : current reviews Pub Date : 2013-01-01
Megan E Patrick, John E Schulenberg
{"title":"Prevalence and predictors of adolescent alcohol use and binge drinking in the United States.","authors":"Megan E Patrick, John E Schulenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Because alcohol use typically is initiated during adolescence and young adulthood and may have long-term consequences, the Monitoring the Future (MTF) study annually assesses various measures of alcohol use among 8th-, 10th-, and 12th-grade students. These analyses have found that although alcohol use among these age groups overall has been declining since 1975, levels remain high. Thus, in 2011 about one-quarter of 8th graders, one-half of 10th graders, and almost two-thirds of 12th graders reported drinking alcohol in the month preceding the interview. Binge drinking (i.e., consumption of five or more drinks in a row) was also prevalent. Specific rates of drinking, binge drinking, and getting drunk varied among different student subgroups based on gender and race/ethnicity. The MTF study has also identified numerous factors that influence the risk of alcohol use among adolescents, including parents and peers, school and work, religiosity and community attachment, exercise and sports participation, externalizing behavior and other drug use, risk taking and sensation seeking, well-being, and drinking attitudes and reasons for alcohol use. Drinking during adolescence can have long-term effects on a person's life trajectory. Therefore, these findings have broad implications for prevention and intervention efforts with this population.</p>","PeriodicalId":56367,"journal":{"name":"Alcohol research : current reviews","volume":"35 2","pages":"193-200"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol metabolism and epigenetics changes. 酒精代谢和表观遗传学的改变。
Alcohol research : current reviews Pub Date : 2013-01-01
Samir Zakhari
{"title":"Alcohol metabolism and epigenetics changes.","authors":"Samir Zakhari","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metabolites, including those generated during ethanol metabolism, can impact disease states by binding to transcription factors and/or modifying chromatin structure, thereby altering gene expression patterns. For example, the activities of enzymes involved in epigenetic modifications such as DNA and histone methylation and histone acetylation, are influenced by the levels of metabolites such as nicotinamide adenine dinucleotide (NAD), adenosine triphosphate (ATP), and S-adenosylmethionine (SAM). Chronic alcohol consumption leads to significant reductions in SAM levels, thereby contributing to DNA hypomethylation. Similarly, ethanol metabolism alters the ratio of NAD+ to reduced NAD (NADH) and promotes the formation of reactive oxygen species and acetate, all of which impact epigenetic regulatory mechanisms. In addition to altered carbohydrate metabolism, induction of cell death, and changes in mitochondrial permeability transition, these metabolism-related changes can lead to modulation of epigenetic regulation of gene expression. Understanding the nature of these epigenetic changes will help researchers design novel medications to treat or at least ameliorate alcohol-induced organ damage.</p>","PeriodicalId":56367,"journal":{"name":"Alcohol research : current reviews","volume":"35 1","pages":"6-16"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31934150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community Indicators 社会指标
Alcohol research : current reviews Pub Date : 2006-01-01 DOI: 10.4135/9781412952583.n106
R. Phillips
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引用次数: 0
From the Editors 来自编辑
Alcohol research : current reviews Pub Date : 1989-11-01 DOI: 10.1080/01402390.2020.1733275
J. F. Kelly, Brett T. Hagman
{"title":"From the Editors","authors":"J. F. Kelly, Brett T. Hagman","doi":"10.1080/01402390.2020.1733275","DOIUrl":"https://doi.org/10.1080/01402390.2020.1733275","url":null,"abstract":"Now that the 2004 election is over, it seems like a good time to remind new officeholders as well as reelected incumbents of the importance of libraries to the health of the nation, and of the need for their support for libraries. In our district in Washington County, we have a new representative to the Tennessee legislature who promises to set up a public forum to find out the concerns of his constituents. My wife and I plan to attend and let him know our thoughts. In many areas the local chapters of the League of Women Voters will be setting up “meet your elected officials” events to provide the citizens of Tennessee with opportunities to talk to their representatives. Then of course, TLA sponsors Library Legislative Day so that we can go to Nashville and make sure that our public servants understand what we do and why it is important.","PeriodicalId":56367,"journal":{"name":"Alcohol research : current reviews","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01402390.2020.1733275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59089021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol and Mortality 酒精与死亡率
Alcohol research : current reviews Pub Date : 1912-11-30 DOI: 10.1136/bmj.2.2709.1557
J. Rehm, K. Shield
{"title":"Alcohol and Mortality","authors":"J. Rehm, K. Shield","doi":"10.1136/bmj.2.2709.1557","DOIUrl":"https://doi.org/10.1136/bmj.2.2709.1557","url":null,"abstract":"Alcohol consumption has long been recognized as a risk factor for mortality. By combining data on alcohol per capita consumption, alcohol-drinking status and alcohol-drinking patterns, risk relationships, and mortality, the Comparative Risk assessment study estimated alcohol-attributable mortality for 1990 and 2010. Alcohol-attributable cancer, liver cirrhosis, and injury were responsible for the majority of the burden of alcohol-attributable mortality in 1990 and 2010. In 2010, alcohol-attributable cancer, liver cirrhosis, and injury caused 1,500,000 deaths (319,500 deaths among women and 1,180,500 deaths among men) and 51,898,400 potential years of life lost (PYLL) (9,214,300 PYLL among women and 42,684,100 PYLL among men). This represents 2.8 percent (1.3 percent for women and 4.1 percent for men) of all deaths and 3.0 percent (1.3 percent for women and 4.3 percent for men) of all PYLL in 2010. The absolute mortality burden of alcohol-attributable cancer, liver cirrhosis, and injury increased from 1990 to 2010 for both genders. In addition, the rates of deaths and PYLL per 100,000 people from alcohol-attributable cancer, liver cirrhosis, and injury increased from 1990 to 2010 (with the exception of liver cirrhosis rates for women). Results of this paper indicate that alcohol is a significant and increasing risk factor for the global burden of mortality.","PeriodicalId":56367,"journal":{"name":"Alcohol research : current reviews","volume":"35 1","pages":"174 - 183"},"PeriodicalIF":0.0,"publicationDate":"1912-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/bmj.2.2709.1557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63739135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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