{"title":"Predicting Pediatric Urological Surgery Duration Through Multimodal Patient-Physician Feature Fusion: Deep Learning Framework Incorporating Clinical Text Embedding.","authors":"Yonggen Zhao, Ruoge Lin, Yiying Sun, Lingdong Chen, Jian Huang, Guangjie Chen, Zhu Zhu, Gang Yu","doi":"10.2196/82329","DOIUrl":"https://doi.org/10.2196/82329","url":null,"abstract":"<p><strong>Background: </strong>Accurate prediction of surgical duration is critical for optimizing operating room scheduling and resource allocation. Existing models, however, exhibit limited applicability in pediatric urology due to the unique anatomical and developmental characteristics of children.</p><p><strong>Objective: </strong>This study aimed to develop and validate a specialty-tailored prediction framework for estimating the duration of pediatric urological surgeries.</p><p><strong>Methods: </strong>We integrated multisource heterogeneous data, encompassing patient demographics, surgical details, surgeon-specific features, and electronic medical record narratives, to develop a customized prediction system. Large language model techniques were used to extract semantic representations from unstructured clinical text, while a multihead perceptron architecture enabled the efficient fusion of structured and unstructured features. Pediatric-specific clinical variables, such as developmental stage and the severity of urinary tract malformations, were explicitly modeled to capture their impact on surgical duration.</p><p><strong>Results: </strong>The proposed approach achieved a mean absolute error of 11.39 minutes and a root mean square error of 15.58 minutes, markedly outperforming existing methods. Comparative analyses demonstrated that the Qwen-based structured preprocessing with text embeddings provided superior feature representation, surpassing both traditional long short-term memory and direct Embedding-3 approaches. Feature importance analysis identified the primary surgical procedure, surgical plan, and preoperative diagnosis as dominant predictive factors.</p><p><strong>Conclusions: </strong>By combining innovative feature engineering with a tailored model architecture, the proposed framework substantially improves the accuracy of surgical duration prediction in pediatric urology. These findings offer robust technical support for precision operating room scheduling and hold significant clinical value in enhancing the efficiency of surgical resource utilization.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e82329"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction: Medical Emergency Resource Allocation Model in Large-Scale Emergencies Based on Artificial Intelligence: Algorithm Development.","authors":"","doi":"10.2196/98669","DOIUrl":"https://doi.org/10.2196/98669","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e98669"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction: Medical Data Feature Learning Based on Probability and Depth Learning Mining: Model Development and Validation.","authors":"","doi":"10.2196/98673","DOIUrl":"https://doi.org/10.2196/98673","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e98673"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction: Artificial Intelligence-Based Neural Network for the Diagnosis of Diabetes: Model Development.","authors":"","doi":"10.2196/98668","DOIUrl":"https://doi.org/10.2196/98668","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e98668"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction: Treatment of Left Ventricular Circulation Disorder: Application of Echocardiography Information Data Monitoring.","authors":"","doi":"10.2196/98672","DOIUrl":"https://doi.org/10.2196/98672","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e98672"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction: Application of a Mathematical Model in Determining the Spread of the Rabies Virus: Simulation Study.","authors":"","doi":"10.2196/98666","DOIUrl":"https://doi.org/10.2196/98666","url":null,"abstract":"","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e98666"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fei Yu, Xiaomeng Wang, Jia Liu, Tian Wang, Siobahn Day Grady, Lixin Song
{"title":"Leveraging MedlinePlus to Improve Health Information Access Among Patients and Caregivers: Systematic Literature Review.","authors":"Fei Yu, Xiaomeng Wang, Jia Liu, Tian Wang, Siobahn Day Grady, Lixin Song","doi":"10.2196/79416","DOIUrl":"https://doi.org/10.2196/79416","url":null,"abstract":"<p><strong>Background: </strong>MedlinePlus, developed by the National Library of Medicine (NLM) in the United States, is one of the most widely used, authoritative, consumer-grade health information resources on the web. Although extensively used and discussed in scholarly work for health literacy and patient education, it is unclear how MedlinePlus has been integrated into clinical care or embedded within health informatics applications.</p><p><strong>Objective: </strong>This study aimed to understand how MedlinePlus has supported patients and caregivers by increasing access to health information for clinical care and illness management. The insights on this topic will inform the design and development of patient-facing digital health intervention tools for improved health communication, decision engagement, informed decision-making, and health outcomes.</p><p><strong>Methods: </strong>We conducted a systematic literature review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. First, we developed a comprehensive literature search strategy, searched 9 citation databases, and aggregated and deduplicated search results before importing them into Covidence for manual screening using predefined inclusion and exclusion criteria. Second, reviewers independently assessed all studies at the title-abstract and full-text levels, resolving discrepancies through ongoing discussions. Third, we applied the PICO (problem/population, intervention, comparison, and outcome) and the Collaborative Chronic Care Model as guiding frameworks for data extraction and analysis. All included studies underwent quality assessment using the Mixed Methods Appraisal Tool.</p><p><strong>Results: </strong>In total, 28 studies reported in 27 sources met our inclusion criteria. We categorized the extracted data into 4 areas. First, regarding bibliometrics, the studies were reported between 2004 and 2024, with 2010 having the highest number of studies. Of these studies, 25 were conducted in the United States, 2 were conducted in Iran, and 1 was conducted in Argentina. Health informatics journals and conference proceedings, as well as library science journals, were prominent publishing venues. The NLM funded half of the studies. Second, regarding participants, most studies focused on outpatients. Other participant roles included physicians, nurses, hospital staff, pharmacists, and librarians. Fewer than half of the studies addressed the social determinants of health. Third, regarding intervention, most studies implemented MedlinePlus information interventions within clinical settings. Other interventions occurred in community pharmacies, community organizations, libraries, online health platforms, or patient portals. Fourth, regarding outcome, only 4 studies assessed clinical outcomes, and the findings were mixed and inconsistent. However, 24 of 28 studies reported positive nonclinical outcomes, including improved attitudes toward ","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e79416"},"PeriodicalIF":3.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13119385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sungjae Lee, Jung-Woo Son, Sung-Ai Kim, Min-Soo Ahn, Sang Jun Lee, Sang-Jin Han, Taehyun Joo, Yeongyeon Na, Sunghoon Joo, Hyun Jin Ahn, Mineok Chang, Yeha Lee, Young Jun Park
{"title":"Deep Learning Model Using Transfer Learning for Detecting Left Ventricular Systolic Dysfunction: Retrospective Algorithm Development and Validation Study.","authors":"Sungjae Lee, Jung-Woo Son, Sung-Ai Kim, Min-Soo Ahn, Sang Jun Lee, Sang-Jin Han, Taehyun Joo, Yeongyeon Na, Sunghoon Joo, Hyun Jin Ahn, Mineok Chang, Yeha Lee, Young Jun Park","doi":"10.2196/83127","DOIUrl":"https://doi.org/10.2196/83127","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence-augmented electrocardiogram (AI-ECG) models for detecting left ventricular systolic dysfunction (LVSD) often exhibit degraded performance in patients with comorbidities.</p><p><strong>Objective: </strong>This study aimed to introduce and validate a recalibration method using longitudinal patient data to enhance prediction accuracy and simulate its clinical utility for ongoing monitoring.</p><p><strong>Methods: </strong>We conducted a multicenter, retrospective cohort study using data from 2 hospitals in Korea. A dataset of paired transthoracic echocardiograms (TTEs) and electrocardiograms (ECGs) matched within a 2-week interval was constructed, separating pairs into baseline (first for each patient) and follow-up assessments. In addition to conventional supervised learning, we developed a patient-wise recalibration strategy that incorporated historical left ventricular ejection fraction measurements and prior AI-ECG outputs to adjust for future predictions, thus empirically mitigating confounding effects. Pretraining was also implemented to enhance the model's performance.</p><p><strong>Results: </strong>The recalibrated 12-lead DeepECG LVSD model achieved an area under the receiver operating curve of 0.956 (95% CI 0.946-0.965) for internal validation and 0.940 (95% CI 0.936-0.945) for external validation of follow-up TTE-ECG pairs. The uncalibrated 12-lead DeepECG LVSD model also showed modest performance, with an area under the receiver operating curve of 0.953 (95% CI 0.941-0.965) in the internal validation and 0.947 (95% CI 0.943-0.951) in the external validation when tested on baseline TTE-ECG pairs. Recalibration yielded statistically significant improvements in the 12-lead DeepECG LVSD models (P<.001), with enhanced and more balanced performance across all clinical subgroups.</p><p><strong>Conclusions: </strong>Patient-wise recalibration improved accuracy and consistency across various comorbidities by mitigating performance degradation and bias. This broadens the application of AI-ECG for LVSD detection from low-risk screening to high-risk longitudinal monitoring.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e83127"},"PeriodicalIF":3.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CO<sub>2</sub> Laser Popularity in Germany: A Five-Year Google Trends Analysis (2020-2025).","authors":"Michael Constantin Kirchberger, Andreas Eisenried","doi":"10.2196/77651","DOIUrl":"https://doi.org/10.2196/77651","url":null,"abstract":"<p><strong>Background: </strong>Fractional carbon dioxide (CO₂) laser resurfacing is widely used for the treatment of scars and photoaging. In recent years, public interest in minimally invasive esthetic procedures has grown, influenced by social media exposure and changing beauty norms. However, data quantifying population-level attention to CO₂ laser treatments in Germany are limited.</p><p><strong>Objective: </strong>This study aimed to assess the long-term trajectory and seasonal patterns of public information-seeking behavior regarding fractional CO₂ laser treatments in Germany from January 2020 to December 2025 using Google Trends data.</p><p><strong>Methods: </strong>Monthly normalized search volume (NSV) for the category \"Health\" and the term \"CO2 laser\" was retrieved for the period January 2020 to December 2025. Seasonal-Trend decomposition (STL) using LOESS (locally estimated scatterplot smoothing) was applied to isolate the long-term trend from seasonal fluctuations. The significance of the upward trajectory was assessed using linear regression on the extracted trend component, and seasonal differences were evaluated via the seasonal component amplitude.</p><p><strong>Results: </strong>Public interest in CO₂ lasers increased significantly, with the annual mean NSV rising from 15.0 in 2020 to 68.1 in 2025. Regression analysis of the STL trend component revealed a steady, statistically significant monthly increase (slope=0.87 NSV/month; 95% CI 0.83-0.92; P<.001). Furthermore, a robust seasonal pattern was identified (P<.001), with search interest consistently peaking in winter (January mean SD 13.8) and reaching a nadir during the summer months (August SD=-14.4).</p><p><strong>Conclusions: </strong>Digital information-seeking behavior regarding fractional CO₂ laser treatments in Germany increased by 354% over the past six years, accompanied by consistent, clinically relevant seasonal peaks in winter. These findings reflect broader shifts in esthetic awareness. The identified temporal patterns provide valuable insights for timing educational messaging, managing patient inquiries, and addressing safety considerations in esthetic medicine.</p>","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e77651"},"PeriodicalIF":3.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qingrui Li, Kapileshwor Ray Amat, Eric L Johnson, Juan Li
{"title":"Modeling Diabetes Risk and Progression With Public Health Data: Ontology-Guided, Simulation-Capable Digital Twin Study.","authors":"Qingrui Li, Kapileshwor Ray Amat, Eric L Johnson, Juan Li","doi":"10.2196/87374","DOIUrl":"https://doi.org/10.2196/87374","url":null,"abstract":"<p><strong>Background: </strong>Digital twins (DTs) offer a paradigm for health care by enabling data-driven, simulation-capable representations of individual health trajectories. However, DT development remains limited by the scarcity of standardized, temporally structured, and multidomain data suitable for modeling chronic disease progression. Most existing DT studies rely on narrowly scoped or proprietary datasets, restricting generalizability. Public health datasets, such as the Midlife in the United States study, provide rich biopsychosocial information but are underused due to structural complexity and lack of semantic integration frameworks.</p><p><strong>Objective: </strong>This study aimed to develop and evaluate an ontology-guided, agent-orchestrated framework for constructing offline, simulation-capable, and progression-aware DTs from public health datasets. Using diabetes as a case study, the framework integrates agent-based orchestration, medical ontologies, and large language model (LLM)-assisted semantic reasoning with machine learning to support explainable feature structuring, risk prediction, and predictive \"what-if\" progression analysis.</p><p><strong>Methods: </strong>A 6-stage DT framework was developed and applied to Midlife in the United States wave 2 (baseline) and wave 3 (follow-up) data. Ontology- and LLM-assisted feature selection identified predictors across biological, behavioral, psychosocial, and socioeconomic domains. Cleaned and harmonized data were used to train predictive models (random forest, eXtreme gradient boosting, and logistic regression) to estimate diabetes onset at follow-up. A state-transition simulator was implemented to model between-wave progression dynamics, quantify transitions across low-, medium-, and high-risk states, and evaluate predictive \"what-if\" scenarios such as weight reduction and lifestyle improvement. Model performance was assessed using accuracy, F1 score, area under the receiver operating characteristic curve (AUC), and calibration metrics.</p><p><strong>Results: </strong>From 9976 candidate variables, ontology- and LLM-guided selection retained the top 200 relevant predictors spanning biological, behavioral, psychosocial, and socioeconomic domains. Predictive modeling achieved strong discrimination, with random forest (AUC=0.82, accuracy=0.76) and eXtreme gradient boosting (AUC=0.81, accuracy=0.75) outperforming logistic regression (AUC=0.78). The state-transition simulator reproduced realistic progression patterns: 33.9% (1414/4174) of participants changed risk states between waves, and the high-risk group increased from 10.8% (451/4174) to 32.2% (1344/4174). Next-state prediction accuracy reached 92.5%. Predictive \"what-if\" analyses showed that with a simulated 10% weight reduction, model-estimated diabetes cases decreased by 98 (from 576 to 478). A placebo test (0% weight change) produced less than 0.3% difference in risk distribution, confirming model stability.</p><p><strong","PeriodicalId":56334,"journal":{"name":"JMIR Medical Informatics","volume":"14 ","pages":"e87374"},"PeriodicalIF":3.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}