Clara Månsson Biehl, Matilda Elliver, Johanna Gudjonsdottir, Martin Salö
{"title":"Utility of Urine Dipstick Testing in Pediatric Appendicitis: Assessing its Role in Identifying Complicated Cases and Retrocecal Appendicitis.","authors":"Clara Månsson Biehl, Matilda Elliver, Johanna Gudjonsdottir, Martin Salö","doi":"10.1055/a-2490-1156","DOIUrl":"10.1055/a-2490-1156","url":null,"abstract":"<p><strong>Background: </strong> Diagnosing appendicitis in children remains a challenge, and the role of urine dipstick is controversial. This study aimed to evaluate the association between abnormal urine dipstick results and appendicitis, particularly appendicitis severity and appendix position.</p><p><strong>Methods: </strong> A prospective cohort study was conducted from 2017 to 2021 at a tertiary hospital in Sweden. Children aged ≤ 15 years with suspected appendicitis were included. Logistic regression was used to assess associations between abnormal urine dipstick results and sex, age, peritonitis, body temperature, C-reactive protein, complicated appendicitis, and appendix position.</p><p><strong>Results: </strong> A total of 311 children with suspected appendicitis were included, with 193 (62%) diagnosed with appendicitis. Among these, 80 (41%) had complicated appendicitis. There was no difference in appendicitis rate between children with positive and normal urine dipstick results. Among children with appendicitis, 119 (62%) had positive urine dipstick results: 49% ketones, 29% erythrocytes, 23% protein, 19% leukocytes, and 2% nitrite. Multivariable analysis revealed that female sex (adjusted odds ratio: 2.41 [95% confidence interval, CI: 1.21-4.80], <i>p</i> = 0.013), retrocecal appendicitis (aOR: 2.39 [95% CI: 1.18-4.84], <i>p</i> = 0.015), and complicated appendicitis (aOR: 2.27 [1.01-5.13], <i>p</i> = 0.015) were significantly associated with abnormal urine dipstick results. Sensitivity and specificity of positive urine dipstick for complicated appendicitis was 56% (95% CI: 45-67%) and 64% (95% CI: 54-73%), respectively, with an area under the curve of 0.62 (95% CI: 0.54-0.70). Limitations in this study include potential unmeasured confounders such as hydration status and urinary tract infections.</p><p><strong>Conclusion: </strong> Abnormal urine dipstick results are common in children with appendicitis. Urine dipstick might help identify cases of complicated and retrocecal appendicitis.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":"269-276"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Holger Till, Hesham Elsayed, Georg Singer, Beate Obermüller, Tristan Till, Richard Gnatzy, Sebastian Tschauner
{"title":"Enhancing AI Readiness in Pediatric Surgery: Impact of a Targeted Workshop on Knowledge and Competencies.","authors":"Holger Till, Hesham Elsayed, Georg Singer, Beate Obermüller, Tristan Till, Richard Gnatzy, Sebastian Tschauner","doi":"10.1055/a-2650-6603","DOIUrl":"10.1055/a-2650-6603","url":null,"abstract":"<p><p>Despite an awareness of the transformative potential of artificial intelligence (AI) in health care, its development in pediatric surgery seems slow. One major reason may be a lack of formal AI training. This study assesses the basic AI knowledge and the effectiveness of AI workshops (AI-WS).Four AI-WS were held at the International Academy of Pediatric Surgery 2024. Topics included AI principles, real-time algorithm training, and potential AI applications in pediatric surgery. Self-developed surveys consisting of eight pre-WS and nine post-WS questions were conducted, focusing on participants' AI competencies, usage, educational needs, barriers, and future perspectives.Out of 57 pediatric surgeons, 53 completed both surveys. None had formal AI training. Although 90% were familiar with AI in diagnostic imaging, most had only basic knowledge of AI technology. After the workshop, participants reported a significant increase in the general understanding of AI/machine learning (ML) (<i>p</i> < 0.001). 96% stated that they were better informed about AI/ML applications for clinical practice; 83% expressed interest in further AI training; 91% believed that AI will be more integrated into clinical practice; and over 80% anticipated that AI will improve patient outcomes.The AI-WS effectively enhanced pediatric surgeons' AI knowledge and their readiness to adopt AI technologies. Even though our study is limited by the relatively low sample size and a potential selection bias, our results still highlight the importance of targeted education in preparing health care professionals for AI integration. The long-term sustainability of knowledge gains, however, has to be examined in further studies.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mikal Obed, Jens Dingemann, Benno Ure, Rim Kiblawi
{"title":"Postoperative Flank Bulge in Infants After Open CDH Repair: An Underreported Complication.","authors":"Mikal Obed, Jens Dingemann, Benno Ure, Rim Kiblawi","doi":"10.1055/a-2649-0722","DOIUrl":"https://doi.org/10.1055/a-2649-0722","url":null,"abstract":"<p><p>Flank bulge (FB) is a rare postoperative complication, most commonly following surgery with retroperitoneal access through flank incision. It is characterized by relaxation of anterolateral wall muscles with abnormal protrusion of the abdominal wall. The assumed pathomechanism is iatrogenic injury of the intercostal nerves T11/T12. During congenital diaphragmatic hernia (CDH) repair, dissection and sutures are necessary at this thoracic level. We aimed to assess the risk of FB in a consecutive series of patients after CDH repair.We retrospectively analyzed charts of all patients after CDH repair (2007-2024) with a follow-up of ≥3 months. FB was diagnosed during clinical follow-up examinations and defined as protrusion of abdominal wall with no sonographic evidence for hernia. Surgical variables and their association with FB were evaluated. For statistical analysis, Pearson's and Student's t-test were used. Multivariate logistic regression was performed to identify independent risk factors associated with FB development after CDH repair.Among 67 infants undergoing CDH repair with follow-up, 76% underwent open surgery and 48% required patch repair. Postoperative FB occurred in 11% of patients, exclusively following open repair with patch, and was significantly associated with rib sutures and higher birth weight. One-third of FB cases resolved spontaneously, while the remainder persisted, though without functional impairment.FB may be an underestimated complication after open CDH repair. Routine assessment of abdominal wall tone is recommended during follow-up after CDH repair. Larger studies are needed to clarify the clinical impact, patient-perceived level of disability, and long-term sequelae.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saioa Santiago-Martínez, Dayang Anita Abdul Aziz, Kristin Bjørland, Catalina Correa, Ruta Gagilyte, Sarah Ellul, Esperanza Hernández, Paula Jimenez Arribas, Judith Lindert, Shireen Anne Nah, Lucie Pos, Helena Reusens, Andrea Schmedding, Shilpa Sharma, Maria-Christina Stefanescu, Touabti Souhem, Sofia Vasconcelos-Castro, Charlotte Vercauteren, Wani Alliance Bisimwa, Azrina Zaman
{"title":"Research Involvement and Gender Disparities Among Pediatric Surgeons: A Multinational Survey.","authors":"Saioa Santiago-Martínez, Dayang Anita Abdul Aziz, Kristin Bjørland, Catalina Correa, Ruta Gagilyte, Sarah Ellul, Esperanza Hernández, Paula Jimenez Arribas, Judith Lindert, Shireen Anne Nah, Lucie Pos, Helena Reusens, Andrea Schmedding, Shilpa Sharma, Maria-Christina Stefanescu, Touabti Souhem, Sofia Vasconcelos-Castro, Charlotte Vercauteren, Wani Alliance Bisimwa, Azrina Zaman","doi":"10.1055/a-2649-0566","DOIUrl":"10.1055/a-2649-0566","url":null,"abstract":"<p><p>There is a lack of background regarding knowledge about the involvement of pediatric surgeons (PSs) in scientific activities. We aimed to investigate scientific activity among PSs worldwide.An anonymous online questionnaire in English collected demographic data, time spent on research, participation in scientific conferences, publications, and funding for conference attendance. Co-authors distributed it through national and international pediatric surgery societies and groups to reach their members.A total of 526 PSs responded (57% female). About 55% of those surveyed reside in Europe. Most worked in university hospitals (61%), 9% at a university faculty, and 0.8% in a research facility. Only 23% were engaged in research, with similar rates for females (21%) and males (26%) (NS).Additional time out of working hours was required for research, particularly among female PSs. Full compensation for research was reported by 10% of females and 29% of males (<i>p</i> < 0.02). Around 73% had attended at least one local, regional, national, or international scientific conference (75% of females vs. 70% of males, NS), while 84% had no funding for at least one event (87% of females vs. 80% of males, NS). Scientific paper was presented by 69% at some conference. At least one scientific paper was published by 20% (17% of females vs. 23% of males, NS).Research involvement among PSs is limited, with unpaid work and funding gaps, particularly among women. Potential solutions include improving research training, structured mentorship (especially for women), institutional support for protected research time, and equitable access to funding opportunities.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Giant Omphalocele: Systematic Review of Pulmonary Complications and Implications for Neonatal Care.","authors":"Joana Peixoto, Joana Neto, Susana Pissarra, Inês Azevedo, Henrique Soares, Gustavo Rocha","doi":"10.1055/a-2649-0781","DOIUrl":"https://doi.org/10.1055/a-2649-0781","url":null,"abstract":"<p><p>The primary objectives were to know the prevalences of pulmonary hypoplasia (PH), persistent pulmonary hypertension of the newborn (PPHN), and mortality in newborn infants with giant omphalocele (GO). A secondary aim was to assess the prevalence of syndromes and other congenital anomalies (SCA) associated with GO.A systematic review according to PRISMA guidelines using MEDLINE/PubMed, Google Scholar, and Scopus platforms was performed. The search strategy combined indexed and in-process citations up to May 22, 2023.Out of 651 articles, 23 met the inclusion criteria, comprising 14 observational studies and 9 case reports. There was no uniformity in the criteria for diagnosing PH and PPHN among the studies. In the observational studies, the prevalence of PH varied between 18.5 and 54% (median: 26%); the prevalence of PPHN varied between 13 and 100% (median: 38.5%); and mortality varied between 4 and 50% (median 23.5%). SCA were reported in 58% of patients. In the case series, PH was present in 27.8% of the neonates, PPHN in 50%, and mortality occurred in 55.5%. About 55.5% had associated SCA. The association of SCA and preterm birth contributed significantly to increase the mortality rate.The reported prevalences of PH, PPHN, mortality, and SCA associated with GO are alarmingly high. Although the heterogeneity and limitations of the included studies prevent definitive prevalence estimates, the findings underscore the urgent need for standardized diagnostic criteria, better prenatal counseling, and management in highly specialized centers.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anas Shikha, Zahraa Zaghloul, Mashal Ahmed, Khalid Eltaeb, Janice Wong
{"title":"Round Ligament Management in Percutaneous Inguinal Hernia Repair: Comparative Outcomes Using the FLAIR Technique in Girls.","authors":"Anas Shikha, Zahraa Zaghloul, Mashal Ahmed, Khalid Eltaeb, Janice Wong","doi":"10.1055/a-2646-2153","DOIUrl":"https://doi.org/10.1055/a-2646-2153","url":null,"abstract":"<p><p>Fenestrated laparoscopic-assisted internal ring-rrhaphy (FLAIR) is a refined percutaneous technique for pediatric inguinal hernia repair. Although its outcomes have been reported in boys, its application in girls, particularly in relation to round ligament management, remains underexplored. Whether to include or exclude the ligament during internal ring closure is still debated.This study evaluated the impact of round ligament management on surgical outcomes in girls undergoing FLAIR. A retrospective cohort of 69 hernias, operated on between July 2016 and December 2023, was reviewed. Patients were divided into two groups: those in whom the round ligament was included in the closure (Inclusion group) and those in whom it was deliberately spared (Exclusion group). Recurrence rates and postoperative complications were compared.All four recurrences (11%) occurred in the Inclusion group, while no recurrences were observed in the Exclusion group (<i>p</i> = 0.048). All recurrences occurred within 3 months postoperatively and were successfully reoperated using the exclusion technique, with no further recurrence during follow-up. No significant differences in other postoperative complications were identified between groups.FLAIR appears to be a safe and effective approach in girls, particularly when the round ligament is excluded from the closure. Exclusion was associated with zero recurrences and no increase in complications. These findings, observed over intermediate-term follow-up, suggest that sparing the round ligament may enhance repair integrity and potentially protect the ligament from entrapment, thereby preserving its anatomical function. Larger, multicenter studies with extended follow-up are needed to validate these results and guide pediatric hernia repair strategies.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulina Vargova, Matej Varga, Beatriz Izquierdo-Hernández, Cristina Gutierrez-Alonso, Ainara Gonazlez-Esgueda, Maria Victoria Cobos-Hernández, Rafael Fernandez-Atuan, Yurema Gonzalez-Ruiz, Paolo Bragagnini-Rodriguez, María Del-Peral-Samaniego, Carolina Corona-Bellostas
{"title":"Artificial Intelligence Enhances Diagnostic Accuracy of Contrast Enemas in Hirschsprung Disease Compared to Clinical Experts.","authors":"Paulina Vargova, Matej Varga, Beatriz Izquierdo-Hernández, Cristina Gutierrez-Alonso, Ainara Gonazlez-Esgueda, Maria Victoria Cobos-Hernández, Rafael Fernandez-Atuan, Yurema Gonzalez-Ruiz, Paolo Bragagnini-Rodriguez, María Del-Peral-Samaniego, Carolina Corona-Bellostas","doi":"10.1055/a-2646-2052","DOIUrl":"10.1055/a-2646-2052","url":null,"abstract":"<p><p>Contrast enema (CE) is widely used in the evaluation of suspected Hirschsprung disease (HD). Deep learning is a promising tool to standardize image assessment and support clinical decision-making. This study assesses the diagnostic performance of a deep neural network (DNN), with and without clinical data, and compares its interpretation with that of pediatric surgeons and radiologists.In this retrospective study, 1,471 CE images from patients <15 years were analyzed, with 218 images used for testing. A DNN, pediatric radiologists, and surgeons independently reviewed the testing set, with and without clinical data. Diagnostic performance was assessed using ROC and PR curves, and interobserver agreement was evaluated using Fleiss' kappa. Rectal biopsy served as the reference standard.The DNN achieved high diagnostic accuracy (area under the receiver operating characteristic curve [AUC-ROC] = 0.87) in CE interpretation, with improved performance when combining anteroposterior and lateral images (AUC-ROC = 0.92). Clinical data integration further enhanced model sensitivity and negative predictive value. The super-surgeon (majority voting of colorectal surgeons) outperformed most individual clinicians (sensitivity 81.8%, specificity 79.1%), while the super-radiologist (majority voting of radiologists) showed moderate accuracy. Interobserver analysis revealed strong agreement between the model and surgeons (Cohen's kappa = 0.73), and overall consistency among experts and the model (Fleiss' kappa = 0.62).Artificial intelligence-assisted CE interpretation achieved higher specificity and comparable sensitivity to that of the clinicians. Its consistent performance and substantial agreement with experts support its potential role in improving CE assessment in HD.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minna Tervahartiala, Antti Koivusalo, Mikko Pakarinen
{"title":"Success of Antegrade Continence Enema (ACE) in Pediatric Patients with Impaired Fecal Control.","authors":"Minna Tervahartiala, Antti Koivusalo, Mikko Pakarinen","doi":"10.1055/a-2646-1919","DOIUrl":"10.1055/a-2646-1919","url":null,"abstract":"<p><p>We aimed to describe long-term outcome, treatment success, and complications of antegrade continence enema (ACE) procedures considering underlying etiologies and associated disorders.Overall, 180 patients undergoing ACE procedure at our institution during 1997-2019 were included in this retrospective study. Treatment success was defined as patient staying clean.The main underlying etiologies included spina bifida (<i>n</i> = 65, 36%), anorectal malformations (<i>n</i> = 58, 32%), Hirschsprung disease (<i>n</i> = 25, 14%), and functional constipation (<i>n</i> = 7, 4%). The most common complications were stomal leakage (<i>n</i> = 39, 22%), stenosis (<i>n</i> = 38, 21%), infection (<i>n</i> = 35, 19%), and granuloma/mucosal prolapse of the stoma (<i>n</i> = 34, 19%), and 29% (<i>n</i> = 52) of the patients reported functional problems. Overall, 48% of the patients (<i>n</i> = 87) experienced at least one ACE-related complication. At the latest follow-up, 61% of the patients were using ACE (<i>n</i> = 110), of whom 86% stayed clean (<i>n</i> = 95). Overall, ACE treatment was successful in 81% of patients (<i>n</i> = 144), defined as being clean with ACE in current use or after discontinuing ACE treatment as unnecessary. In total, 31% of the patients had stopped using ACE as unnecessary (<i>n</i> = 45). Spina bifida patients were least likely to discontinue ACE usage (<i>n</i> = 9, 14%), followed by anorectal malformation patients (<i>n</i> = 17, 29%), while 32% of Hirschsprung patients (<i>n</i> = 8) and 71% of constipation patients (<i>n</i> = 5) discontinued ACE as unnecessary.As previous studies have also shown, we demonstrated that ACE treatment can be successfully utilized in majority of children with impaired fecal control. Two-thirds of patients continued ACE treatment over 5 years of whom 86% patients were staying clean.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gökhan Arkan, Betül Öğüt, Aylar Poyraz, Yusuf Hakan Çavuşoğlu
{"title":"Polydatin as a Potential Therapeutic in Pediatric Intestinal Volvulus: Evidence from an Experimental I/R Injury Model.","authors":"Gökhan Arkan, Betül Öğüt, Aylar Poyraz, Yusuf Hakan Çavuşoğlu","doi":"10.1055/a-2646-1987","DOIUrl":"https://doi.org/10.1055/a-2646-1987","url":null,"abstract":"<p><p>Small bowel volvulus is a clinical condition that causes intestinal ischemia-reperfusion (I/R) injury, leading to severe tissue damage and high mortality rates. Polydatin, a natural stilbenoid polyphenol, has demonstrated anti-inflammatory and antioxidant properties. This study aimed to evaluate the protective effects of polydatin on I/R injury using an experimental small bowel volvulus model.A total of 24 healthy female Wistar albino rats were divided into four groups: Sham (Group 1), Polydatin (Group 2), I/R (Group 3), and Treatment (Group 4). In Group 1, no I/R procedure was applied, and intraperitoneal saline was administered. Group 2 received 20 mg/kg intraperitoneal polydatin without I/R. In Group 3, a 5-cm segment of the small intestine was twisted 360 degrees clockwise, leading to 2 hours of ischemia and 2 hours of reperfusion. Group 4 received 20 mg/kg intraperitoneal polydatin before reperfusion. Blood and intestinal tissue samples were collected for biochemical and histopathological analysis.Serum total antioxidant status (TAS) levels were significantly higher in the treatment group compared with the I/R group (<i>p</i> = 0.004). Serum total oxidant status (TOS) levels were significantly elevated in the I/R group compared with all other groups (<i>p</i> < 0.001) but were significantly reduced in the treatment group (<i>p</i> < 0.001). Tissue oxidative stress index (OSI) values were significantly lower in the treatment group compared with the I/R group (<i>p</i> = 0.004). Although serum OSI levels and tissue TAS and TOS values showed a favorable trend, they were not statistically significant. Histopathological evaluations revealed a marked reduction in tissue damage in the treatment group compared with the I/R group.Polydatin exerts protective effects against I/R injury in an experimental small bowel volvulus model by reducing oxidative stress and histopathological damage. These findings highlight its therapeutic potential and warrant further clinical research.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boaz Karmazyn, Matthew R Wanner, Monica M Forbes-Amrhein, Britney L Grayson, Megan B Marine, S Gregory Jennings, George J Eckert, Deborah F Billmire
{"title":"Beyond the AP View: The Diagnostic Value of Lateral Duodenal and Colonic Assessment in Pediatric Malrotation.","authors":"Boaz Karmazyn, Matthew R Wanner, Monica M Forbes-Amrhein, Britney L Grayson, Megan B Marine, S Gregory Jennings, George J Eckert, Deborah F Billmire","doi":"10.1055/a-2646-1826","DOIUrl":"https://doi.org/10.1055/a-2646-1826","url":null,"abstract":"<p><p>This study aimed to assess if the position of the duodenal-jejunal junction in the anteroposterior view can reliably diagnose malrotation and if atypical position of the duodenal-jejunal junction (medial to the left pedicle to midline) is associated with a low risk of narrow mesenteric root.Children diagnosed with intestinal rotational abnormalities (2007-2023) through upper gastrointestinal fluoroscopy (UGI) studies who underwent surgery were reviewed independently by two pediatric radiologists. Key observations included the duodenal-jejunal junction location in the anteroposterior view, duodenal position in the lateral view, jejunal loop position, and colon anatomy.Radiologists independently reviewed the UGI studies and disagreements between radiologists were resolved by consensus readings. Chi-square tests were used to compare the anatomical variables and the presence of surgically confirmed narrow mesenteric roots.Of the examined 79 children (mean age, 2 years), 60 (75.9%) underwent Ladd's procedure after confirming a narrow mesenteric root.According to the consensus, 77.1% of children with atypical duodenal-jejunal junction in the anteroposterior view had narrow mesenteric roots, and one had midgut volvulus. The likelihood of missing a surgically confirmed narrow mesenteric root was significantly lower (<i>p</i> = 0.0167) when considering the position of the duodenum in the lateral view, along with the jejunal loops and colonic position (0/3), compared with relying solely on duodenal-jejunal junction position in the anteroposterior view (29/37).The anteroposterior view alone is insufficient for diagnosing malrotation. Reviewing the lateral view of the duodenum, and when necessary, the colonic anatomy, reduces the risk of missing cases with surgically confirmed narrow mesenteric roots.</p>","PeriodicalId":56316,"journal":{"name":"European Journal of Pediatric Surgery","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}