Karla J Faig, Aidan E Steeves, Chris A McGibbon, Molly A Gallibois, Alanna K Bohnsack, Josée S Haché, Grant A Handrigan, Carole C Tranchant, Andrew M Sexton, Samantha M Knill, Pamela G Jarrett
{"title":"Adverse Events in Older Adults at Risk for Dementia During Remote Physical Exercise and Cognitive Training.","authors":"Karla J Faig, Aidan E Steeves, Chris A McGibbon, Molly A Gallibois, Alanna K Bohnsack, Josée S Haché, Grant A Handrigan, Carole C Tranchant, Andrew M Sexton, Samantha M Knill, Pamela G Jarrett","doi":"10.5770/cgj.29.891","DOIUrl":"10.5770/cgj.29.891","url":null,"abstract":"<p><strong>Background: </strong>SYNchronizing Exercises, Remedies in GaIt and Cognition @Home (SYNERGIC@Home/SYNERGIE~Chez soi) is a home-based, double-blind, randomized controlled trial. Sixty community dwelling older adults (aged 60-90 years), living in New Brunswick, Canada, who were at risk of dementia participated remotely using secure videoconferencing. Participants underwent 16 weeks (three sessions/week) of cognitive and physical interventions. This research aimed to determine the frequency, severity, and relationship of adverse events (AEs) that occurred during the physical and cognitive intervention phase of the SYNERGIC@Home study. This study addressed a critical question: Whether AEs occurring during a remote exercise and cognitive intervention for older adults at risk of dementia can be managed safely and effectively to optimize participation.</p><p><strong>Methods: </strong>All AEs were recorded, including type, severity, and their relatedness to the intervention. Intervention modifications due to AEs were also recorded.</p><p><strong>Results: </strong>Participant's mean age was 69.5 years (SD=6.47), 76.7% were female, and 58.4% were living in suburban or urban communities. A total of 88 AEs affected 42 (70.0%) participants. Most AEs (71.6%) were unrelated to the intervention, and 69.3% were classified as mild, with musculoskeletal issues being the most common AE (39.8%). One unrelated serious AE was recorded. Modifications to the physical intervention were made for 31 participants, and two discontinued due to unrelated medical issues.</p><p><strong>Conclusions: </strong>When delivered remotely, physical and cognitive interventions resulted in no serious related AEs and the few related, mostly mild AEs, were safely managed through modifications to the physical interventions.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"29 1","pages":"8-14"},"PeriodicalIF":1.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shailesh Nadkarni, Samin Barakati, Neil Dinesh Dattani, Sudip Saha
{"title":"Evaluating the Impact of an Emotion-Focused Model of Dementia Care on Patient Outcomes in Acute Care Settings.","authors":"Shailesh Nadkarni, Samin Barakati, Neil Dinesh Dattani, Sudip Saha","doi":"10.5770/cgj.29.858","DOIUrl":"10.5770/cgj.29.858","url":null,"abstract":"<p><p>Emotion-focused model of care delivery creates a supportive environment for persons with dementia. There is a lack of certainty regarding one such emotion-focused model's effectiveness (Butterfly) in an acute care environment, primarily because prior research has been confined to long-term care (LTC) facilities. Studies have demonstrated reduced neuropsychiatric symptoms (NPS) when person-centred dementia care models are deployed for persons living with dementia (PLWD). A multi-site cross-sectional design assessed NPS in PLWD using the NPI-Q scale in hospitalized patients on a Emotion-focused unit for 7-21 days. We identified 177 PLWD (88 from an acute care for elderly unit, 89 from general medicine units). The two cohorts had 40 female and 48 male patients in the ACE unit and 35 female and 54 male patients in the general medicine unit. The average age between the two groups was 83 and 84 yrs, respectively. NPI-Q symptom severity was lower on the ACE unit in comparison to the general medicine unit. Mean improvement for motor behaviours and sleep were significant. Caregiver distress scores were significantly lower for delusions, agitation, anxiety, irritability, motor behaviour and sleep. Emotion-focused care made a statistically significant change in NPS severity and caregiver distress when compared to care provided in general medicine units.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"29 1","pages":"23-27"},"PeriodicalIF":1.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erin D Davis, Prangad Gupta, Chantelle R Zimmer, Caitlin McClurg, Jayna M Holroyd-Leduc
{"title":"Cultural and Ethnic Dimensions of Mealtime Practices in Long-Term and Residential Care: a Comprehensive Scoping Review.","authors":"Erin D Davis, Prangad Gupta, Chantelle R Zimmer, Caitlin McClurg, Jayna M Holroyd-Leduc","doi":"10.5770/cgj.29.878","DOIUrl":"10.5770/cgj.29.878","url":null,"abstract":"<p><strong>Background: </strong>As ethnically diverse populations increasingly access long-term care (LTC) and residential care facilities (RCF), mealtimes emerge as vital opportunities to preserve cultural identity, foster social connections, and support well-being. However, systemic barriers and institutional limitations often prevent culturally inclusive mealtimes, marginalizing minority populations and perpetuating inequities in mealtime delivery. This review explores the state of knowledge on cultural and ethnically diverse mealtime practices and menu options within LTC and RCF.</p><p><strong>Methods: </strong>Using the Joanna Briggs Institute framework and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Review (PRISMA-ScR) guidelines, a comprehensive scoping review was conducted. Databases and grey literature sources were systematically screened, with data extracted and analyzed using a hybrid thematic analysis. Findings were organized by the socioecological model, exploring influences at intrapersonal, interpersonal, community, institutional, and societal levels.</p><p><strong>Results: </strong>A total of 126 full-text manuscripts were reviewed and 42 were included in the final analysis. Key themes emphasized food's role in cultural identity, and highlighted best practices in ethnic-specific facilities, which tailored menus and rituals to residents' needs. Barriers included budget constraints, limited access to culturally specific ingredients, insufficient staff training, and standardized menus. Families often bridged these gaps, straining their resources. Promising practices included flexible meal schedules, resident-centred menu planning, staff training, and partnerships with cultural organizations. Recommendations focused on increasing funding, implementing flexible policies, and studying the long-term impacts of inclusive practices.</p><p><strong>Conclusions: </strong>Culturally inclusive mealtime practices have the potential to transform LTC and RCF by promoting dignity, enhancing quality of life, and addressing systemic inequities. Ethnic-specific facilities provide effective models, but broader adoption of best practices is necessary for mainstream care settings.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"29 1","pages":"31-49"},"PeriodicalIF":1.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucas Xavier Perri, Afolasade Fakolade, Karen Okrainec, Warren Lewin
{"title":"Caring Across Generations: The Urgent Need to Support Young Carers in Canada's Aging Population.","authors":"Lucas Xavier Perri, Afolasade Fakolade, Karen Okrainec, Warren Lewin","doi":"10.5770/cgj.29.921","DOIUrl":"10.5770/cgj.29.921","url":null,"abstract":"<p><p>Young carers-youth aged 15 to 24 years who provide unpaid care to older adults-represent an essential yet often invisible component of Canada's caregiving landscape. Over one million young Canadians provide unpaid care to family members, with approximately 40% caring for older adults such as grandparents. As Canada's population ages and chronic illness prevalence rises, the number of young people assuming caregiving responsibilities continues to grow. Despite their significant contributions, young carers face unique challenges including impacts on mental health, educational attainment, and social development, often without formal recognition or support. This Perspectives article reviews the current evidence on young carers of older adults in Canada, examines their lived experiences, and identifies systemic gaps in health, education, and social systems. Unlike the United Kingdom, which has enacted legislation formally recognizing and supporting young carers, Canada lacks comprehensive policies and support structures for this population. Innovative programs are emerging, including foundational training for health professionals, online peer support communities, and cross-sector collaborations between health-care providers, educators, and community organizations. The article recommends actionable steps including legislative recognition of young carers, improved data collection and monitoring, expanded professional training, investment in peer support programs, and implementation of family-centered care models. Primary care teams are uniquely positioned to identify young carers, recognize their contributions, and connect families with available supports. Without adequate recognition and intervention, young carers remain at risk of long-term social, academic, and mental health difficulties affecting both themselves and those for whom they care.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"29 1","pages":"65-68"},"PeriodicalIF":1.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manan Ahuja, Kaitlin Lewis, Sawayra Owais, Jordana Compagnone, Laura Fallico, Francine Fishbein, Isabella Stefanova, Kai Man Xu, Shannon Gui, Tricia Woo, Sharon Marr, Justin Lee
{"title":"Evaluation of a Student-Older Adult Telephone Befriending Program to Reduce Social Isolation During the COVID-19 Pandemic.","authors":"Manan Ahuja, Kaitlin Lewis, Sawayra Owais, Jordana Compagnone, Laura Fallico, Francine Fishbein, Isabella Stefanova, Kai Man Xu, Shannon Gui, Tricia Woo, Sharon Marr, Justin Lee","doi":"10.5770/cgj.29.857","DOIUrl":"10.5770/cgj.29.857","url":null,"abstract":"<p><p>Social isolation and loneliness are associated with many adverse health outcomes. The COVID-19 pandemic increased its prevalence and disproportionately affected older adults. Since telephone befriending was a potentially feasible and safe intervention during the pandemic, the McMaster Phone-a-Friend Program (PFP) was developed using this strategy to try to reduce social isolation and loneliness among older adults. Thus, this study aimed to evaluate the effectiveness and long-term feasibility of PFP. Community-dwelling older adults in Ontario, Canada were matched to trained university student volunteers, who provided social engagement and pandemic-related education through weekly telephone calls. Two main referral sources were used: 1) older adults identified by their primary care provider as at risk for social isolation; and 2) older adults referred for multi-modal frailty rehabilitation, where telephone befriending was a desired component intervention. Older adults completing ≥4 calls were contacted to participate in a telephone survey to provide program feedback. Of the 220 active participants in August 2021, 60 participated in our survey. At the time of survey completion, the mean number of calls completed was 8.3. The mean age of participants was 75.6 years and 71.7% (n=43) identified as female. Furthermore, 58.3% (n=35) of the participants agreed or strongly agreed that they felt less lonely after participating in the program and 68.3% (n=41) stated they would participate in the program after the pandemic resolves. The intergenerational PFP telephone befriending program is a safe and effective method of reducing or possibly preventing social isolation and loneliness among at-risk community-dwelling older adults.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"29 1","pages":"15-22"},"PeriodicalIF":1.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Paula B D'Elia, Melissa K Andrew, Henrique Pott
{"title":"Herpes Zoster and Frailty in Older Adults: a Systematic Review.","authors":"Maria Paula B D'Elia, Melissa K Andrew, Henrique Pott","doi":"10.5770/cgj.29.916","DOIUrl":"10.5770/cgj.29.916","url":null,"abstract":"<p><strong>Background: </strong>Herpes zoster (HZ) and its complications, postherpetic neuralgia (PHN), are common in adults, particularly the frail. Frailty may affect infection outcomes and vaccine efficacy. This study evaluated the association between frailty and HZ/PHN risk, and examined vaccine uptake, immunogenicity, and efficacy in frail versus non-frail individuals.</p><p><strong>Methods: </strong>We systematically reviewed PubMed/MEDLINE, the Cochrane Library, Embase, and grey literature for studies published from January 2015 to January 2025. Eligible studies included observational and randomized controlled trials evaluating frailty in adults aged ≥50 years and reporting HZ incidence, severity, PHN, or vaccination. Two reviewers independently selected studies, extracted data using a standardized form, and assessed quality using JBI tools. Due to heterogeneity, data were synthesized narratively.</p><p><strong>Results: </strong>Eight studies met the inclusion criteria, with a sample size exceeding 15,000 participants. Two studies identified an association between frailty and an increased incidence of HZ, while two others indicated an elevated risk of PHN among frail individuals. One study highlighted low vaccine uptake in a frail Italian cohort. Three studies assessed the immunogenicity of the zoster vaccine, suggesting that although absolute immune responses may be diminished in frail individuals, relative responses are often maintained. A pooled analysis of recombinant zoster vaccine trials demonstrated consistently high efficacy (exceeding 90%) across all frailty levels.</p><p><strong>Conclusions: </strong>Frailty may increase vulnerability to HZ and PHN. Routine frailty assessment may improve vaccine uptake and prevention. Further longitudinal studies using standardized frailty measures are needed to understand the causal pathways and optimize care.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"29 1","pages":"50-58"},"PeriodicalIF":1.8,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren E Griffith, Graciela Muniz Terrera, Edwin van den Heuvel, Jayati Khattar, David B Hogan, Megan O'Connell, Mélanie Levasseur, Parminder Raina
{"title":"Physical, Psychological, Cognitive and Social Frailty Domains in Community-Dwelling Adults Aged 45-85: a Cross-sectional Analysis of the Canadian Longitudinal Study on Aging (CLSA).","authors":"Lauren E Griffith, Graciela Muniz Terrera, Edwin van den Heuvel, Jayati Khattar, David B Hogan, Megan O'Connell, Mélanie Levasseur, Parminder Raina","doi":"10.5770/cgj.28.872","DOIUrl":"10.5770/cgj.28.872","url":null,"abstract":"<p><strong>Background: </strong>Reported estimates of frailty prevalence vary considerably. At least partially attributable to differences in the conceptualization of frailty used, a better understanding of the inter-relationships among frailty domains could clarify contributors to the noted heterogeneity.</p><p><strong>Methods: </strong>A global frailty index (FI) created from baseline data on 30,097 Canadian Longitudinal Study on Aging comprehensive cohort participants was used to define physical, psychological, cognitive, and social domain-specific FIs. These were divided into quintiles with the highest 20% (Q5) representing the frailest participants. Logistic regression was used to estimate the associations between age group and biological sex with domain-specific FIs in unadjusted and adjusted (income, smoking status, nutritional risk, physical activity, social participation, interaction between sex and age group) models. The association between Q5 membership among the frailty domains was estimated using polychoric correlation coefficients.</p><p><strong>Results: </strong>The prevalence of physical and cognitive frailty increased with age, but psychological frailty decreased, especially in males. Social frailty showed gradual increases with age in females that were only evident in the oldest age group (75-85) among men. The age-groups*sex interaction <i>p</i> value was <i>p</i><.001 for social. Polychoric correlations were highest between the psychological/physical and psychological/social domains, and decreased with increasing age for all combinations.</p><p><strong>Conclusion: </strong>We found that domain-specific frailty prevalences differed by age group and sex with low associations among frailty domains, particularly at older ages. Understanding the evolution of these findings could be instrumental in developing tailored interventions to prevent frailty or modify its trajectory.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"28 4","pages":"343-352"},"PeriodicalIF":1.2,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth K Boyd, Idrissa Beogo, Barbara Liu, Fabien Schneider, Mireille Norris
{"title":"Experiences and Perspectives of Caregivers of Francophone Older Adults Accessing Community Health Services in Toronto: an Exploratory Qualitative Study.","authors":"Elizabeth K Boyd, Idrissa Beogo, Barbara Liu, Fabien Schneider, Mireille Norris","doi":"10.5770/cgj.28.861","DOIUrl":"10.5770/cgj.28.861","url":null,"abstract":"<p><strong>Background: </strong>Canada is a bilingual country; however, outside of Quebec, health-care services are predominantly offered in English. With the increasing older adult population and stretched health-care resources, Francophone older adults may face significant challenges in accessing care due to their linguistic minority status. This study explores the experiences of caregivers of Francophone older adults in the Greater Toronto Area (GTA).</p><p><strong>Methods: </strong>Using a convenience sampling strategy, caregivers of patients who had undergone geriatric assessment at the Centre Francophone du Grand Toronto (CFGT) were recruited. Participants underwent 45-minute, semi-structured interviews and completed demographic questionnaires. Three independent reviewers conducted qualitative content analysis of the interview transcripts, using the socioecological model of health and NVivo12.</p><p><strong>Results: </strong>Nine participants were primarily female (n=5), with age ranges of 40-49 (n=2), 50-59 (n=3), and 60+ (n=4). They originated from North America (n=5), Africa (n=3), and the Middle East (n=1); about half preferred English over French. Thematic analysis identified three key themes: 1) Barriers Accessing Health Care in the French Language; 2) The Need for Interpreter Support; 3) Importance of Comprehensive Francophone Community Services.</p><p><strong>Conclusions: </strong>Despite the presence of organizations (e.g., CFGT), this study reveals a significant gap in French-language services for older adults in the GTA, leading to increased challenges for their caregivers. Due to linguistic barriers, caregivers must act as interpreters to mitigate the risks associated with miscommunication and potentially worse health outcomes. Addressing these issues requires increasing bilingual health-care providers, enhancing funding for Francophone community services, and improving support systems (e.g., interpreters).</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"28 4","pages":"328-335"},"PeriodicalIF":1.2,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kayla Atchison, Pauline Wu, Dallas Seitz, Jennifer A Watt, Zahra Goodarzi
{"title":"Diagnostic Accuracy of Tools to Identify Anxiety Symptoms and Disorders in Persons with Dementia: a Systematic Review Update.","authors":"Kayla Atchison, Pauline Wu, Dallas Seitz, Jennifer A Watt, Zahra Goodarzi","doi":"10.5770/cgj.28.875","DOIUrl":"10.5770/cgj.28.875","url":null,"abstract":"<p><p>Limited anxiety tools validated against a diagnostic gold standard in the context of dementia have been identified. A systematic review update was completed to identify publications since 2017 describing tools to detect anxiety in persons with dementia compared to a diagnostic gold standard. The original search strategy was replicated in MEDLINE, Embase, and PsycINFO. Pooled prevalence and diagnostic accuracy estimates were calculated based on three or more studies presenting comparable information from either the original or updated review search. No pooled estimates were calculated in the original review given limited evidence. One study evaluating the Rating Anxiety in Dementia (RAID) scale, Neuropsychiatric Inventory, and Hamilton Anxiety Rating Scale met review inclusion criteria. The pooled prevalence of generalized anxiety disorder (GAD) (n=3, 36.7%, 95% Confidence Interval (CI): 24.3-49.2%) and diagnostic accuracy outcomes for the RAID scale (≥11 cut-off) to detect GAD (n=3, sensitivity: 89%, 95% CI: 78-95%; specificity: 73%, 95% CI: 60-82%) were calculated using data from two studies identified in the original review and the newly included study from the review update. The RAID scale has the most evidence and adequate sensitivity to support its use in identifying anxiety in persons with dementia. Validated tools to detect anxiety in persons with dementia remain understudied.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"28 4","pages":"374-381"},"PeriodicalIF":1.2,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}