{"title":"Conclusion","authors":"V. de Parades","doi":"10.3166/cer-2020-0123","DOIUrl":"https://doi.org/10.3166/cer-2020-0123","url":null,"abstract":"","PeriodicalId":56167,"journal":{"name":"Colon and Rectum","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69373429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colon and RectumPub Date : 2019-11-01Epub Date: 2019-08-07DOI: 10.1152/ajplung.00080.2018
Hang Yu, Norah Alruwaili, Bing Hu, Melissa R Kelly, Bin Zhang, Dong Sun, Michael S Wolin
{"title":"Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia.","authors":"Hang Yu, Norah Alruwaili, Bing Hu, Melissa R Kelly, Bin Zhang, Dong Sun, Michael S Wolin","doi":"10.1152/ajplung.00080.2018","DOIUrl":"10.1152/ajplung.00080.2018","url":null,"abstract":"<p><p>Changes in reactive oxygen species and extracellular matrix seem to participate in pulmonary hypertension development. Because we recently reported evidence for chronic hypoxia decreasing expression of cartilage oligomeric matrix protein (COMP) and evidence for this controlling loss of pulmonary arterial smooth muscle bone morphogenetic protein receptor-2 (BMPR2) and contractile phenotype proteins, we examined if changes in superoxide metabolism could be an important factor in a bovine pulmonary artery (BPA), organoid cultured under hypoxia for 48 h model. Hypoxia (3% O<sub>2</sub>) caused a depletion of COMP in BPA, but not in bovine coronary arteries. Knockdown of COMP by small-interfering RNA (siRNA) increased BPA levels of mitochondrial and extra-mitochondrial superoxide detected by MitoSOX and dihydroethidium (DHE) HPLC products. COMP siRNA-treated BPA showed reduced levels of SOD2 and SOD3 and increased levels of NADPH oxidases NOX2 and NOX4. Hypoxia increased BPA levels of MitoSOX-detected superoxide and caused changes in NOX2 and SOD2 expression similar to COMP siRNA, and exogenous COMP (0.5 μM) prevented the effects of hypoxia. In the presence of COMP, BMPR2 siRNA-treated BPA showed increases in superoxide detected by MitoSOX and depletion of SOD2. Superoxide scavengers (0.5 μM TEMPO or mitoTEMPO) maintained the expression of contractile phenotype proteins calponin and SM22α decreased by 48 h hypoxia (1% O<sub>2</sub>). Adenoviral delivery of BMPR2 to rat pulmonary artery smooth muscle cells prevented the depletion of calponin and SM22α by COMP siRNA. Thus, COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in BPA superoxide and its potential regulation of contractile phenotype proteins.</p>","PeriodicalId":56167,"journal":{"name":"Colon and Rectum","volume":"2 1","pages":"L569-L577"},"PeriodicalIF":4.9,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/ajplung.00080.2018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74452422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Parades, D. Bouchard, N. Fathallah, J. Contou, J. Zeitoun
{"title":"Louis Ombrédanne (1871–1956) de la pince…","authors":"V. Parades, D. Bouchard, N. Fathallah, J. Contou, J. Zeitoun","doi":"10.3166/cer-2019-0106","DOIUrl":"https://doi.org/10.3166/cer-2019-0106","url":null,"abstract":"","PeriodicalId":56167,"journal":{"name":"Colon and Rectum","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69373355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comptes-rendus du congrès de l’ASCO 2019","authors":"T. Walter, A. Lievre, T. Aparicio","doi":"10.3166/cer-2019-0107","DOIUrl":"https://doi.org/10.3166/cer-2019-0107","url":null,"abstract":"","PeriodicalId":56167,"journal":{"name":"Colon and Rectum","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47349922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Pourtal, L. Volondat, S. Lambert, J. Robert, M. Rousselet, M. Grall-Bronnec
{"title":"Les troubles périnéosphinctériens chez les patients souffrant de troubles du comportement alimentaire","authors":"C. Pourtal, L. Volondat, S. Lambert, J. Robert, M. Rousselet, M. Grall-Bronnec","doi":"10.3166/cer-2019-0115","DOIUrl":"https://doi.org/10.3166/cer-2019-0115","url":null,"abstract":"Contexte : Les troubles périnéosphinctériens (TPS) survenant chez les patients souffrant de trouble du comportement alimentaire (TCA) sont des complications sous-abord ées dans la littérature. Le but de cette revue de la littérature était de faire le point sur l’état des connaissances actuelles pour aider le clinicien prenant en charge les TPS à les mettre en lien avec les TCA, et le clinicien prenant en charge les TCA à les prévenir et à les repérer le plus précocement possible, dans une perspective de réduction des risques et des dommages.\u0000Méthode : Deux revues de littérature ont été conduites, l’une portant sur les TPS d’origine digestive, l’autre sur les TPS d’origine urinaire. La sélection des articles s’est faite en nous référant aux recommandations PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) et à partir des bases de données PubMed et ScienceDirect.\u0000Résultats : Douze articles ont été retenus. Les TPS identifies sont la constipation, l’incontinence fécale, l’incontinence urinaire et le prolapsus rectal. Ils sont secondaires aux effets de la malnutrition sur la composante musculaire ainsi qu’à la pression abdominale exercée par des comportements visant à réguler la prise de poids, tels que les exercices physiques réalisés en hyperpression, les efforts de poussée lors de l’émission des selles et les vomissements provoqués.\u0000Conclusion : Une anamnèse précise et méticuleuse chez les personnes présentant un indice de masse corporel bas semble primordiale. L’usage de laxatifs est à proscrire avant un programme de renutrition d’au moins trois semaines.","PeriodicalId":56167,"journal":{"name":"Colon and Rectum","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69373425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Définition et mesure de l’obstruction à la défécation","authors":"L. Siproudhis","doi":"10.3166/cer-2019-0110","DOIUrl":"https://doi.org/10.3166/cer-2019-0110","url":null,"abstract":"Le syndrome d’obstruction défécatoire est une situation peu satisfaisante à la fois pour les malades qui s’en plaignent et les médecins consultés. Les premiers ont des réticences à évoquer des symptômes jugés dégradants. Les seconds ont des difficultés de prise en charge liées à des stratégies peu différenciées (constipation). Cependant, une évaluation symptomatique précise (consistance des selles), un examen dynamique anorectal (anisme, rectocèle) et un test d’expulsion au ballonnet permettent de planifier la prise en charge dans les situations les plus habituelles.","PeriodicalId":56167,"journal":{"name":"Colon and Rectum","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69373367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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