Journal of Academic Research in Medicine-JAREM最新文献

{"title":"Retrospective Evaluation of the Neonatal Cholestasis Cases","authors":"Elif Sağ, E. Öztürk, H. S. Yalçın Cömert, Y. Arslan, S. Karahan, M. Çakır","doi":"10.4274/JAREM.GALENOS.2021.25733","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2021.25733","url":null,"abstract":"","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"90-96"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46868059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of Cervical Disc Prosthesis Dislocation: A Retrospective Clinical Study","authors":"Y. Akyuva, Özkan Özger, B. Urfalı, Necati Kaplan, Ali Maksut Aykut","doi":"10.4274/JAREM.GALENOS.2020.3774","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2020.3774","url":null,"abstract":"Objective: The most commonly used method for the surgical treatment of cervical disc herniation (CDH) is anterior disc excision with Smith-Robinson’s approach. Following the excision of pathological disc space, disc prosthesis is placed if a continuation of dynamic movement in the disc space is desired and a cervical cage is placed for the purpose of fusion. Cervical disc prosthesis seems superior to cervical cage; however, it is not suitable for every patient and can cause serious complications. Our study include data of patients who developed complications following the dislocation of cervical prosthesis and who were referred to our clinic. The aim of our study is to emphasize that the cervical prosthesis is not suitable for every patient and may cause serious complications. Methods: Data of the patients who were operated due to the diagnosis of CDH in other centers and underwent revision surgery for the development of cervical prosthesis dislocation between 2013 and 2020 were collected. Results: This study analysed the data of four male and three female patients. The median value of patient ages was 42 (28-53). Neck pain and swallowing difficulty were the most common reasons for admission to the clinic. Dislocation was found to develop after trauma in three patients. Anterior and posterior dislocations were found to develop in five and two patients, respectively. Seven patients underwent revision surgery. All these patients were found to have dislocations at the C5-6 level. Conclusion: The prosthesis to be placed in the surgical treatment of CDH should be determined based on the patient. Detailed information should be provided to the patient for whom cervical disc prosthesis is to be placed and prosthesis of the most appropriate size for disc space should be placed properly.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"1-4"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42308248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do INI1 and E-cadherin Expression Loss Have Any Significance in Endometrial Carcinomas?","authors":"S. Karabağ","doi":"10.4274/JAREM.GALENOS.2021.3974","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2021.3974","url":null,"abstract":"Objective: Endometrial carcinoma (EC) is a highly heterogeneous malignancy in terms of morphology, clinical course, response to treatment and prognosis. This study aimed to investigate the loss of INI1 (SWI/SNF family member) and E-cadherin expression in type 1 and 2 ECs to elucidate the mechanisms that may elucidate on the differences in pathogenesis and prognosis between lowand high-grade histological types. Methods: Immunohistochemistry (IHC) was applied for INI1 and E-cadherin in 72 patients who underwent hysterectomy for EC. Loss of INI1 and E-cadherin expression was compared between subjects with lowand high-grade EC. Results: A total of 63 patients had type 1 (endometrioid) and nine had type 2 (non-endometrioid) tumours. IHC staining revealed loss of INI1 expression in eight cases. While three of these cases were serous carcinoma, three were endometrioid carcinoma with villoglandular pattern and two were grade 3 endometrioid carcinoma. A significant difference was found in the loss of INI1 expression between low-grade (G1-G2) and highgrade (G3 endometrioid carcinoma and non-endometrioid carcinoma) tumours (p=0.004). Loss of expression was observed only in one case of dedifferentiated carcinoma in IHC staining performed for E-cadherin in 72 cases. Conclusion: A significantly greater loss of INI1 expression was observed in high-grade compared with low-grade endometrial carcinoma. This finding confirms that INI1 loss is a poor prognostic factor in these tumours as in other tumours reported in the literature and sheds light on the different pathogeneses seen in high-grade EC. To the best of our knowledge, this is the first systematic study to investigate INI1 loss in different types of endometrial carcinoma. Our results support the notion that SWI/SNF chromatin remodelling complex plays a role in the pathogenesis of high-grade EC and type 1 endometrioid carcinoma with villoglandular pattern.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"32-37"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48520723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Total Hip Arthroplasty in Unilateral Crowe Type IV Hip Dysplasia","authors":"Mehmet Özbey Büyükkuşcu, Muhammed Bilal Kürk, Yakup Alpay, Seckin Basilgan, H. Başar","doi":"10.4274/JAREM.GALENOS.2020.3864","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2020.3864","url":null,"abstract":"Objective: To investigate the functional outcomes of femoral shortening osteotomy concomitant with cementless total hip arthroplasty (THA) in unilateral Crowe type IV hip dysplasia. Methods: A total of 57 patients that underwent THA with femoral shortening osteotomy having the diagnosis of Crowe type IV developmental dysplasia of the hip between January 2005 and March 2016 were retrospectively reviewed. The Harris hip score and Western Ontario and McMaster Universities Osteoarthritis index were used to evaluate functional results. Abductor function was evaluated with the Trendelenburg sign before and after surgery. Major complications were assessed. The pre-operative and post-operative leg height inequality was also measured for all patients. Results: The mean follow-up period of patients with a follow-up of at least 2 years was 47.8 months. The Trendelenburg sign, which was positive in all patients before surgery, was positive in three patients (5.2%) during the last follow-up. The mean pre-operative leg inequality was 6.9±2.4 cm, and decreased to 1.3±0.3 cm postoperatively. During the last follow-up, five patients (8.7%) had a complaint of leg length discrepancy due to a longer leg on the THA side. Functional scores of patients during the last follow-up were statistically significant higher compared to the pre-operative period. Conclusion: Applying cementless THA in patients with unilateral Crowe type IV has satisfactory clinical results. To relieve pain and improve functional scores and quality of life, THA is the best treatment option. The rate of complications is high; however, patient can be managed with a secondary intervention or only observation.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"5-10"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43635702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMAD4 Gene Methylation May Be Effective in Adenocarcinoma Lung Cancers","authors":"M. Budak","doi":"10.4274/JAREM.GALENOS.2021.54264","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2021.54264","url":null,"abstract":"Objective: In this study, we aimed to investigate the effect of promoter region methylation of small mothers against decapentaplegic 4 (SMAD4) gene in adenoma type lung cancer cases. Adenocarcinoma and squamous type carcinomas are the most common types of lung cancer. SMAD4 gene is an intracellular signal protein. The protein of this gene, which is one of the transcription factors, functions in tissue homeostasis during embryonic development and has effects in the cancer process. Methods: In this retrospective study, a total of 40 samples including 20 paraffin-embedded tumor tissues of 20 patients with adenocarcinoma lung cancer and normal lung tissue of the same patients were included. After DNA isolation from this paraffin-embedded adenocarcinoma lung tumor tissue and its normal counterparts, methylation specific polymerase chain reaction followed by agarose gel imaging methods were applied to investigate the SMAD4 promoter methylation after bisulfite modification. Results: As a result of our study, an increased presence of methylation in the promoter region of the SMAD4 gene in the tumor tissue of a total of 12 (60%) of 20 adenocarcinoma cases compared to normal tissue was detected. A statistically significant increase in methylation rate of approximately 25-45% was found in tumor tissues of these cases compared to normal tissues (p<0.05). Conclusion: As a result of our study, we suggested that SMAD4 gene methylation may be a tumor marker for lung cancers and may contribute to the development of cancer by inhibiting SMAD4 protein expression by gene methylation and disrupting the intracellular signal pathway.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"86-89"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45924951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effects of Topical Ebselen, Propolis and Steroid Applications on Acute Radiodermatitis: Preliminary Results","authors":"Işıl Akgün Demir, S. Şirvan, S. Hasçiçek, C. Özdemir, Semra Karşıdağ","doi":"10.4274/JAREM.GALENOS.2020.3936","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2020.3936","url":null,"abstract":"Objective: Radiodermatitis is one of the early complications of radiotherapy (RT). In an acute setting, skin changes may vary from mild hyperemia to necrosis. This study aimed to compare the effects of vaseline, mometasone furoate (MF), propolis and ebselen on acute radiodermatitis and demonstrate an alternative topical treatment method that could be suggested to reduce adverse effects. Methods: A total of 40 male Wistar-Hannover rats were separated into 4 groups with 10 members to be applied with vaseline, steroid (0.01% MF), propolis (30%) and ebselen (1%), respectively. All groups received radiation at a dose of 3,000 cGy. Following the application of RT, topical applications were applied to all groups and repeated once daily until the experiment was terminated. Skin biopsies were taken from all subjects and examined in terms of erosion, epidermis atrophy, basal layer degeneration, neovascularisation, polymorphonuclear leukocyte (PMNL) infiltration, loss of hair follicles and collagenisation. Results: The level of erosion was found to be significantly lower in the MF group. Epidermal atrophy was statistically significant lower in propolis and vaseline groups. Propolis significantly decreased basal layer degeneration compared to other treatments. Neovascularisation rates were significantly higher in vaseline and ebselen groups. No significant difference was found between groups in terms of PMNL, loss of hair follicles and collagenisation. Conclusion: Different agents with different mechanisms of action may be used according to the physiopathological progress of radiodermatitis. Data obtained in this study suggest that combined use of MF, propolis and ebselen according to erythema phases may mitigate the clinical progression of acute radiodermatitis.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"11-16"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43832992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Risk Factors of Unplanned Hospital Readmission Following Percutaneous Nephrolithotomy","authors":"Y. O. Danacıoğlu, D. N. Özlü, F. Akkaş, Mustafa Gürkan Yenice, A. Taşçi","doi":"10.4274/JAREM.GALENOS.2021.3915","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2021.3915","url":null,"abstract":"Objective: Percutaneous nephrolithotomy (PNL) is currently recommended as the first treatment option for complex kidney stones larger than 2 cm. Although it is a safe and effective treatment, emergency room admissions and hospitalisations occur because of PNL complications. This study aimed to examine patient-related independent risk factors that may cause unplanned hospital readmission after PNL. Methods: Data of patients who were admitted to our clinic due to upper urinary system calculi and underwent conventional PNL operation between January 2015 and December 2019 were evaluated retrospectively. Hospital readmission was defined as unscheduled rehospitalisation within 30 days after discharge. The study cohort was divided into two groups: the readmission (group A) and non-readmission groups (group B). Post-operative complication scoring was performed according to the Clavien-Dindo classification. Multivariate logistic regression analysis was used to evaluate independent prognostic risk factors on readmission after PNL. Results: A total of 390 patients were included in our study. Of patients, 24 (6.1%) were readmitted to our clinic in the post-operative period. Gender, age, body mass index and stone volume were statistically similar between the groups. Based on multivariate analysis, the presence of Clavien 3a and 3b complications, post-operative blood transfusion, presence of preoperative hydronephrosis, American Society of Anaesthesiologist score and low stone density (<859 Hounsfield units) were determined as significant independent risk factors for readmission. Conclusion: Determination of preoperative risk factors will reduce hospital readmissions rates, thus reducing the potential burden on the health system and increasing patient comfort.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"69-74"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43219345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Pregnancy and Lactation-related Expressions in the Summary of Product Characteristics and Patient Information Leaflets of the Drugs Used for the Treatment of Nausea and Vomiting","authors":"V. Aydın, Ayfer Bahar, D. Bayram, Caner Vizdiklar, A. Akıcı","doi":"10.4274/JAREM.GALENOS.2021.35744","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2021.35744","url":null,"abstract":"Objective: Concerns and limited data on drug use in pregnancy and lactation raise the importance of relevant information in summary of product characteristics (SmPC) and patient information leaflets (PIL). This study aimed to examine the consistency of the information related to pregnancy/ lactation periods in SmPCs/PILs of drugs used for the treatment of nausea/vomiting. Methods: Details of the statements regarding pregnancy and lactation periods included in the current SmPCs/PILs of a total of 118 preparations, 21 of which were original, belonging to 12 drugs with nausea/vomiting indication, were examined. SmPCs/PILs of the generic drugs was compared with that of the original drugs to identify any “minor” or “major” difference. ÖZ Amaç: Gebelik ve laktasyonda ilaç kullanımına dair çekinceler ve veri kısıtlılığı, bu dönemleri ilgilendiren ilaç kısa ürün bilgisi (KÜB) ve kullanma talimatındaki (KT) bilgilerin önemini artırmaktadır. Bu çalışmada bulantı/kusma tedavisinde kullanılan ilaçların KÜB/KT’lerindeki gebelik ve laktasyon dönemleriyle ilişkili bilgilerdeki uyumun incelenmesi amaçlandı. Yöntemler: Bulantı/kusma endikasyonu bulunan 12 ilaca ait 21’i orijinal toplam 118 müstahzarın güncel KÜB/KT’lerinde yer alan gebelik ve emzirme dönemlerine ilişkin ifadelerin ayrıntıları incelendi. Jenerik ilaçların KÜB/KT’leri orijinaline göre “minör” veya “majör” farklılık varlığı açısından araştırıldı. Bulgular: KÜB/KT’lerin hiçbirinde gebelik endikasyonu ve buna ilişkin pozoloji bilgisi bulunmamaktaydı. Tropisetron müstahzarlarının tamamında gebelik, metoklopramid müstahzarlarının %38,5’inde gebelik, %46,2’sinde emzirme ve dimenhidrinat müstahzarlarının %66,7’sinde emzirme kontrendikeydi. Müstahzarların %60,2’sinde ilacın süte; %35,6’sında plasentaya geçtiğine ilişkin ifade KÜB’lerinde mevcuttu. Plasentaya geçişine ilişkin ifadenin varlığı durumu yalnızca metoklopramid müstahzarları arasında tutarsızlık göstermekteydi. KT’de “kullanım öncesi dikkat edilecekler” kısmında “hamilelik” ve “emzirme”nin varlığı; dimenhidrinat, metoklopramid, ondansetron ve domperidonun kendi müstahzarları arasında değişkenlik göstermekteydi. İlaçların orijinal ile jenerik müstahzarlarının KÜB/KT’lerindeki ifadeler karşılaştırıldığında, aprepitant hariç tüm ilaçlarda en az bir majör farklılık saptandı. Majör farklara en fazla KT’de laktasyon ile ilgili ifadenin yer aldığı kısımda (%15,0) rastlandı. Sonuç: Gebelikte bulantı/kusma tedavisinde olduğu gibi klinik pratikte kritik önemdeki belirli ifadelerin ilaç müstahzarları bilgilendirme belgelerinde yer alma durumlarının farklılık gösterebildiği belirlendi. Yedi ilacın altısına ait dokümanlarda en az bir majör farklılık bulunması ve ilaçların orijinallerinin KÜB/KT’lerindeki uyarı bilgilerinin jeneriklerinkilere kıyasla azımsanmayacak düzeyde farklılıklar göstermesi dikkati çekmektedir. Çalışmada elde edilen tespitler, KÜB/KT’deki bilgi içerikleri oluşturulurken hem standardizasyon hem de klinik pratikte kullanışlılık bakımından ","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"107-116"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42634467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Feto-maternal Effects of Twin Pregnancies and Twin Pregnancies Caused By Assisted Reproductive Technology","authors":"Mustafa Doğan Özçil","doi":"10.4274/JAREM.GALENOS.2020.3773","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2020.3773","url":null,"abstract":"Objective: Comparison of the effects of twin pregnancies using assisted reproductive technology (ART) and spontaneous twin pregnancies on maternal-fetal parameters. Methods: A total of 5,670 patients who were deliveried in our clinic between 01.01.2011 and 31.12.2017 were analyzed retrospectively. The fetomaternal results of 94 mothers who deliveried to twins and their infants were compared. Results: Of the 5,670 patients who gave birth, 94 were twins (1/60) and 8 were triplets (1/709). Twin births account for 92% of multiple births. The incidence of spontaneous twin pregnancy was 1/77 and constituted 79% of all the twin deliveries. The effect of ART on was found to be 21% [17% in vitro fertilization (IVF), 4% ovulation induction]. Mean maternal age was 29.25±6.00 years in twin pregnancy deliveries, 28.50±6.09 years in mothers who had spontaneous twin group, and 32.54±5.09 years in twin births due to ART. When anemia was excluded, maternal morbidity was 27% in twin pregnancy deliveries. Pre-eclampsia was determined in 19% of the cases and anemia in 63%. Delivery before 37 gestational weeks was recorded in 72.3% of IVF twins and 70.2% of spontaneous twins. The rate of live births was found to be higher in spontaneously conceived twins (p=0.004). The fetal mortality rate was 5.4% in spontaneous twin pregnancies and 20% in Hatay Mustafa Kemal Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Hatay, Türkiye İkiz Gebelikler ve Yardımcı Üreme Teknikleri ile Oluşan İkiz Gebeliklerin Feto-maternal Etkilerinin Karşılaştırılması Comparison of Feto-maternal Effects of Twin Pregnancies and Twin Pregnancies Caused By Assisted Reproductive Technology ÖZ Amaç: Yardımcı üreme teknikleri (YÜT) kullanılarak oluşan ikiz gebelikler ile spontan oluşan ikiz gebeliklerin maternal-fetal parametreler üzerine etkilerinin karşılaştırılmasıdır. Yöntemler: Kliniğimizde doğum yapan 01.01.2011-31.12.2017 tarihleri arasında toplam 5.670 hasta retrospektif olarak incelendi. İkiz doğum yapan 94 anne ve bebeklerinin feto-maternal sonuçları karşılaştırıldı. Bulgular: Doğum yapan 5.670 hastadan 94 tanesi ikiz (1/60), 8 tanesi ise üçüzdü (1/709). İkiz doğumlar, çoğul doğumların %92’sini oluşturmaktadır. Spontan ikiz gebelik insidansını 1/77 bulduk. Spontan oluşan ikiz gebelik doğumları, tüm ikiz doğumların %79’unu oluşturmaktadır. YÜT’nin ikiz gebeliğe etkisi %21 olarak saptandı [%17 tüp bebek (IVF), %4 ovulasyon indüksiyonu]. İkiz gebelik doğumlarında anne yaş ortalaması 29,25±6,00 yıl, spontan ikiz doğum yapan annelerin yaş ortalaması 28,50±6,09 yıl, YÜT’e bağlı ikiz doğumlarda anne yaş ortalaması 32,54±5,09 yıl bulundu. İkiz gebelik doğumlarında, anemi dışlandığında, maternal morbideteyi %27 idi. Olguların %63’ünde anemi, %19’unda preeklampsi saptandı. IVF ikizlerinin %72,3’ü, spontan ikizlerin %70,2’si 37 gebelik haftasından önce doğum yapmıştır. Canlı doğan bebek oranı spontan ikizlerde daha yüksek bulundu (p=0,004). Fetal mortalite oranı, spontan ikiz gebel","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"17-23"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44503547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Oral Anticoagulant Usage Satisfaction in Home Care Patients Using Warfarin","authors":"S. Akgün, Sibel Tunç Karaman, Sonay Özdemir, O. Basat","doi":"10.4274/JAREM.GALENOS.2021.3732","DOIUrl":"https://doi.org/10.4274/JAREM.GALENOS.2021.3732","url":null,"abstract":"Results: The ages of 97 patients included in the study ranged from 19 to 92 years; moreover, 71.1% (n=69) of the patients were women. In total, 41.2% (n=40) of the patients have had haemorrhagic events during the use of warfarin. The DASS mean score of the patients was 57.67±14.56, 20.46±5.89 for the limitations with the treatment, 21.54±7.46 for the hassles and burdens, and 15.67±4.87 for the positive impacts. It was determined that the number of additional chronic diseases and bleeding conditions while using warfarin had a significant effect on the total score and subscale scores of DASS (for total score, p=0.046; for subscale scores, p<0.001) and reduced satisfaction.","PeriodicalId":56162,"journal":{"name":"Journal of Academic Research in Medicine-JAREM","volume":"11 1","pages":"38-45"},"PeriodicalIF":0.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44323791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}