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Evaluating artificial intelligence performance in medical image analysis: Sensitivity, specificity, accuracy, and precision of ChatGPT-4o on Kellgren-Lawrence grading of knee X-ray radiographs 评估人工智能在医学图像分析中的表现:chatgpt - 40在膝关节x线片kelgren - lawrence分级中的敏感性、特异性、准确性和精密度
IF 1.6 4区 医学
Knee Pub Date : 2025-04-23 DOI: 10.1016/j.knee.2025.04.008
Mustafa Hüseyin Temel , Yakup Erden , Fatih Bağcıer
{"title":"Evaluating artificial intelligence performance in medical image analysis: Sensitivity, specificity, accuracy, and precision of ChatGPT-4o on Kellgren-Lawrence grading of knee X-ray radiographs","authors":"Mustafa Hüseyin Temel ,&nbsp;Yakup Erden ,&nbsp;Fatih Bağcıer","doi":"10.1016/j.knee.2025.04.008","DOIUrl":"10.1016/j.knee.2025.04.008","url":null,"abstract":"<div><h3>Background</h3><div>Recent advancements in artificial intelligence, including ChatGPT, have enabled its application in medical image analysis.This study aimed to evaluate the sensitivity and specificity of ChatGPT in assessing knee osteoarthritis (KOA) radiographs using the Kellgren-Lawrence (KL) grading system.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted at Izzet Baysal Physical Therapy and Rehabilitation Training and Research Hospital. Anteroposterior weight-bearing knee X-rays from 226 patients (excluding 26 due to prostheses or foreign bodies) were evaluated. Two specialists assessed the radiographs using the KL grading system, with a third specialist resolving discrepancies. ChatGPT-4o evaluated the images using the prompt, “Please evaluate this knee anteroposterior radiographic image according to the Kellgren-Lawrence grading system.” Diagnostic accuracy metrics, receiver operating characteristic (ROC) curves, and area under the curve (AUC) values were calculated.</div></div><div><h3>Results</h3><div>ChatGPT showed low sensitivity across all grades. The accuracy of the model was calculated to be 0.230. ROC AUC values were low for all grades, for KL grade 0 at 0.53, KL grade 1 at 0.56, KL grade 2 at 0.43, KL grade 3 at 0.54, KL grade 4 at 0.49, micro-average at 0.52, macro-average at 0.51, and weighted average at 0.52.</div></div><div><h3>Conclusions</h3><div>The findings of this study highlight the model’s inability to reliably distinguish between KL grades, suggesting that its utility in this specific classification task is limited and requires further optimization to improve its predictive accuracy and reliability. The model’s current limitations preclude its use as a reliable diagnostic tool. Further refinement is necessary to improve its clinical applicability.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 79-84"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fractures in Oxford unicompartmental knee arthroplasty are associated with medial positioning of the femoral component – A retrospective cohort study 牛津单室膝关节置换术中的骨折与股骨成分的内侧定位有关——一项回顾性队列研究
IF 1.6 4区 医学
Knee Pub Date : 2025-04-22 DOI: 10.1016/j.knee.2025.04.007
Julius Watrinet , Daniel Berger , Philipp Blum , Paul Reidler , Joerg Arnholdt , Sebastian Siebenlist , Rolf Schipp , Wolfgang Reng , Matthias P. Fabritius
{"title":"Fractures in Oxford unicompartmental knee arthroplasty are associated with medial positioning of the femoral component – A retrospective cohort study","authors":"Julius Watrinet ,&nbsp;Daniel Berger ,&nbsp;Philipp Blum ,&nbsp;Paul Reidler ,&nbsp;Joerg Arnholdt ,&nbsp;Sebastian Siebenlist ,&nbsp;Rolf Schipp ,&nbsp;Wolfgang Reng ,&nbsp;Matthias P. Fabritius","doi":"10.1016/j.knee.2025.04.007","DOIUrl":"10.1016/j.knee.2025.04.007","url":null,"abstract":"<div><h3>a. Purpose</h3><div>This study aimed to evaluate the relationship between femoral component positioning and the incidence of periprosthetic fractures in Oxford unicompartmental knee arthroplasty (UKA), as well as the effects of component size and preoperative coronal lower limb alignment on fracture risk.</div></div><div><h3>b. Methods</h3><div>A retrospective single-center study was conducted, including 1,642 cases of medial UKA performed between July 2015 and December 2022. Patients with symptomatic isolated medial knee osteoarthritis meeting specific selection criteria underwent surgery using either press-fit or cemented fixation based on individual bone quality. Radiographic evaluations were performed preoperatively and postoperatively to assess component positioning and alignment. Statistical analyses included the Mann-Whitney <em>U</em> test, Wilcoxon test, and Pearson’s chi-squared test to compare fracture and non-fracture groups.</div></div><div><h3>c. Results</h3><div>Out of 1,642 cases, 15 (0.9%) experienced a tibial periprosthetic fracture. These fractures were significantly associated with medial positioning of the femoral component and smaller component sizes. The fracture group had a higher mean age (74.3 ± 6.2 years) and a higher percentage of females (80%) compared to the non-fracture group. No significant differences were observed in Body Mass Index (BMI) or preoperative coronal alignment between the groups.</div></div><div><h3>d. Conclusion</h3><div>Medial positioning of the femoral component and smaller component sizes in Oxford UKA are associated with an increased risk of tibial periprosthetic fractures. Accurate implant positioning is crucial to minimize fracture risk and improve clinical outcomes. These findings underscore the importance of precise surgical techniques and may inform future guidelines for UKA procedures.</div><div>Trial registration: This study was retrospectively registered and ethical approval was waived by the local ethical committee (No. 22-0990KB).</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 70-78"},"PeriodicalIF":1.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of intraoperative kinematics between cruciate-retaining and medial-stabilized inserts in total knee arthroplasty using a CT-free navigation system 无ct导航系统下全膝关节置换术中椎体保留与中位稳定假体的运动学比较
IF 1.6 4区 医学
Knee Pub Date : 2025-04-21 DOI: 10.1016/j.knee.2025.04.003
Hibiki Kakiage , Shogo Hashimoto , Ryota Takase , Takeshi Shimada , Takashi Ohsawa , Hirotaka Chikuda
{"title":"Comparison of intraoperative kinematics between cruciate-retaining and medial-stabilized inserts in total knee arthroplasty using a CT-free navigation system","authors":"Hibiki Kakiage ,&nbsp;Shogo Hashimoto ,&nbsp;Ryota Takase ,&nbsp;Takeshi Shimada ,&nbsp;Takashi Ohsawa ,&nbsp;Hirotaka Chikuda","doi":"10.1016/j.knee.2025.04.003","DOIUrl":"10.1016/j.knee.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>The kinematics of total knee arthroplasty (TKA) have been shown to affect postoperative function and patient satisfaction. A medial stabilized (MS) insert was designed to improve kinematics by enhancing medial stability and inducing lateral rollback in comparison to cruciate-retaining (CR) inserts. This study aimed to compare the intraoperative kinematic patterns between CR and MS inserts in TKA using a CT-free navigation system.</div></div><div><h3>Methods</h3><div>A total of 23 knees from 21 patients who underwent primary TKA for osteoarthritis were included. A CT-free navigation system (BrainLab KNEE3) was used to record intraoperative kinematics during the CR and MS insert trials. Kinematic parameters, including kinematic patterns, such as anteroposterior (AP) translation of the medial and lateral condyles and rotational angles, were analyzed based on range of motion.</div></div><div><h3>Results</h3><div>The MS insert exhibited significantly less medial AP translation compared to the CR insert (7.0 ± 5.0 vs. 10.3 ± 5.1 mm, <em>p</em> = 0.04). No significant differences were observed in the lateral AP translation (11.5 ± 6.2 vs. 12.8 ± 5.2 mm, <em>p</em> = 0.41), rotational angle (6.3 ± 4.5 vs. 4.7 ± 4.4, <em>p</em> = 0.20), or kinematic patterns.</div></div><div><h3>Conclusion</h3><div>MS inserts may enhance stability by reducing medial translation. Their effect on reproducing medial pivot kinematics is comparable to that of the CR inserts.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 55-61"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the knee joint more vulnerable to injury in unplanned cutting tasks? An EMG vector field analysis of high-level female athletes 在计划外的切割任务中,膝关节是否更容易受伤?高水平女运动员肌电矢量场分析
IF 1.6 4区 医学
Knee Pub Date : 2025-04-21 DOI: 10.1016/j.knee.2025.04.002
Kevin Bill , Patrick Mai , Uwe G. Kersting , Tron Krosshaug
{"title":"Is the knee joint more vulnerable to injury in unplanned cutting tasks? An EMG vector field analysis of high-level female athletes","authors":"Kevin Bill ,&nbsp;Patrick Mai ,&nbsp;Uwe G. Kersting ,&nbsp;Tron Krosshaug","doi":"10.1016/j.knee.2025.04.002","DOIUrl":"10.1016/j.knee.2025.04.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Neuromuscular activation and peak external knee abduction moments (pKAM) are risk factors for anterior cruciate ligament injuries during sidestep cutting. This study aimed to: 1) compare thigh muscle activity between preplanned and unplanned sidestep cuts, 2) assess rank correlations of mean thigh muscle pre-activity in both cuts, 3) investigate the relationship between pKAM and thigh muscle activity in 31 experienced female handball players.</div></div><div><h3>Methods</h3><div>Four-component (vastus medialis, vastus lateralis, semitendinosus, biceps femoris) electromyogram vector fields were compared from 100 ms before ground contact until toe-off using Statistical Parametric Mapping. Spearman’s rank correlation coefficient was used to assess rank correlations of mean pre-activity of individual muscles between cuts. Relationships between pKAM and the four-component electromyogram vector fields were assessed using Canonical Correlation Analysis.</div></div><div><h3>Results</h3><div>Four-component muscle activity differed before ground contact and push-off, mostly due to activity differences in muscle pairs. Individual analyses showed lower vastus medialis activity in unplanned cuts right before ground contact. High pre-activity rank correlations were found for vastus medialis and lateralis, moderate for semitendinosus, and none for biceps femoris between preplanned and unplanned cuts. Canonical correlation analyses indicated no relationship between muscle activity and pKAM.</div></div><div><h3>Conclusion</h3><div>The knee might be more vulnerable to injury in unplanned tasks due to lower muscular pre-activity. Muscle activity does not vary with pKAM, suggesting passive structures must absorb higher loads with increasing pKAM. Differences in vastus medialis pre-activity and inconsistencies in biceps femoris pre-activity ranking highlight areas for targeted neuromuscular training to better protect the knee against external loads.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 62-69"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The degree of degenerative changes and medial meniscal extrusion of the knee progress with increasing severity of posterior root lesions of the medial meniscus in middle age: A cross-sectional study 随着中年中半月板后根病变严重程度的增加,膝关节退行性改变和内侧半月板挤压的程度进展:一项横断面研究
IF 1.6 4区 医学
Knee Pub Date : 2025-04-18 DOI: 10.1016/j.knee.2025.03.009
Young Mo Kim, Yong Bum Joo, Young Cheol Park, Min Jae Sung
{"title":"The degree of degenerative changes and medial meniscal extrusion of the knee progress with increasing severity of posterior root lesions of the medial meniscus in middle age: A cross-sectional study","authors":"Young Mo Kim,&nbsp;Yong Bum Joo,&nbsp;Young Cheol Park,&nbsp;Min Jae Sung","doi":"10.1016/j.knee.2025.03.009","DOIUrl":"10.1016/j.knee.2025.03.009","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to evaluate the relationships between radiologic features and the severity of medial meniscal posterior root (MMPR) lesions.</div></div><div><h3>Methods</h3><div>Patients were classified into three groups: Group I, MMPR degeneration (<em>n</em> = 50); Group II, partial MMPR tear (MMPRT; <em>n</em> = 46); and Group III, complete MMPRT (<em>n</em> = 54). Forty-three patients without intra-articular pathologies formed a control group. Knee radiographs were assessed for mechanical femorotibial angle, Kellgren–Lawrence grade and joint space width of the medial compartment. MRIs were assessed for MMPR-related findings, including extent of medial meniscal extrusion (MME), insertional osseous change at the MMPR attachment, cartilage status, subchondral bone marrow lesions, effusion, and osteophytes of the medial compartment.</div></div><div><h3>Results</h3><div>Varus degree and proportions of Kellgren–Lawrence grade 2 and 3 were higher as the severity of MMPR lesions increased (<em>P</em> &lt; 0.001, respectively). Joint space width decreased as the severity of the MMPR lesion increased (<em>P</em> &lt; 0.001). On MRI, MME, ratio of pathologic MME (&gt;3 mm), the International Cartilage Research Society grade of the medial compartment, the proportions of moderate and high effusion, and proportions of grade 2 and 3 osteophytes increased as the severity of MMPR lesions increased (<em>P</em> &lt; 0.001, respectively). A higher proportion of intraosseous cysts was seen in Group I than in the other groups (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The extent of MME and ratio of pathologic MME increased as the severity of MMPR lesions increased. Radiologic features reflecting osteoarthritis worsened as the severity of MMPR lesions increased. On MRI, MMPR degeneration is significantly associated with intraosseous cyst at the MMPR insertion site.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 43-54"},"PeriodicalIF":1.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bicruciate knee ligament deficiency is less harmful to the meniscus and chondral tissue than isolated cruciate injuries 双十字韧带缺失对半月板和软骨组织的伤害比孤立的交叉韧带损伤小
IF 1.6 4区 医学
Knee Pub Date : 2025-04-18 DOI: 10.1016/j.knee.2025.03.011
Sérgio Rocha Piedade , Daniel Miranda Ferreira , Nicola Maffulli
{"title":"Bicruciate knee ligament deficiency is less harmful to the meniscus and chondral tissue than isolated cruciate injuries","authors":"Sérgio Rocha Piedade ,&nbsp;Daniel Miranda Ferreira ,&nbsp;Nicola Maffulli","doi":"10.1016/j.knee.2025.03.011","DOIUrl":"10.1016/j.knee.2025.03.011","url":null,"abstract":"<div><h3>Objective</h3><div>Simultaneous injury to both cruciate ligaments seriously compromises the kinematics of the knee joint. This study aims to retrospectively investigate the incidence of meniscus and chondral injuries and extra-articular injuries in a series of 25 consecutive patients with chronic bicruciate knee ligament injuries managed surgically.</div></div><div><h3>Material and methods</h3><div>The patient’s mean age was 27.7 ± 5.1, median 28.00 (17.00–37.00), and 80% were male (<em>n</em> = 20). The average injury time to surgery was 12 months (1–96 months). Recorded data on intra- and extra-articular knee injuries were compared between genders, according to age, meniscal and chondral injuries, and mechanism of trauma in 25 patients with bicruciate knee ligament injury. Knee magnetic resonance imaging (MRI) exams were collected and examined.</div></div><div><h3>Results</h3><div>Meniscal injuries occurred in 40% of patients, with intra-substance signal alteration (grade I and II), meniscocapsular injury or small extension of the injury to the articular surface of the meniscus. No complex meniscal injury or displaced meniscal fragments were observed at MRI and at surgery, with minor chondral injuries or bone bruises.</div></div><div><h3>Conclusion</h3><div>Bicruciate knee ligament deficiency is less harmful to the meniscus and chondral tissue than isolated anterior cruciate ligament (ACL) tears, suggesting that this injury pattern leads to lower abnormal compression and shear forces on the joint surfaces. It could indicate that the “compass right-arm injury” of the femoral condyle on tibial components (meniscus and chondral tissue) is heightened in isolated cruciate knee ligament injuries, resulting in more complex damage than in bicruciate ligament tears. Given the high-energy trauma involved, extra-articular injuries could take place, and they should be taken into account in surgical decision-making.</div><div><strong>Level of evidence IV:</strong> Case series.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 33-42"},"PeriodicalIF":1.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional activities and patient satisfaction after total knee arthroplasty for valgus knee are inferior to those for varus knee: A propensity-matched cohort study 外翻膝全膝关节置换术后的功能活动和患者满意度低于膝内翻:一项倾向匹配的队列研究
IF 1.6 4区 医学
Knee Pub Date : 2025-04-10 DOI: 10.1016/j.knee.2025.03.004
Kohei Nishitani, Shinichi Kuriyama, Shinichiro Nakamura, Yugo (侑吾) Morita, Hiromu Ito, Shuichi Matsuda
{"title":"Functional activities and patient satisfaction after total knee arthroplasty for valgus knee are inferior to those for varus knee: A propensity-matched cohort study","authors":"Kohei Nishitani,&nbsp;Shinichi Kuriyama,&nbsp;Shinichiro Nakamura,&nbsp;Yugo (侑吾) Morita,&nbsp;Hiromu Ito,&nbsp;Shuichi Matsuda","doi":"10.1016/j.knee.2025.03.004","DOIUrl":"10.1016/j.knee.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to compare the clinical outcomes of total knee arthroplasty (TKA) for valgus and varus knees in a background-matched cohort.</div></div><div><h3>Method</h3><div>Preoperative and two years postoperative original and new Knee Society Scores (OKSS and 2011KSS, respectively) were obtained from patients who underwent primary TKA. Propensity score-matched cohorts were assessed for valgus and varus knees with malalignment ≥3°, ensuring parity in age, sex, primary diagnosis, body mass index, deviation from neutral alignment, surgical approach, patellar resurfacing, and implant type. Multiple linear regression analysis was performed on the 2011KSS Functional activities.</div></div><div><h3>Results</h3><div>Of the 1158 TKAs involving 122 valgus, 110 neutral, and 924 varus knees, propensity score matching yielded 106 valgus–varus knee pairs. Preoperatively, both groups exhibited similar scores, except for 2011KSS expectations. At two years, valgus knee showed inferior OKSS Function Score (valgus: 69.5 ± 26.7, varus: 79.6 ± 19.3, <em>P</em> = 0.005) and 2011KSS Functional activities (valgus: 57.8 ± 23.3, varus: 66.9 ± 20.4, <em>P</em> = 0.007) to varus knees. Valgus knees also showed inferior 2011KSS Satisfaction at two years (valgus: 25.1 ± 7.8, varus: 28.5 ± 7.8, <em>P</em> = 0.006). In the multiple linear regression analysis, older age, preoperative valgus deformity, rheumatoid arthritis, higher BMI, and lower functional scores were significant independent variables that predicted lower 2011KSS Functional activities (<em>R</em><sup>2</sup> = 0.28).</div></div><div><h3>Conclusion</h3><div>Postoperative clinical scores related to function after TKA were inferior in valgus knees to varus knees in the background-matched comparison. Valgus knees carry the risk of limited postoperative function after TKA.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 24-32"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of microRNA in meniscal repair and regeneration microRNA在半月板修复和再生中的治疗潜力
IF 1.6 4区 医学
Knee Pub Date : 2025-04-10 DOI: 10.1016/j.knee.2025.03.002
George Jacob , Kazunori Shimomura , Hiroto Hanai , Taro Akimori , Tomoki Ohori , Akira Tsujii , Yu Moriguchi , Norimasa Nakamura
{"title":"Therapeutic potential of microRNA in meniscal repair and regeneration","authors":"George Jacob ,&nbsp;Kazunori Shimomura ,&nbsp;Hiroto Hanai ,&nbsp;Taro Akimori ,&nbsp;Tomoki Ohori ,&nbsp;Akira Tsujii ,&nbsp;Yu Moriguchi ,&nbsp;Norimasa Nakamura","doi":"10.1016/j.knee.2025.03.002","DOIUrl":"10.1016/j.knee.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Managing meniscal injuries is challenging due to the complex nature of the tissue and its limited healing capacity. MicroRNAs (miRNAs) are key regulators of cellular processes, making them promising candidates for therapeutic interventions aimed at enhancing meniscal repair. This study explores the potential role of miRNAs in meniscal healing.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in July 2024 using the PubMed (MEDLINE) and EMBASE databases, without any date restrictions. Relevant studies involving the use of miRNAs in meniscal injury or repair were identified, and a narrative review was performed.</div></div><div><h3>Results</h3><div>The search yielded three in-vitro studies and one animal study, with no clinical studies found. The identified studies suggest that miRNAs may enhance meniscal healing by promoting angiogenesis and reducing inflammation.</div></div><div><h3>Conclusions</h3><div>This review underscores the emerging potential of miRNA-based therapies for meniscal repair and regeneration. While progress has been made in understanding the mechanisms of action, several challenges remain before clinical application, including safety concerns, the need for standardized protocols, and the development of clinical-grade miRNA products.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 18-23"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ChatGPT versus expert arthroplasty surgeons in total knee arthroplasty patient counseling ChatGPT与专家关节置换外科医生在全膝关节置换术患者咨询中的比较
IF 1.6 4区 医学
Knee Pub Date : 2025-04-08 DOI: 10.1016/j.knee.2025.03.005
Jonathan Liu, Mohammad Daher, Jacob Laperche, Noah Gilreath, Edward J. Testa, Mouhanad M. El-Othamni, Thomas J. Barrett, Valentin Antoci Jr.
{"title":"ChatGPT versus expert arthroplasty surgeons in total knee arthroplasty patient counseling","authors":"Jonathan Liu,&nbsp;Mohammad Daher,&nbsp;Jacob Laperche,&nbsp;Noah Gilreath,&nbsp;Edward J. Testa,&nbsp;Mouhanad M. El-Othamni,&nbsp;Thomas J. Barrett,&nbsp;Valentin Antoci Jr.","doi":"10.1016/j.knee.2025.03.005","DOIUrl":"10.1016/j.knee.2025.03.005","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to assess the effectiveness of AI compared directly with expert arthroplasty surgeons regarding patient counseling for total knee arthroplasty (TKA).</div></div><div><h3>Methods</h3><div>A set of 10 commonly asked generic and nonspecific, single-step patient questions were selected based on review of existing patient resources and expert consensus. Responses were then collected from ChatGPT-4.0 as well as five expert arthroplasty attendings at our institution. A, B, C, D, and E represent attending responses, while F represents the ChatGPT responses. The collected responses were then blinded and independently assessed by the same five arthroplasty surgeons using a five-point Likert scale in four performance areas including empathy, accuracy, completeness, and overall quality. Average scores for each question were determined.</div></div><div><h3>Results</h3><div>Set F, the ChatGPT answers scored significantly higher than sets A, B, and D in all categories. However, set F did not differ significantly from set C, and E in all the categories. The mean score for set D was above a mean of 4, above neutral, for all four categories. This was only the case for sets C and E.<!--> <!-->When the attendings scores were combined and compared with ChatGPT, the latter had higher ratings for empathy (4.4 vs. 3.5), accuracy (4.4 vs. 3.7), completeness (4.4 vs. 3.5), and overall quality (4.4 vs. 3.6) (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>A preliminary evaluation of ChatGPT-4.0 shows potential for large language AI models to serve as a supplementary resource of patients considering TKA.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 12-17"},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Managing class imbalance in the training of a large language model to predict patient selection for total knee arthroplasty”: Comment★ “在一个大型语言模型的训练中管理班级不平衡,以预测全膝关节置换术患者的选择”:评论。
IF 1.6 4区 医学
Knee Pub Date : 2025-04-08 DOI: 10.1016/j.knee.2025.03.008
Hinpetch Daungsupawong , Viroj Wiwanitkit
{"title":"“Managing class imbalance in the training of a large language model to predict patient selection for total knee arthroplasty”: Comment★","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.knee.2025.03.008","DOIUrl":"10.1016/j.knee.2025.03.008","url":null,"abstract":"","PeriodicalId":56110,"journal":{"name":"Knee","volume":"54 ","pages":"Pages 349-350"},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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