Physica Medica-European Journal of Medical Physics最新文献

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Dose escalation in pediatric pelvic Ewing's Sarcoma: Insights from a national treatment planning exercise. 儿童骨盆尤文氏肉瘤的剂量递增:来自国家治疗计划练习的见解。
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.ejmp.2025.105063
G Beldjoudi, F Goudjil, C Lafond, S Raucoules, C Moignier, D Maneval, C Bartau, G Hangard, D Trauchessec, V Anthonipillai, W Gehin, T Lacornerie, L Claude, L Ollivier
{"title":"Dose escalation in pediatric pelvic Ewing's Sarcoma: Insights from a national treatment planning exercise.","authors":"G Beldjoudi, F Goudjil, C Lafond, S Raucoules, C Moignier, D Maneval, C Bartau, G Hangard, D Trauchessec, V Anthonipillai, W Gehin, T Lacornerie, L Claude, L Ollivier","doi":"10.1016/j.ejmp.2025.105063","DOIUrl":"10.1016/j.ejmp.2025.105063","url":null,"abstract":"<p><strong>Purpose: </strong>The Inter Ewing-1 trial investigates dose escalation in definitive radiotherapy (randomization 54 Gy versus 64.8 Gy). Prior to the trial's initiation, the French Pediatric Radiotherapy Group conducted a national treatment planning exercise to assess dosimetric discrepancies associated with this dose escalation.</p><p><strong>Methods and materials: </strong>A non-operated pelvic pediatric case of Ewing's sarcoma was selected. CT-scan and delineated structures were distributed to accredited participants for pediatric radio- and/or proton-therapy. Treatment planning included a simultaneous integrated boost: 54 Gy in 30 fractions (1.80 Gy/fraction) for the pre-chemotherapy tumor volume, and 63.9 Gy (2.13 Gy/fraction) for the post-chemotherapy volume. Dose constraints for organs-at-risk and target coverage were provided. All treatment plans were collected, analyzed for deviations and compared. Data were projected in a 21-dimensional(D) space and reduced to 2-D for visual representation.</p><p><strong>Results and discussion: </strong>Eleven French centers submitted 14 plans (10 photon/4 proton plans). One photon plan exhibited one major and two minor deviations on organ-at-risk constraints. All photon plans presented a minor deviation regarding the constraint D0.1 cc Testis. No significant difference was observed between photons and protons for target coverage or for sparing most critical organs; however, protons showed significant advantages in DmeanBowel (9.9+/-1.1 Gy (photons) vs 3.5+/-0.4 Gy (protons), p < 0.01), and DmeanAnalCanal (3.8+/-0.7 Gy (photons) vs 2.2+/-0.9 Gy (protons), p < 0.01). Data projection revealed 3 clusters: one for protons, one for photons and one with two photon outliers.</p><p><strong>Conclusion: </strong>This initiative provided valuable insights into the Ewing-1 protocol, demonstrating treatment planning homogeneity among centers along with successful adherence to dose escalation constraints, with protons offering additional benefits as lower integral doses to critical organs.</p>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"105063"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual radiotherapy plan quality education: Perspectives from a global setting 虚拟放疗计划质量教育:全球视角
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-09-01 DOI: 10.1016/j.ejmp.2025.105069
Caroline M. Colbert , Emily Kruse , Dustin Jacqmin , Jose Carlos Pichardo , Chunhao Wang , Leah K. Schubert , Stephanie Bennett , Mu-Han Lin , Lindsey Olsen , Benjamin Li , Minsun Kim
{"title":"Virtual radiotherapy plan quality education: Perspectives from a global setting","authors":"Caroline M. Colbert ,&nbsp;Emily Kruse ,&nbsp;Dustin Jacqmin ,&nbsp;Jose Carlos Pichardo ,&nbsp;Chunhao Wang ,&nbsp;Leah K. Schubert ,&nbsp;Stephanie Bennett ,&nbsp;Mu-Han Lin ,&nbsp;Lindsey Olsen ,&nbsp;Benjamin Li ,&nbsp;Minsun Kim","doi":"10.1016/j.ejmp.2025.105069","DOIUrl":"10.1016/j.ejmp.2025.105069","url":null,"abstract":"<div><h3>Purpose</h3><div>Evaluation of treatment plan quality is a critical element of training for radiotherapy professionals. With the increased adoption of intensity modulated radiotherapy internationally, this training is crucial to address patient care inequity. We aim to evaluate learning outcomes from a 14-session remote training course targeting critical elements of plan quality with advanced modalities.</div></div><div><h3>Methods</h3><div>The virtual training course was delivered to over 500 radiotherapy professionals in North Africa. Attendees completed online pre- and post-course knowledge assessments, and surveys of their confidence in core competencies. Paired t-tests, general linear regression, and ANOVA were used to evaluate learning outcomes.</div></div><div><h3>Results</h3><div>On the pre-course knowledge assessment, attendees scored a mean of 3.97 ± 1.54 out of 10. After the course, remaining attendees’ scores increased to a mean of 4.88 ± 1.86 (p &lt; 0.001). Mean confidence scores increased from 2.28 ± 1.22 to 3.70 ± 0.76 out of 5. Confidence scores varied significantly with enrollees’ years of experience, clinical role, and involvement in treatment planning (p &lt; 0.05). However, pre-course knowledge scores only varied based on clinicians’ current involvement in advanced treatment planning (p &lt; 0.01). The improvement in knowledge score from baseline increased significantly with course attendance (p = 0.02).</div></div><div><h3>Conclusions</h3><div>This course produced positive overall learning outcomes, particularly with advanced treatment planning modalities. Attendees gained practical experience applying rigorous plan quality criteria. The study results support the crucial importance of continuing education and hands-on experience in the rapidly advancing technological environment of radiation oncology.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105069"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aims & Scope & Editorial Board 目标、范围和编委会
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-09-01 DOI: 10.1016/S1120-1797(25)00212-1
{"title":"Aims & Scope & Editorial Board","authors":"","doi":"10.1016/S1120-1797(25)00212-1","DOIUrl":"10.1016/S1120-1797(25)00212-1","url":null,"abstract":"","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105102"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification of computed tomography scans: a novel approach implementing an enforced random forest algorithm 计算机断层扫描分类:一种实现强制随机森林算法的新方法
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-28 DOI: 10.1016/j.ejmp.2025.105080
Michelangelo Biondi , Eleonora Bortoli , Lorenzo Marini , Rossella Avitabile , Antonietta Bartoli , Elena Busatti , Antonio Tozzi , Maria Cristina Cimmino , Lucia Piccini , Elisa Brinchi Giusti , Andrea Guasti
{"title":"Classification of computed tomography scans: a novel approach implementing an enforced random forest algorithm","authors":"Michelangelo Biondi ,&nbsp;Eleonora Bortoli ,&nbsp;Lorenzo Marini ,&nbsp;Rossella Avitabile ,&nbsp;Antonietta Bartoli ,&nbsp;Elena Busatti ,&nbsp;Antonio Tozzi ,&nbsp;Maria Cristina Cimmino ,&nbsp;Lucia Piccini ,&nbsp;Elisa Brinchi Giusti ,&nbsp;Andrea Guasti","doi":"10.1016/j.ejmp.2025.105080","DOIUrl":"10.1016/j.ejmp.2025.105080","url":null,"abstract":"<div><h3>Introduction</h3><div>Medical imaging faces critical challenges in radiation dose management and protocol standardisation. This study introduces a machine learning approach using a random forest algorithm to classify Computed Tomography (CT) scan protocols. By leveraging dose monitoring system data, we provide a data-driven solution for establishing Diagnostic Reference Levels while minimising computational resources.</div></div><div><h3>Materials and method</h3><div>We developed a classification workflow using a Random Forest Classifier to categorise CT scans into anatomical regions: head, thorax, abdomen, spine, and complex multi-region scans (thorax + abdomen and total body). The methodology featured an iterative “human-in-the-loop” refinement process involving data preprocessing, machine learning algorithm training, expert validation, and protocol classification. After training the initial model, we applied the methodology to a new, independent dataset.</div></div><div><h3>Results</h3><div>By analysing 52,982 CT scan records from 11 imaging devices across five hospitals, we train the classificator to distinguish multiple anatomical regions, categorising scans into head, thorax, abdomen, and spine. The final validation on the new database confirmed the model’s robustness, achieving a 97 % accuracy.</div></div><div><h3>Discussion</h3><div>This research introduces a novel medical imaging protocol classification approach by shifting from manual, time-consuming processes to a data-driven approach integrating a random forest algorithm.</div></div><div><h3>Conclusion</h3><div>Our study presents a transformative approach to CT scan protocol classification, demonstrating the potential of data-driven methodologies in medical imaging. We have created a framework for managing protocol classification and establishing DRL by integrating computational intelligence with clinical expertise. Future research will explore applying this methodology to other radiological procedures.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105080"},"PeriodicalIF":2.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of practice of image guided particle therapy for extremity tumours: A site specific multi-institutional survey of European particle therapy network 影像引导粒子治疗四肢肿瘤的实践模式:欧洲粒子治疗网络的一个特定地点的多机构调查
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-28 DOI: 10.1016/j.ejmp.2025.105094
Lorenzo Placidi , Juliette Thariat , Alexandru Dasu , Markus Stock , Iuliana Toma-Dasu , Petra Trnková , Julia Thiele , Akmal Ahmed Safwat , Maria Rosaria Fiore , Pavel Vitek , Alessia Pica , Lamberto Widesott , Aswin Hoffmann , Alessandra Bolsi
{"title":"Patterns of practice of image guided particle therapy for extremity tumours: A site specific multi-institutional survey of European particle therapy network","authors":"Lorenzo Placidi ,&nbsp;Juliette Thariat ,&nbsp;Alexandru Dasu ,&nbsp;Markus Stock ,&nbsp;Iuliana Toma-Dasu ,&nbsp;Petra Trnková ,&nbsp;Julia Thiele ,&nbsp;Akmal Ahmed Safwat ,&nbsp;Maria Rosaria Fiore ,&nbsp;Pavel Vitek ,&nbsp;Alessia Pica ,&nbsp;Lamberto Widesott ,&nbsp;Aswin Hoffmann ,&nbsp;Alessandra Bolsi","doi":"10.1016/j.ejmp.2025.105094","DOIUrl":"10.1016/j.ejmp.2025.105094","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the current practice patterns in image-guided proton therapy (IGPT) for extremities.</div></div><div><h3>Methods</h3><div>A multi-institutional survey was distributed to European particle therapy centres to analyse the current practice of IGPT for tumours of the extremities. A Delphi consensus analysis was developed to define minimum requirements and optimal workflow for clinical practice within eight centres participating in the European Particle Therapy Network (EPTN).</div></div><div><h3>Results</h3><div>Eight centres participated in the survey. Patient immobilization methods varied, with supine position being optimal for selected tumor locations in most of the centres and prone position being optional in some centres. Multimodal imaging, in particular magnetic resonance imaging (MRI), was routinely used for across all centres, especially for delineation. Setup verification involved 2D imaging predominantly, with a few centres employing 3D imaging. Imaging for treatment evaluation varied, with differing intervals between treatment and first control computer tomography (CT) scans. Current limitations highlighted the need for improved software tools, streamlined workflow processes, and more comprehensive guidelines. Five centres participated in the Delphi consensus analysis. The full consensus was reached on the use of specific imaging modalities, adaptive techniques, and dedicated protocols for paediatric patients, with a need for standardization and guidelines.</div></div><div><h3>Conclusion</h3><div>There are differences in extremity IGPT clinical practice among European particle therapy centres. The optimal workflow identified by the expert consensus has not yet been reached, partly due to the small number of patients treated annually. To standardize clinical practice and improve IGPT quality for extremity tumours, consensus guidelines are strongly needed.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105094"},"PeriodicalIF":2.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-Treatment 18F-FDG PET/CT reveals altered brain metabolic network connectivity in patients with diffuse large B-cell lymphoma: Implications for cancer-related cognitive impairment 治疗前18F-FDG PET/CT显示弥漫性大b细胞淋巴瘤患者脑代谢网络连通性改变:癌症相关认知障碍的意义
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-28 DOI: 10.1016/j.ejmp.2025.105079
Xiaoyan Zheng , Qi Tian , Runying Li , Yubin Wang , Weishan Zhang , Xiaoyi Duan , Guogang Luo , Zhichao Zhang , Kun Zhu
{"title":"Pre-Treatment 18F-FDG PET/CT reveals altered brain metabolic network connectivity in patients with diffuse large B-cell lymphoma: Implications for cancer-related cognitive impairment","authors":"Xiaoyan Zheng ,&nbsp;Qi Tian ,&nbsp;Runying Li ,&nbsp;Yubin Wang ,&nbsp;Weishan Zhang ,&nbsp;Xiaoyi Duan ,&nbsp;Guogang Luo ,&nbsp;Zhichao Zhang ,&nbsp;Kun Zhu","doi":"10.1016/j.ejmp.2025.105079","DOIUrl":"10.1016/j.ejmp.2025.105079","url":null,"abstract":"<div><h3>Background</h3><div>Cancer-related cognitive impairment (CRCI) is prevalent among patients with diffuse large B-cell lymphoma (DLBCL), often manifesting prior to treatment and frequently remaining unrecognized.</div></div><div><h3>Purpose</h3><div>This study aims to assess CRCI in DLBCL patients before treatment by utilizing 18F-FDG PET/CT metabolic networks to facilitate early detection and intervention.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study involving 77 participants from our hospital’s PET-CT center, which included 15 healthy controls and 62 DLBCL patients (29 in stages I + II and 33 in stages III + IV). Using the automated anatomical atlas 3 (AAL3) template, we segmented the 18F-FDG PET brain images into 90 regions, extracted the standard uptake value (SUV) for each region, and calculated its ratio (SUVr) using the cerebellum as a reference. We analyzed connectivity within the brain’s metabolic network across the three groups.</div></div><div><h3>Results</h3><div>DLBCL patients exhibited significantly lower mean degree, closeness centrality, degree of participation in connected components (DPCC), average clustering coefficient (ACC), and clustering coefficient compared to controls (P &lt; 0.001). Patients in stages III + IV demonstrated even lower values. The average shortest path length (ASPL) was significantly higher in DLBCL patients, with stage III + IV patients showing an ASPL nearly three times that of controls and twice that of stage I + II patients. Significant differences in mean degree, closeness centrality, and clustering coefficient were observed among the groups (P &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>CRCI is apparent in DLBCL patients at early stages and deteriorates with disease progression. It is crucial to integrate early detection and cognitive assessments into clinical practice for DLBCL patients.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105079"},"PeriodicalIF":2.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monte Carlo study of the eye lens exposure of medical staff administering Sc-47 and Cu-67 labelled radiopharmaceuticals 使用Sc-47和Cu-67标记的放射性药物的医务人员的眼晶状体暴露的蒙特卡罗研究
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-27 DOI: 10.1016/j.ejmp.2025.105077
P. Ferrari , F. Becker , J. Dabin , J. Eakins , Z. Jovanović , D. Krstić , E. Michaś-Majewska , K. Tymińska , A. Benali , R. Bouwman , A. McCann , K. Hürkamp , F. Fioroni
{"title":"Monte Carlo study of the eye lens exposure of medical staff administering Sc-47 and Cu-67 labelled radiopharmaceuticals","authors":"P. Ferrari ,&nbsp;F. Becker ,&nbsp;J. Dabin ,&nbsp;J. Eakins ,&nbsp;Z. Jovanović ,&nbsp;D. Krstić ,&nbsp;E. Michaś-Majewska ,&nbsp;K. Tymińska ,&nbsp;A. Benali ,&nbsp;R. Bouwman ,&nbsp;A. McCann ,&nbsp;K. Hürkamp ,&nbsp;F. Fioroni","doi":"10.1016/j.ejmp.2025.105077","DOIUrl":"10.1016/j.ejmp.2025.105077","url":null,"abstract":"<div><h3>Purpose</h3><div>In the last decades, new technologies and new radiopharmaceuticals for diagnosis and therapy have continuously grown, and that growth was accompanied by an increasing use in clinical practice, but, as with any other application involving radiation, the extent to which they may contribute to increasing the radiation dose to the operator must be studied. For that reason, EURADOS (European Radiation Dosimetry Group) decided to evaluate the exposure of medical staff in nuclear medicine to new possible radiopharmaceuticals labelled with Sc-47 and Cu-67.</div></div><div><h3>Methodology</h3><div>Modified ICRP voxel model were employed to determine the exposure of the eye lens and of the thyroid of operators administrating radiopharmaceuticals in a typical Peptide Receptor Radionuclide Therapy scenario. The simulations were validated comparing Monte Carlo results with TLD measurements performed in hospital with Lu-177 labelled compounds.</div></div><div><h3>Results</h3><div>Doses to the eye lens and thyroid are derived from the photon emissions (the beta contribution is three order of magnitude lower). The agreement obtained for Lu-177 provides confidence that, notwithstanding the limits of the simulations, the robustness of the followed approach can be extended also to the evaluation performed for Sc-47 and Cu-67.</div></div><div><h3>Conclusions</h3><div>The dose to the lens of the eye is of the order of 2 µSv/GBq per patient for Lu-177 compounds and, due to the different energies and yields, about 8 µSv/GBq for both Sc-47 and Cu-67. These evaluations can be useful to optimize the radiation protection of medical staff in the nuclear medicine environment and assess the correct personnel workload in these kinds of practices.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105077"},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The benefit of DIBH on irradiated lung volume is overestimated in right-sided breast cancer VMAT with node involvement 在有淋巴结累及的右侧乳腺癌VMAT中,DIBH对辐照肺体积的益处被高估了
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-27 DOI: 10.1016/j.ejmp.2025.105095
Mikko Mankinen , Tuomas Virén , Jan Seppälä , Kristiina Vuolukka , Kimmo Myllyoja , Janne Heikkilä , Tuomas Koivumäki
{"title":"The benefit of DIBH on irradiated lung volume is overestimated in right-sided breast cancer VMAT with node involvement","authors":"Mikko Mankinen ,&nbsp;Tuomas Virén ,&nbsp;Jan Seppälä ,&nbsp;Kristiina Vuolukka ,&nbsp;Kimmo Myllyoja ,&nbsp;Janne Heikkilä ,&nbsp;Tuomas Koivumäki","doi":"10.1016/j.ejmp.2025.105095","DOIUrl":"10.1016/j.ejmp.2025.105095","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Deep inspiration breath-hold (DIBH) is the preferred technique over free-breathing (FB) to reduce the irradiated lung volume, based on direct comparisons of dose-volume histogram (DVH) values. This study employs deformable image registration (DIR) to account for the non-uniform lung expansion in assessing the actual benefit of DIBH in volumetric modulated arc therapy (VMAT) of right-sided breast cancer with regional node involvement.</div></div><div><h3>Methods</h3><div>The study included 25 patients, divided between two treatment planners, with retrospective VMAT plans for right-sided breast cancer with regional node involvement in both DIBH and FB anatomy. The irradiated ipsilateral lung volumes of V16Gy, V8Gy and V4Gy were transferred from DIBH CT onto the FB CT image using DIR. DVH parameters were calculated based on the transferred irradiated lung volumes and compared to the planned values in the FB image anatomy.</div></div><div><h3>Results</h3><div>The irradiated V16Gy, V8Gy and V4Gy volumes of the ipsilateral lung increased after transferring from DIBH CT to FB CT (21.3 % to 23.1 %, 35.6 % to 38.9 % and 53.4 % to 57.3 % by median, respectively, p &lt; 0.001), regardless of planner (p &gt; 0.49). To achieve dosimetric benefits with DIBH compared to FB, reductions in lung DVH parameters between −7.2 % and −4.9 %, relative to planned FB values, are required.</div></div><div><h3>Conclusions</h3><div>The apparent dosimetric benefit of DIBH on the irradiated lung volume over FB is overestimated at the planning stage. However, DIBH can reduce the dose to all organs at risk through rigorous treatment planning.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105095"},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protoacoustic range verification by direct comparison with beam range measurements using a tissue-equivalent polymer gel 通过使用组织等效聚合物凝胶与光束距离测量的直接比较来验证原声距离
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-27 DOI: 10.1016/j.ejmp.2025.105099
Takeshi Miyashita , Ye Chen , Yasutoshi Kuriyama , Masashi Tomida , Hidenobu Tachibana , Yoshihisa Iwashita , Takayuki Nonoyama , Sena Hidani , Taichi Murakami , Taeko Matsuura
{"title":"Protoacoustic range verification by direct comparison with beam range measurements using a tissue-equivalent polymer gel","authors":"Takeshi Miyashita ,&nbsp;Ye Chen ,&nbsp;Yasutoshi Kuriyama ,&nbsp;Masashi Tomida ,&nbsp;Hidenobu Tachibana ,&nbsp;Yoshihisa Iwashita ,&nbsp;Takayuki Nonoyama ,&nbsp;Sena Hidani ,&nbsp;Taichi Murakami ,&nbsp;Taeko Matsuura","doi":"10.1016/j.ejmp.2025.105099","DOIUrl":"10.1016/j.ejmp.2025.105099","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Protoacoustics offers a promising method for in vivo range verification in proton therapy. To experimentally assess the protoacoustic range accuracy, conventional tissue-mimicking phantoms (TMPs) often require Monte Carlo (MC) simulations to estimate the ground truth. However, limited knowledge of material properties and/or insufficient fine-tuning of dose models can introduce range errors in MC simulations. This study aims to propose a TMP capable of measuring the dose distribution concurrently with the protoacoustic measurement, thereby circumventing the need for MC simulations and their associated uncertainties.</div></div><div><h3>Methods</h3><div>Normoxic <em>N</em>-vinylpyrrolidone-based polymer gel dosimeters were employed as TMPs. Two gel dosimeters of varying sizes were irradiated with a 226.5 MeV proton beam from a clinical synchrocyclotron. Post-irradiation, magnetic resonance imaging was used to determine the beam range within the gels. Concurrently, protoacoustic ranges were measured using an optical hydrophone, employing both a time-of-arrival (TOA) method and an acoustic simulation-based approach. The ranges obtained from the gel dosimeters were then compared with those from the protoacoustic methods.</div></div><div><h3>Results</h3><div>The range differences between the gel dosimeter measurements and both protoacoustic methods were within 1 mm for both gel sizes. In contrast, the maximum deviation between the protoacoustic range and the MC simulation-derived range was 2.1 mm, potentially attributable to inaccuracies in the assumed material properties within the MC simulation.</div></div><div><h3>Conclusions</h3><div>Polymer gel dosimeters provide a direct method for validating protoacoustic beam range measurements in clinical proton beams, circumventing the reliance on MC simulations and their associated uncertainties.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105099"},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foetal dose in novel full body cone beam computed tomography device 新型全身锥束计算机体层摄影装置中的胎儿剂量
IF 2.7 3区 医学
Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-26 DOI: 10.1016/j.ejmp.2025.105082
Siru M. Kaartinen, Mimmi K. Liukkonen, Ari-Petteri Ronkainen
{"title":"Foetal dose in novel full body cone beam computed tomography device","authors":"Siru M. Kaartinen,&nbsp;Mimmi K. Liukkonen,&nbsp;Ari-Petteri Ronkainen","doi":"10.1016/j.ejmp.2025.105082","DOIUrl":"10.1016/j.ejmp.2025.105082","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate foetal doses at different stages of pregnancy in sinus and cervical spine imaging protocols using a novel supine cone beam computed tomography (CBCT) device.</div></div><div><h3>Method</h3><div>Foetal doses were measured at three different stages of the pregnancy in sinus and spine imaging protocols using an anthropomorphic phantom and a solid-state dosimeter.</div></div><div><h3>Results</h3><div>The foetal doses varied between 0.4 and 3.9 µGy and 2.2 and 32.6 µGy, in sinus and cervical spine examinations, respectively, being highest in the third trimester of pregnancy. A conversion factor for calculating the estimate of the foetus dose from kerma area product (KAP) varies between 0.0002–0.007 μGy/mGy cm<sup>2</sup>.</div></div><div><h3>Conclusions</h3><div>Foetal doses for sinus and cervical spine examinations in a supine CBCT device are low and do not produce a concern about radiation detriment to the foetus.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105082"},"PeriodicalIF":2.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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