Physica Medica-European Journal of Medical Physics最新文献

{"title":"Erratum to \"Stability of radiomic features in magnetic resonance imaging of the female pelvis: A multicentre phantom study\" [Phys. Medica 130 (2025) 104895].","authors":"Roberto Sghedoni, Daniela Origgi, Noemi Cucurachi, Giuseppe Castiglioni Minischetti, Davide Alio, Giovanni Savini, Francesca Botta, Simona Marzi, Marco Aiello, Tiziana Rancati, Davide Cusumano, Letterio Salvatore Politi, Vittorio Didonna, Raffaella Massafra, Antonella Petrillo, Antonio Esposito, Sara Imparato, Luca Anemoni, Chandra Bortolotto, Lorenzo Preda, Luca Boldrini","doi":"10.1016/j.ejmp.2025.104948","DOIUrl":"https://doi.org/10.1016/j.ejmp.2025.104948","url":null,"abstract":"","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":" ","pages":"104948"},"PeriodicalIF":3.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast density prediction model in digital versus synthetic mammograms from a radiomic point of view: A retrospective study","authors":"E. Loi ,&nbsp;G. Feliciani ,&nbsp;M. Amadori ,&nbsp;A. Bettinelli ,&nbsp;F. Marturano ,&nbsp;I. Azzali ,&nbsp;E. Mezzenga ,&nbsp;P.A. Sanna ,&nbsp;D. Severi ,&nbsp;S. Rivetti ,&nbsp;M. Paiusco ,&nbsp;G. Martinelli ,&nbsp;A. Sarnelli ,&nbsp;F. Falcini","doi":"10.1016/j.ejmp.2025.104942","DOIUrl":"10.1016/j.ejmp.2025.104942","url":null,"abstract":"<div><h3>Purpose</h3><div>In this retrospective study, we develop radiomics prediction models from synthetic mammograms(SM) and digital mammograms(DM) images to identify which imaging modality has the most predictive power when employed for prediction of breast density.</div></div><div><h3>Methods</h3><div>Patients aged between 45 and 74 years, were included in the study. For each, a SM in standard resolution (ST) and High Resolution (HR) were obtained, and a 150 x 150 pixels square area was defined on the images to be used for texture analysis of the breast parenchyma. A semi-automated placing strategy was used to reduce user reliance on the segmentation location. S-IBEX software was employed to extract radiomics features. Feature robustness analysis was also done to ensure model reproducibility. The Least Absolute Shrinkage and Selection Operator(LASSO) logistic regression model was trained to predict dichotomized breast density according to BIRADS classification model performance was assessed through receiver operating curves (ROC) for DM, HR, and ST.</div></div><div><h3>Results</h3><div>We extracted 123 features from the 10 ROIs of 96 patient. After robustness analysis, the most predictive features were employed to build logistic regression-based models.</div><div>The average performance of the models were 0.74, 0.67, and 0.64 on DM, HR, and ST, respectively, suggesting that DM maintains the highest informative content on breast density.</div></div><div><h3>Conclusions</h3><div>This study investigated how well radiomics models trained on various imaging modalities predicted breast density. Our results may be pertinent to the debate over screening mammography technique optimization using quantitative measures based on radiomics features.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104942"},"PeriodicalIF":3.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a cerebral CT perfusion phantom: A structured approach","authors":"Liselot C. Goris ,&nbsp;Abdallah H.A. Zaid Al-Kaylani ,&nbsp;Richte C.L. Schuurmann ,&nbsp;Marcel J.W. Greuter ,&nbsp;Reinoud P.H. Bokkers ,&nbsp;Srirang Manohar","doi":"10.1016/j.ejmp.2025.104944","DOIUrl":"10.1016/j.ejmp.2025.104944","url":null,"abstract":"<div><h3>Introduction</h3><div>Computed tomography perfusion (CTP) imaging is crucial in diagnosing and managing vascular diseases, e.g, stroke. Differences in scanners and protocols may lead to different results, affecting clinical decision-making. Objective validation and evaluation of CTP imaging are therefore important. Perfusion phantoms are essential test objects to facilitate the validation and evaluation of perfusion imaging. Therefore, this study aimed to develop, validate and evaluate a brain perfusion phantom for the evaluation of cerebral CTP.</div></div><div><h3>Methods</h3><div>A cerebral perfusion phantom was developed to evaluate CTP imaging of the brain using a workflow based on the Design Science Research Methodology. The reliability and repeatability of the phantom’s perfusion parameters derived from the time-density curves (TDCs) in CTP were evaluated.</div></div><div><h3>Results</h3><div>A 3D-printed modular perfusion phantom was developed, filled with sodium alginate beads, and connected to a pumping system to mimic microvasculature and flow dynamics. The phantom consisted of three compartments that simulated different states of perfusion. The phantom showed reliable TDCs, with a relative standard deviation of &lt;6.6 % for peak intensity and time-to-peak (TTP) over two sets of five repeated experiments for all compartments, and repeatable TTP and mean transit time values with a repeatability coefficient of &lt;2.3 s compared to the mean.</div></div><div><h3>Conclusions</h3><div>The developed perfusion phantom demonstrated high reliability and could be employed for investigating CTP imaging under various flow speeds. The presented workflow promotes transparency in the development, validation, and application of CTP phantoms, and facilitates cross-study comparisons through structured iterative development and unified evaluation metrics.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104944"},"PeriodicalIF":3.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and consistency of effective atomic number over object size using deep silicon photon-counting detector CT","authors":"Teva N. Shapiro ,&nbsp;Aria M. Salyapongse ,&nbsp;Meghan G. Lubner ,&nbsp;Giuseppe V. Toia ,&nbsp;Zhye Yin ,&nbsp;Scott Slavic ,&nbsp;Timothy P. Szczykutowicz","doi":"10.1016/j.ejmp.2025.104945","DOIUrl":"10.1016/j.ejmp.2025.104945","url":null,"abstract":"<div><h3>Purpose</h3><div>Photon-counting detector (PCD) CT is the newest generation of CT detector technology. It is critical to characterize its performance in measuring important biomarkers used in quantitative CT including effective atomic number (Z_eff). More accurate Z_eff measurements could be beneficial in tissue classification and proton therapy tasks.</div></div><div><h3>Methods</h3><div>A phantom of varying water-equivalent diameter (WED) containing clinically relevant inserts was scanned using a prototype deep silicon PCD CT and a dual-energy (DE) energy integrating detector (EID) CT. Z_eff maps were generated. Measured Z_eff values were compared across WEDs and to theoretical values.</div></div><div><h3>Results</h3><div>The measured Z_eff of the polystyrene, solid water, iodine, and bone (50% CaCO3) inserts differed from the theoretical value by a maximum of −14.0%, 4.6%, 8.4% and 13.0% respectively on EID vs 4.5%, 5.2%, 2.3% and 7.2% on PCD. The maximum variation in Z_eff over the WED range on EID was 0.71, 0.27, 0.66, and 1.22 vs 0.47, 0.64, 0.1 and 0.22 on PCD for polystyrene, solid water, iodine, and bone (50% CaCO3) respectively.</div></div><div><h3>Conclusion</h3><div>This is the first study to evaluate Z_eff measurements made using a prototype whole body PCD CT system. We found that PCD CT outperformed the EID CT in terms of Z_eff accuracy and consistency over the WED range on most of the insert materials. Similarly, PCD CT outperformed most previous study’s findings using EID CT. The high consistency and accuracy of measured Z_eff using deep silicon PCD CT could make quantitative CT increasingly possible over a large range of patient sizes.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104945"},"PeriodicalIF":3.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone beam CT (CBCT) in radiotherapy: Assessment of doses using a pragmatic setup in an international setting","authors":"Mario Djukelic ,&nbsp;Colin John Martin ,&nbsp;Abdullah Abuhaimed ,&nbsp;Tomas Kron ,&nbsp;Sebastien Gros ,&nbsp;Tim Wood ,&nbsp;Piotr Pankowski ,&nbsp;Ngie Min Ung ,&nbsp;Jenia Vassileva ,&nbsp;María Cristina Plazas ,&nbsp;Snezana Vostinic ,&nbsp;Anja Lazovic ,&nbsp;Ana Cravo Sá ,&nbsp;Isabelle Nilsson ,&nbsp;Marianna Koutrouli ,&nbsp;Lavanya Murugan ,&nbsp;Hein Fourie ,&nbsp;Aliaksandr Miadzvetski ,&nbsp;Buthaina Al Ameri ,&nbsp;Mirta Dumancic ,&nbsp;William Small Jr.","doi":"10.1016/j.ejmp.2025.104937","DOIUrl":"10.1016/j.ejmp.2025.104937","url":null,"abstract":"<div><h3>Introduction</h3><div>The imaging modality kV CBCT on linear accelerators (linacs) is utilised to verify positioning and anatomy in cancer patients undergoing radiotherapy treatment. There is a need for optimisation of radiological protection in kV CBCT imaging protocols to avoid unnecessarily high exposures to normal tissues surrounding the target.</div></div><div><h3>Methods</h3><div>A network of ICRP mentees from 23 countries were surveyed for available dosimetry equipment. Standardised measurements on CBCT linac imaging systems were conducted using a cone beam dose index (CBDI) devised as a straightforward measurement for wide beam doses. Measurements were made with (a) 100 mm ionisation chambers or (b) 0.6 cc Farmer ionisation chambers and cylindrical CT PMMA phantoms, and (c) an alternative setup of Farmer chambers and cubical phantoms comprised of slabs of water equivalent material readily available in radiotherapy centres. The measurements were compared with Monte Carlo (MC) simulations.</div></div><div><h3>Results</h3><div>The survey showed limited availability for the reference setup using 100 mm chambers and CT phantoms. Correction factors were derived to convert normalised CBDI from alternative setups to the reference setup and are on average within 2% of MC simulations.</div></div><div><h3>Conclusion</h3><div>The slab phantom in combination with a Farmer chamber provides an alternative to quantify CBCT radiation dose indices from linac-based image-guided radiotherapy using materials accessible in most centres worldwide. A method is presented to use correction factors for Varian Truebeam linacs if traditional 100 mm chambers and cylindrical CT phantoms are not available. This will enable most radiotherapy centres across the world to engage in meaningful imaging dose measurement and optimisation.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104937"},"PeriodicalIF":3.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Linac-based VMAT total body irradiation technique on Elekta platform using surface-guided radiation therapy","authors":"Magali Sandt ,&nbsp;Stéphanie Marcet ,&nbsp;Nathalie Guesnel ,&nbsp;Line Claude ,&nbsp;Isabelle Martel ,&nbsp;Marie-Claude Biston","doi":"10.1016/j.ejmp.2025.104940","DOIUrl":"10.1016/j.ejmp.2025.104940","url":null,"abstract":"<div><h3>Background/introduction</h3><div>To present an optimal workflow using a rotatable tabletop and a surface guided radiation therapy (SGRT) system for volumetric modulated arc therapy (VMAT) based total-body irradiation (TBI).</div></div><div><h3>Methods</h3><div>Twenty patients having received either 2 Gy, 8 Gy, or 12 Gy in 2 Gy per fraction were included. They were immobilized using a vacuum cushion and a three-points mask and positioned on a rotatable tabletop. VMAT treatment plans were performed on Monaco 6.1 (Elekta LTD, Stockholm) treatment planning system and then perturbed by applying shifts of 5mm on the isocenters coordinates to evaluate the robustness. Patients were treated on a Synergy or a VersaHD (Elekta LTD, Stockholm) Linac. Pretreatment positioning was performed either with cone-beam CT images combined with surface guided radiation therapy (SGRT) or with SGRT only. During treatment, intra-fraction motion was controlled with SGRT. Dosimetric data, robustness results and sessions duration were collected.</div></div><div><h3>Results</h3><div>In terms of PTV coverage and lung-sparing, all plans met the requirements of the most recent recommendations. The use of 20–30 cm distances between isocenters, and a 90° collimator rotation, enabled to obtain a linear dose gradient between two consecutive beams, which ensured sufficient robustness against 5 mm shifts in isocenter coordinates in all directions. With an average duration of 1 h ± 12 min between the first and last beams, the first sessions were comparable in length to the extended source-to-skin distance technique.</div></div><div><h3>Conclusion</h3><div>Thanks to the rotatable tabletop and to the SGRT system, accurate and secured VMAT-based TBI treatments were performed within a reasonable timeframe, while ensuring patient comfort.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104940"},"PeriodicalIF":3.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Towards estimating the carbon footprint of external beam radiotherapy\" [Phys. Med. 112 (2023) 102652].","authors":"Robert Chuter, Catherine Stanford-Edwards, James Cummings, Clare Taylor, Gerry Lowe, Eleanor Holden, Rehanah Razak, Eloise Glassborow, Stephen Herbert, Genotan Reggian, Thomas Mee, Katie Lichter, Marianne Aznar","doi":"10.1016/j.ejmp.2025.104936","DOIUrl":"https://doi.org/10.1016/j.ejmp.2025.104936","url":null,"abstract":"","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":" ","pages":"104936"},"PeriodicalIF":3.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an updated pencil beam algorithm for enhanced dosimetric accuracy in stereotactic radiotherapy","authors":"Paul Retif ,&nbsp;Motchy Saleh ,&nbsp;Abdourahamane Djibo Sidikou ,&nbsp;Romain Letellier ,&nbsp;Anwar Al Salah ,&nbsp;Estelle Pfletschinger ,&nbsp;Fabian Taesch ,&nbsp;Emilie Verrecchia-Ramos ,&nbsp;Xavier Michel","doi":"10.1016/j.ejmp.2025.104941","DOIUrl":"10.1016/j.ejmp.2025.104941","url":null,"abstract":"<div><h3>Introduction</h3><div>This study evaluates enhancements introduced in version 4.0 of Brainlab’s Pencil Beam algorithm within the Elements treatment planning system (TPS) for radiotherapy dose calculations. These updates include a new scatter model to improve dose calculation accuracy and updated commissioning recommendations involving asynchronous sweeping gap (a-SG) measurements to refine multileaf collimator (MLC) parameters such as dynamic leaf shift (DLS) and tongue-and-groove (TG) size.</div></div><div><h3>Materials and methods</h3><div>The original (version 3.0) and updated (version 4.0) implementations of the Pencil Beam algorithm were compared using a Varian TrueBeam STx accelerator with 6-MV flattening filter-free energy and high-definition MLC. Dosimetric accuracy was assessed through phantom-based point dose and volumetric measurements for clinical cases, including treatments for single and multiple brain metastases with volumetric modulated arc therapy (VMAT) and dynamic conformal arcs (DCA).</div></div><div><h3>Results</h3><div>The updated algorithm demonstrated superior performance compared to the original version. Point dose measurements showed a reduction in discrepancies between calculated and measured doses, with improvements of up to 2.1 % for smaller targets. Volumetric measurements revealed increased gamma pass rates, with improvements of up to 15.9 % at a 95 % dose threshold in VMAT and DCA treatments.</div></div><div><h3>Conclusion</h3><div>These findings highlight advancements in dose calculation accuracy, particularly for small fields and multiple targets. These improvements of the Pencil Beam algorithm, driven by the scatter model and enhanced MLC parameter commissioning, contribute to more reliable dose predictions. As findings are specific to the 6-MV FFF beam and TrueBeam STx system, further investigations are needed for other energies and linear accelerators.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104941"},"PeriodicalIF":3.3,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study for revising diagnostic reference levels for intra-oral radiology in Cyprus","authors":"Anastasia C. Hadjiconstanti ,&nbsp;Constantinos Koshiaris ,&nbsp;Constantinos Zervides","doi":"10.1016/j.ejmp.2025.104930","DOIUrl":"10.1016/j.ejmp.2025.104930","url":null,"abstract":"<div><h3>Background</h3><div>Intra-oral radiography (IOR) is an imaging technique that uses X-rays to diagnose dental conditions. Establishing Diagnostic Reference Levels (DRLs) is crucial to optimising radiation doses and enhancing patient safety.</div></div><div><h3>Objective</h3><div>This study was undertaken to propose national DRLs for IOR in Cyprus for both children and adults. The study also sought to compare dose values across different detector types, a task of significant importance in dental radiography.</div></div><div><h3>Methods</h3><div>Data was collected from 115 intraoral units in 87 private centres in Cyprus, using incident air kerma (Ki) as the parameter. Statistical analysis was conducted based on Adulthood and detector types, such as direct digital detector (DDD), indirect digital detector (IDD) and film.</div></div><div><h3>Results</h3><div>The study revealed variability in dosing values, with third-quartile doses higher for adults than paediatric patients. DDD exhibited the lowest dose values, while film had the highest. Proposed DRLs were notably lower than the current valid DRL in Cyprus, emphasising the need for re-establishment.</div></div><div><h3>Conclusion</h3><div>The values obtained can aid the national authority in establishing national DRLs in IOR. Establishing national intraoral DRLs in Cyprus is a crucial step towards ensuring the safety and fairness of dental care in the country. With the implementation of this initiative, patients can be assured that they are receiving the highest quality of care possible.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104930"},"PeriodicalIF":3.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]FDG administered activity reduction capabilities of a 32-cm axial field-of-view solid-state digital bismuth germanium oxide PET/CT system while maintaining EARL compliance","authors":"Alina van de Burgt ,&nbsp;Petra Dibbets-Schneider ,&nbsp;Fotis Kotasidis ,&nbsp;Lioe-Fee de Geus-Oei ,&nbsp;Daphne D.D. Rietbergen ,&nbsp;Floris H.P. van Velden","doi":"10.1016/j.ejmp.2025.104935","DOIUrl":"10.1016/j.ejmp.2025.104935","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the lower [¹⁸F]FDG limit in administered activity and/or scan time reduction capabilities of a digital-BGO 32-cm axial field-of-view PET system while being compliant with current and updated EANM Research Ltd Fluorine-18 accreditation specifications (EARL₁ and EARL₂).</div></div><div><h3>Methods</h3><div>EARL₁ and EARL₂ compliance of the digital-BGO system (Omni Legend 32 cm) was tested for several reconstructions, including those that apply precision deep learning-based image enhancement (PDL) as postprocessing, using the calibration QC and NEMA IEC phantom measurements. The image quality QC scan was repeated every hour for 7 h, with each subsequent hour representing a lower administered activity, and reconstructed for various times per bed position, i.e. 30, 60, 120, 180, and 300 s. For each of the image quality QC images, coefficient of variation (COV) of the background compartment, and mean, maximum and peak activity concentration recovery coefficients (RC_mean, RC_max and RC_peak) of differently-sized spheres were calculated and compared to current and updated EARL accreditation specifications.</div></div><div><h3>Results</h3><div>When we apply 1 min per bed position for PET acquisition, [¹⁸F]FDG administration can be reduced by a factor of ∼ 4 for EARL₁, by a factor of ∼ 8 for EARL₂ (2 mm voxels) and by a factor of ∼ 4 for EARL₂ (4 mm voxels) using both standard reconstructions and PDL post-processing compared to current EANM recommendations for [¹⁸F]FDG administration (7 MBq^<img>min^<img>bed^-1<img>kg^-1).</div></div><div><h3>Conclusions</h3><div>Reduction in [¹⁸F]FDG administered activity is possible by at least a factor 4 for 1 min/bed with the Omni Legend 32 cm PET/CT while maintaining EARL₁ and EARL₂ compliance.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"131 ","pages":"Article 104935"},"PeriodicalIF":3.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}