Journal of Nippon Medical School最新文献_第9页

Pediatric Retroperitoneal Paraganglioma Invading the Inferior Vena Cava: A Case Report and Literature Review. 小儿腹膜后副神经节瘤侵袭下腔静脉1例报告及文献复习。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-603

Masaki Miyao, Tsubasa Takahashi, Jun Hayakawa, Makoto Migita, Toshikazu Itabashi, Takahiro Ueda, Hiroshi Yoshida

引用次数: 0

Changing Characteristics of Young Severe Suicide Attempters Admitted to an Emergency Room in Tokyo, Japan. 日本东京急诊室收治的年轻严重自杀企图者不断变化的特征。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-514

Ryuichiro Narishige, Yasushi Otaka, Amane Tateno

{"title":"Changing Characteristics of Young Severe Suicide Attempters Admitted to an Emergency Room in Tokyo, Japan.","authors":"Ryuichiro Narishige, Yasushi Otaka, Amane Tateno","doi":"10.1272/jnms.JNMS.2024_91-514","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2024_91-514","url":null,"abstract":"Background: The decreasing trend in the number of young suicides in Japan changed to a flat/increasing trend in 2017. To identify how this change was reflected in young suicide attempters, we investigated changes in the characteristics of young suicide attempters admitted to our emergency room.Methods: The subjects were suicide attempters younger than 30 years admitted to the Critical Care Medical Center of Nippon Medical School Hospital between January 1, 2010, and December 31, 2021. The means of suicide attempt, sociodemographic data, psychiatric diagnoses, and causes and motives of suicide attempts were retrospectively examined from medical records. We compared post-2017 to pre-2017 suicide attempts and performed a statistical analysis.Results: The proportion of suicide attempters younger than 30 years was 27.9% (143 of 513) before 2017 and 38.0% (132 of 347) after 2017, a significant increase. From 2017 to 2021, there was a significant increase in the number of female suicide attempters younger than 30 years and in the percentage of drug overdoses.Conclusions: The proportion of suicide attempters younger than 30 years was significantly higher after the start of 2017 than before 2017, possibly because of an increase in drug overdoses.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 5","pages":"488-494"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Vocal Fold Abduction Dysfunction: A Report of Two Neonatal Cases. 双侧声带内收功能障碍：两个新生儿病例的报告

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-202

Kenta Igami, Yoshio Shima, Sakae Kumasaka, Musashi Hibio, Haruka Iwata, Naoyuki Ikari, Toshiaki Shimizu

{"title":"Bilateral Vocal Fold Abduction Dysfunction: A Report of Two Neonatal Cases.","authors":"Kenta Igami, Yoshio Shima, Sakae Kumasaka, Musashi Hibio, Haruka Iwata, Naoyuki Ikari, Toshiaki Shimizu","doi":"10.1272/jnms.JNMS.2024_91-202","DOIUrl":"10.1272/jnms.JNMS.2024_91-202","url":null,"abstract":"Stridor is caused by oscillation of the narrowed upper airway. The most common cause of neonatal stridor is laryngomalacia, followed by vocal fold abduction dysfunction. Herein, we present two neonatal cases of idiopathic dysfunction of vocal fold abduction. A neonate was admitted to the neonatal intensive care unit (NICU) on day 4 of life for inspiratory stridor, intermittent subcostal retraction, and cyanosis. A second neonate was admitted to the NICU on day 7 of life for inspiratory stridor and cyanosis when crying. Neither patient had dysmorphic features or unusual cardiac ultrasonography findings. The diagnosis was confirmed by laryngo-bronchoscopy. Conservative treatment with biphasic positive airway pressure was effective in both cases and symptoms resolved within a few months. Resolution of vocal fold abduction dysfunction was confirmed by repeat endoscopy. Clinical manifestations of vocal fold abduction dysfunction vary widely. Although most cases resolve spontaneously, prolonged tube feeding, or even tracheostomy, is needed in some severe cases. Diagnosis of vocal fold abduction dysfunction requires a laryngo-bronchoscopy study; thus, there may be a large number of undiagnosed patients. Vocal fold abduction dysfunction should be considered in the differential diagnosis for neonatal inspiratory stridor.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 2","pages":"249-251"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes and Recurrence Rate of Esophageal Varices after Endoscopic Treatment in Patients with Alcoholic Cirrhosis and Viral Cirrhosis. 酒精性肝硬化和病毒性肝硬化患者食管静脉曲张内镜治疗后的疗效和复发率

IF 1 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-209

Yoshihiro Furuichi, Ryohei Nishiguchi, Takeshi Shimakawa, Tomoyuki Fujiwara, Koichiro Sato, Hiroyuki Kato

{"title":"Outcomes and Recurrence Rate of Esophageal Varices after Endoscopic Treatment in Patients with Alcoholic Cirrhosis and Viral Cirrhosis.","authors":"Yoshihiro Furuichi, Ryohei Nishiguchi, Takeshi Shimakawa, Tomoyuki Fujiwara, Koichiro Sato, Hiroyuki Kato","doi":"10.1272/jnms.JNMS.2024_91-209","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2024_91-209","url":null,"abstract":"Background: The incidence of alcoholic liver cirrhosis (ALC) is increasing. However, few reports have focused on ALC-derived esophageal varices (EV). We retrospectively examined differences in overall survival (OS) and EV recurrence rate in patients after endoscopic injection sclerotherapy (EIS) for ALC and hepatic B/C virus liver cirrhosis (B/C-LC).Methods: We analyzed data from 215 patients (B/C-LC, 147; ALC, 68) who underwent EIS. The primary endpoints were OS and EV recurrence in patients with unsuccessful abstinence ALC and those with uncontrolled B/C-LC, before and after propensity score matching (PSM) to unify the patients' background. The secondary endpoints were predictors associated with these factors, as determined by multivariate analysis.Results: The observation period was 1,430 ± 1,363 days. In the analysis of all patients, OS was significantly higher in the ALC group than in the B/C-LC group (p = 0.039); however, there was no difference in EV recurrence rate (p = 0.502). Ascites and history of hepatocellular carcinoma (HCC) (p = 0.019 and p < 0.001, respectively) predicted OS, whereas age and EV size predicted recurrence (p = 0.011 and 0.024, respectively). In total, 96 patients without an HCC history were matched by PSM, and there was no significant difference in OS or EV recurrence rate (p = 0.508 and 0.246, respectively).Conclusion: When limited to patients without a history of HCC, OS and the EV recurrence rate were comparable in patients with ALC who continued to consume alcohol and those with B/C-LC without viral control.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 2","pages":"180-189"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candesartan Attenuates Vasculitis in a Mouse Model of Kawasaki Disease Induced by Candida albicans Water-Soluble Fraction. 坎地沙坦可减轻白色念珠菌水溶性馏分诱导的川崎病小鼠模型中的血管炎

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-307

Ryosuke Matsui, Ryuji Fukazawa, Ryohei Fukunaga, Yusuke Motoji, Yoshiaki Hashimoto, Makoto Watanabe, Noriko Nagi-Miura, Yasuhiko Itoh

{"title":"Candesartan Attenuates Vasculitis in a Mouse Model of Kawasaki Disease Induced by Candida albicans Water-Soluble Fraction.","authors":"Ryosuke Matsui, Ryuji Fukazawa, Ryohei Fukunaga, Yusuke Motoji, Yoshiaki Hashimoto, Makoto Watanabe, Noriko Nagi-Miura, Yasuhiko Itoh","doi":"10.1272/jnms.JNMS.2024_91-307","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2024_91-307","url":null,"abstract":"Background: The standard treatment for Kawasaki disease is immunoglobulin therapy, but the high frequency of coronary sequelae in immunoglobulin-refractory cases indicates a need for further improvement in treatment.Methods: Kawasaki disease-like vasculitis was induced in 5-week-old DBA/2 mice by intraperitoneal administration of 0.5 mg Candida albicans water-soluble fraction (CAWS) daily for 5 days followed by daily administration of candesartan, an angiotensin receptor blocker. The vasculitis suppression effect was confirmed histologically and serologically in mice sacrificed at 28 days after the start of candesartan.Results: The area of inflammatory cell infiltration at the aortic root was 2.4±1.4% in the Control group, 18.1±1.9% in the CAWS group, and 7.1±2.3%, 5.8±1.4%, 7.6±2.4%, and 7.9±5.0% in the CAWS+candesartan 0.125-mg/kg, 0.25-mg/kg, 0.5-mg/kg, and 1.0-mg/kg groups, respectively (p=0.0200, p=0.0122, p=0.0122, and p=0.0200 vs. CAWS, respectively). The low-dose candesartan group also showed significantly reduced inflammatory cell infiltration. A similar trend was confirmed by immunostaining of macrophages and TGFβ receptors. Measurement of the inflammatory cytokines IL-1β, IL-6, and TNF-α confirmed the anti-vasculitis effect of candesartan.Conclusions: Candesartan inhibited vasculitis even at clinical doses used in children, making it a strong future candidate as an additional treatment for immunoglobulin-refractory Kawasaki disease.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 3","pages":"285-295"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ganglia-Induced Tarsal Tunnel Syndrome. 神经节诱发的跗骨隧道综合症

IF 1 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-203

Kenta Koketsu, Kyongsong Kim, Takato Tajiri, Toyohiko Isu, Daijiro Morimoto, Rinko Kokubo, Hiroyuki Dan, Akio Morita

{"title":"Ganglia-Induced Tarsal Tunnel Syndrome.","authors":"Kenta Koketsu, Kyongsong Kim, Takato Tajiri, Toyohiko Isu, Daijiro Morimoto, Rinko Kokubo, Hiroyuki Dan, Akio Morita","doi":"10.1272/jnms.JNMS.2024_91-203","DOIUrl":"10.1272/jnms.JNMS.2024_91-203","url":null,"abstract":"Background: Tarsal tunnel syndrome (TTS) is a common entrapment neuropathy that is sometimes elicited by ganglia in the tarsal tunnel.Methods: Between August 2020 and July 2022, we operated on 117 sides with TTS. This retrospective study examined data from 8 consecutive patients (8 sides: 5 men, 3 women; average age 67.8 years) with an extraneural ganglion in the tarsal tunnel. We investigated the clinical characteristics and surgical outcomes for these patients.Results: The mass was palpable through the skin in 1 patient, detected intraoperatively in 1 patient, and visualized on MRI scanning in the other 6 patients. Symptoms involved the medial plantar nerve area (n = 5), lateral plantar nerve area (n = 1), and medial and lateral plantar nerve areas (n = 2). The interval between symptom onset and surgery ranged from 4 to 168 months. Adhesion between large (≥20 mm) ganglia and surrounding tissue and nerves was observed intraoperatively in 4 patients. Of the 8 patients, 7 underwent total ganglion resection. There were no surgery-related complications. On their last postoperative visit, 3 patients with a duration of symptoms not exceeding 10 months reported favorable outcomes.Conclusions: Because ganglia eliciting TTS are often undetectable by skin palpation, imaging studies may be necessary. Early surgical intervention appears to yield favorable outcomes.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 1","pages":"114-118"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glue in Lockdown Technique to Embolize Peripheral Arterial Aneurysms. 胶锁技术栓塞外周动脉动脉瘤。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-607

Shimpei Ikeda, Takahiko Mine, Shohei Mizushima, Soh Ueshima, Seigoh Happoh, Masahiro Fujii, Tatsuo Ueda, Shin-Ichiro Kumita

引用次数: 0

Real-World Screening Data for Liver Fibrosis in Psoriasis Patients Treated with Biologics. 生物制剂治疗银屑病患者肝纤维化的真实世界筛选数据

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-613

Susumu Ichiyama, Michiko Ito, Saeko Ozaki, Taeang Arai, Masanori Atsukawa, Katsuhiko Iwakiri, Teppei Hagino, Toshihiko Hoashi, Naoko Kanda, Hidehisa Saeki

{"title":"Real-World Screening Data for Liver Fibrosis in Psoriasis Patients Treated with Biologics.","authors":"Susumu Ichiyama, Michiko Ito, Saeko Ozaki, Taeang Arai, Masanori Atsukawa, Katsuhiko Iwakiri, Teppei Hagino, Toshihiko Hoashi, Naoko Kanda, Hidehisa Saeki","doi":"10.1272/jnms.JNMS.2024_91-613","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2024_91-613","url":null,"abstract":"Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is positively associated with the prevalence and severity of psoriasis. The fibrosis-4 (FIB-4) index was developed to predict significant liver fibrosis. Using the FIB-4 index, the present study evaluated screening data for liver fibrosis, including MASLD, in patients with refractory psoriasis treated with biologics.Methods: All adult patients with psoriasis who were prescribed biologics at Nippon Medical School from August 2023 to May 2024 were included in this study. The FIB-4 index was classified as high (≥2.67), intermediate (1.30-2.66), and low (<1.30). Patients younger than 65 years were referred to a hepatologist if the FIB-4 index was high. If the score was intermediate, type IV collagen 7S (4COL7S) was checked, and they were referred to a hepatologist if it was ≥4.8 ng/mL. Patients aged ≥65 years were referred to a hepatologist if the FIB-4 index was high. If it was 2.00-2.66, they were referred to a hepatologist if the 4COL7S level was ≥4.8 ng/mL.Results: Data from 96 patients were analyzed. The FIB-4 index was high in 10 patients, intermediate in 35 patients, and low in 51 patients. Eleven of 96 registered patients were newly referred to a hepatologist. Of these 11 patients, 5 received lifestyle guidance.Conclusions: For patients with refractory psoriasis, close cooperation between dermatologists and hepatologists is essential to prevent progression of liver fibrosis.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"91 6","pages":"534-540"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigeminal Neuralgia due to Venous Compression Successfully Transposed by Suprameatal Tubercle Drilling. 三叉神经痛的静脉压迫成功转位的胸膜上结节钻。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-608

Katsuya Umeoka, Fumihiro Matano, Yasuo Murai

引用次数: 0

A Case of X-Linked Agammaglobulinemia and COVID-19 in a Japanese Infant. 1例日本婴儿x连锁无球蛋白血症和COVID-19

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2024-01-01 DOI: 10.1272/jnms.JNMS.2024_91-606

Junya Sugihara, Mami Kurihara, Hikaru Takeshita, Hanako Tajima, Jun Hayakawa, Hidehiko Narazaki, Makoto Migita, Yasuhiko Itoh

引用次数: 0