Journal of Nippon Medical School最新文献_第6页

Food Preference in Parkinson's Disease. 帕金森病的食物偏好。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-304

Michika Sakamoto, Kentaro Suzuki, Hiroshi Nagayama, Kazumi Kimura

{"title":"Food Preference in Parkinson's Disease.","authors":"Michika Sakamoto, Kentaro Suzuki, Hiroshi Nagayama, Kazumi Kimura","doi":"10.1272/jnms.JNMS.2025_92-304","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-304","url":null,"abstract":"Background: Several studies have reported that persons with Parkinson's disease (PD) exhibit a preference for sweet foods. However, because many people favor such foods, this study investigated whether the preference for sweet foods was stronger among patients with PD than among those without PD.Methods: We analyzed 150 patients treated in the neurology department of Nippon Medical School Hospital between July 2021 and November 2021. Forty-nine (33%) had PD and 101 patients (control group) did not. Participants were asked to rate three sweet foods, three salty foods, and three bitter foods (total, nine foods) on a questionnaire where a score of 3 indicated \"like\", 2 indicated \"neutral\", and 1 indicated \"dislike\". The score for each taste preference was defined as the sum of the scores for the three foods representing each taste. Differences in baseline characteristics and taste preference scores between patients with and without PD were then statistically analyzed.Results: The PD group was significantly older than the control group. The PD group obtained a significantly higher sweetness score than the control group (8 [6-9] vs. 7 [3-9], p<0.01). There was no difference in scores for either saltiness (7 [3-9] vs. 7 [3-9], p=0.49) or bitterness (7 [4-9] vs. 7 [3-9], p=0.25). The sweetness score was not significantly correlated with L-dopa dose, L-dopa equivalent dose, or PD disease duration.Conclusion: Patients with PD were more likely than those without PD to prefer sweet foods. These results are important new information on the taste preferences of persons with Parkinson's disease.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 3","pages":"248-252"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Predictive Postoperative Inflammatory Response Indicators of Infectious Complications Following Gastrectomy for Gastric Cancer". 对“胃癌胃切除术后感染性并发症的预测炎症反应指标”的评论。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-411

On Kei Angel Tai, Akihisa Matsuda, Yuta Kikuchi, Hiroshi Yoshida

引用次数: 0

Impact of IMP3 Expression on Chemotherapy Response and Prognosis in Triple-Negative Breast Cancer: A Retrospective Cohort Study. IMP3表达对三阴性乳腺癌化疗反应和预后的影响：一项回顾性队列研究

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-109

Mio Yagi, Koji Nagata, Megumi Sano, Keiko Yanagihara, Ryuji Ohashi, Hiroyuki Takei

{"title":"Impact of IMP3 Expression on Chemotherapy Response and Prognosis in Triple-Negative Breast Cancer: A Retrospective Cohort Study.","authors":"Mio Yagi, Koji Nagata, Megumi Sano, Keiko Yanagihara, Ryuji Ohashi, Hiroyuki Takei","doi":"10.1272/jnms.JNMS.2025_92-109","DOIUrl":"10.1272/jnms.JNMS.2025_92-109","url":null,"abstract":"Background: Although advances in neoadjuvant chemotherapy (NAC) are improving the rate of pathological complete response (pCR) and outcomes for triple-negative breast cancer (TNBC) patients, the prognosis remains poor. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression was recently reported to be associated with chemotherapy resistance and poor prognosis in TNBC.Methods: We evaluated IMP3 expression in 40 female TNBC patients to assess its association with NAC sensitivity and outcome.Results: Among the cohort, 11 patients (27.5%) had IMP3-positive TNBC, which was associated with a higher Ki-67 labeling index (p = 0.119), indicating greater malignancy. However, IMP3 positivity showed no significant correlation with NAC resistance or differences in disease-free survival (DFS) as compared with IMP3-negative patients.Conclusions: Patients receiving effective immunotherapy or high-dose chemotherapy achieved pCR regardless of IMP3 status, which suggests that the NAC regimen is more important than IMP3 status for pCR. Even in IMP3-positive TNBC, NAC may improve prognosis by achieving pCR. Thus, while IMP3 might predict poor prognosis, it may not serve as a definitive marker in the context of NAC. Because IMP3 is involved in cancer stem cell (CSC) function, further research is necessary to understand its complex role in CSCs and TNBC.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"44-51"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-Scene Time and Outcomes in Patients with Out-of-Hospital Cardiac Arrest and Return of Spontaneous Circulation at the Scene: A Post-Hoc Analysis of a Multicenter Cohort Study. 院外心脏骤停和现场自发循环恢复患者的现场时间和结果：一项多中心队列研究的事后分析

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-207

Hiroto Numata, Takashi Tagami, Kensuke Suzuki, Ryusei Tabata, Megumi Kohri, Tomohito Amano, Suzuka Hagiwara, Shinnosuke Kitano, Nobuya Kitamura, Yosuke Homma, Satoo Ogawa

{"title":"On-Scene Time and Outcomes in Patients with Out-of-Hospital Cardiac Arrest and Return of Spontaneous Circulation at the Scene: A Post-Hoc Analysis of a Multicenter Cohort Study.","authors":"Hiroto Numata, Takashi Tagami, Kensuke Suzuki, Ryusei Tabata, Megumi Kohri, Tomohito Amano, Suzuka Hagiwara, Shinnosuke Kitano, Nobuya Kitamura, Yosuke Homma, Satoo Ogawa","doi":"10.1272/jnms.JNMS.2025_92-207","DOIUrl":"10.1272/jnms.JNMS.2025_92-207","url":null,"abstract":"Background: The optimal on-scene time after the return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrest (OHCA) has not been established. This study aimed to investigate the relationship between the on-scene time after ROSC and neurological outcomes.Methods: We analyzed data recorded in the SOS-KANTO 2017 registry between September 2019 and March 2021. Patients with OHCA who achieved ROSC on the scene were included and categorized into three groups based on on-scene time after ROSC (0-<6 min, 6-<10 min, and ≥10 min). Comparisons were performed using multiple propensity score analysis. The primary outcome was favorable neurological status at one month, defined as cerebral performance categories 1 and 2.Results: In total, 331 patients were included. Favorable neurological outcomes at one month were observed in 29.1% (32/123) of patients in the 0-<6 min group, 37.2% (35/104) in the 6-<10 min group, and 36.3% (29/104) in the ≥10 min group. There was no significant association between shorter on-scene times (0-<6 min) and favorable neurological outcomes at one month compared to the other groups (adjusted odds ratio [AOR], 0.97; 95% confidence interval [CI], 0.39-2.41 for 6-<10 min; AOR, 0.90; 95% CI, 0.30-2.70 for ≥10 min).Conclusion: Differences in on-scene time after ROSC were not significantly associated with favorable neurological outcomes at one month. Future research should focus on identifying factors that may influence outcomes, and on exploring strategies to enhance care in the Japanese EMS context.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"163-169"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Seasonal Changes on Emergency Transports for Vertigo/Dizziness: A Study Based on Emergency Triage and Weather Factors. 季节变化对眩晕/头晕急诊转运的影响：基于急诊分诊和天气因素的研究

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-308

Makoto Suzaki, Masato Miyauchi, Naoto Matsuda, Asaka Onodera, Naoko Onodera, Masatoku Arai, Hideya Hyodo, Toshihiko Ohara, Masahiro Yasutake, Shoji Yokobori, Gen Takagi

{"title":"Influence of Seasonal Changes on Emergency Transports for Vertigo/Dizziness: A Study Based on Emergency Triage and Weather Factors.","authors":"Makoto Suzaki, Masato Miyauchi, Naoto Matsuda, Asaka Onodera, Naoko Onodera, Masatoku Arai, Hideya Hyodo, Toshihiko Ohara, Masahiro Yasutake, Shoji Yokobori, Gen Takagi","doi":"10.1272/jnms.JNMS.2025_92-308","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-308","url":null,"abstract":"Background: We investigated the association between the number of patients presenting to an emergency room (ER) with vertigo/dizziness (V/D) and seasonal variations, monthly trends, and weather factors.Methods: We retrospectively investigated age, sex, cause of V/D, emergency triage level (Japan Triage and Acuity Scale), month, and seasonality among patients with V/D transported to the ER of Nippon Medical School between October 2014 and September 2017. We examined weather data, including monthly average precipitation and humidity, with respect to the number of patients with V/D.Results: Among 706 patients with V/D, 481 presented with vertigo and 225 with dizziness. The mean age was 59±18 years and 66% were female. Regarding triage level, emergent (level 2) and urgent (level 3) cases accounted for 86% of cases and were more frequent in June-September (p=0.012). Regarding seasonality, 158 (22%), 195 (28%), 183 (26%), and 170 (24%) patients presented in spring, summer, autumn, and winter, respectively (p=0.744). The monthly number of V/D emergency transports tended to be higher between June and October and was significantly associated with average temperature (r=0.648, p=0.023), precipitation (r=0.655, p=0.021), humidity (r=0.676, p=0.016), and vapor pressure (r=0.648, p=0.023).Conclusions: Although no apparent seasonality was observed in the monthly number of V/D-related emergency transports, the emergency triage level increased from the rainy season to early autumn. The monthly number of V/D cases transported by emergency services was significantly associated with average temperature, precipitation, humidity, and vapor pressure. These findings could inform public health policy and increase emergency preparedness.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 3","pages":"268-278"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitral Regurgitation Associated with Mitral Annulus Remodeling and Left Atrial Dilatation. 二尖瓣返流与二尖瓣环重构和左房扩张相关。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-203

Yuki Izumi, Yukichi Tokita, Hiroshi Honma, Kanako Ito-Hagiwara, Yu-Ki Iwasaki, Kuniya Asai

{"title":"Mitral Regurgitation Associated with Mitral Annulus Remodeling and Left Atrial Dilatation.","authors":"Yuki Izumi, Yukichi Tokita, Hiroshi Honma, Kanako Ito-Hagiwara, Yu-Ki Iwasaki, Kuniya Asai","doi":"10.1272/jnms.JNMS.2025_92-203","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-203","url":null,"abstract":"Background: Atrial functional mitral regurgitation (MR) involves functional MR with left atrial (LA) dilatation and mitral annulus (MA) remodeling. The relationship between LA dilatation and MA remodeling, and the mechanism of MR associated with MA remodeling, are unclear and were investigated in this study.Methods: This single-center, cross-sectional retrospective study prospectively enrolled 97 consecutive patients with atrial fibrillation (AF) referred for three-dimensional transesophageal echocardiography. Mitral valve echocardiographic data of 18 AF patients with moderate or severe MR (MR group) and 79 with mild or less severe MR (non-MR group) were analyzed.Results: The LA volume index was larger and tenting height was lower in the MR group than in the non-MR group (63.9±17.9 mL/m2 vs. 43.6±13.9 mL/m2; p<0.001; 3.9 mm vs. 4.9 mm; p = 0.041). Anteroposterior (AP) diameter, annulus area, and sphericity index (AP diameter/anterolateral-posteromedial diameter) of MA were larger in the MR group than in the non-MR group (30.1 mm vs. 26.4 mm; p<0.001; 8.8 cm2 vs. 7.4 cm2; p = 0.002; 80.1% vs. 74.5%; p<0.001, respectively). Linear regression analysis indicated that AP diameter was moderately correlated with LA volume index (R = 0.535, p<0.001). The area under the receiver operating characteristics curve of the AP diameter for the association with significant MR was significantly larger than that for the annulus area (0.8003 vs. 0.7180; p = 0.003). Multivariable analysis revealed that AP diameter (p = 0.006) and sphericity index (p = 0.041) were independently associated with significant MR, but annulus area was not (p = 0.083).Conclusions: LA dilatation correlated with MA remodeling, primarily via enlargement of AP diameter. Circular change with AP diameter enlargement in MA may be a key mechanism of MR associated with MA remodeling.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"145-153"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saisei-Gakusha and Hideyo Noguchi's Temporary Return to Japan. 生成学社和野口英代暂时返回日本。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-213

Toshiro Shimura, Akihiko Gemma, Takeyuki Tokura

{"title":"Saisei-Gakusha and Hideyo Noguchi's Temporary Return to Japan.","authors":"Toshiro Shimura, Akihiko Gemma, Takeyuki Tokura","doi":"10.1272/jnms.JNMS.2025_92-213","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-213","url":null,"abstract":"During the period from September 5 to November 4, 1915 (Taisho 4), the bacteriologist Dr. Hideyo Noguchi temporarily returned to Japan after living and working in the United States for 15 years. This article discusses the many lectures he delivered during his visit, particularly those at the alumni meeting of Saisei-Gakusha, the institution from which he graduated, and the Mita Speech Meeting at Keio University. Additionally, this paper provides an overview of Saisei-Gakusha, a private medical school from the Meiji era that later became the predecessor of Nippon Medical School, highlighting its founding philosophy of \"Saisei\" (to save lives). It also introduces materials such as Noguchi's handwritten Curriculum Vitae and Autograph, which he prepared while studying abroad at the Rockefeller Institute for Medical Research. Furthermore, we examine an article from The New York Times reporting on Noguchi's serious illness several years after his return to the United States, as well as related articles from Japanese newspapers. We also present a thank-you postcard and a business card sent by Noguchi to his close friend Dr. Shinichi Wani, a fellow alumnus of Saisei-Gakusha, illustrating their enduring friendship. These materials reflect Noguchi's meticulous nature, thoughtful personality, and warm character, as seen through his relationship with his dear friend Wani.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"138-144"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence Rate and Risk Factors for In-Hospital Ischemic Stroke among 83,990 Hospitalized Patients. 83990例住院患者院内缺血性脑卒中发病率及危险因素分析

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-209

Seira Sakurai, Kentaro Suzuki, Takuya Nishino, Daisuke Hayashi, Tomonari Saito, Yuki Sakamoto, Junya Aoki, Yasuhiro Nishiyama, Kazumi Kimura

{"title":"Incidence Rate and Risk Factors for In-Hospital Ischemic Stroke among 83,990 Hospitalized Patients.","authors":"Seira Sakurai, Kentaro Suzuki, Takuya Nishino, Daisuke Hayashi, Tomonari Saito, Yuki Sakamoto, Junya Aoki, Yasuhiro Nishiyama, Kazumi Kimura","doi":"10.1272/jnms.JNMS.2025_92-209","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-209","url":null,"abstract":"Background: Details of in-hospital stroke are unknown. This study aimed to clarify the incidence rate and risk factors for in-hospital stroke among all inpatients.Methods: This retrospective single-center study included consecutive patients admitted to our hospital. Patients aged <18 years, discharged within 24 h, and admitted to the neurology and neurosurgery departments were excluded. The incidence rate for in-hospital stroke was calculated, and patients were divided into stroke and control groups based on ischemic stroke occurrence, and the risk factors were assessed using multivariate analysis.Results: Of the 83,990 enrolled patients, 101 (0.12%) developed stroke. The stroke group had a higher proportion of patients with older age (76 vs 69 years; P <.01), hypertension (49% vs 26%; P <.01), diabetes mellitus (34% vs 22%; P =.01), atrial fibrillation (25% vs 8%; P <.01), cardiovascular disease (20% vs 11%; P =.01), and emergency admission (68% vs 32%; P <.01) compared to the control group. The risk factors for in-hospital stroke were old age (odds ratio [OR], 1.03; P <.01), hypertension (OR, 1.57; P =.04), diabetes mellitus (OR, 1.61; P =.03), atrial fibrillation (OR, 2.43; P <.01), emergency admission (OR, 3.38; P <.01), and low serum albumin (OR, 0.66; P =.03).Conclusion: The incidence rate of in-hospital stroke was 0.12% and the independent risk factors were old age, history of hypertension, diabetes mellitus, atrial fibrillation, emergency admission, and low serum albumin.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"181-187"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Sex Differences in Oligodendrocytes and Their Progenitor Cells on the Pathophysiology of Neuropsychiatric Disorders. 少突胶质细胞及其祖细胞的性别差异对神经精神疾病病理生理的影响。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-306

Daisuke Kato

{"title":"Impact of Sex Differences in Oligodendrocytes and Their Progenitor Cells on the Pathophysiology of Neuropsychiatric Disorders.","authors":"Daisuke Kato","doi":"10.1272/jnms.JNMS.2025_92-306","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-306","url":null,"abstract":"Neuropsychiatric disorders such as multiple sclerosis, Alzheimer's disease, and autism spectrum disorder exhibit significant sex differences in prevalence, progression, and response to treatment. Emerging evidence suggests that oligodendrocytes (OLs) and oligodendrocyte precursor cells (OPCs) play pivotal roles in these pathologies via mechanisms involving neuroinflammation, energy metabolism, and hormonal modulation, resulting in distinct functional outcomes. Specifically, female OPCs display higher proliferative and migratory capacities, whereas male OPCs are more prone to differentiation and myelination, thus contributing to robust myelin integrity. Dysregulation of these cells disrupts myelination and exacerbates disease progression. Addressing sex-specific gene expression in OPCs and OLs is therefore considered crucial for the development of targeted therapeutic strategies. This review highlights the significance of sex differences in the proliferation and differentiation of OPCs, as well as gene expression changes in OPCs and OLs, and emphasizes their contribution to the pathophysiology of neuropsychiatric disorders. Improved understanding of these differences is vital for advancing personalized sex-specific treatments and improving the clinical outcomes of neuropsychiatric disorders.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 3","pages":"226-233"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nationwide Survey of Pharmacist Involvement in Managing Cancer Pain in Children. 全国药剂师参与管理儿童癌症疼痛的调查。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-406

Kayoko Morio, Chikako Iwai, Shuntaro Yasuda, Takehiro Kawashiri, Noriaki Hidaka, Aina Suzuki, Mayako Uchida, Hisamitsu Takase

{"title":"Nationwide Survey of Pharmacist Involvement in Managing Cancer Pain in Children.","authors":"Kayoko Morio, Chikako Iwai, Shuntaro Yasuda, Takehiro Kawashiri, Noriaki Hidaka, Aina Suzuki, Mayako Uchida, Hisamitsu Takase","doi":"10.1272/jnms.JNMS.2025_92-406","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-406","url":null,"abstract":"Background: Cancer pain distresses pediatric patients, affects quality of life, and is a psychological burden for families. The purpose of this study was to clarify the role of pharmacists in assisting children with cancer pain and their families.Methods: Between February and May 2024, a nationwide questionnaire survey was conducted among hospital pharmacists from the Japanese Society for Pharmaceutical Palliative Care and Sciences. The survey examined pharmacist involvement with children <15 years of age with cancer pain and their families, particularly in pain assessment, explaining analgesic use, and managing psychological, social, and spiritual pain.Results: Of 2,720 pharmacists, 219 (8.1%) responded, 57 of whom (26.0%) had pediatric palliative care experience. Most pharmacists performed pain assessments, provided analgesic explanations (86.0%), and intervened in psychological, social, and spiritual pain (54.4%). Among those who intervened, more than 90% either communicated with patients and their families or listened to their concerns. Pharmacists with ≥5 years of experience were significantly more involved in psychological, social, and spiritual pain than were those with <5 years of experience (odds ratio, 3.46; 95% confidence interval, 1.04-11.54). However, most pharmacists reported difficulties in pain assessment and providing analgesic explanations; the main reasons were \"due to patient age and comprehension\" (87.0%) and \"reluctance to initiate opioid analgesics by patients or their families\" (68.3%), respectively.Conclusions: Pharmacists were actively engaged in pain management for children with cancer and their families. However, most reported difficulties, particularly in pain assessment and analgesic explanations. Therefore, educational programs should be developed to facilitate effective pain management.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 4","pages":"337-348"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0