Progress in Orthodontics最新文献

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Patient experiences and discomfort associated with mid-palatal temporary skeletal anchorage devices.
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2025-02-07 DOI: 10.1186/s40510-024-00549-9
Aoife P Barry, Vanessa Knode, Padhraig S Fleming, Björn Ludwig
{"title":"Patient experiences and discomfort associated with mid-palatal temporary skeletal anchorage devices.","authors":"Aoife P Barry, Vanessa Knode, Padhraig S Fleming, Björn Ludwig","doi":"10.1186/s40510-024-00549-9","DOIUrl":"10.1186/s40510-024-00549-9","url":null,"abstract":"<p><strong>Background: </strong>Mid-palatal placement of temporary skeletal anchorage devices (TSADs) has become increasingly popular among clinicians due to high success rates, low associated risk and streamlining and enhanced customization of associated supra-structures. There is however limited patient data in relation to associated experiences and impacts.</p><p><strong>Methods: </strong>A survey of patients undergoing mid-palatal TSAD insertion was undertaken using a 27-item bespoke questionnaire. Questionnaires were sent using both electronic and surface mail with a 3-month period allowed for response. Pain experience; the use of analgesia; requirement for additional visits; impacts on hygiene, speech, eating, and hobbies; and social impacts were assessed. Reponses involved the use of a Visual Analogue Scale as well as binary information.</p><p><strong>Results: </strong>Overall, 152 responses were obtained with 87.5% describing experience of TSAD insertion either \"as expected\" or \"better\". Procedural pain was reported as mild in 62.5%. Local post-operative pain was scored as moderate in 21.1%. Some functional impairment was reported with 63.2% attributing difficulty with speech and 67.8% difficulty with eating due to the implant. However, these functional impairments were generally considered mild (by 68.1% and 60.2%, respectively) and most were very likely to recommend this treatment to others, with 65.1% (n = 99) scoring 8 or above out of 10.</p><p><strong>Conclusions: </strong>Appreciable levels of pain, discomfort and functional impairment were noted with the use of mid-palatal TSADs. However, any unpleasant experiences were generally regarded as mild with most highly likely to recommend mid-palatal TSADs to prospective patients.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"26 1","pages":"5"},"PeriodicalIF":4.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional quantitative temporomandibular joint changes in skeletal class I malocclusion treated with extraction and non-extraction protocols: a comparative study of fixed orthodontic appliances and clear aligners. 拔牙与非拔牙治疗骨骼I类错颌的三维定量颞下颌关节变化:固定正畸矫治器与透明矫正器的比较研究
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2025-01-20 DOI: 10.1186/s40510-024-00551-1
Majedh Abdo Ali Al-Somairi, Bowen Zheng, Xaiofeng Yang, Yongxin Zhang, Maged S Alhammadi, Hao Xu, Najah Alhashimi, Bushra Sufyan Almaqrami, Naseem Ali Al-Worafi, Enas Senan Alyafrusee, Barakat Al-Tayar, Yi Liu
{"title":"Three-dimensional quantitative temporomandibular joint changes in skeletal class I malocclusion treated with extraction and non-extraction protocols: a comparative study of fixed orthodontic appliances and clear aligners.","authors":"Majedh Abdo Ali Al-Somairi, Bowen Zheng, Xaiofeng Yang, Yongxin Zhang, Maged S Alhammadi, Hao Xu, Najah Alhashimi, Bushra Sufyan Almaqrami, Naseem Ali Al-Worafi, Enas Senan Alyafrusee, Barakat Al-Tayar, Yi Liu","doi":"10.1186/s40510-024-00551-1","DOIUrl":"10.1186/s40510-024-00551-1","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the positional and morphological changes in the temporomandibular joint (TMJ) in adult patients with skeletal Class I malocclusion treated with fixed orthodontic appliances (FAs) and clear aligners (CAs), both with and without premolar extractions.</p><p><strong>Methods: </strong>This retrospective study involved 120 adult patients divided into non-extraction and extraction groups, each further subdivided equally into those treated with FAs and CAs. Cone beam computed tomography (CBCT) was used to assess the TMJ measurements before (T0) and after treatment (T1). Statistical analyses were conducted to compare the mean changes in intra- and inter-groups. A significance level of p ≤ 0.05 was considered.</p><p><strong>Results: </strong>In the non-extraction group, specifically in FAs, significant increases were observed in TMJ parameters; anteroposterior condylar position (APCP) and mediolateral condylar inclination (MCI). Conversely, significant decreases were noted in vertical condylar position (VCP) and vertical condylar inclination (VCI). In the extraction group, significant increases were noted in APCP and anterior joint space (AJS), while posterior joint space (PJS) and anteroposterior condylar joint position (APCJP) decreased. For inter-group comparisons, the extraction group showed significant increases in APCP in FAs compared to CAs, and a significant decrease in APCJP in FAs compared to CAs.</p><p><strong>Conclusion: </strong>FAs significantly impact condylar positions and joint spaces, especially in extraction cases. Monitoring TMJ parameters during orthodontic treatment is crucial to ensure positive outcomes and prevent TMJ disorders (TMDs). These findings may guide the selection of orthodontic appliances based on individual malocclusion characteristics.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"26 1","pages":"4"},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tooth wear and tertiary crowding: a 13-year cohort study in Amazon Indigenous populations. 牙齿磨损和三级拥挤:一项为期13年的亚马逊原住民队列研究。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2025-01-06 DOI: 10.1186/s40510-024-00550-2
Renata Travassos da Rosa Moreira Bastos, Eduardo Oliveira da Costa, David Normando
{"title":"Tooth wear and tertiary crowding: a 13-year cohort study in Amazon Indigenous populations.","authors":"Renata Travassos da Rosa Moreira Bastos, Eduardo Oliveira da Costa, David Normando","doi":"10.1186/s40510-024-00550-2","DOIUrl":"https://doi.org/10.1186/s40510-024-00550-2","url":null,"abstract":"<p><strong>Background: </strong>Tooth wear is an important mechanism for reducing dental dimensions and, consequently, dental crowding. The objective of this cohort study was to examine the relation of tooth wear, adjusted for covariates (age, tooth loss, arch perimeter and intercanine width), on tertiary crowding in Amazon Indigenous populations.</p><p><strong>Methods: </strong>A sample of 40 Indigenous people in permanent dentition at T0 (baseline) and after 13 years (T1) were evaluated. The sample included 16 males and 24 females belonging to two villages, Arara (n = 22, mean ages 16.6 and 29.9 years) and Assurini do Xingu (n = 18, mean ages 16.0 and 29.6 years). Clinical, intraoral photograph and dental cast evaluations were performed at both times. The anterior crowding was measured using Little's Irregularity Index (LI) and modeled through a multilevel linear regression with the predictor variables: village, tooth wear (T1-T0), age (T0), tooth loss (T1-T0), changes in intercanine width (T1-T0) and changes in arch perimeter (T1-T0).</p><p><strong>Results: </strong>A slight increase was observed (< 1 mm) in anterior dental crowding and a decrease in arch perimeter < 1.5 mm, while tooth wear increased between 0.65 and 0.99 units. The contextual variable (village) had no significant association with LI. In the upper arch, tooth loss was the only variable that showed an inverse association with LI (β=-0.41, p < 0.05). In the lower arch, the increase in dental crowding was inversely associated with tooth wear (β=-1.30, p < 0.05) and changes in arch perimeter (β=-0.31, p < 0.05). The other variables did not show significant associations.</p><p><strong>Conclusion: </strong>After 13 years, dental crowding and tooth wear increased, while the arch dimensions tended to decrease. The changes in long-term dental crowding seem to have distinct etiological components for each dental arch. In the mandible, the changes in incisor alignment were associated with increased tooth wear and decreased dental arch dimensions. Whereas in the maxilla, only tooth loss caused alterations in tooth alignment. It is suggested that the effect of increased tooth wear on the etiology of tertiary crowding is of small magnitude and restricted to the lower dental arch.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"26 1","pages":"1"},"PeriodicalIF":4.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Effect of anti-sclerostin antibody on orthodontic tooth movement in ovariectomized rats. 校正:抗硬化抗体对去卵巢大鼠正畸牙齿运动的影响。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2025-01-03 DOI: 10.1186/s40510-024-00552-0
Hyunna Ahn, Wonse Park, Sung-Hwan Choi, Namki Hong, Jisun Huh, Seoyeon Jung
{"title":"Correction to: Effect of anti-sclerostin antibody on orthodontic tooth movement in ovariectomized rats.","authors":"Hyunna Ahn, Wonse Park, Sung-Hwan Choi, Namki Hong, Jisun Huh, Seoyeon Jung","doi":"10.1186/s40510-024-00552-0","DOIUrl":"10.1186/s40510-024-00552-0","url":null,"abstract":"","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"26 1","pages":"3"},"PeriodicalIF":4.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanosensor YAP mediates bone remodeling via NF-κB p65 induced osteoclastogenesis during orthodontic tooth movement. 在正畸牙齿移动过程中,机械传感器YAP通过NF-κB p65诱导的破骨细胞生成介导骨重塑。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2025-01-02 DOI: 10.1186/s40510-024-00548-w
Jie Deng, Yu-Ning Zhang, Ru-Shui Bai, Ting-Ting Yu, Yi Zhao, Hao Liu, Yun-Fan Zhang, Tian-Min Xu, Bing Han
{"title":"Mechanosensor YAP mediates bone remodeling via NF-κB p65 induced osteoclastogenesis during orthodontic tooth movement.","authors":"Jie Deng, Yu-Ning Zhang, Ru-Shui Bai, Ting-Ting Yu, Yi Zhao, Hao Liu, Yun-Fan Zhang, Tian-Min Xu, Bing Han","doi":"10.1186/s40510-024-00548-w","DOIUrl":"10.1186/s40510-024-00548-w","url":null,"abstract":"<p><strong>Background: </strong>Yes-associated protein (YAP) is a crucial mechanosensor involved in mechanotransduction, but its role in regulating mechanical force-induced bone remodeling during orthodontic tooth movement (OTM) is unclear. This study aims to elucidate the relationship between mechanotransduction and mechanical force-induced alveolar bone remodeling during OTM.</p><p><strong>Results: </strong>Our study confirms an asynchronous (temporal and spatial sequence) remodeling pattern of the alveolar bone under mechanical force during OTM. Both compression and tension activate osteoclasts recruiting to the alveolar bone, whereas no significant presence of osteoblasts in the alveolar bone at the early stages of bone remodeling. Specifically, applying different force magnitudes (10, 25, 50, 100 g) to rats' 1st molars affected OTM distance. Force-induced alveolar bone remodeling was characterized by osteoclastogenesis and YAP activation at compressive/tensile sites on day 1 of OTM. Notably, 25 g force triggered peak YAP expression and osteoclastic activity early on. Time-course analysis revealed two YAP activity peaks on day1 and 14, contrasting with one peak of type I collagen expression on day14. In addition, RNA-sequencing highlighted increased nuclear factor kappa B (NF-κB) signaling, mineral absorption, and osteoclast differentiation at day-1 and 3. Moreover, gene expression analysis showed similar trends for NF-κB p65, YAP1, and TEA domain 1 (TEAD1) during this time. Furthermore, experiments on osteoclast cultures indicated YAP activation via large tumor suppressor (LATS) and TEAD under mechanical stimuli (compression/tension), promoting osteoclastogenesis by regulating NF-κB p65 and receptor activator of NF-κB (RANK). Inhibiting YAP with verteporfin delayed OTM by impairing force-induced osteoclastic activities in vivo and ex-vivo.</p><p><strong>Conclusions: </strong>We propose that YAP mediates alveolar bone remodeling through NF-κB p65-induced osteoclastogenesis in an asynchronous remodeling pattern during OTM. Both compression and tension activate osteoclasts recruiting to the alveolar bone at early stages of bone remodeling, offering evidence for orthodontists as a reference.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"26 1","pages":"2"},"PeriodicalIF":4.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The microbiome alterations of supragingival plaque among adolescents using clear aligners: a metagenomic sequencing analysis. 使用清晰对准器的青少年龈上菌斑的微生物组改变:宏基因组测序分析。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2024-12-16 DOI: 10.1186/s40510-024-00547-x
Chunlin Wang, Chao Zhang, Shan He, Qiuyu Wang, Hai Gao
{"title":"The microbiome alterations of supragingival plaque among adolescents using clear aligners: a metagenomic sequencing analysis.","authors":"Chunlin Wang, Chao Zhang, Shan He, Qiuyu Wang, Hai Gao","doi":"10.1186/s40510-024-00547-x","DOIUrl":"10.1186/s40510-024-00547-x","url":null,"abstract":"<p><strong>Background: </strong>White spot lesions (WSLs) may develop in adolescents undergoing clear aligner (CA) therapy with poor oral hygiene. The specific effects of CAs on the microbial composition and functional characteristics of supragingival plaques remain unclear. The present study investigated the shift in the supragingival microbial community induced by CAs in adolescents through metagenomic technology.</p><p><strong>Methods: </strong>Fifteen adolescents (12-15 years old) with Invisalign appliances were recruited. Supragingival plaque specimens were obtained twice, before treatment (T<sub>1</sub>) and three months after treatment (T<sub>2</sub>). All the bacterial plaque specimens were analyzed for microbial communities and functions using metagenomic analyses.</p><p><strong>Results: </strong>A total of 2,840,242,722 reads disclosed 180 phyla, 3,975 genera, and 16,497 microbiome species. During the first three months, the microbial community was relatively stable. The genus level revealed a higher relative abundance of Capnocytophaga, Neisseria, and Arachnia in the T<sub>2</sub> period. Furthermore, the functional analysis suggested that the relative abundances of folate biosynthesis, biotin metabolism and biofilm formation-vibrio cholerae were increased in the T<sub>2</sub> period compared to the T<sub>1</sub> period. Finally, virulence factor analysis demonstrated that the relative abundance of genes associated with type IV pili (VF0082) and polar flagella (VF0473) was higher in the T<sub>2</sub> period than in the T<sub>1</sub> period.</p><p><strong>Conclusion: </strong>In adolescents undergoing CA therapy with poor plaque control, caries progresses quickly within three months and noticeable WSLs develop on the tooth surface. Although the microbial community remained relatively steady and CA therapy did not cause significant changes in the overall functional gene composition in the first three months, virulence factors, including type IV pili and flagella, were more abundant and actively contributed to microorganism adhesion and biofilm formation.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"48"},"PeriodicalIF":4.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional finite element analysis of maxillary molar distalization treated with clear aligners combined with different traction methods. 明确矫正器联合不同牵引方法治疗上颌磨牙离体的三维有限元分析。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2024-12-09 DOI: 10.1186/s40510-024-00546-y
Hongyu Gao, Liangyu Luo, Jun Liu
{"title":"Three-dimensional finite element analysis of maxillary molar distalization treated with clear aligners combined with different traction methods.","authors":"Hongyu Gao, Liangyu Luo, Jun Liu","doi":"10.1186/s40510-024-00546-y","DOIUrl":"10.1186/s40510-024-00546-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyze the effects of maxillary molar distalization using clear aligners with different intramaxillary and intermaxillary traction via the three-dimensional (3D) finite element method.</p><p><strong>Methods: </strong>A 3D finite element model consisting of the maxilla, mandible, dentitions, periodontal ligaments (PDLs), attachments, and clear aligners was constructed. Five groups were established based on different traction modalities: group 1 (control group); group 2 (orthodontic mini-implants (OMIs) were implanted between the maxillary first molars and the second premolars on the buccal side); group 3 (OMIs were implanted in the infrazygomatic crest area between the maxillary first and second molars on the buccal side); group 4 (OMIs were implanted between the maxillary first molars and the second premolars on the palatal side); and group 5 (class II elastics were utilized between the maxillary canines and the mandibular first molars). OMIs were implanted 4 mm away from the alveolar crest in each experimental group. A force of 1.5 N was applied to each experimental group. The 3D displacement of the target teeth and stress distribution around the PDLs were analyzed.</p><p><strong>Results: </strong>Group 4 exhibited the least amount of torque change in the upper anterior teeth and the highest displacement of the maxillary second molars. Group 3 showed smaller changes in anterior teeth torque and higher molar distalization efficiency compared to group 2. Group 5 showed adverse effects such as anterior teeth extrusion and mandibular anchorage loss.</p><p><strong>Conclusion: </strong>OMIs implanted on the palatal side have advantages in preserving anterior teeth anchorage and improving the efficiency of molar distalization compared to those positioned on the buccal side. OMIs implanted in the infrazygomatic crest area between the first and second molars on the buccal side demonstrate benefits in the aforementioned aspects when compared to OMIs implanted between the first molars and the second premolars on the buccal side.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"47"},"PeriodicalIF":4.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of maxillary premolar distalization with different designed clear aligners: a 4D finite element study with staging simulation. 不同设计的透明矫正器对上颌前磨牙离体的影响:4D有限元研究与分期模拟。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2024-12-02 DOI: 10.1186/s40510-024-00545-z
Bochun Mao, Yajing Tian, Dawei Liu, Yanheng Zhou, Shuo Wang
{"title":"The effect of maxillary premolar distalization with different designed clear aligners: a 4D finite element study with staging simulation.","authors":"Bochun Mao, Yajing Tian, Dawei Liu, Yanheng Zhou, Shuo Wang","doi":"10.1186/s40510-024-00545-z","DOIUrl":"https://doi.org/10.1186/s40510-024-00545-z","url":null,"abstract":"<p><strong>Background: </strong>Molar distalization with clear aligners (CAs) is a common treatment. However, when the molars reach their target position and the distal movement of premolars begins, the mesial movement of molars might reduce the overall efficiency of molar distalization. This study aimed to investigate tooth movement patterns under different CA designs in the premolar distalization stage using a four-dimensional mechanical simulation method.</p><p><strong>Methods: </strong>A finite element method (FEM) model encompassing the maxillary dentition, periodontal ligaments, attachments, and associated CAs was constructed. The simulation aimed to replicate a premolar distalization of 2 mm within 10 sequential steps. Buccal interradicular mini-implants were used. Three groups of CAs were designed: the conventional CA design group (Con group), the second molar half-wrap group (SMHW group) and the all-molar half-wrap group (MHW group). An iterative computational approach was employed to simulate prolonged tooth movement resulting from orthodontic forces. Additionally, morphological alterations in the CA throughout the staging process were simulated utilizing the thermal expansion method.</p><p><strong>Results: </strong>Compared with the Con and SMHW groups, the MHW group presented significantly reduced mesial movement of the first and second molars. However, the MHW group presented the greatest displacement of canines and incisors. The distalization efficiency of premolars in the MHW group reached 95.5-96.5%, which was substantially greater than that in the Con group (84.5-85%) and the SMHW group (75-75.5%).</p><p><strong>Conclusions: </strong>The four-dimensional mechanical simulation results indicate that during the process of premolar distalization with CA, removing the distal portion of the aligner covering the first and second molars (MHW group) can effectively reduce the mesial movement of molars. Consequently, this approach can increase the overall efficiency of molar distalization.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"46"},"PeriodicalIF":4.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of anti-sclerostin antibody on orthodontic tooth movement in ovariectomized rats. 抗硬骨蛋白抗体对卵巢切除大鼠牙齿畸形移动的影响
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2024-11-25 DOI: 10.1186/s40510-024-00544-0
Hyunna Ahn, Wonse Park, Sung-Hwan Choi, Namki Hong, Jisun Huh, Seoyeon Jung
{"title":"Effect of anti-sclerostin antibody on orthodontic tooth movement in ovariectomized rats.","authors":"Hyunna Ahn, Wonse Park, Sung-Hwan Choi, Namki Hong, Jisun Huh, Seoyeon Jung","doi":"10.1186/s40510-024-00544-0","DOIUrl":"10.1186/s40510-024-00544-0","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effect of systemically administered anti-sclerostin antibodies (Anti-Scl Ab) on orthodontic tooth movements (OTM) in an ovariectomized rat.</p><p><strong>Methods: </strong>Twenty-four 12-week-old female Sprague-Dawley rats were randomly divided into two groups: (1) ovariectomy (OVX) group, (2) ovariectomy + romosozumab (ROMO) group. OTM was performed 8 weeks after OVX. The ROMO group received subcutaneous injections of romosozumab twice a week, starting two weeks after OVX. Eight weeks after the OVX, an orthodontic force of 50 g was measured and applied by connecting orthodontic elastic bands between the maxillary first molar and a mini-screw to facilitate tooth movement (orthodontic treatment). Subsequently, the three rats were sacrificed on days 5, 7, 10, and 14. The plaster models were scanned to measure the amount of tooth movement. The effects on alveolar bone and periodontal tissues were evaluated through micro-computed tomography (micro-CT) analysis, tartrate-resistant acid phosphatase (TRAP) staining, and immunohistochemistry (IHC) analysis.</p><p><strong>Results: </strong>The ROMO group showed more tooth movement on day 7 of orthodontic treatment. Conversely, on days 10 and 14, relatively less movement was observed. Analysis of the root furcation area of the maxillary first molars revealed that from the 7th day, BV/TV, Tb.N., Tb.Th. increased, while Tb.Sp. decreased in the ROMO group. More TRAP-positive cells were observed in the compression side of the OVX group, the ROMO group exhibited a marked decrease in the positive expression of the RANKL, OPG, and sclerostin. The OPG/RANKL ratio showed significant differences in expression between the two groups. The ROMO group exhibited a higher OPG/RANKL ratio than the OVX group, and the tension side exhibited a higher OPG/RANKL ratio demonstrating significant differences.</p><p><strong>Conclusion: </strong>Romosozumab initially accelerated tooth movements, but later decreased tooth movement. As new alveolar bone is formed, the micro-CT parameters are also improved. Osteoclasts, RANKL, OPG, and sclerostin decreased, while the OPG/RANKL ratio became higher.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"45"},"PeriodicalIF":4.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seeking orderness out of the orderless movements: an up-to-date review of the biomechanics in clear aligners. 从无序运动中寻求有序:对透明矫治器生物力学的最新研究。
IF 4.8 2区 医学
Progress in Orthodontics Pub Date : 2024-11-18 DOI: 10.1186/s40510-024-00543-1
Jiawei Li, Jiarui Si, Chaoran Xue, Hui Xu
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