Progress in Orthodontics最新文献

{"title":"Mechanosensor YAP mediates bone remodeling via NF-κB p65 induced osteoclastogenesis during orthodontic tooth movement.","authors":"Jie Deng, Yu-Ning Zhang, Ru-Shui Bai, Ting-Ting Yu, Yi Zhao, Hao Liu, Yun-Fan Zhang, Tian-Min Xu, Bing Han","doi":"10.1186/s40510-024-00548-w","DOIUrl":"10.1186/s40510-024-00548-w","url":null,"abstract":"<p><strong>Background: </strong>Yes-associated protein (YAP) is a crucial mechanosensor involved in mechanotransduction, but its role in regulating mechanical force-induced bone remodeling during orthodontic tooth movement (OTM) is unclear. This study aims to elucidate the relationship between mechanotransduction and mechanical force-induced alveolar bone remodeling during OTM.</p><p><strong>Results: </strong>Our study confirms an asynchronous (temporal and spatial sequence) remodeling pattern of the alveolar bone under mechanical force during OTM. Both compression and tension activate osteoclasts recruiting to the alveolar bone, whereas no significant presence of osteoblasts in the alveolar bone at the early stages of bone remodeling. Specifically, applying different force magnitudes (10, 25, 50, 100 g) to rats' 1st molars affected OTM distance. Force-induced alveolar bone remodeling was characterized by osteoclastogenesis and YAP activation at compressive/tensile sites on day 1 of OTM. Notably, 25 g force triggered peak YAP expression and osteoclastic activity early on. Time-course analysis revealed two YAP activity peaks on day1 and 14, contrasting with one peak of type I collagen expression on day14. In addition, RNA-sequencing highlighted increased nuclear factor kappa B (NF-κB) signaling, mineral absorption, and osteoclast differentiation at day-1 and 3. Moreover, gene expression analysis showed similar trends for NF-κB p65, YAP1, and TEA domain 1 (TEAD1) during this time. Furthermore, experiments on osteoclast cultures indicated YAP activation via large tumor suppressor (LATS) and TEAD under mechanical stimuli (compression/tension), promoting osteoclastogenesis by regulating NF-κB p65 and receptor activator of NF-κB (RANK). Inhibiting YAP with verteporfin delayed OTM by impairing force-induced osteoclastic activities in vivo and ex-vivo.</p><p><strong>Conclusions: </strong>We propose that YAP mediates alveolar bone remodeling through NF-κB p65-induced osteoclastogenesis in an asynchronous remodeling pattern during OTM. Both compression and tension activate osteoclasts recruiting to the alveolar bone at early stages of bone remodeling, offering evidence for orthodontists as a reference.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"26 1","pages":"2"},"PeriodicalIF":4.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microbiome alterations of supragingival plaque among adolescents using clear aligners: a metagenomic sequencing analysis.","authors":"Chunlin Wang, Chao Zhang, Shan He, Qiuyu Wang, Hai Gao","doi":"10.1186/s40510-024-00547-x","DOIUrl":"10.1186/s40510-024-00547-x","url":null,"abstract":"<p><strong>Background: </strong>White spot lesions (WSLs) may develop in adolescents undergoing clear aligner (CA) therapy with poor oral hygiene. The specific effects of CAs on the microbial composition and functional characteristics of supragingival plaques remain unclear. The present study investigated the shift in the supragingival microbial community induced by CAs in adolescents through metagenomic technology.</p><p><strong>Methods: </strong>Fifteen adolescents (12-15 years old) with Invisalign appliances were recruited. Supragingival plaque specimens were obtained twice, before treatment (T₁) and three months after treatment (T₂). All the bacterial plaque specimens were analyzed for microbial communities and functions using metagenomic analyses.</p><p><strong>Results: </strong>A total of 2,840,242,722 reads disclosed 180 phyla, 3,975 genera, and 16,497 microbiome species. During the first three months, the microbial community was relatively stable. The genus level revealed a higher relative abundance of Capnocytophaga, Neisseria, and Arachnia in the T₂ period. Furthermore, the functional analysis suggested that the relative abundances of folate biosynthesis, biotin metabolism and biofilm formation-vibrio cholerae were increased in the T₂ period compared to the T₁ period. Finally, virulence factor analysis demonstrated that the relative abundance of genes associated with type IV pili (VF0082) and polar flagella (VF0473) was higher in the T₂ period than in the T₁ period.</p><p><strong>Conclusion: </strong>In adolescents undergoing CA therapy with poor plaque control, caries progresses quickly within three months and noticeable WSLs develop on the tooth surface. Although the microbial community remained relatively steady and CA therapy did not cause significant changes in the overall functional gene composition in the first three months, virulence factors, including type IV pili and flagella, were more abundant and actively contributed to microorganism adhesion and biofilm formation.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"48"},"PeriodicalIF":4.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional finite element analysis of maxillary molar distalization treated with clear aligners combined with different traction methods.","authors":"Hongyu Gao, Liangyu Luo, Jun Liu","doi":"10.1186/s40510-024-00546-y","DOIUrl":"10.1186/s40510-024-00546-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyze the effects of maxillary molar distalization using clear aligners with different intramaxillary and intermaxillary traction via the three-dimensional (3D) finite element method.</p><p><strong>Methods: </strong>A 3D finite element model consisting of the maxilla, mandible, dentitions, periodontal ligaments (PDLs), attachments, and clear aligners was constructed. Five groups were established based on different traction modalities: group 1 (control group); group 2 (orthodontic mini-implants (OMIs) were implanted between the maxillary first molars and the second premolars on the buccal side); group 3 (OMIs were implanted in the infrazygomatic crest area between the maxillary first and second molars on the buccal side); group 4 (OMIs were implanted between the maxillary first molars and the second premolars on the palatal side); and group 5 (class II elastics were utilized between the maxillary canines and the mandibular first molars). OMIs were implanted 4 mm away from the alveolar crest in each experimental group. A force of 1.5 N was applied to each experimental group. The 3D displacement of the target teeth and stress distribution around the PDLs were analyzed.</p><p><strong>Results: </strong>Group 4 exhibited the least amount of torque change in the upper anterior teeth and the highest displacement of the maxillary second molars. Group 3 showed smaller changes in anterior teeth torque and higher molar distalization efficiency compared to group 2. Group 5 showed adverse effects such as anterior teeth extrusion and mandibular anchorage loss.</p><p><strong>Conclusion: </strong>OMIs implanted on the palatal side have advantages in preserving anterior teeth anchorage and improving the efficiency of molar distalization compared to those positioned on the buccal side. OMIs implanted in the infrazygomatic crest area between the first and second molars on the buccal side demonstrate benefits in the aforementioned aspects when compared to OMIs implanted between the first molars and the second premolars on the buccal side.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"47"},"PeriodicalIF":4.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of maxillary premolar distalization with different designed clear aligners: a 4D finite element study with staging simulation.","authors":"Bochun Mao, Yajing Tian, Dawei Liu, Yanheng Zhou, Shuo Wang","doi":"10.1186/s40510-024-00545-z","DOIUrl":"https://doi.org/10.1186/s40510-024-00545-z","url":null,"abstract":"<p><strong>Background: </strong>Molar distalization with clear aligners (CAs) is a common treatment. However, when the molars reach their target position and the distal movement of premolars begins, the mesial movement of molars might reduce the overall efficiency of molar distalization. This study aimed to investigate tooth movement patterns under different CA designs in the premolar distalization stage using a four-dimensional mechanical simulation method.</p><p><strong>Methods: </strong>A finite element method (FEM) model encompassing the maxillary dentition, periodontal ligaments, attachments, and associated CAs was constructed. The simulation aimed to replicate a premolar distalization of 2 mm within 10 sequential steps. Buccal interradicular mini-implants were used. Three groups of CAs were designed: the conventional CA design group (Con group), the second molar half-wrap group (SMHW group) and the all-molar half-wrap group (MHW group). An iterative computational approach was employed to simulate prolonged tooth movement resulting from orthodontic forces. Additionally, morphological alterations in the CA throughout the staging process were simulated utilizing the thermal expansion method.</p><p><strong>Results: </strong>Compared with the Con and SMHW groups, the MHW group presented significantly reduced mesial movement of the first and second molars. However, the MHW group presented the greatest displacement of canines and incisors. The distalization efficiency of premolars in the MHW group reached 95.5-96.5%, which was substantially greater than that in the Con group (84.5-85%) and the SMHW group (75-75.5%).</p><p><strong>Conclusions: </strong>The four-dimensional mechanical simulation results indicate that during the process of premolar distalization with CA, removing the distal portion of the aligner covering the first and second molars (MHW group) can effectively reduce the mesial movement of molars. Consequently, this approach can increase the overall efficiency of molar distalization.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"46"},"PeriodicalIF":4.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of anti-sclerostin antibody on orthodontic tooth movement in ovariectomized rats.","authors":"Hyunna Ahn, Wonse Park, Sung-Hwan Choi, Namki Hong, Jisun Huh, Seoyeon Jung","doi":"10.1186/s40510-024-00544-0","DOIUrl":"10.1186/s40510-024-00544-0","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effect of systemically administered anti-sclerostin antibodies (Anti-Scl Ab) on orthodontic tooth movements (OTM) in an ovariectomized rat.</p><p><strong>Methods: </strong>Twenty-four 12-week-old female Sprague-Dawley rats were randomly divided into two groups: (1) ovariectomy (OVX) group, (2) ovariectomy + romosozumab (ROMO) group. OTM was performed 8 weeks after OVX. The ROMO group received subcutaneous injections of romosozumab twice a week, starting two weeks after OVX. Eight weeks after the OVX, an orthodontic force of 50 g was measured and applied by connecting orthodontic elastic bands between the maxillary first molar and a mini-screw to facilitate tooth movement (orthodontic treatment). Subsequently, the three rats were sacrificed on days 5, 7, 10, and 14. The plaster models were scanned to measure the amount of tooth movement. The effects on alveolar bone and periodontal tissues were evaluated through micro-computed tomography (micro-CT) analysis, tartrate-resistant acid phosphatase (TRAP) staining, and immunohistochemistry (IHC) analysis.</p><p><strong>Results: </strong>The ROMO group showed more tooth movement on day 7 of orthodontic treatment. Conversely, on days 10 and 14, relatively less movement was observed. Analysis of the root furcation area of the maxillary first molars revealed that from the 7th day, BV/TV, Tb.N., Tb.Th. increased, while Tb.Sp. decreased in the ROMO group. More TRAP-positive cells were observed in the compression side of the OVX group, the ROMO group exhibited a marked decrease in the positive expression of the RANKL, OPG, and sclerostin. The OPG/RANKL ratio showed significant differences in expression between the two groups. The ROMO group exhibited a higher OPG/RANKL ratio than the OVX group, and the tension side exhibited a higher OPG/RANKL ratio demonstrating significant differences.</p><p><strong>Conclusion: </strong>Romosozumab initially accelerated tooth movements, but later decreased tooth movement. As new alveolar bone is formed, the micro-CT parameters are also improved. Osteoclasts, RANKL, OPG, and sclerostin decreased, while the OPG/RANKL ratio became higher.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"45"},"PeriodicalIF":4.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeking orderness out of the orderless movements: an up-to-date review of the biomechanics in clear aligners.","authors":"Jiawei Li, Jiarui Si, Chaoran Xue, Hui Xu","doi":"10.1186/s40510-024-00543-1","DOIUrl":"10.1186/s40510-024-00543-1","url":null,"abstract":"<p><strong>Introduction: </strong>Although with increasing popularity due to aesthetic appeal and comfort, clear aligners (CAs) are facing challenges in efficacy and predictability. Advancement in the underlying biomechanical field is crucial to addressing these challenges. This paper endeavors to provide a comprehensive framework for understanding the biomechanics of CA and enlightening biomechanics-based improvements on treatment strategies.</p><p><strong>Methods: </strong>A thorough review of the English-language literature accessible through PubMed and Google Scholar, without any publication year restrictions, was undertaken to unravel the biomechanical aspects of CA.</p><p><strong>Results: </strong>This review presented an up-to-date understanding of aligner biomechanics arranged by the framework of the material-dependent mechanical characteristics of CA, the geometric characteristics-dependent force transmission of the CA system, methods for studying the biomechanics of CA, and the biomechanical analyses for different types of tooth movement.</p><p><strong>Conclusions: </strong>Biomechanics should be the fundamental concern for concepts, methods and adjuncts attempting to enhance the accuracy and predictability of tooth movement induced by CA. Improvement on material properties and alteration of geometric design of CA are two main approaches to develop biomechanically optimized force system. Exploration of real-world force sensing and monitoring system would make substantial progresses in aligner biomechanics.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"44"},"PeriodicalIF":4.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-stratified assessment of orthodontic tooth movement outcomes with clear aligners.","authors":"Mariamma Chaluparambil, Sarah Abu Arqub, Chia-Ling Kuo, Lucas Da Cunha Godoy, Madhur Upadhyay, Sumit Yadav","doi":"10.1186/s40510-024-00542-2","DOIUrl":"10.1186/s40510-024-00542-2","url":null,"abstract":"<p><strong>Objective: </strong>This study compared the achieved tooth movement to that predicted in the preliminary simulated digital treatment plan between adults and teenagers.</p><p><strong>Materials and methods: </strong>Records of 60 patients (30 adults; mean age: 36.6 ± 11.36 years, and 30 teenagers; mean age: 16.23 ± 2.25 years) were randomly selected. Initial and predicted models were obtained from the initial simulated treatment plan. The first model of the refinement scan was labeled as achieved. SlicerCMF software (version 3.1; https://www.slicer.org ) was used to superimpose the achieved and predicted digital models over the initial ones with regional superimposition on relatively stable first molars. 600 teeth were measured in each group for horizontal, vertical, angular movements, and transverse dimensions. Accuracy was defined as the achieved amount of movement minus predicted and was calculated for each individual and compared between teens and adults.</p><p><strong>Results: </strong>The mandibular inter-canine width accuracy was statistically significant between groups (p = 0.050). Significant under-correction in horizontal movements was noted for mandibular first premolars in teenagers compared to adults (p = 0.037). There was considerable over-correction in horizontal movements for mandibular central and lateral incisors between groups (p < 0.05). No significant difference was observed between groups in the vertical plane. Rotations were underachieved for maxillary first premolars, more in adults than teenagers (p = 0.017).</p><p><strong>Conclusion: </strong>The accuracy of achieved versus predicted tooth movement between adults and teenagers was significant for the inter-canine width. Mandibular central and lateral incisors showed significantly greater over-correction in adults in the horizontal plane. The accuracy of rotations and vertical movements was comparable.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"43"},"PeriodicalIF":4.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of orthodontists in the multidisciplinary management of obstructive sleep apnea.","authors":"Jorge Faber, Aliciane Mota, Lai-In Ho, M Ali Darendeliler","doi":"10.1186/s40510-024-00541-3","DOIUrl":"10.1186/s40510-024-00541-3","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is a complex disorder characterized by interruptions in breathing during sleep, leading to a range of adverse outcomes from reduced quality of life to serious health risks, including cardiovascular diseases and increased mortality.</p><p><strong>Main body: </strong>This manuscript reviews the orthodontists' essential role in the multidisciplinary healthcare team tasked with managing OSA. It particularly highlights critical orthodontic interventions, such as surgical-orthodontic maxillomandibular advancement (MMA), mandibular advancement appliances (MAAs), and rapid maxillary expansion (RME). These interventions are pivotal in modifying craniofacial structures to enhance airway patency. The importance of conducting a thorough airway analysis is underscored, assessing the complete anatomical and functional factors contributing to airway obstruction.</p><p><strong>Conclusion: </strong>The paper calls for increased collaborative research efforts to develop standardized, evidence-based orthodontic procedures for effectively managing OSA, aiming to improve patient outcomes through specialized, tailored interventions.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"40"},"PeriodicalIF":4.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymerization kinetics of 3D-printed orthodontic aligners under different UV post-curing conditions.","authors":"Thomas Manoukakis, Alexandros K Nikolaidis, Elisabeth A Koulaouzidou","doi":"10.1186/s40510-024-00540-4","DOIUrl":"10.1186/s40510-024-00540-4","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the study was to measure the degree of conversion (DC) of direct-printed aligners (DPA) that were post-cured under ambient and nitrogen atmosphere at specific time intervals and investigate the kinetics of polymerization reaction of this material.</p><p><strong>Methods: </strong>A total of 48 aligners were produced in 4 printing series by a 3D printer with TC-85DAC resin (Graphy Inc). From each series of printing, 12 aligners were included. The aligners were divided into two groups according to their post-curing conditions. One group was post-cured under ambient air with the presence of oxygen and the other under a nitrogen atmosphere, both using the same UV post-curing unit recommended by the company. The aligners were post-cured at six different time intervals: 1, 2, 3, 5, 10, and 20 min. Each time interval included 8 aligners, with 2 aligners from each series. The DC of the cured aligners was measured by means of attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) through acquisition of the respective spectra for each UV-curing condition. Statistical analysis was performed to compare the results and differences within each atmosphere post-curing protocol, as well as between the different selected atmosphere conditions. Statistical significance level was set at p-value ≤ 0.05.</p><p><strong>Results: </strong>Pairwise analysis between post-curing protocols showed statistically significant differences only at the first minute of polymerization. Post-curing with nitrogen did not yield statistically significant results across different time intervals. Post-curing in ambient air showed some significant differences on the 1st and 2nd minute of the post-curing process.</p><p><strong>Conclusions: </strong>Almost complete double bond conversion was observed. Significant differences were observed only during the first minute of polymerization under the nitrogen atmosphere.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"42"},"PeriodicalIF":4.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of AI-assisted cephalometric analysis and orthodontist-performed digital tracing analysis.","authors":"Sabahattin Bor, Saadet Çınarsoy Ciğerim, Seda Kotan","doi":"10.1186/s40510-024-00539-x","DOIUrl":"10.1186/s40510-024-00539-x","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare and evaluate three AI-assisted cephalometric analysis platforms-CephX, WeDoCeph, and WebCeph-with the traditional digital tracing method using NemoCeph software.</p><p><strong>Material and method: </strong>A total of 1500 lateral cephalometric films that met the inclusion criteria were classified as Class I, Class II, and Class III. Subsequently, 40 patients were randomly selected from each class. These selected films were uploaded to 3 AI-assisted cephalometric analysis platforms and analyzed without any manual intervention. The same films were also analyzed by an orthodontist using the NemoCeph program.</p><p><strong>Results: </strong>The results revealed significant differences in key angular measurements (ANB, FMA, IMPA, and NLA) across Class I, II, and III patients when comparing the four cephalometric analysis methods (WebCeph, WeDoCeph, CephX, and NemoCeph). Notably, ANB (p < 0.05), FMA (p < 0.001), IMPA (p < 0.001), and NLA (p < 0.001) varied significantly. Linear measurements also differed, with significant differences in U1-NA (p = 0.002) and Co-A (p = 0.002) in certain classes. Repeated measurement analysis revealed variation in SNA (p = 0.011) and FMA (p = 0.030), particularly in the Class II NemoCeph group, suggesting method-dependent variability.</p><p><strong>Conclusion: </strong>AI-assisted cephalometric analysis platforms such as WebCeph, WeDoCeph, and CephX give rise to notable variation in accuracy and reliability compared to traditional manual digital tracing, specifically in terms of angular and linear measurements. These results emphasize the importance of meticulous selection and assessment of analysis methods in orthodontic diagnostics and treatment planning.</p>","PeriodicalId":56071,"journal":{"name":"Progress in Orthodontics","volume":"25 1","pages":"41"},"PeriodicalIF":4.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}