Amy Zheng, Lena Faust, Anthony D Harries, Pedro Avedillo, Michael Akodu, Miranda Galvan, Beatriz Barreto-Duarte, Bruno B Andrade, César Ugarte-Gil, Alberto L Garcia-Basteiro, Marcos Espinal, Joshua L Warren, Leonardo Martinez
{"title":"Changes in incarceration and tuberculosis notifications from prisons during the COVID-19 pandemic in Europe and the Americas: a time-series analysis of national surveillance data","authors":"Amy Zheng, Lena Faust, Anthony D Harries, Pedro Avedillo, Michael Akodu, Miranda Galvan, Beatriz Barreto-Duarte, Bruno B Andrade, César Ugarte-Gil, Alberto L Garcia-Basteiro, Marcos Espinal, Joshua L Warren, Leonardo Martinez","doi":"10.1016/s2468-2667(24)00325-6","DOIUrl":"https://doi.org/10.1016/s2468-2667(24)00325-6","url":null,"abstract":"<h3>Background</h3>The COVID-19 pandemic disrupted tuberculosis control programmes globally; whether or not this disproportionately affected people who were incarcerated is unknown. We aimed to evaluate changes in incarceration and tuberculosis notifications in prisons in Europe and the Americas during the COVID-19 pandemic.<h3>Methods</h3>Data from WHO Pan American Health Organization (PAHO) and WHO Europe were used to conduct a joint hierarchical Bayesian negative binomial time-series. This approach accounted for world region, country-specific temporal trends, and country-specific autocorrelated random effects to simultaneously model and predict both annual prison population (ie, the offset) and prison tuberculosis cases (ie, the primary outcome). Results were used to calculate percentage differences between predicted and observed annual tuberculosis notifications and prison populations during the COVID-19 pandemic years (2020–22).<h3>Findings</h3>In total, 22 of 39 countries from PAHO and 25 of 53 countries from WHO Europe were included (representing 4·9 million people incarcerated annually), contributing 520 country-years of follow-up. Observed tuberculosis notifications in prisons were lower than predicted in 2020 (–26·2% [95% credible interval –66·3 to 7·8), 2021 (–46·4% [–108·8 to 3·9]), and 2022 (–48·9 [–124·4 to 10·3]). These decreasing trends were consistent across Europe and the Americas, but larger decreases were seen in low-burden settings in 2020 (–54·8% [–112·4 to –4·8]) and 2021 (–68·4% [–156·6 to –2·9]), high-burden settings in 2021 (–89·4% [–190·3 to –10·4]), and Central and North America in 2021 (–100·3% [–239·0 to –6·3]). Observed incarceration levels were similar to predicted levels (<10% difference overall) during all COVID-19 pandemic years.<h3>Interpretation</h3>Tuberculosis notifications in prisons from 47 countries in Europe and the Americas were lower than expected (at times >50% lower) during COVID-19 pandemic years, despite consistent incarceration levels. Reasons for this change in tuberculosis notifications might be multifactorial and include missed diagnoses and implementation of COVID-19 pandemic measures, reducing transmission. Greater prioritisation of people who are incarcerated is needed to ensure appropriate access to care in the face of future pandemics.<h3>Funding</h3>Canadian Institutes of Health Research, National Institutes of Health, and Oswaldo Cruz Foundation, Brazil.","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"183 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stuart A Kinner, Lucas Calais-Ferreira, Jesse T Young, Rohan Borschmann, Alan Clough, Ed Heffernan, Scott Harden, Matthew J Spittal, Susan M Sawyer
{"title":"Rates, causes, and risk factors for death among justice-involved young people in Australia: a retrospective, population-based data linkage study","authors":"Stuart A Kinner, Lucas Calais-Ferreira, Jesse T Young, Rohan Borschmann, Alan Clough, Ed Heffernan, Scott Harden, Matthew J Spittal, Susan M Sawyer","doi":"10.1016/s2468-2667(25)00042-8","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00042-8","url":null,"abstract":"<h3>Background</h3>Children and adolescents exposed to the youth justice system have poor health profiles, but little is known about their subsequent mortality. We aimed to examine mortality outcomes in a large, state-wide cohort of young people in Australia who had contact with the youth justice system.<h3>Methods</h3>We linked youth justice records in the state of Queensland, Australia from July 1, 1993, to June 30, 2014, with adult correctional records and the National Death Index, for records up to Jan 31, 2017. We calculated all-cause and cause-specific crude mortality rates per 100 000 person-years, and age-standardised and sex-standardised mortality ratios with 95% CIs. Calculations were performed for the whole cohort and in subgroups defined by sex, Indigenous status, and youth justice history. We used survival analysis to identify demographic and criminal justice factors associated with all-cause mortality.<h3>Findings</h3>Of 49 011 individuals in the study sample, 321 were excluded due to data linkage or data quality issues and 20 were excluded as they did not have an age or date of birth recorded, which resulted in 48 670 (99·3%) participants. 11 897 (24·4%) participants were female, 36 773 (75·6%) were male, and 13 250 (27·2%) were Indigenous. During a median of 13·5 years (IQR 8·4–18·4) of follow-up, we observed 1431 (2·9%) deaths among the 48 670 participants. Median age at end of follow-up was 28·6 years (IQR 23·6–33·6). The most common causes of death were suicide (495 [34·6%]), transport accidents (244 [17·1%]), and accidental drug poisoning (209 [14·6%]). The all-cause crude mortality rate was 218·9 deaths (95% CI 207·9–230·6) and the all-cause standard mortality ratio was 4·2 (3·9–4·4). In multivariable analyses, mortality rates were higher for males (adjusted hazard ratio [aHR] 1·5 [95% CI 1·3–1·7]); those who had been subject to community supervision (aHR 1·3 [1·1–1·5]), or detention (aHR 2·1 [1·8–2·4]) versus charge only; and those under adult correctional supervision in the community (aHR 1·9 [1·5–2·4]) versus unsupervised. More than half of the observed deaths occurred before 25 years of age, and very few (1·6%) occurred in custody.<h3>Interpretation</h3>Justice-involved young people are at markedly increased risk of premature death from largely preventable causes. Reducing the burden of preventable death among these young people will require coordinated, multi-sectoral responses that extend beyond the criminal justice system.<h3>Funding</h3>National Health and Medical Research Council, Australia.","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"53 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health care universalism in Italy: a debunked myth","authors":"Anna Odone, Riccardo Vecchio","doi":"10.1016/s2468-2667(25)00064-7","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00064-7","url":null,"abstract":"Almost 50 years ago the Italian National Health Service (NHS) was established under the principles of health care universalism, equity, and solidarity. Where do we stand today? In an ageing society, where there is a struggle to balance increasing health needs with available resources to sustain health care, answering this question is imperative. In <em>The Lancet Public Health</em>, The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) Italian Collaborators have taken up the challenge again,<span><span><sup>1</sup></span></span> after a previous attempt in 2019.<span><span><sup>2</sup></span></span>","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"42 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new perspective on the health of people experiencing homelessness","authors":"Maurizio Marceca, Giulia Civitelli, Serafina Torchiaro, Giuseppinanna Merlino, Salvatore Geraci","doi":"10.1016/s2468-2667(25)00063-5","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00063-5","url":null,"abstract":"As noted by Di Simone and colleagues in their Correspondence,<span><span><sup>1</sup></span></span> the change in Italian law introducing the right to public primary health care for people experiencing homelessness through registration with a general practitioner (GP) represents an important first step against inequities in health care.","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"58 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effective interventions for active workplaces: time to get evidence into practice","authors":"Elizabeth Goyder, Kelly Mackenzie","doi":"10.1016/s2468-2667(25)00046-5","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00046-5","url":null,"abstract":"No Abstract","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"56 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of the COVID-19 pandemic on incarceration and tuberculosis","authors":"Emma H Plugge, Nicola Cocco","doi":"10.1016/s2468-2667(25)00012-x","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00012-x","url":null,"abstract":"Although preventable and curable, 10·8 million people were diagnosed with tuberculosis and 1·25 million people died from tuberculosis in 2023.<span><span><sup>1</sup></span></span> It is a disease that disproportionately affects marginalised groups—for instance, it has been clearly shown that there is a high tuberculosis incidence and low case detection rate in prison populations globally.<span><span><sup>2</sup></span></span> Indeed, WHO has identified incarcerated people as an important population who should be prioritised for tuberculosis control efforts.<span><span><sup>3</sup></span></span> However, although data show an adverse effect of the COVID-19 pandemic on the years of progress tackling tuberculosis at global, regional, and country levels,<span><span><sup>4</sup></span></span> there has been a paucity of data investigating the effect on specific marginalised populations. Amy Zheng and colleagues’ study,<span><span><sup>4</sup></span></span> which examined annual trends in incarceration rates and tuberculosis notifications among incarcerated people in Europe and the Americas before (pre-2020) and during (2020–22) the COVID-19 pandemic, is therefore an important contribution to the understanding of disease control in prisons during the pandemic.","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"38 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"State of health and inequalities among Italian regions from 2000 to 2021: a systematic analysis based on the Global Burden of Disease Study 2021","authors":"Mohsen Naghavi","doi":"10.1016/s2468-2667(25)00045-3","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00045-3","url":null,"abstract":"<h3>Background</h3>Over the past two decades, the Italian National Health Service has been gradually decentralised, with Italy's 21 regional governments now responsible for managing their health services. This change, coupled with austerity measures and a steadily ageing population, has adversely affected universal health coverage and equity, exacerbating inequalities and regional disparities. This study aimed to analyse time trends and subnational differences in the burden of disease from 2000 to 2019, and from 2019 to 2021 to capture the effects of the COVID-19 pandemic.<h3>Methods</h3>This study uses estimates for Italy from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. We analyse trends and geographical differences in disease burden from 2000 to 2021. Metrics include life expectancy, health-adjusted life expectancy (HALE), years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) observed at national, macroregional, and subnational levels. Percent changes in rates, with both all-age and age-standardised rates, and 95% uncertainty intervals (95% UIs) are reported.<h3>Findings</h3>Life expectancy at birth in Italy increased from 79·6 years in 2000 to 83·4 years in 2019, dropped to 82·2 years in 2020 due to COVID-19, and recovered slightly to 82·7 years in 2021. HALE was 70·9 years (95% UI 67·4–73·8) in 2021. Substantial regional disparities were observed: in general, despite higher YLD rates, northern regions had better health outcomes, with higher life expectancy and HALE and lower YLL rates compared with southern regions. Overall, the top causes of YLDs were low back pain (1556·5 [1098·5–2080·2]), falls (926·2 [638·8–1253·8]), and headache disorders (858·0 [173·7–1808·2]). Anxiety and depressive disorders both had substantial increases in the period from 2019 to 2021 (19·8% and 17·3%, respectively). YLDs for Alzheimer's disease and diabetes increased substantially from 2000 to 2019 and 2019 to 2021 (70·6% and 3·0% for Alzheimer's disease and 46·8% and 7·9%, respectively for each timepoint). YLL rates declined for ischaemic heart disease from 2000 (–29·9% in 2019), but increased for Alzheimer's disease and other dementias (54·5%). DALY rates decreased overall from 2000 to 2019, but rose again in 2021 due to the COVID-19 pandemic.<h3>Interpretation</h3>The study highlights considerable regional disparities in Italy's health outcomes, driven by demography, heterogeneous health service quality, and economic inequalities. Addressing the increasing burden of Alzheimer's disease, diabetes, and mental health disorders, as well as regional disparities, requires strengthened preventive measures, equitable health service access, and socioeconomic policies, both at the national and regional levels.<h3>Funding</h3>Bill & Melinda Gates Foundation.","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"33 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Rouyard, Emilie Yoda, Katika Akksilp, Anna Valeria Dieterich, Sarin Kc, Saudamini V Dabak, Andre Matthias Müller
{"title":"Effects of workplace interventions on sedentary behaviour and physical activity: an umbrella review with meta-analyses and narrative synthesis","authors":"Thomas Rouyard, Emilie Yoda, Katika Akksilp, Anna Valeria Dieterich, Sarin Kc, Saudamini V Dabak, Andre Matthias Müller","doi":"10.1016/s2468-2667(25)00038-6","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00038-6","url":null,"abstract":"<h3>Background</h3>Physical inactivity is rising globally, exacerbating the burden of preventable deaths and diseases. Despite extensive research on promoting physical activity in the workplace, synthesising the existing literature is challenging due to the wide variety of interventions and outcomes. This study aims to provide a comprehensive synthesis of intervention effects to inform health promotion initiatives and guide future research efforts.<h3>Methods</h3>In this umbrella review, we conducted systematic searches of six databases (Cochrane, MEDLINE, Embase, CINAHL, Scopus, and Web of Science) for systematic reviews and meta-analyses published between Jan 1, 2000, and May 31, 2024, evaluating workplace interventions targeting sedentary behaviour or physical activity in working adults aged 18 years and older without specific health conditions or mobility impairments. Outcomes encompassed any behavioural changes related to sedentary behaviour or physical activity. Evidence for each relevant combination of intervention and outcome categories was summarised using either meta-analysis or narrative synthesis, with primary study data extracted as needed. This study is registered with PROSPERO, CRD42020171774.<h3>Findings</h3>We included 36 systematic reviews and meta-analyses covering 214 unique primary studies. Despite considerable heterogeneity in the evidence, several effect trends emerged with moderate-to-high confidence. First, sit-to-stand workstations produced the largest reductions in sedentary time, decreasing it by up to 75 min per day (95% CI –109 to –41) when used alone, with reductions increasing by up to 33% when paired with psychosocial strategies. However, these interventions did not significantly increase physical activity at any intensity. Second, self-monitoring combined with psychosocial strategies yielded the largest increases in step count, with average gains of 1056 steps per day (371 to 1740). Third, no specific strategy consistently increased moderate-to-vigorous physical activity, although the available evidence remains sparse. Additional trends were observed but with lower confidence levels. Analysis of publication bias suggested an inflated effect of environmental-level interventions on occupational sedentary time. Adjusting for this bias using the trim-and-fill method only slightly reduced the effect size, but this result should be interpreted with caution due to high heterogeneity (<em>I</em><sup>2</sup>=84·80%).<h3>Interpretation</h3>Current evidence highlights the modest effect of existing workplace interventions on physical activity. Some strategies, such as sit-to-stand workstations and gamified interventions, effectively reduce sedentary behaviour and encourage lighter forms of physical activity, but none consistently improves moderate-to-vigorous physical activity, which provides the greatest health benefits. With many countries falling short of the WHO target to reduce physical inactivity prevalence by 15% from","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"72 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Public health under Trump 2.0: the first 50 days","authors":"","doi":"10.1016/s2468-2667(25)00071-4","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00071-4","url":null,"abstract":"Jan 20, 2025, US President Donald Trump took charge of the Oval Office and began by signing an array of executive orders spanning from withdrawal from WHO and the Paris Climate Agreement to freezing trillions of US$ worth of federal funding and a ban on diversity, equity, and inclusion programmes. The new US Administration's onslaught on some of the world's most respected scientific public health institutions such as the Centers for Disease Control and Prevention (CDC) and National Institutes of Health threatens to undermine decades of progress and leadership. The immediate results are confusion, fear, uncertainty, disruption, and chaos; in the longer term: a disaster for domestic and international public health.","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"26 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three decades of population health changes in Japan, 1990–2021: a subnational analysis for the Global Burden of Disease Study 2021","authors":"","doi":"10.1016/s2468-2667(25)00044-1","DOIUrl":"https://doi.org/10.1016/s2468-2667(25)00044-1","url":null,"abstract":"<h3>Background</h3>Given Japan's rapidly ageing demographic structure, comprehensive and long-term evaluations of its national and subnational health progress are important to inform public health policy. This study aims to assess Japan's population health, using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 to analyse the country's evolving disease patterns.<h3>Methods</h3>GBD 2021 used Japanese data from 1474 sources, covering 371 diseases, including COVID-19, and 88 risk factors. The analysis included estimates of life expectancy, mortality, and disability-adjusted life-years (DALYs). Estimates were generated using the standardised GBD methodology, which incorporates various data sources through statistical modelling, including the Cause Of Death Ensemble Model for mortality, Bayesian Meta-Regression Disease Model for non-fatal outcomes, and risk factor estimation frameworks to quantify attributable burdens. Life expectancy decomposition by cause of death and annualised rates of change of age-standardised mortality and DALYs were calculated for 1990–2005, 2005–15, and 2015–21.<h3>Findings</h3>Between 1990 and 2021, life expectancy in Japan rose from 79·4 years (95% uncertainty interval 79·3–79·4) to 85·2 years (85·1–85·2), with prefecture-level disparities widening. Gains were primarily driven by reduced mortality from stroke (adding 1·5 years to life expectancy), ischaemic heart disease (1·0 years), and neoplasms, particularly stomach cancer (0·5 years), with variation across prefectures. Leading causes of death in 2021 were Alzheimer's disease and other dementias (135·3 deaths [39·5–312·3] per 100 000 population), stroke (114·9 [89·8–129·3] per 100 000), ischaemic heart disease (96·5 [77·7–106·7] per 100 000), and lung cancer (72·1 [61·8–77·5] per 100 000). Age-standardised mortality for major non-communicable diseases declined, but the pace of this decline has slowed. All-cause annualised rate of change in mortality rate decreased from –1·6% for 2005–15 to –1·1% for 2015–21. Age-standardised COVID-19 mortality rates were 0·8 deaths (0·7–0·9) per 100 000 population (accounting for 0·3% of all deaths) in 2020 and 3·0 (2·5–3·7) per 100 000 population in 2021 (1·0% of deaths). Age-standardised DALY rates for diabetes worsened, with annualised rate of change increasing from 0·1% for 2005–15 to 2·2% for 2015–21. This change parallels worsening trends in major risk factors, particularly high fasting plasma glucose (annualised rate of change of attributable DALYs –0·8% for 2005–15 and 0·8% for 2015–21) and high BMI (0·2% and 1·4%, respectively). Age-standardised DALYs attributable to other major risk factors continued to decrease, albeit slower.<h3>Interpretation</h3>Japan's health gains over the past 30 years are now stalling, with rising regional disparities. The increasing burdens of Alzheimer's disease and other dementias and diabetes, alongside high fasting plasma glucose and high BMI, highlight areas needing focus","PeriodicalId":56027,"journal":{"name":"Lancet Public Health","volume":"1 1","pages":""},"PeriodicalIF":50.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}