Global Heart最新文献

{"title":"Clinical Characteristics and Outcomes of Elderly Patients Undergoing Primary Percutaneous Coronary Intervention: An Observational Cohort Study.","authors":"Ahmed Hassan, Amr Yosry Emam, Mohammed Thabet, Ahmed Osman, Khaled Ahmed Shams, Mina Samir Labib, Ahmed Elguindy","doi":"10.5334/gh.1383","DOIUrl":"https://doi.org/10.5334/gh.1383","url":null,"abstract":"<p><strong>Background: </strong>The global trend of population aging has resulted in more frequent cardiovascular disease among seniors. Primary percutaneous coronary intervention (pPCI) is the standard of care for ST-elevation myocardial infarction (STEMI) without an upper age limit. Nevertheless, the outcomes are variable among studies, and data on pPCI outcomes in the elderly in Africa is scarce. Thus, we attempted to gain better insight into the outcomes of primary PCI in this age group from a single center in upper Egypt.</p><p><strong>Objective: </strong>To study the patient characteristics and in-hospital outcomes of pPCI in elderly patients presenting with STEMI in a tertiary cardiac center in upper Egypt.</p><p><strong>Methods and results: </strong>This observational cohort study was based on data from the pPCI registry in a tertiary cardiac center in upper Egypt, which included 3,627 consecutive patients who underwent pPCI between January 2014 and June 2023. The elderly were defined as those aged 70 years or older and represented 15.9% (575 patients) of the entire cohort, of whom 103 (2.8%) were octogenarians. Clinical characteristics, procedural details, and in-hospital outcomes were compared between the age groups. The elderly had a significant trend of being female and hypertensive, and having chronic kidney disease (CKD), worse Killip class, more frequent severe non-culprit vessel lesions, and left main trunk involvement. The in-hospital mortality was significantly higher than that of younger patients (14.1 vs. 4%, p = <0.001), with higher mortality in octogenarians (23.3%). Killip class ≥II was independently associated with increased hospital mortality in all study age groups. Contrast-induced nephropathy and TIMI major bleeding were also significantly higher.</p><p><strong>Conclusion: </strong>Compared to younger patients, elderly patients undergoing pPCI had a higher prevalence of hypertension and CKD and were more likely to have a worse Killip class. The radial approach was utilized less often in the elderly group. In-hospital complications and mortality, particularly among the octogenarians, were significantly higher than in younger patients.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"99"},"PeriodicalIF":3.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and Perceptions towards the Role of Systemic Inflammation and High-Sensitivity C-reactive Protein as a Biomarker in Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease: The Multinational FLAME-ASCVD Survey amongst Cardiologists.","authors":"Nikolaus Marx, Issei Komuro, Preethy Prasad, Juying Qian, José Francisco Kerr Saraiva, Amir Abbas Mohseni Zonoozi, Abhijit Shete, Alberico L Catapano","doi":"10.5334/gh.1382","DOIUrl":"10.5334/gh.1382","url":null,"abstract":"","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"98"},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Albumin-Bilirubin (ALBI) Score and All-cause Mortality Risk in Intensive Care Unit Patients with Heart Failure.","authors":"Jiuyi Wang, Kai Wang, Guibo Feng, Xin Tian","doi":"10.5334/gh.1379","DOIUrl":"10.5334/gh.1379","url":null,"abstract":"<p><strong>Background: </strong>The albumin-bilirubin (ALBI) score has demonstrated prognostic value in a range for liver and heart diseases. However, its association with all-cause mortality in intensive care unit (ICU) patients with heart failure remains uncertain.</p><p><strong>Objective: </strong>This study sought to investigate the relationship between the ALBI score and the risk of all-cause mortality in ICU patients with heart failure.</p><p><strong>Methods and results: </strong>The ICU patients diagnosed with heart failure were selected from the Medical Information Mart for Intensive Care IV database (MIMIC-IV, version 2.2) and stratified into tertiles according to their ALBI scores. The primary outcome of interest was the occurrence of all-cause mortality within 365 days post-discharge. The analysis encompassed a cohort of 4,239 patients, with Kaplan-Meier curves indicating that individuals with higher ALBI levels exhibited an elevated risk of all-cause mortality (log-rank p < 0.001). Multivariate adjusted Cox regression and subgroup analysis demonstrated that individuals in T2 (hazard ratio (HR) 1.09, 95% CI 0.99-1.21) and T3 (HR 1.17, 95% CI 1.02-1.34) had an increased risk of mortality compared to individuals in T1 (p for trend < 0.001), and each incremental tertile in ALBI was linked to a 10% rise in mortality risk, while each individual unit increase in ALBI was associated with a 36% increase in mortality risk. This relationship was consistently observed across most subgroups, except for using or not using inotropes or vasopressors, different ages, different creatinine levels. The restricted cubic spline (RCS) analysis indicated a linear relationship between ALBI levels and the risk of all-cause mortality.</p><p><strong>Conclusion: </strong>The ALBI scores are independently associated with the risk of all-cause mortality in ICU patients with heart failure, particularly in those not using inotropes or vasopressors, younger patients, and with lower levels of creatinine. ALBI may help identify high-risk patients and optimize risk stratification in this population.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"97"},"PeriodicalIF":3.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Laboratory Validation Study of a High Sensitivity Troponin I Assay on a POCT (Point of Care Testing) Device.","authors":"Fabio Grunspun Pitta, Adriana Caschera Leme, Simone Rodrigues Gomes, Tarsila Perez Mota, Fernanda Vieira Paladino, José Leão de Souza Júnior, Rosemeire de Paula Braz, Thais Cristine Rodrigues Leonel Lamounier, Jéssica Buzin Gomes Ferreira, Carlos Eduardo Dos Santos Ferreira","doi":"10.5334/gh.1377","DOIUrl":"10.5334/gh.1377","url":null,"abstract":"<p><strong>Background: </strong>In Acute Coronary Syndrome without ST-segment elevation, the use of high-sensitivity troponins in rapid protocols is considered the gold standard for diagnostic exclusion/confirmation, in conjunction with clinical stratification. The biggest concern regarding the techniques for troponin evaluation is the time required between collection and delivery of the result.</p><p><strong>Objective: </strong>The objective of the present study is the clinical/laboratory validation of a POCT device for TnI.</p><p><strong>Methods: </strong>In the first phase of the study, samples from 108 patients with known troponin values High Sensitivity Automated Troponin T (TnT) assay from <i>Roche Diagnostics</i> were analyzed for analytical comparability between hs-cTnI of the Analyzer Atellica® vTLi and hs-cTnT Cobas®. The second phase of the study was performed with samples from 51 patients who reported to the emergency department with chest pain for a clinical prospective evaluation and correlation between the hs-cTnI assays of the Analyzer Atellica® vTLi, hs-cTnT Cobas® and Atellica IM 1300.</p><p><strong>Results: </strong>There was a correlation between the POCT Atellica® vTLi and hs-cTnT Cobas® in the serum samples of the control group (r = 0.660, p < 0.0001). Besides, there was a correlation between the Atellica® vTLi, serum hs-cTnT Cobas®, plasma hs-cTnT Cobas®, serum Atellica IM and plasma Atellica IM 1300 platforms in the second phase (p < 0.0001 in all cases).</p><p><strong>Conclusion: </strong>In the present study, the Siemens POCT Atellica® vTLi device showed excellent performance in laboratory validation and correlation with the high-sensitivity TnT assay in different troponin concentration ranges. Given these results, the device can be used in institutions that intend to use a POCT device for 0- and 1-hour chest pain protocols.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"96"},"PeriodicalIF":3.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Experience of the Salim Yusuf Emerging Leaders Programme: A Journey Beyond Borders.","authors":"Vagner Madrini Junior, Vernice R Peterson, Patrick Ngassa Piotie, Swagata Kumar Sahoo, Sonali Munot, Rochelle Regina Cruz, Daniele Rodolico, James Ayodele Ogunmodede, Gonzalo Rodriguez","doi":"10.5334/gh.1381","DOIUrl":"10.5334/gh.1381","url":null,"abstract":"","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"95"},"PeriodicalIF":3.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of ACC/AHA and ESC Sudden Cardiac Death Risk Guidelines in Diverse Hypertrophic Cardiomyopathy Cohort: Stratification HCM Study.","authors":"Murillo Oliveira Antunes, Fabio Fernandes, Edmundo Arteaga-Fernandez, Félix José Alvarez Ramires, Vinicius Machado Correia, Juliano Novaes Cardoso, Cristhian Espinoza Romero, Henrique Martins Sousa, Marília Taily Soliani, Matheus Ramos Ramos Dal Piaz, Anna Danielle Rodrigues Gandarella, Ruiza Gonçalves Rocha Teixeira, Charles Mady, Caio Assis Moura Tavares, Patricia O Guimarães, Vagner Madrini Junior","doi":"10.5334/gh.1380","DOIUrl":"10.5334/gh.1380","url":null,"abstract":"<p><strong>Background: </strong>Sudden cardiac death (SCD) is a major concern in patients with hypertrophic cardiomyopathy (HCM). The American College of Cardiology/American Heart Association (ACC/AHA) and the European Society of Cardiology (ESC) have different guidelines for SCD risk stratification. Their comparative performance in diverse populations remains uncertain.</p><p><strong>Objective: </strong>Evaluate the performance of the 2020 ACC/AHA and 2014 ESC guidelines for SCD stratification in a Brazilian cohort with HCM.</p><p><strong>Methods: </strong>This retrospective cohort study included patients diagnosed with HCM who were followed in a dedicated clinic at a tertiary hospital in Brazil. The primary outcome was SCD, aborted cardiac arrest due to ventricular fibrillation (VF), sustained ventricular tachycardia (SVT), an episode of VF or SVT, or appropriate ICD therapy. Risk prediction models were assessed using the C-index.</p><p><strong>Results: </strong>A total of 187 patients were included, with a mean follow-up of 8.3 years. The 2020 ACC/AHA guidelines classified 106 (56%) patients as high-risk for SCD, while the 2014 ESC guidelines identified 54 (29%). The primary outcome occurred in 12% of the high-risk group identified by the ACC/AHA guidelines and 13% of the high-risk group identified by the ESC guidelines. Both guidelines showed low discriminatory power for SCD risk in this Brazilian cohort, with AUC values of 0.634 and 0.581 for the ACC/AHA and ESC guidelines, respectively.</p><p><strong>Conclusions: </strong>The 2020 ACC/AHA and 2014 ESC guidelines have limitations in predicting SCD events and defining ICD indications in Brazilian HCM patients. Further studies are needed to refine risk stratification and optimize SCD prevention in this population.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"94"},"PeriodicalIF":3.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Antihypertensive and Statin Treatment Protocols for Cardiovascular Disease Prevention in Low- and Middle-Income Countries.","authors":"Andrew E Moran, Obehi Aimiosior, Reena Gupta, Anupam Pathni, Swagata Kumar Sahoo, Girma Dessie, Kufor Osi, Xiulei Zhang, Bolanle Banigbe, Renu Garg, Thomas R Frieden","doi":"10.5334/gh.1376","DOIUrl":"10.5334/gh.1376","url":null,"abstract":"<p><p>In low- and middle-income countries where the majority of preventable cardiovascular disease deaths occur, less than 10% of eligible patients receive statins for primary cardiovascular disease prevention. Since 2017, the Global Hearts initiative has implemented simple World Health Organization (WHO) HEARTS hypertension and diabetes treatment protocols. In this editorial, we propose an approach of integrating statin treatment into existing HEARTS hypertension and diabetes protocols as a way of expanding statin coverage in low-and middle-income countries.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"93"},"PeriodicalIF":3.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decomposing the Poor-Non-Poor Gap in the Prevalence of Undiagnosed and Untreated Hypertension Among Bangladeshi Population.","authors":"Mosiur Rahman, Mahfuza Khatun, Asrafun Naher Pinkey, Syed Emdadul Haque, Farhana Akhter Liza, Md Nuruzzaman Haque, Prosannajid Sarkar, Tapan Kumar Roy, G M Rabiul Islam, Md Rashed Alam, Mahmudul Hasan, Izzeldin Fadl Adam, Nguyen Huu Chau Duc, Saber Al-Sobaihi, Abid Hasan","doi":"10.5334/gh.1372","DOIUrl":"10.5334/gh.1372","url":null,"abstract":"<p><strong>Objectives: </strong>Our objectives were to ascertain: the prevalence and socio-economic distribution of hypertension, as well as the rates of undiagnosed and untreated hypertension; the association between socioeconomic status (SES) and the occurrence of hypertension, as well as the rates of undiagnosed and untreated hypertension; and the factors influencing the poor-non-poor gap in terms of the prevalence, diagnosis, and treatment of hypertension.</p><p><strong>Design: </strong>Cross-sectional nationally representative study.</p><p><strong>Methods: </strong>Data from the 2017-18 Bangladesh Demographic Health Survey were used. 11,776 participants who were 18 years of age or older responded to our analysis. We used the wealth index as a proxy for SES. The prevalence of hypertension, both diagnosed and undiagnosed, as well as its untreated states, were the outcome variables.</p><p><strong>Results: </strong>The age-adjusted prevalence of hypertension, undiagnosed as having hypertension, and untreated cases were 25.1%, 57.2%, and 12.3%, respectively. People in the poor SES groups had a 0.88 times (95% confidence interval [CI] 0.77-0.99) lower likelihood of having hypertension compared to those in the non-poor SES group. Individuals belonging to the poor SES group exhibited a likelihood of 1.68 and 1.53 times greater for having untreated hypertension and being undiagnosed with the condition, respectively, compared to those in the non-poor SES group. The results indicated that BMI played a role in increasing the disparity between the poor and non-poor populations concerning hypertension risk. Additionally, factors such as age, gender, and education were found to exacerbate the gap in the risk of undiagnosed hypertension between these two groups.</p><p><strong>Conclusion: </strong>The results of this study suggest that appropriate policy measures be developed for ongoing care and early identification, especially for older adults, men, and individuals with low levels of education from low socioeconomic backgrounds. Additionally, efforts must be made to reduce the prevalence of overweight and obesity among people in the non-poor SES category.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"90"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Services Availability and Readiness for Management of Hypertension and Diabetes in Primary Care Health Facilities in Ghana: a Cardiovascular Risk Management project.","authors":"Thomas Hinneh, Bernard Mensah, Hosea Boakye, Oluwabunmi Ogungbe, Yvonne Commodore-Mensah","doi":"10.5334/gh.1375","DOIUrl":"10.5334/gh.1375","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension and diabetes are leading causes of adult hospital admissions and mortality across health facilities in Ghana. Timely screening and diagnosis at primary health facilities are crucial to initiate treatment and avert complications. This study explored service availability and readiness of health systems for managing hypertension and diabetes in selected district hospitals in Ghana.</p><p><strong>Methods: </strong>We adapted the World Health Organization (WHO) Service Availability and Readiness Assessment (SARA) tool to assess hypertension and diabetes management practices between June and July 2022 in four district hospitals in Ghana. Domain scores of service readiness were calculated based on the mean score of tracer item availability, transformed into percentages, and stratified by facility ownership. The mean readiness index was based on basic clinical logistics and equipment, diagnostic capacity, and first-line medications. Service availability was based on the core health workforce and specific service arrangements for the management of hypertension and diabetes. Facilities were considered 'ready' for services at a cut-off readiness score of 70%.</p><p><strong>Results: </strong>All facilities (n = 4, 100%) provided hypertension and diabetes services, with a median of 118 nurses (IQR 103-140) and 5 physicians (IQR 2-8). Only one facility (n = 1, 25%) had conducted cardiovascular disease training in the past year. All basic equipment (weighing scales, stethoscopes, glucometers, and blood pressure monitors) were available in all 4 facilities. Antihypertensives, including ACE inhibitors (n = 3; 75%), calcium channel blockers (n = 4; 100%), centrally acting agents (n = 4; 100%), and thiazides (n = 4; 100%), were available, as were antidiabetic medications like metformin (n = 4; 100%) and insulin (n = 2; 50%). Only two facilities (n = 2; 50%) could perform the required test (Hemoglobin A1c, full blood count, renal function, serum creatinine, blood urea, electrolytes, and blood lipid tests). Overall readiness score was 75.5%, essential medications (83.5%), basic equipment (78%), clinical guidelines for the management of cardiovascular disease management (75%), and diagnostic capacity (65.5%). Mission facilities had a higher readiness score (96%) and government facilities (55%).</p><p><strong>Conclusion: </strong>Facilities demonstrated high readiness for basic hypertension and diabetes care, with higher availability of some essential medications and basic clinical logistics and equipment. Limited diagnostic capacity and cardiovascular disease training, highlight areas of improvement to strengthen hypertension and diabetes services in Ghana.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"92"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus-Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study.","authors":"Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu","doi":"10.5334/gh.1373","DOIUrl":"10.5334/gh.1373","url":null,"abstract":"<p><strong>Background: </strong>Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that can result in limb pain, disability, or mortality. Notably, diabetes mellitus (DM) stands out as one of the most significant risk factors for the development of PAD. Compared to individuals with PAD but no DM, those with concurrent DM and PAD (DM-PAD, diabetes mellitus-peripheral artery disease) face a seven-fold higher risk of critical limb ischemia and a five-fold higher risk of amputation. However, the pathogenic factors and effective therapeutic targets for DM-PAD still remain elusive.</p><p><strong>Method: </strong>To identify candidate hub genes and develop insights into the pathogenesis of DM-PAD, we employed a comprehensive approach encompassing two-sample Mendelian Randomization (two-sample MR), summary data-based Mendelian randomization (SMR), and Bayesian colocalization (COLOC) methods. These methodologies facilitated the integration of summary-level data derived from genome-wide association studies of DM-PAD with expression quantitative trait locus (eQTLs) studies conducted on blood samples.</p><p><strong>Result: </strong><i>DENND5B, C4A</i>, and <i>CYP21A2</i> were found to have passed two-sample MR and SMR analyses, indicating their status as hub genes associated with DM-PAD through mechanisms involving not linkage but rather causality. The COLOC analysis provided strong evidence suggesting that <i>DENND5B</i> and the DM-PAD trait were influenced by the common causal variant rs1150948.</p><p><strong>Conclusion: </strong>Our study has pinpointed several crucial genes (<i>DENND5B, C4A</i>, and <i>CYP21A2</i>), notably the <i>DENND5B</i> gene, as potential regulators in the pathogenesis of DM-PAD. These discoveries hold promises for shedding light on the underlying mechanisms and novel targets of the disease in future research.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"91"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}