Global Heart最新文献

{"title":"The Association of Micro-RNA 21 and Hypertension: A Meta-Analysis.","authors":"Caihong Xin, Wei He, Xin Sun, Mianxian Li, Hongli Wang","doi":"10.5334/gh.1325","DOIUrl":"10.5334/gh.1325","url":null,"abstract":"<p><p>Hypertension is a multifactorial, complex disease with high morbidity and mortality rates. Studies have found that micro-RNA 21 (miR-21) levels are significantly increased in patients with hypertension. However, other studies have reported opposite results. Therefore, the relationship between miR-21 expression and hypertension remains controversial. This meta-analysis was conducted to statistically evaluate the miR-21 levels of patients with hypertension. A literature research was conducted using Web of Science, Embase, PubMed, and CNKI. To search for titles or abstracts, 'hypertension' in combination with the terms 'miR-21,' 'microRNA-21,' or 'miRNA-21' were used as keywords. Standardized mean differences (SMD) with corresponding 95% confidence intervals (CIs) were determined from the results of the meta-analysis. In total, 12 articles were included in this meta-analysis, involving 546 cases and 436 controls. The results of the meta-analysis showed that miR-21 levels in patients with hypertension were significantly higher than those in the controls (SMD: 1.22; 95% CI [0.35, 2.09]). This meta-analysis is the first to evaluate miR-21 in patients with hypertension. MiR-21 may be a new target for the prediction and treatment of hypertension. Further high-quality studies are needed to better support the association between miR-21 and hypertension.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"41"},"PeriodicalIF":3.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11067968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine Antenatal Echocardiography in High-Prevalence Areas of Rheumatic Heart Disease: A WHO-Guideline Systematic Review.","authors":"Samuel Seitler, Mahmood Ahmad, Sanjali Anil Chu Ahuja, Malik Takreem Ahmed, Alexander Stevenson, Tamar Rachel Schreiber, Prem Singh Sodhi, Hiruna Kojitha Diyasena, Osarumwense Ogbeide, Sankavi Arularooran, Farhad Shokraneh, Miryan Cassandra, Eloi Marijon, David S Celermajer, Mohammed Y Khanji, Rui Providencia","doi":"10.5334/gh.1318","DOIUrl":"10.5334/gh.1318","url":null,"abstract":"<p><strong>Background: </strong>Rheumatic Heart Disease (RHD) is the most common cause of valvular heart disease worldwide. Undiagnosed or untreated RHD can complicate pregnancy and lead to poor maternal and fetal outcomes and is a significant factor in non-obstetric morbidity. Echocardiography has an emerging role in screening for RHD. We aimed to critically analyse the evidence on the use of echocardiography for screening pregnant women for RHD in high-prevalence areas.</p><p><strong>Methods: </strong>We searched MEDLINE and Embase to identify the relevant reports. Two independent reviewers assessed the reports against the eligibility criteria in a double-blind process.</p><p><strong>Results: </strong>The searches (date: 4 April 2023) identified 432 records for screening. Ten non-controlled observational studies were identified, five using portable or handheld echocardiography, comprising data from 23,166 women. Prevalence of RHD varied across the studies, ranging from 0.4 to 6.6% (I², heterogeneity >90%). Other cardiac abnormalities (e.g., congenital heart disease and left ventricular systolic dysfunction) were also detected <1% to 2% of cases. Certainty of evidence was very low.</p><p><strong>Conclusion: </strong>Echocardiography as part of antenatal care in high-prevalence areas may detect RHD or other cardiac abnormalities in asymptomatic pregnant women, potentially reducing the rates of disease progression and adverse labor-associated outcomes. However, this evidence is affected by the low certainty of evidence, and lack of studies comparing echocardiography versus standard antenatal care.</p><p><strong>Prospective registration: </strong>PROSPERO 2022 July 4; CRD42022344081 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=344081.</p><p><strong>Research question: </strong>'In areas with a high prevalence of rheumatic heart disease, should handheld echocardiography be added to routine antenatal care?'</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"39"},"PeriodicalIF":3.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11049603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decentralization and Integration of Advanced Cardiac Care for the World's Poorest Billion Through the PEN-Plus Strategy for Severe Chronic Non-Communicable Disease.","authors":"Sheila L Klassen, Emmy Okello, Jose M E Ferrer, Faraz Alizadeh, Prebo Barango, Pilly Chillo, Yamikani Chimalizeni, Wubaye Walelgne Dagnaw, Jean-Luc Eiselé, Lauren Eberly, Anu Gomanju, Neil Gupta, Bhagawan Koirala, Jacques Kpodonu, Gene Kwan, Bright G D Mailosi, Lilian Mbau, Reuben Mutagaywa, Colin Pfaff, Daniel Piñero, Fausto Pinto, Emmanuel Rusingiza, Usman Abiola Sanni, Amy Sanyahumbi, Urmila Shakya, Sanjib Kumar Sharma, Kunjang Sherpa, Isaac Sinabulya, Emily B Wroe, Gene Bukhman, Ana Mocumbi","doi":"10.5334/gh.1313","DOIUrl":"10.5334/gh.1313","url":null,"abstract":"<p><p>Rheumatic and congenital heart disease, cardiomyopathies, and hypertensive heart disease are major causes of suffering and death in low- and lower middle-income countries (LLMICs), where the world's poorest billion people reside. Advanced cardiac care in these counties is still predominantly provided by specialists at urban tertiary centers, and is largely inaccessible to the rural poor. This situation is due to critical shortages in diagnostics, medications, and trained healthcare workers. The Package of Essential NCD Interventions - Plus (PEN-Plus) is an integrated care model for severe chronic noncommunicable diseases (NCDs) that aims to decentralize services and increase access. PEN-Plus strategies are being initiated by a growing number of LLMICs. We describe how PEN-Plus addresses the need for advanced cardiac care and discuss how a global group of cardiac organizations are working through the PEN-Plus Cardiac expert group to promote a shared operational strategy for management of severe cardiac disease in high-poverty settings.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"33"},"PeriodicalIF":3.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A Randomized Controlled Trial to Examine the Relationship Between Peer Mentoring for Physical Activity and Cardiometabolic Health.","authors":"Moradeke Bamgboye, David Adeyemi, Emmanuel Agaba, Susan Yilme, Clement A Adebamowo, Sally N Adebamowo","doi":"10.5334/gh.1317","DOIUrl":"10.5334/gh.1317","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.5334/joc.1268.].</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"32"},"PeriodicalIF":3.7,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Facilities Readiness and Determinants to Manage Cardiovascular Disease in Afghanistan, Bangladesh, and Nepal: Evidence from the National Service Provision Assessment Survey.","authors":"Md Durrul Huda, Mosiur Rahman, Md Golam Mostofa, Prosannajid Sarkar, Md Jahirul Islam, Izzeldin Fadl Adam, Nguyen Huu Chau Duc, Saber Al-Sobaihi","doi":"10.5334/gh.1311","DOIUrl":"10.5334/gh.1311","url":null,"abstract":"<p><strong>Background: </strong>In South Asia, cardiovascular diseases (CVDs) are an increasing public health concern. One strategy for dealing with the growing CVDs epidemic is to make health facilities more ready to provide CVDs services. The study's objectives were to: (1) assess healthcare facilities' readiness to offer CVDs services; and (2) identify the variables that influence such readiness.</p><p><strong>Methods: </strong>This study employed data from the Afghanistan Service Provision Assessment Survey 2018-2019, Bangladesh Health Facility Survey 2017, and Nepal Health Facility Survey 2021 that were cross-sectional and nationally representative. In Afghanistan, Bangladesh, and Nepal, 117, 368, and 1,381 health facilities, respectively, were examined. A total of 10 items/indicators were used to measure a health facility's readiness to provide CVDs services across three domains.</p><p><strong>Results: </strong>The mean readiness scores of managing CVDs were 6.7, 5.6, and 4.6 in Afghanistan, Bangladesh, and Nepal, respectively. Availability of trained staff for CVD services are not commonly accessible in Afghanistan (21.5%), Bangladesh (15.3%), or Nepal (12.9%), except from supplies and equipment. Afghanistan has the highest levels of medicine and other commodity availability. Among the common factors linked with readiness scores, we ought to expect a 0.02 unit rise in readiness scores for three nations for every unit increase in number of CVDs care providers. In Afghanistan, Bangladesh, and Nepal, availability of both diagnosis and treatment facilities was associated with increases in readiness scores of 27%, 9%, and 17%, respectively. Additionally, an association was observed between nation-specific facility types and the readiness scores.</p><p><strong>Conclusions: </strong>Country-specific factors as well as universal factors present in all three nations must be addressed to improve a health facility's readiness to provide CVDs care. To create focused and efficient country-specific plans to raise the standard of CVD care in South Asia, more investigation is necessary to ascertain the reasons behind country-level variations in the availability of tracer items.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"31"},"PeriodicalIF":3.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"India Hypertension Control Initiative: Blood Pressure Control Using Drug and Dose-Specific Standard Treatment Protocol at Scale in Punjab and Maharashtra, India, 2022.","authors":"Prabhdeep Kaur, Manikandanesan Sakthivel, Vettrichelvan Venkatasamy, Padmaja Jogewar, Sandeep S Gill, Abhishek Kunwar, Meenakshi Sharma, Anupam Khungar Pathni, Kiran Durgad, Swagata Kumar Sahoo, Amol Wankhede, Navneet Kumar, Vishwajit Bharadwaj, Bidisha Das, Tejpalsinh Chavan, Suhas Khedkar, Lalit Sarode, Sampada D Bangar, Ashish Krishna, Roopa Shivashankar, Parasuraman Ganeshkumar, Pragati Pragya, Balram Bhargava","doi":"10.5334/gh.1305","DOIUrl":"10.5334/gh.1305","url":null,"abstract":"<p><strong>Background: </strong>Hypertension treatment coverage is low in India. A stepwise simple treatment protocol is one of the strategies to improve hypertension treatment in primary care. We estimated the effectiveness of various protocol steps to achieve blood pressure (BP) control in public sector health facilities in Punjab and Maharashtra, India, where the India Hypertension Control Initiative (IHCI) was implemented.</p><p><strong>Methods: </strong>We analyzed the records of people enrolled for hypertension treatment and follow-up under IHCI between January 2018 and December 2021 in public sector primary and secondary care facilities across 23 districts from two states. Each state followed a different treatment protocol. We calculated the proportion with controlled BP at each step of the protocol. We also estimated the mean decline in BP pre- and post-treatment.</p><p><strong>Results: </strong>Of 281,209 patients initiated on amlodipine 5 mg, 159,292 continued on protocol drugs and came for a follow-up visit during the first quarter of 2022. Of 33,450 individuals who came for the follow-up in Punjab and 125,842 in Maharashtra, 70% and 76% had controlled BP, respectively, at the first step with amlodipine 5 mg. In Punjab, at the second step with amlodipine 10 mg, the cumulative BP control increased to 75%. A similar 5% (76%-81%) increase was seen in the second step after adding telmisartan 40 mg in Maharashtra. Overall, the mean (SD) systolic blood pressure (SBP) decreased by 16 mmHg from 148 (15) mmHg at the baseline in Punjab. In Maharashtra, the decline in the mean (SD) SBP was about 15 mmHg from the 144 (18) mmHg baseline.</p><p><strong>Conclusion: </strong>Simple drug- and dose-specific protocols helped achieve a high control rate among patients retained in care under program conditions. We recommend treatment protocols starting with a single low-cost drug and escalating with the same or another antihypertensive drug depending on the cost and availability.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"30"},"PeriodicalIF":3.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Intersection of Atrial Fibrillation and Coronary Artery Disease in Middle Eastern Patients. Analysis from the Jordan Atrial Fibrillation Study.","authors":"Ayman Hammoudeh, Yahya Badaineh, Ramzi Tabbalat, Anas Ahmad, Mohammad Bahhour, Darya Ja'ara, Joud Shehadeh, Mohammad A Jum'ah, Afnan Migdad, Mohammad Hani, Imad A Alhaddad","doi":"10.5334/gh.1312","DOIUrl":"10.5334/gh.1312","url":null,"abstract":"<p><strong>Background: </strong>There is a scarcity of clinical studies which evaluate the association of atrial fibrillation (AF) and coronary artery disease (CAD) in the Middle East. The aim of this study was to evaluate the impact of CAD on baseline clinical profiles and one-year outcomes in a Middle Eastern cohort with AF.</p><p><strong>Methods: </strong>Consecutive AF patients evaluated in 29 hospitals and cardiology clinics were enrolled in the Jordan AF Study (May 2019-December 2020). Clinical and echocardiographic features, use of medications and one-year outcomes in patients with AF/CAD were compared to AF/no CAD patients.</p><p><strong>Results: </strong>Of 2020 AF patients enrolled, 216 (10.7%) had CAD. Patients with AF/CAD were more likely to be men and had significantly higher prevalence of hypertension, diabetes, dyslipidemia, heart failure and chronic kidney disease compared to the AF/no CAD patients. They also had lower mean left ventricular ejection fraction and larger left atrial size. Mean CHA₂DS₂ VASc and HAS-BLED scores were higher in AF/CAD patients than those with AF/no CAD (4.3 ± 1.7 vs. 3.6 ± 1.8, p < 0.0001) and (2.0 ± 1.1 vs. 1.6 ± 1.1, p < 0.0001), respectively. Oral anticoagulant agents were used in similar rates in the two groups (83.8% vs. 82.9%, p = 0.81), but more patients with AF/CAD were prescribed additional antiplatelet agents compared to patients with AF/no CAD (73.7% vs. 41.5%, p < 0.0001). At one year, AF/CAD patients, compared to AF/no CAD patients had significantly higher hospitalization rate (39.4% vs. 29.2%, p = 0.003), more acute coronary syndrome and coronary revascularization (6.9% vs. 2.4%, p = 0.004), and higher all-cause mortality (18.5% vs. 10.9%, p = 0.002).</p><p><strong>Conclusions: </strong>In this cohort of Middle Eastern patients with AF, one in 10 patients had CAD. The coexistence of AF and CAD was associated with a worse baseline clinical profile and one-year outcomes. Clinical study registration: the study is registered on clinicaltrials.gov (unique identifier number NCT03917992).</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"29"},"PeriodicalIF":3.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Better Understanding of Cardiovascular Risk in the Transgender and Gender-Diverse Community: A Global Call to Action.","authors":"Jorge Eduardo Cossío Aranda, Viveka Jain, Lourdes M Figueiras-Graillet, Alexandra Arias-Mendoza, Julio López Cuéllar, Ana Berni Betancourt, Álvaro Sosa Liprandi, Fausto Pinto, Jean-Luc Eiselé, Daniel José Pineiro","doi":"10.5334/gh.1300","DOIUrl":"10.5334/gh.1300","url":null,"abstract":"<p><p>On World Heart Day 2022, the Mexican Society of Cardiology, the Inter-American Society of Cardiology, and the World Heart Federation collaborated on a public call to action regarding the increased risk of adverse cardiovascular health outcomes in transgender and gender diverse (TGD) individuals. The aim of this article is to unpack the numerous factors that contribute to this, such as the social stigma faced by members of the TGD community, their reduced access to clinical care, and the scarcity of research regarding the unique needs of their community, which makes it difficult for clinicians to provide individualized medical care. Decreasing the incidence of adverse cardiovascular events among TGD individuals requires interventions such as educational reform in the medical community, an increase in inclusive research studies, and broader social initiatives intended to reduce the stigma faced by TGD individuals.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"27"},"PeriodicalIF":3.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study.","authors":"Lulu Said Fundikira, Pilly Chillo, Mohamed Z Alimohamed, Henry Mayala, Engerasiya Kifai, Geofrey M Aloyce, Appolinary Kamuhabwa, Gideon Kwesigabo, Linda W van Laake, Folkert W Asselbergs","doi":"10.5334/gh.1298","DOIUrl":"10.5334/gh.1298","url":null,"abstract":"<p><strong>Background: </strong>Non-ischemic dilated cardiomyopathy (NIDCM) is a common cause of heart failure with progressive tendency. The disease occurs in one in every 2,500 individuals in the developed world, with high morbidity and mortality. However, detailed data on the role of NIDCM in heart failure in Tanzania is lacking.</p><p><strong>Aim: </strong>To characterize NIDCM in a Tanzanian cohort with respect to demographics, clinical profile, imaging findings and management.</p><p><strong>Methods: </strong>Characterization of non-ischemic dilated cardioMyOpathY in a native Tanzanian cOhort (MOYO) is a prospective cohort study of NIDCM patients seen at the Jakaya Kikwete Cardiac Institute. Patients aged ≥18 years with a clinical diagnosis of heart failure, an ejection fraction of ≤45% on echocardiography and no evidence of ischemia were enrolled. Clinical data, echocardiography, electrocardiography (ECG), coronary angiography and stress ECG information were collected from February 2020 to March 2022.</p><p><strong>Results: </strong>Of 402 patients, n = 220 (54.7%) were males with a median (IQR) age of 55.0 (41.0, 66.0) years. Causes of NIDCM were presumably hypertensive n = 218 (54.2%), idiopathic n = 116 (28.9%), PPCM n = 45 (11.2%), alcoholic n = 10 (2.5%) and other causes n = 13 (3.2%). The most common presenting symptoms were dyspnea n = 342 (85.1%), with the majority of patients presenting with New York Heart Association (NYHA) Class III n = 195 (48.5%). The mean (SD) left ventricular ejection fraction (LVEF) was 29.4% (±7.7), and severe systolic dysfunction (LVEF <30%) was common n = 208 (51.7%). Compared with other forms of DCM, idiopathic DCM patients were significantly younger, had more advanced NYHA class (p < 0.001) and presented more often with left bundle branch block on ECG (p = 0.0042). There was suboptimal use of novel guidelines recommended medications ARNI n = 10 (2.5%) and SGLT2 2-inhibitors n = 2 (0.5%).</p><p><strong>Conclusions: </strong>In our Tanzanian cohort, the majority of patients with NIDCM have an identified underlying cause, and they present at late stages of the disease. Patients with idiopathic DCM are younger with more severe disease compared to other forms of NIDCM.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"26"},"PeriodicalIF":3.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Serum Calcium Levels in Elderly Dilated Cardiomyopathy Patients.","authors":"Xinyi Li, Wenfei He, Qiqi Song, Qingshan Ding, Xiaonan Zhang, Zhigang Zeng, Weiping Deng, Gang Deng, Lichang Guan, Wanzi Hong, Yaoxin Liu, Fen Shu, Lishu Xu, Ning Tan, Jinjin Ma, Lei Jiang","doi":"10.5334/gh.1304","DOIUrl":"10.5334/gh.1304","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether serum calcium on admission is associated with clinical outcomes in dilated cardiomyopathy (DCM). In this study, we conducted a retrospective study spanning a decade to investigate the prognostic value of baseline calcium in elderly patients with DCM.</p><p><strong>Methods: </strong>A total of 1,089 consecutive elderly patients (age ≥60 years) diagnosed with DCM were retrospectively enrolled from January 2010 to December 2019. Univariate and multivariate analyses were performed to investigate the association of serum calcium with their clinical outcomes.</p><p><strong>Results: </strong>In this study, the average age of the subjects was 68.36 ± 6.31 years. Receiver operating characteristic (ROC) curve analysis showed that serum calcium level had a great sensitivity and specificity for predicting in-hospital death, with an AUC of 0.732. Kaplan-Meier survival analysis showed that patients with a serum calcium >8.62 mg/dL had a better prognosis than those with a serum calcium ≤8.62 mg/dL (log-rank χ² 40.84, p < 0.001). After adjusting for several common risk factors, a serum calcium ≤8.62 mg/dL was related to a higher risk of long-term mortality (HR: 1.449; 95% CI: 1.115~1.882; p = 0.005).</p><p><strong>Conclusions: </strong>Serum calcium level could be served as a simple and affordable tool to evaluate patients' prognosis in DCM.</p>","PeriodicalId":56018,"journal":{"name":"Global Heart","volume":"19 1","pages":"25"},"PeriodicalIF":3.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}