Visceral Medicine最新文献

{"title":"Erratum.","authors":"","doi":"10.1159/000551145","DOIUrl":"10.1159/000551145","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1159/000548387.].</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":"96"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Islet-on-a-Chip\": A Microfluidic System Design for Preservation of Viability and Function of Human Islets of Langerhans - A Systematic Review.","authors":"Vidas Petrauskas, Kestutis Strupas, Aiste Kielaite Gulla","doi":"10.1159/000547931","DOIUrl":"10.1159/000547931","url":null,"abstract":"<p><strong>Introduction: </strong>There are multiple designs of microfluidic devices to study islets of Langerhans in vitro. There is an ongoing debate which design of microfluidic device is optimal in maintaining highest viability and function of the islets in vitro.</p><p><strong>Methods: </strong>A systematic literature review was conducted to evaluate the most common designs used of microfluidic devices to culture human pancreatic islets in vitro. The review included the following microfluidic designs: microwell, hanging drop, hydrodynamic trap, encapsulation, and hydrogel scaffolds. PubMed and Google Scholar databases were searched for all relevant studies (articles in English; case studies were excluded, reference period January 2013 to June 2023). Data on islet function (insulin stimulation index [ISI]) and viability, duration of experiment, design of microfluidic device, and type of cells in the experiment were collected. ANOVA was utilized for statistical analysis.</p><p><strong>Results: </strong>A total of 1,646 studies were identified in the electronic database search. There were 310 duplications, 1,152 studies were excluded after the initial screening, additionally 143 studies were excluded after reading a full-text article. Forty-one studies were included in the final analysis. The highest viability was reported in hydrogel scaffold group 97% (one study), followed by hydrodynamic trap 93.0% (±4.2), microwell 89.2% (±10.1), encapsulation 88.7% (±6.3) accordingly. ANOVA showed no difference among the designs (<i>F</i> = 0.434, df 3.29, <i>p</i> = 0.731). The highest ISI was observed in hanging drop microfluidic devices 8.5 (±4.9), followed by microwell 2.94 (±1.1), hydrogel scaffolds 2.9 (±0.6), hydrodynamic trap 2.09 (±1.0), encapsulation 1.81 (±1.0). After utilizing ANOVA test, significant differences among the mean values of ISI were observed (<i>F</i> = 8,826 [df 3.35], <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Hydrogel scaffold design of microfluidic devices might be associated with the highest viability of islets, and islet function is best preserved by hanging drop systems. More research is needed to further investigate the optimal design for further islet viability and function in vitro.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"42 2","pages":"71-84"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Pyoderma Gangrenosum: Rare Infection Mimic and Diagnostic Challenge - A Case Report.","authors":"Saeed Aldarwish, Clemens Schafmayer, Sebastian Hinz","doi":"10.1159/000550349","DOIUrl":"10.1159/000550349","url":null,"abstract":"<p><strong>Background: </strong>Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that can occur in the postoperative period, often mimicking surgical site infections (SSIs). The clinical overlap between PG and SSIs - including erythema, wound dehiscence, and purulent discharge - makes timely diagnosis challenging.</p><p><strong>Case presentation: </strong>A 61-year-old female with a history of ovarian cancer and metachronous liver metastasis underwent an open left hemihepatectomy. On the fifth postoperative day, she developed erythema, wound dehiscence, and necrosis unresponsive to broad-spectrum antibiotics. Wound cultures remained sterile. Dermatologic consultation and histopathology confirmed the diagnosis of PG, characterized by dense neutrophilic infiltration and pyogenic folliculitis. High-dose corticosteroid therapy led to marked clinical improvement within 5 days, with full wound healing achieved by discharge.</p><p><strong>Conclusion: </strong>Postoperative PG should be considered in non-resolving postoperative wound complications with negative cultures and antibiotic failure. In this context, prior exposure to PARP inhibitors may be a biologically plausible cofactor through immune modulation; however, a causal link remains unproven. Early dermatology consultation and biopsy are essential to avoid harmful debridement and expedite immunosuppression.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":"92-95"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplantable Orthotopic Mouse Models for Colorectal Cancer Research: Current Strategies and Future Directions.","authors":"Chen Chen, Josefine Schardey, Tobias S Schiergens, Jens Werner, Florian Kühn","doi":"10.1159/000551356","DOIUrl":"https://doi.org/10.1159/000551356","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) remains a leading cause of cancer mortality, and metastatic disease still carries a poor prognosis, highlighting the need for preclinical models that better reflect human tumor biology. Orthotopic murine CRC models more closely recapitulate the native tumor microenvironment and metastatic routes than subcutaneous or in vitro systems.</p><p><strong>Summary: </strong>In this review, we summarize transplantable orthotopic CRC mouse models and discuss their establishment techniques, applications, and limitations. A systematic literature search was performed in PubMed using the terms \"murine colorectal cancer model,\" \"orthotopic colorectal cancer,\" \"cecal implantation,\" \"rectal cancer mouse model,\" and \"tumor organoid transplantation.\" We describe commonly used approaches, including open surgical implantation and minimally invasive transanal methods, and compare key design choices such as tumor source (syngeneic vs. xenograft), implantation site, and readouts for local growth and metastasis. We also highlight practical considerations, including immune competence and technical complexity that influence reproducibility and model selection for specific research questions.</p><p><strong>Key messages: </strong>Transplantable orthotopic models are indispensable for studying site-specific tumor-host interactions and metastasis in CRC. Model choice should be guided by the intended biological question, immune context, and procedural feasibility. Continued refinement and standardization, including integration of immune and microenvironmental components, will further improve translational relevance.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-ERCP Pancreatitis: New Insights, Evolving Therapies, and the Road Ahead.","authors":"Zaheer Nabi, D Nageshwar Reddy","doi":"10.1159/000551545","DOIUrl":"https://doi.org/10.1159/000551545","url":null,"abstract":"<p><strong>Background: </strong>Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most common and clinically relevant complication of ERCP. While mechanical, hydrostatic, and chemical injury have been classically implicated in its pathogenesis, recent studies highlight additional mechanisms, including microvascular dysfunction, pancreatic steatosis, and calcium-calcineurin-driven acinar injury. Recent advances have reshaped our understanding of risk factors, optimal cannulation techniques, pharmacologic prophylaxis, and early diagnostic approaches.</p><p><strong>Summary: </strong>This review combines established knowledge with current evidence for the prevention and early recognition of PEP. The number of pancreatic duct wire passages has been identified as a strong, objective predictor of PEP, beyond the traditional definitions of difficult cannulation. The DIPPP randomized trial confirms that rectal indomethacin and diclofenac offer equivalent prophylactic efficacy. Somatostatin analogs reduce overall and moderate PEP but show limited impact on mild or severe disease. Pancreatic steatosis has emerged as a significant risk phenotype. Perfusion CT provides a promising physiologic biomarker for early detection of PEP. These data support the development of a prevention algorithm integrating NSAIDs, evidence-based cannulation strategy, selective pancreatic duct stenting, lactated Ringer's hydration, and early post-procedure risk assessment.</p><p><strong>Key messages: </strong>Established interventions supported by high-quality RCTs: (1) Rectal NSAIDs remain the cornerstone of PEP prophylaxis and should be given to all the eligible patients. (2) Prophylactic pancreatic duct stenting provides additional benefit in high-risk cases. (3) Minimizing papillary trauma through guidewire-first cannulation and early adoption of advanced rescue techniques is a critical modifiable determinant of PEP risk. Adjunctive or investigational strategies: (1) Aggressive hydration should be individualized as trials do not show consistent incremental benefit over NSAIDs alone. (2) Combination regimens (NSAIDs + hydration or stenting) appear promising in indirect analyses, but definitive superiority over optimized NSAID-based prophylaxis remains unproven. (3) Emerging approaches including calcineurin inhibition, cryoprevention, and AI-based risk prediction are mechanistically compelling but remain investigational pending prospective validation.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"After the Congress Is before the Congress: NEXT GEN Day at Viszeralmedizin 2026 - Empowering Future Visceral Medicine Specialists.","authors":"Lisa K Deharde, Verena Tripke, Johanna Strotmann, Anna-Lena Abels, Stefanie Brunner, Josefine Schardey","doi":"10.1159/000551287","DOIUrl":"https://doi.org/10.1159/000551287","url":null,"abstract":"<p><p>NEXT GEN Day is a joint initiative of the CAJC (Working Group of Young Surgeons of the DGAV) and JUGA, the young professionals' section of the DGVS, embedded within the annual Congress for Visceral Medicine. Targeting residents and early career specialists, the program integrates interdisciplinary education, hands-on workshops, and structured networking at the interface of surgery and internal medicine. Following record participation in 2025, NEXT GEN 2026 will return with an updated program, including the renewed \"President Meets NEXT GEN\" format, further strengthening education and collaboration in visceral medicine.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Therapy in Barrett's Esophagus.","authors":"Julia L Gauci, Roos E Pouw","doi":"10.1159/000550939","DOIUrl":"10.1159/000550939","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic eradication therapy (EET) is the standard of care for dysplastic Barrett's esophagus (BE) and early esophageal adenocarcinoma (EAC). Successful outcomes require a structured, evidence-based approach.</p><p><strong>Summary: </strong>Recognising and removing visible neoplasia is a crucial step in EET. Endoscopic mucosal resection (EMR) is efficient and safe for most dysplastic lesions, while endoscopic submucosal dissection (ESD) enables en bloc resection and more precise staging when submucosal invasion is suspected. Radiofrequency ablation remains the most established method for eradicating residual BE, with hybrid APC and cryoballoon ablation emerging as potential alternatives. Optimal therapy also depends on appropriate patient selection, multidisciplinary team involvement (MDT), effective acid control, and structured surveillance.</p><p><strong>Key messages: </strong>(1) EET is effective, safe, and now central to managing dysplastic BE and early EAC. (2) High-quality optical diagnosis, careful technique selection, meticulous resection, and accurate histopathology assessment underpin good outcomes. (3) In most cases, ablation is recommended for durable remission, with RFA the first-line option. (4) Care is best delivered by specialist, multidisciplinary centres that adapt therapy to the individual patient within their wider clinical context.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Appendicitis in Pregnancy: A Single-Center Retrospective Cohort Study.","authors":"Ivana Lochmanová, Jan Zapletal, Borek Sehnal, Petr Waldauf, Martin Oliverius","doi":"10.1159/000545862","DOIUrl":"10.1159/000545862","url":null,"abstract":"<p><strong>Introduction: </strong>During pregnancy, acute appendicitis is responsible for about two-thirds of nontraumatic surgical emergencies. The aim of this study was to investigate whether the group of pregnant patients differs from the group of the normal population in perioperative features and whether surgery during pregnancy affects its further course.</p><p><strong>Methods: </strong>We retrospectively analyzed a cohort of 1,054 patients who underwent surgery for signs of acute appendicitis. The cohort included 16 pregnant patients (1.5%), 6 patients (37.5%) in the first trimester, 10 patients (62.5%) in the second. Perioperative features of the groups were compared, and postoperative course of pregnancy was followed.</p><p><strong>Results: </strong>We discovered that pregnant patients had a higher ratio of negative appendectomies (25% vs. 5.3%, <i>p</i> = 0.010) and shorter operating time (40 min vs. 51 min, <i>p</i> = 0.013).</p><p><strong>Conclusion: </strong>Based on our data, acute appendectomy in pregnancy is associated with a higher rate of negative appendectomy and shorter operating time. Due to the small number of pregnant patients in the group and the occurrence of only one first trimester miscarriage of unknown etiology, it is not possible to clearly draw conclusion about the impact of acute appendectomy on the further course of pregnancy and further investigation is needed.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed Tomography Texture Analysis of Lymph Nodes for Improved Staging Accuracy in Patients with Colon Cancer.","authors":"Jakob Leonhardi, Matthias Mehdorn, Sigmar Stelzner, Uwe Scheuermann, Anne-Kathrin Höhn, Daniel Seehofer, Timm Denecke, Hans-Jonas Meyer","doi":"10.1159/000546336","DOIUrl":"10.1159/000546336","url":null,"abstract":"<p><strong>Introduction: </strong>Texture analysis can provide quantitative imaging markers and better characterize tumor tissue in oncological imaging. The present analysis investigated the diagnostic benefit of computed tomography (CT)-derived texture analysis to categorize and stage lymph nodes in patients with colon cancer.</p><p><strong>Methods: </strong>In this study, 85 patients were included (<i>n</i> = 39 females, 45.9%) with a mean age of 70.3 ± 14.8 years. All patients were surgically resected, and the lymph nodes were histopathologically analyzed. All investigated lymph nodes were further investigated with texture analysis using the MaZda package.</p><p><strong>Results: </strong>Out of a total of 279 extracted CT texture features, 7 parameters independently showed statistically significant differences between lymph node positive to negative ones. For instance, the texture parameter S(1,0)AngScMom showed statistically significant differences regarding lymph node metastasis status (0.007 ± 0.004 for N0 vs. 0.005 ± 0.001 for N1-2, <i>p</i> = 0.001). A multivariate model was developed based on <i>n</i> = 7 independent texture parameters. The diagnostic accuracy reached an area under the curve of 0.79 (95% CI: 0.69-0.89) with a sensitivity of 0.77 and a specificity of 0.70, resulting in an accuracy of 0.73.</p><p><strong>Discussion: </strong>Texture analysis can improve the diagnostic accuracy for nodal CT staging in patients with colon cancer. Further validation studies are needed to confirm the present results.</p>","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":"7-14"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Metastatic Colorectal Cancer in Pregnancy: A Systematic Review of a Multidisciplinary Challenge.","authors":"Florian Scholz, Teresa Starrach, Julian Holch, Volker Heinemann, Ulrich Wirth, Jens Werner, Florian Kühn","doi":"10.1159/000545464","DOIUrl":"10.1159/000545464","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The global incidence of colorectal cancer (CRC) in patients under 50 years of age, also referred to as \"early-onset\" CRC (EO-CRC), has increased significantly in recent decades. According to current projections, CRC is expected to become the leading cause of cancer-related deaths among individuals aged 20-49 by 2030. The American Cancer Society noted a significant rise in the proportion of CRC cases in adults under 55, increasing from 11% in 1995 to 20% by 2019. Furthermore, the incidence of EO-CRC is projected to surge by over 140% by 2030. At the same time, there has been a trend in industrialized countries towards a later age at first childbirth. In 2022, the mean age of women at the birth of their first child was over 30 years in seven EU Member States. Given those trends, an increase in gestational CRC diagnoses is anticipated, but the number of reports on the treatment of CRC during pregnancy is very limited.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Due to bioethical concerns and the rarity of the condition, there is a lack of clinical studies and evidence-based guidelines. In this context, we conducted a literature review of the published case reports and series on patients diagnosed with metastatic CRC during pregnancy and complemented the results with an illustrative case from our institution. We aimed to summarize the current knowledge on the treatment of CRC during pregnancy and to advance the discussion on optimal therapeutic approaches in this complex clinical situation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive literature review was conducted using PubMed, MEDLINE, and Embase to identify studies and case reports on metastatic CRC during pregnancy, focusing on therapeutic interventions and clinical outcomes. Articles published between 1990 and 2024 were screened; studies where treatment was initiated postpartum were excluded. Data on patient characteristics, treatment, and outcomes were extracted and synthesized narratively due to heterogeneity in study designs. An anonymized illustrative case was constructed from a retrospective analysis of patient records.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Our literature review identified 26 cases of metastatic CRC during pregnancy, reported in both case reports and case series. The primary symptoms at diagnosis were abdominal pain, constipation, and rectal bleeding. Most cases involved hepatic metastases, with some reports noting additional pulmonary, peritoneal, or ovarian spread. Chemotherapy, including FOLFOX and FOLFIRI regimens, was administered in many cases during pregnancy, with mixed outcomes. Several reports documented normal child development and maternal survival, while others noted adverse outcomes such as stillbirth, small-for-gestational-age infants, and maternal mortality. Surgical intervention was performed in select cases, with varying maternal and fetal outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Although data on the treatment of metastatic CRC during pre","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":" ","pages":"27-37"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}