Visceral Medicine最新文献_第3页

Microbiota Manipulation as an Emerging Concept in Cancer Therapy 操纵微生物群是癌症治疗的新概念

IF 1.9 4区医学

Visceral Medicine Pub Date : 2023-12-12 DOI: 10.1159/000534810

M. Spalinger, Michael Scharl

{"title":"Microbiota Manipulation as an Emerging Concept in Cancer Therapy","authors":"M. Spalinger, Michael Scharl","doi":"10.1159/000534810","DOIUrl":"https://doi.org/10.1159/000534810","url":null,"abstract":"Background: The human body is colonized by billions of bacteria that provide nutrients to the host, train our immune system, and importantly affect our heath. It has long been suggested that microbes might play a role in tumor pathogenesis; however, compelling evidence was only provided in the past decades when novel detection methods that do not depend on culturing techniques had been developed. Summary: The microbiome impacts tumor development and anti-tumor therapies on various levels. Bacteria can promote or suppress tumor growth via direct interactions with cancer cells, production of metabolites that promote or inhibit tumor growth, and via stimulation or suppression of the local and systemic immune response. Cancer patients harbor a distinct microbiome when compared to healthy controls, which could potentially be employed to detect, identify, and treat cancer. Manipulation of the microbiome either via supplementation of single strains, bacterial consortia, fecal microbiota transfer or the use of pre- and probiotics has been suggested as therapeutic approach to directly target tumor growth or to enhance the efficacy of current state-of-the-art treatment options. Key Messages: (1) Bacteria have a tremendous impact on anti-cancer immune responses. (2) Cancer patients harbor a distinct microbiome when compared to healthy controls. (3) The microbiome seems to be cancer-type specific. (4) Exploitation of bacteria to promote anti-tumor therapy is a novel, very promising venue in cancer treatment.","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"33 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Open-Pore Film Drainage Systems in Endoscopic Vacuum Therapy: Current Status and Review of the Literature 开孔膜引流系统在内窥镜真空治疗中的作用：现状与文献综述

IF 1.9 4区医学

Visceral Medicine Pub Date : 2023-12-11 DOI: 10.1159/000535029

Konstantinos Kouladouros, Dörte Wichmann, Gunnar Loske

{"title":"The Role of Open-Pore Film Drainage Systems in Endoscopic Vacuum Therapy: Current Status and Review of the Literature","authors":"Konstantinos Kouladouros, Dörte Wichmann, Gunnar Loske","doi":"10.1159/000535029","DOIUrl":"https://doi.org/10.1159/000535029","url":null,"abstract":"Background: Endoscopic vacuum therapy (EVT) is an increasingly popular endoscopic technique used for the treatment of wall defects in the gastrointestinal tract. Open-pore film drainage (OFD) systems are a new addition to the armamentarium of EVT and have shown encouraging results in a wide spectrum of applications. The aim of this review is to summarize the current literature on the applications of OFD systems in the gastrointestinal tract. Summary: Open-pore film drainage (OFD) systems have been used for the treatment of several defects of the gastrointestinal tract. The small size and easy placement of these devices make them very useful, particularly for the treatment of defects that are small in size or difficult to reach. OFDs have been successfully used for both perforations and anastomotic leaks in various locations, with most reports focusing on the treatment of duodenal defects, although successful applications in the esophagus, stomach, and colon have also been reported. Lately, the role of OFDs in preemptive EVT has also been explored. Key Messages: OFD systems are easy to use, particularly for small defects and challenging localizations. The current literature, consisting mainly of small case series and case reports, shows encouraging results, but further prospective studies are needed to explore and verify the indications and technical aspects of this innovative method.","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"43 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiota Therapy: Ready for Clinical Practice? 微生物群疗法:准备好临床实践了吗?

4区医学

Visceral Medicine Pub Date : 2023-11-14 DOI: 10.1159/000534778

Michael Scharl, Gerhard Rogler

引用次数: 0

Interdisciplinary Frontiers – The View of Surgery 跨学科的前沿-外科的观点

4区医学

Visceral Medicine Pub Date : 2023-10-27 DOI: 10.1159/000533743

Pompiliu Piso, Maximilian Babucke, Vanessa Schmitt, Sebastian Blaj

引用次数: 0

Hydatid Disease of the Liver. 肝棘球蚴病。

IF 1.8 4区医学

Visceral Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-25 DOI: 10.1159/000533807

Virandera Pal Bhalla, Souvik Paul, Ernst Klar

{"title":"Hydatid Disease of the Liver.","authors":"Virandera Pal Bhalla, Souvik Paul, Ernst Klar","doi":"10.1159/000533807","DOIUrl":"10.1159/000533807","url":null,"abstract":"Background: Echinococcosis also known as hydatid disease is a zoonotic parasitic disease caused by a tapeworm. It has a worldwide distribution. For long, it was thought to be a problem of the poorly sanitized \"third world\" and not given the importance it deserved. However, its occurrence in countries like Australia and New Zealand and recently in countries in Central Europe has meant that it is included in a WHO list of neglected diseases, has recently been the subject of extensive epidemiological studies, and has been the recipient of increased research funding.Summary: The diagnosis is still based on clinical presentation in an endemic area corroborated with typical findings on imaging which routinely include ultrasound and CT scan. Serological tests have been used in some centers to support the diagnosis. Treatment depends on the site of involvement and can vary from wait and watch to extensive radical surgical procedures. The common element of all treatments is the addition of albendazole which forms an essential cornerstone of all treatment protocols. Inspite having been used for a fairly long time, there is still no consensus on the dose, duration, and timing of therapy with albendazole.Key message: Hydatid disease continues to be a significant global health problem inspite of a good understanding of its life cycle and rising standards of public sanitation. Though diagnosis is straightforward and not expensive, treatment can sometimes be complicated. The addition of albendazole to all treatment protocols is an important advance, but firm guidelines on duration of its use are still awaited.","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"39 5","pages":"112-120"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Value of Clip-and-Snare Assisted Endoscopic Submucosal Resection in Treatment of Rectal Neuroendocrine Tumors. 钳夹和圈套辅助内镜下黏膜下切除术治疗直肠神经内分泌肿瘤的临床价值。

IF 1.8 4区医学

Visceral Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-05 DOI: 10.1159/000533393

Xin-Tong Jiang, Yang Hu, Jian Gong, Shi-Bin Guo

{"title":"Clinical Value of Clip-and-Snare Assisted Endoscopic Submucosal Resection in Treatment of Rectal Neuroendocrine Tumors.","authors":"Xin-Tong Jiang, Yang Hu, Jian Gong, Shi-Bin Guo","doi":"10.1159/000533393","DOIUrl":"10.1159/000533393","url":null,"abstract":"Introduction: The aim of the study was to introduce a new endoscopic technology, clip-and-snare assisted endoscopic submucosal resection (CS-ESMR), for treatment of rectal neuroendocrine tumors (NETs) and then to investigate the therapeutic value of CS-ESMR.Methods: In this retrospective study, 67 patients who underwent endoscopic treatment of rectal NETs from March 2017 to December 2021 were analyzed. According to the endoscopic resection methods (endoscopic mucosal resection [EMR], CS-ESMR, and endoscopic submucosal dissection [ESD]), the cases were divided into CS-ESMR group (27 cases), ESD group (31 cases), and EMR group (9 cases). The pathological R0 resection rate and the incidence of adverse events (bleeding and perforation) were compared among the three groups.Results: There was a significant difference about the pathological R0 resection between the CS-ESMR group and the EMR group and between the CS-ESMR group and the ESD group (both p < 0.05). Compared with ESD group, the procedure time, intraoperative bleeding, and the cost of CS-ESMR group are significantly decreased (p < 0.001, p < 0.05, p < 0.001, respectively).Conclusion: CS-ESMR may be a safe and effective treatment for rectal NETs with a diameter of less than 10 mm, without muscularis propria invasion and metastasis.","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"39 5","pages":"140-147"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Ultrasound in Pancreatology: Focus on Inflammatory Diseases and Interventions. 胰腺科的内镜超声：聚焦炎症性疾病和介入治疗。

IF 1.8 4区医学

Visceral Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-05 DOI: 10.1159/000533433

Francesco Vitali, Sebastian Zundler, Daniel Jesper, Deike Strobel, Dane Wildner, Nicoló de Pretis, Luca Frulloni, Stefano Francesco Crinó, Markus F Neurath

{"title":"Endoscopic Ultrasound in Pancreatology: Focus on Inflammatory Diseases and Interventions.","authors":"Francesco Vitali, Sebastian Zundler, Daniel Jesper, Deike Strobel, Dane Wildner, Nicoló de Pretis, Luca Frulloni, Stefano Francesco Crinó, Markus F Neurath","doi":"10.1159/000533433","DOIUrl":"10.1159/000533433","url":null,"abstract":"Background: Endoscopic ultrasound (EUS) is a main tool in pancreatology for both diagnosis and therapy. It allows minimally invasive differentiation of various diseases, with a minimal degree of inflammation or anatomic variations. EUS also enables interventional direct access to the pancreatic parenchyma and the retroperitoneal space, the pancreatic duct, the pancreatic masses, cysts, vascular structures for diagnostic and therapeutic purposes.Summary: This review aimed to summarize the new developments of EUS in the field of pancreatology, with special interest on inflammation and interventions. EUS enables way to perform pseudocyst drainage, necrosectomy, transenteral drainage and transenteric access of the main pancreatic duct, or the direct visualization or therapy of vascular structures adjacent to the pancreas.Key messages: EUS has a deep impact on pancreatology, and the development of new diagnostic and interventional approaches to the retroperitoneal space and the pancreas has increased in the last years exponentially, allowing minimal invasive diagnostics and therapy and avoiding surgery and percutaneous therapy.","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"39 5","pages":"131-139"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parasitic Disease of the Gastrointestinal Tract: Surgical Aspects. 胃肠道寄生虫病：外科方面。

IF 1.8 4区医学

Visceral Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-15 DOI: 10.1159/000533352

Ernst Klar

引用次数: 0

Diagnostic Endoscopic Ultrasound in Pancreatology: Focus on Normal Variants and Pancreatic Masses. 胰腺科的诊断性内镜超声：关注正常变异和胰腺肿块。

IF 1.8 4区医学

Visceral Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-05 DOI: 10.1159/000533432

Francesco Vitali, Sebastian Zundler, Daniel Jesper, Dane Wildner, Deike Strobel, Luca Frulloni, Markus F Neurath

{"title":"Diagnostic Endoscopic Ultrasound in Pancreatology: Focus on Normal Variants and Pancreatic Masses.","authors":"Francesco Vitali, Sebastian Zundler, Daniel Jesper, Dane Wildner, Deike Strobel, Luca Frulloni, Markus F Neurath","doi":"10.1159/000533432","DOIUrl":"10.1159/000533432","url":null,"abstract":"Background: Endoscopic ultrasound (EUS) is a main tool in gastroenterology for both diagnosis and exclusion of pancreatic pathology. It allows minimally invasive assessment of various diseases or anatomic variations affecting the pancreas also with the help of new Doppler technologies, elastography, contrast-enhanced imaging including post hoc image processing with quantification analyses, three-dimensional reconstruction, and artificial intelligence. EUS also allows interventional direct access to the pancreatic parenchyma and the retroperitoneal space, to the pancreatic duct, pancreatic masses, cysts, and vascular structures.Summary: This review aimed to summarize new developments of EUS in the field of pancreatology. We highlight the role of EUS in evaluating pancreatic pathology by describing normal anatomic variants like pancreas divisum, pancreatic lipomatosis, pancreatic fibrosis in the elderly and characterizing pancreatic masses, both in the context of chronic pancreatitis and within healthy pancreatic parenchyma. EUS is considered the optimal imaging modality for pancreatic masses of uncertain dignity and allows both cytological diagnosis and histology, which is essential not only for neoplastic conditions but also for tailoring therapy for benign inflammatory conditions.Key messages: EUS plays an indispensable role in pancreatology and the development of new diagnostic and interventional approaches to the retroperitoneal space and the pancreas exponentially increased over the last years. The development of computer-aided diagnosis and artificial intelligence algorithms hold the potential to overcome the obstacles associated with interobserver variability and will most likely support decision-making in the management of pancreatic disease.","PeriodicalId":56003,"journal":{"name":"Visceral Medicine","volume":"39 5","pages":"121-130"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral Medicine: The View of GI 内脏医学:GI的观点

4区医学

Visceral Medicine Pub Date : 2023-09-12 DOI: 10.1159/000533435

Peter Huebener, Tania Amin, Ansgar W. Lohse

引用次数: 0