Practica Medicala最新文献

{"title":"Prognostic factors for relapse in young breast cancer patients","authors":"Oana Şaptefraţi, X. Bacinschi, D. Badiu, G. Popescu, A. Zgura, L. Galeș, D. Serban, R. Anghel","doi":"10.37897/rjmp.2022.2.3","DOIUrl":"https://doi.org/10.37897/rjmp.2022.2.3","url":null,"abstract":"Objective. Breast cancer is the leading cause of cancer mortality in women. Most deaths from breast cancer are due to recurrences or metastatic disease. The purpose of this study is to determine the impact of age in treatment strategy correlated with clinicopathological features. Methodology: In this retrospective study, 60 female patients with histologically-confirmed primary breast cancer were included. The women were treated in the Oncofort Hospital Bucharest, Romania between 2018 and 2020. The estrogen receptor (ER), progesterone receptor (PR) and HER2 status were determined using immunohistochemistry. Results. The mean age was 34.14 years (range = 24 – 40 years). Invasive ductal carcinoma of no specific type was seen in 84.1% of patients. The rates of grade I, II and III carcinomas were 6.7%, 28,3% and 65%, respectively. Among all patients, 33.3% had estrogen receptor, progesterone receptor positive tumors and 66.66% had estrogen receptor, progesterone receptor negative tumors. The proportion of patients overexpressing oncoprotein HER2 was 13.3%. Conclusion. Prognostic value of proliferation index (Ki-67) and hormonal receptors, may vary depending on age.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46092638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential protective effect of Hydrastasis canadensis on the cervico-vaginal lesions","authors":"S. Petrea, N. Bacalbaşa, I. Bălescu, C. Stoica, L. Pop, V. Varlas, Cristina Martac, Andrei Voichitoiu","doi":"10.37897/rjmp.2022.2.7","DOIUrl":"https://doi.org/10.37897/rjmp.2022.2.7","url":null,"abstract":"Homeopathic principles have been widely investigated and proposed even from the ancient times in order to treat different wounds, to prevent inflammation and to treat infections. Although initially they have been tested in regard to skin wounds, their use was also tested in regard to different internal viscera with promising results. Therefore, such extracts have been proposed as part of the topical products proposed for treating certain pathologies of the uterine cervix such as infections, cervicitis or even in order to prevent the risk of uterine cervical cancer development. The aim of the current paper is to discuss about the potential protective role of Hydrastasis canadensis in treating different cervico-vaginal lesions.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43168815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous grafts for vascular resections after extended resections for locally advanced or borderline resectable pancreatic tumors","authors":"N. Bacalbaşa, I. Bălescu, C. Stoica, L. Pop, V. Varlas, Cristina Martac, Andrei Voichitoiu, Tarig Massawi","doi":"10.37897/rjmp.2022.2.6","DOIUrl":"https://doi.org/10.37897/rjmp.2022.2.6","url":null,"abstract":"Once the surgical techniques improved, vascular resections have been proposed in order to increase the radicality in borderline or locally advanced pancreatic cancer. Traditionally, vascular reconstructions in such cases have been performed by using synthetic grafts; however, these prostheses have been associated with significant complications such as infection, thrombosis or leaks, leading to a very difficult postoperative recovery. Therefore, attention was focused on replacing these artificial materials with biological ones such as cadaveric grafts, autologous grafts or even animal grafts. These grafts proved to be more efficient when it comes to the rates of perioperative complications, thrombosis, infection or leakage being more rarely reported. The aim of the current paper is to discuss about the most frequently used biological grafts.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48784162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional rhinoseptoplasty vs Preserving rhinoplasty – Literature Review","authors":"Rodica Urs, I. Anghel, Adriana Oana Rajput Anghel, A. Anghel","doi":"10.37897/rjmp.2022.1.1","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.1","url":null,"abstract":"The nasal pyramid is an essential structure in the physiognomy of the individual, and the external appearance of the nose is very important in the modern society in which we find ourselves. That is why the anatomical diversity of the nasal pyramids has led to the development of various surgical technique for reshaping the nasal structures. Rhinoseptoplasty has changed considerably in recent decades, from a standardized reduction procedure to a procedure focused on very differentiated problems, reductions, relocations and augmentations of frequently combined tissues Most surgeons around the world have agreed on a new concept of surgery, that of preserving different structures of the nose given the fact that the principle of preservation is better than that of resection, with a more natural result. Material and method. Review of the two surgical concept of rhinoplasty regarding the main advantages and disadvantages of each type of rhinoseptoplasty surgery. Results and conclusions. Proper patient selection is important for good results. Before surgery, nasal analysis should be performed clinically and photographically to determine the necessary corrections. Rhinoplasty is still one of the most challenging procedures in facial plastic surgery. With the right surgical experience and proper surgical techniques the results are most often good and the patients are satisfied.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42995268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between hand grip strength and NYHA class II-III heart failure","authors":"Diana Turcu, Anca-Ioana Roman, Matei Teodorescu, M. Popescu, R. Ploeşteanu, L. Ghilencea, N. Gică, Andreea GROSU BULARDA, M. Berteanu","doi":"10.37897/rjmp.2022.1.8","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.8","url":null,"abstract":"The physical rehabilitation of patients with cardiovascular pathology is poorly studied and developed in our country, especially in patients with heart failure. There are studies in the literature that confirm that a decrease in the grasping force of the hand is associated with an increase in morbidity and mortality. The physical deconditioning of patients with heart failure can be assessed with the help of the Amadeo robot, which is a device capable of measuring the flexion and extension force of the hand in kilograms. Material and methods. We prospectively analyzed a group of 44 patients diagnosed with heart failure class II-III NYHA who were hospitalized between June 17 and July 15, 2019 in the Cardiology Department of Elias Hospital. We evaluated the grasping force of the hand of patients with heart failure using the Amadeo robot. The Amadeo robot is a device used in the rehabilitation of stroke patients, which can measure the flexion and extension force of the hand using sensors attached to the hand and fingers. Results. By evaluating patients with heart failure using the Amadeo robot, the average value of the hand extension force was 2.364 kg at admission and 2.264 kg at discharge. The flex-ion force of the hand was 6.78 kg at admission and 7.361 kg at discharge. Patients enrolled in the study who had valvulopathies, atrial fibrillation and diabetes had a lower value of the extension force of the hand compared to patients with heart failure who did not have these pathologies. Patients with valvulopathies, high blood pressure, and ischemic heart disease also had a lower flexion strength than those without these diseases. Conclusions. It is known that the grasping force of the hand is an important indicator in assessing the fragility status of patients. Patients with heart failure are frail patients with multiple comorbidities in which physical deconditioning acts as a negative prognostic factor on morbidity, mortality, and increased hospitalization rates. Thus, the physical rehabilitation of patients with heart failure is essential for increasing the quality of life and also for decreasing morbidity and mortality and the rate of hospitalization.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46927904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiazides and mineralocorticoid receptor antagonists in chronic kidney disease","authors":"A. Niculae, Mihai-Emil Gherghina, M. Tiglis, T. Neagu, I. Peride, I. Checherita","doi":"10.37897/rjmp.2022.1.3","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.3","url":null,"abstract":"The latest treatment guidelines for patients with arterial hypertension continues to indicate as the first line therapy a minimal association between renin-angiotensin system (RAS) blockers and a thiazide-type or a thiazide-like diuretic. In addition, according to 2018 ESC/ESH (European Society of Cardiology/European Society of Hypertension) guidelines for the management of arterial hypertension, a mineralocorticoid receptor antagonist may be added in resistant hypertension cases (uncontrolled hypertension under at least 3 classes of antihypertensive drugs including a RAS blocker, thiazide diuretic and a calcium channel blocker) for general population. For chronic kidney disease (CKD) patients, achieving the optimal blood pressure (BP) level can be difficult because high complication rates can be encountered in any antihypertensive class mentioned, especially for RAS blockers and mineralocorticoid receptor inhibitors. This brief review aims to highlight the importance of diuretics use in CKD patients and the boundaries of their usage.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44041842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilm assessment on voice prosthesis used for vocal rehabilitation in laryngectomized patients","authors":"Mara Caciandone, Maria Minodora Matasaru, A. Bunea, R. Popescu, A. Bîrcă, A. Anghel, I. Anghel","doi":"10.37897/rjmp.2022.1.6","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.6","url":null,"abstract":"Background. Voice rehabilitation in patients undergoing total laryngectomy is fundamental for the social reinsertion of the patient. The gold standard to fulfill this objective is the implantation of a voice prosthesis (VP). The main limitation of VP use is the blockage with fluids and deterioration due to biofilm colonization, which leads to frequent replacements. Objectives. The purpose of the study is to identify the microorganisms that develop within the biofilm colonizing the collected VPs surfaces and the implantation situ and to determine whether that biofilm formation is the main reason for deterioration of VP proper function, leading to frequent replacements of VP. Material and methods. In our retrospective observational study we assessed the biofilm composition of 41 dysfunctional VP from 10 laryngectomized patients by collecting samples for microbiologic tests. The morphology of the biofilm was also observed using scanning electron microscopy, a precious tool for providing an extensive understanding of the microbial colonizing the behavior of the medical device. Outcomes. The microbiologic evaluation revealed a complex, mixed bacterial-fungal multispecies composition and the average time of exploitation for each VP was established. Deterioration of the silicone properties contributes to a large extent to the malfunction of VP. Conclusions. Further research in the medical engineering field and innovative approaches are expected to improve the device lifespan, by proving anti-biofilm properties and thus enhancing the quality of life for laryngectomized patients.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41474191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thumb Carpometacarpal joint dislocation: Case report and short review","authors":"T. Neagu, M. Tiglis, I. Sebe, L. Răducu, I. Lascar","doi":"10.37897/rjmp.2022.1.9","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.9","url":null,"abstract":"Thumb carpometacarpal (CMC) joint dislocation is rare, and the treatment options may vary from conservatives’ strategies to open reduction and fixation. In face of pain and joint instability persistence, surgical intervention is required. We present the case of a 67-year-old male that was referred to our hospital with pain and edema of the left hand, after the failure of a conservative treatment. After initial refusal of open surgery, due to the persistent joint instability, open reduction of the CMC joint dislocation was performed, and stabilized using two percutaneous Kirschner wires after repairing the joint capsule and dorsoradial ligament. Immobilization was required for 4 weeks. After that, the Kirschner wires were removed. Along with physiotherapy, the follow-up showed no pain persistence nor CMC joint luxation reoccurrence while the joint recovered its mobility. Further studies are required in order to determine the optimal therapy for such cases and to provide standardized recommendations, taking into account that the restoration of thumb CMC joint mobility is one of the most important goals in hand surgery.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48561434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A statistical analysis of acute ischemic stroke before and during the COVID-19 pandemic","authors":"Bogdan Ioan Coculescu, C. Stocheci, Alexandra Ripszky Totan, E. Coculescu","doi":"10.37897/rjmp.2022.1.7","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.7","url":null,"abstract":"Strokes are very serious neurological disorders, most often with sudden onset, unpredictable evolution and very high mortality. According to the World Health Organization, about 15 million people survive a stroke each year, and 5-6 million die each year from it. Globally, strokes are one of the leading causes of morbidity and mortality. Relatively recent clinical data show that strokes are the second leading cause of death worldwide. Thus, in Europe, new strokes occur annually in 100-200 cases per 100,000 inhabitants. For Romania, the epidemiological analysis of the data of our study shows that strokes are the leading cause of death in vascular diseases, i.e. cerebrovascular and cardiovascular diseases put together.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48824553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of lidocaine in perioperative pain and recovery management","authors":"M. Tiglis, T. Neagu, L. Răducu, I. Lascar","doi":"10.37897/rjmp.2022.1.5","DOIUrl":"https://doi.org/10.37897/rjmp.2022.1.5","url":null,"abstract":"Pain control is crucial in surgical patients, being an essential part of enhanced recovery after surgery protocols. Lidocaine, an amide local anesthetic, was primarily used as an antiarrhythmic. It has analgesic, antihyperalgesic and anti-inflammatory effects, with various actions on cardiovascular, respiratory, and digestive systems. Lidocaine has been shown to also have antithrombotic, antimicrobial, and antitumoral effects. Numerous studies have reported its safe profile and role in managing perioperative pain after breast cancer, abdominal, genitourinary, gynecologic, obstetric, orthopedic, cardiothoracic, spine, thyroid, and upper airway surgery. Lidocaine, as part of multimodal analgesia, also shows promising results in ambulatory surgery. Therefore, the use of intravenous lidocaine in the perioperative period is mainly associated with better pain control, reduced opioid use, diminished incidence of postoperative nausea, vomiting, and ileus, and exhibits antithrombotic effects.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48157636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}