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The enigma of memory T cells in viral infections (including SARS-CoV-2) 病毒感染（包括严重急性呼吸系统综合征冠状病毒2型）中记忆T细胞之谜
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.5
S. Buzinschi
{"title":"The enigma of memory T cells in viral infections (including SARS-CoV-2)","authors":"S. Buzinschi","doi":"10.37897/rjmp.2022.3.5","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.5","url":null,"abstract":"Viral infections and vaccinations produce immune responses mostly through B cells (plasmocytes/ antibodies) and effector T cells (helper and cytotoxic). After removing the antigen, 90-95% of the effector cells disappear, but the remaining ones turn into T cells with long memory. The maintenance of cellular memory, the mode of information storage and the lifespan of T cells are insufficiently known. After measles, resident T cells in the plasma will offer protection only against the measles virus, generating a long period of immunodepression (immune amnesia).After the flu, memory T cells generate immune protection for 1-2 years for secretory IgA and longer for serum IgG. In SARS-CoV-2 infection, memory T cells (B and T) respond quickly to reinfection for 8-10 months. In conditions of intense stimulation in SARS-CoV-2, SARS-CoV, MARS infection, marked leukopenia occurs with lymphopenia generating immunodepression and high mortality, disorders similar to septic shock. An important role in these disorders is played by the host's genetic structure and epigenome.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46946356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radically extended modified mastectomy of t4b-dn0-3m0 primary inflammatory breast cancer as a tool to minimize the risk of recurrence t4b-dn0-3m0原发性炎性乳腺癌症根治性改良乳房切除术可降低复发风险
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.2
I. Smolanka, I. Y. Bagmut, Movchan Oleksii Volodimirovich, M. Sheremet, Lyashenko Andriy Oleksandrovich, I. Kolisnyk, Y. Kostiuchenko, O. Piskorskyi, Anastasia Mikhailivna Hnatyuk, R. Hnatyuk
{"title":"Radically extended modified mastectomy of t4b-dn0-3m0 primary inflammatory breast cancer as a tool to minimize the risk of recurrence","authors":"I. Smolanka, I. Y. Bagmut, Movchan Oleksii Volodimirovich, M. Sheremet, Lyashenko Andriy Oleksandrovich, I. Kolisnyk, Y. Kostiuchenko, O. Piskorskyi, Anastasia Mikhailivna Hnatyuk, R. Hnatyuk","doi":"10.37897/rjmp.2022.3.2","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.2","url":null,"abstract":"Introduction. Breast cancer (BC) is an important public health problem. These are BC patients in young age, hereditary (BRCA-associated) BC patients, inflammatory BC patients, synchronous cancer patients etc. In case of a large size of tumor or diffuse form of BC we often need to use extended surgery techniques in order to perform it radically and minimize a risk of recurrence. The aim of the study to evaluate the effectiveness of surgery approaches in inflammatory BC patients. Materials and research methods. Тhe first stage of our research was to evaluate extended surgical treatment using techniques by Handelhail and Beck on the risk of local recurrence. The study included 39 patients with breast cancer T4b-dN0-3M0 who in the period from 2014 to 2019 received complex treatment at National Cancer Institute of Ukraine. Besides neo- and adjuvant chemotherapy, an extended radical mastectomy using a technique by Handelhail and Beck was performed in 19 patients. In 20 patients a traditional (Madden) modified radical mastectomy was done. Results. When studying the data of a group of 20 patients we received a very high percentage of recurrence. Recurrences were classified as locoregional if they occurred in the ipsilateral breast or the axillary or supraclavicular lymph nodes, and as distant metastasis, if they occurred at any other site. Radical extended modified mastectomy consisted in the removal of the mammary gland and adjacent skin along the perimeter with subcutaneous tissue at a distance of 2-3 cm outward from the macroscopic edges of the gland, subclavian-axillary-subscapularis lymphadenectomy. The resulting defect was closed using a technique by Handelhail and Beck. The use of extended surgery made it possible to improve recurrence-free survival.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47535533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloperoxidase (MPO) - possible diagnosis biomarker and risk stratification in myocardial inotropism deficit induced by chronic ischemic heart disease 髓过氧化物酶（MPO）-慢性缺血性心脏病引起的心肌向力缺陷的可能诊断生物标志物和风险分层
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.4
Gabi Valeriu Dincă, A. Diaconu, Bogdan Ioan Coculescu, G. Manole, H. Vultur, E. Coculescu
{"title":"Myeloperoxidase (MPO) - possible diagnosis biomarker and risk stratification in myocardial inotropism deficit induced by chronic ischemic heart disease","authors":"Gabi Valeriu Dincă, A. Diaconu, Bogdan Ioan Coculescu, G. Manole, H. Vultur, E. Coculescu","doi":"10.37897/rjmp.2022.3.4","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.4","url":null,"abstract":"The myeloperoxidase levels of 208 patients with ischemic heart disease hospitalized for congestive heart failure were tested at admission, and discharge after 14 days. The calculations for the serum average concentration/lot/date, were made, subsequent, using the values of the tested parameters regarding MPO (admission and discharge) the mean concentration/lot was made, regardless of time of determination. The calculated average values analyses of the three MPO serum parameters were constantly elevated and permanently matched the myocardial contractility deficiency class. The integrated data of the study, allows us to propose the MPO’s circulating concentration as a diagnosis and risk assessment biomarker in the etiology of myocardial ischemia for chronic cardiac failure.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43314036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study on metal versus zirconium dioxide infrastructure manufacturing in prosthetic rehabilitation in the maxillary frontal zone 金属与二氧化锆基础设施制造在上颌额骨修复中的比较研究
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.3
S. Drafta, V. Perieanu, R. Costea, O. Eftene, M. Burlibașa, Raluca Maria Manea, Florentina Caministeanu, Mircea Carabela, ioana-Cristina neagoe, Raluca Costea, I. Beuran, N. Măru
{"title":"Comparative study on metal versus zirconium dioxide infrastructure manufacturing in prosthetic rehabilitation in the maxillary frontal zone","authors":"S. Drafta, V. Perieanu, R. Costea, O. Eftene, M. Burlibașa, Raluca Maria Manea, Florentina Caministeanu, Mircea Carabela, ioana-Cristina neagoe, Raluca Costea, I. Beuran, N. Măru","doi":"10.37897/rjmp.2022.3.3","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.3","url":null,"abstract":"Prosthetic rehabilitation of the maxillary front teeth is an extremely laborious problem for the dental team, consisting of the dentist and the dental technician. If for the physiognomic component the most recommended materials are the ceramic masses, for the resistance substrate there are several variants. Conventional technologies using dental alloys and modern ones involving the use of zirconium dioxide can be used successfully in performing fixed prosthetic restorations in the maxillary frontal area, both options having both advantages and disadvantages, as we will describe in this material.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49569506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence and risk factors for visceral hemangiomas in children with infantile cutaneous hemangiomas 婴幼儿皮肤血管瘤患儿内脏血管瘤患病率及危险因素分析
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.1
Mirela Ritivoiu, I. Codreanu, V. Comanici, A. Bălănescu, P. Bălănescu, D. Matei, Alina Angelica Ciolpan, Alina-Maria Robu, I. Stan
{"title":"The prevalence and risk factors for visceral hemangiomas in children with infantile cutaneous hemangiomas","authors":"Mirela Ritivoiu, I. Codreanu, V. Comanici, A. Bălănescu, P. Bălănescu, D. Matei, Alina Angelica Ciolpan, Alina-Maria Robu, I. Stan","doi":"10.37897/rjmp.2022.3.1","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.1","url":null,"abstract":"One of the most frequent benign tumor pathology in children is represented by infantile hemangiomas (IHs). Although they are mostly cutaneous, sometimes they can develop at visceral level, the liver being the most common localization. Objectives. Estimating visceral hemangiomas (VHs) prevalence, and identification of risk factors for VHs in patients with infantile cutaneous hemangiomas (ICHs). Materials and methods. 6 years cross-sectional study (2012-2017) including children diagnosed with ICHs, admitted in I.N.S.M.C “Alfred-Rusescu“. All patients underwent an ultrasound screening for the detection of VHs. In order to identify possible risk factors, we collected demographic and perinatal data. Outcomes. 138 patients diagnosed with infantile cutaneous hemangiomas (ICHs) were included, with a slight predominance of girls (58%). The prevalence of the VHs in our study was 7,24% (10 patients). The liver was the most common visceral localization (7 patients). Conclusions. Female gender, preterm birth, low birth weight, and multiple gestations were described as potential risk factors for IHs. In our study, only multiple gestations tend to be associated with visceral hemangiomas, but without a significant statistical correlation.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42188142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovarian cancer – where are we today? 卵巢癌——我们今天在哪里?
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.8
I. Bălescu, Nicoale Bacalbasa, I. Brezean, C. Stoica, C. Tomescu, Cristina Martac, Andrei Voichitoiu, B. Gaspar
{"title":"Ovarian cancer – where are we today?","authors":"I. Bălescu, Nicoale Bacalbasa, I. Brezean, C. Stoica, C. Tomescu, Cristina Martac, Andrei Voichitoiu, B. Gaspar","doi":"10.37897/rjmp.2022.3.8","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.8","url":null,"abstract":"Despite progress reported in terms of paraclinical tests and imagistic studies, ovarian cancer represents one of the most lethal malignancies affecting women worldwide. Therefore attention was focused on identifying new prognostic markers in order to better identify candidates for primary cytoreductive surgery versus interval debulking surgery. Moreover, the wide introduction of the concept of personalized medicine gave the opportunity to benefit from more targeted treatments according to each patient needs and particularities. This is a literature review of the current status of ovarian cancer worldwide.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41522840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D supplementation – still a subject of debate 维生素D补充——仍然是一个争论的话题
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.7
Vlad Dima, G. Iancu, R. Bohîlțea, L. Nastase, A. Toma, V. Varlas, A. Davitoiu
{"title":"Vitamin D supplementation – still a subject of debate","authors":"Vlad Dima, G. Iancu, R. Bohîlțea, L. Nastase, A. Toma, V. Varlas, A. Davitoiu","doi":"10.37897/rjmp.2022.3.7","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.7","url":null,"abstract":"Vitamin D is a standard vitamin supplementation for children in many countries, used mainly for preventing rickets. Many studies were published about the efficiency of vitamin D administration in children and adults for other pathologies besides rickets. Very often the results were contradictory, but nevertheless, more and more articles are published on this matter. There is no consensus for the effective vitamin D dosage nor for the vitamin D normal serum values. Both vitamin D deficiency and vitamin intoxication are dangerous for children. Recently some studies are showing controversial data that advise being more careful in prescribing vitamin D as a routine.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41685114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breef overview of gestational diabetes mellitus 妊娠期糖尿病的Breef综述
Practica Medicala Pub Date : 2022-09-30 DOI: 10.37897/rjmp.2022.3.6
Madalina-Ioana Melestean-Bratu, C. Mehedințu, V. Varlas, Francesca Frîncu, R. Mateescu, A. Edu, Vlad Dima, C. Andreescu, M. Plotogea
{"title":"Breef overview of gestational diabetes mellitus","authors":"Madalina-Ioana Melestean-Bratu, C. Mehedințu, V. Varlas, Francesca Frîncu, R. Mateescu, A. Edu, Vlad Dima, C. Andreescu, M. Plotogea","doi":"10.37897/rjmp.2022.3.6","DOIUrl":"https://doi.org/10.37897/rjmp.2022.3.6","url":null,"abstract":"As obesity increases worldwide, so do the incidence of gestational diabetes mellitus (GDM) and the related perinatal complications. Pancreatic β-cell secretion is altered by hormonal changes during pregnancy. It appears, however, that patients who develop gestational diabetes have pre-existing insulin resistance. However, there are other risk factors to be considered, such as obesity, age, ethnicity, and polycystic ovary syndrome. Screening for gestational diabetes is very important to avoid maternal and fetal complications. For most pregnant women, glycemic control is achieved through dietary and lifestyle changes, although a small percentage requires pharmacological treatment.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43707794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pubic bone resection as part of extended pelvic resections for locally advanced or relapsed pelvic malignancies 耻骨切除术作为扩大骨盆切除术的一部分治疗局部晚期或复发性骨盆恶性肿瘤
Practica Medicala Pub Date : 2022-08-15 DOI: 10.37897/rjmp.2022.s3.15
N. Bacalbaşa, I. Bălescu, V. Varlas
{"title":"Pubic bone resection as part of extended pelvic resections for locally advanced or relapsed pelvic malignancies","authors":"N. Bacalbaşa, I. Bălescu, V. Varlas","doi":"10.37897/rjmp.2022.s3.15","DOIUrl":"https://doi.org/10.37897/rjmp.2022.s3.15","url":null,"abstract":"For a long period of time, the presence of pubic bone invasion has been considered as the sign of an unresectable lesion and therefore, the patient was further submitted to radiotherapy alone or in association with chemotherapy. Even in these conditions, during irradiation a pubo-vesical leak might develop and therefore, aggressive surgery including resection of the pubic bone might be needed. The aim of the current paper is to discuss about the indications of extended pelvic resections including pubic bone resections.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49656827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of preoperative platelet count in vulvar cancer patients 癌症患者术前血小板计数的影响
Practica Medicala Pub Date : 2022-08-15 DOI: 10.37897/rjmp.2022.s3.7
N. Bacalbaşa, I. Bălescu, C. Stoica, L. Pop, V. Varlas, Cristina Martac, Andrei Voichitoiu, B. Gașpar
{"title":"The impact of preoperative platelet count in vulvar cancer patients","authors":"N. Bacalbaşa, I. Bălescu, C. Stoica, L. Pop, V. Varlas, Cristina Martac, Andrei Voichitoiu, B. Gașpar","doi":"10.37897/rjmp.2022.s3.7","DOIUrl":"https://doi.org/10.37897/rjmp.2022.s3.7","url":null,"abstract":"The preoperative platelet count proved to be a significant prognostic factor for short term and long-term prognostic in gynecological cancers such as endometrial or ovarian cancer. However, more recently it has been supposed that this parameter could also influence the outcomes of vulvar cancer patients. The aim of the current paper is to study the influence of the preoperative platelet count on the perioperative outcomes in vulvar cancer patients submitted to surgery between June 2021 and May 2022 in “Cantacuzino” Clinical Hospital.","PeriodicalId":55841,"journal":{"name":"Practica Medicala","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42732650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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