Epigenomes最新文献_第10页

H3K4 Methylation in Aging and Metabolism. 衰老和代谢中的H3K4甲基化。

IF 2.5

Epigenomes Pub Date : 2021-06-18 DOI: 10.3390/epigenomes5020014

Chia-Ling Hsu, Yi-Chen Lo, Cheng-Fu Kao

{"title":"H3K4 Methylation in Aging and Metabolism.","authors":"Chia-Ling Hsu, Yi-Chen Lo, Cheng-Fu Kao","doi":"10.3390/epigenomes5020014","DOIUrl":"10.3390/epigenomes5020014","url":null,"abstract":"During the process of aging, extensive epigenetic alterations are made in response to both exogenous and endogenous stimuli. Here, we summarize the current state of knowledge regarding one such alteration, H3K4 methylation (H3K4me), as it relates to aging in different species. We especially highlight emerging evidence that links this modification with metabolic pathways, which may provide a mechanistic link to explain its role in aging. H3K4me is a widely recognized marker of active transcription, and it appears to play an evolutionarily conserved role in determining organism longevity, though its influence is context specific and requires further clarification. Interestingly, the modulation of H3K4me dynamics may occur as a result of nutritional status, such as methionine restriction. Methionine status appears to influence H3K4me via changes in the level of S-adenosyl methionine (SAM, the universal methyl donor) or the regulation of H3K4-modifying enzyme activities. Since methionine restriction is widely known to extend lifespan, the mechanistic link between methionine metabolic flux, the sensing of methionine concentrations and H3K4me status may provide a cogent explanation for several seemingly disparate observations in aging organisms, including age-dependent H3K4me dynamics, gene expression changes, and physiological aberrations. These connections are not yet entirely understood, especially at a molecular level, and will require further elucidation. To conclude, we discuss some potential H3K4me-mediated molecular mechanisms that may link metabolic status to the aging process.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5020014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease. 表观遗传过程对与年龄相关的认知能力衰退和阿尔茨海默病的影响。

IF 2.5

Epigenomes Pub Date : 2021-06-18 DOI: 10.3390/epigenomes5020015

Aina Bellver-Sanchis, Mercè Pallàs, Christian Griñán-Ferré

{"title":"The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease.","authors":"Aina Bellver-Sanchis, Mercè Pallàs, Christian Griñán-Ferré","doi":"10.3390/epigenomes5020015","DOIUrl":"10.3390/epigenomes5020015","url":null,"abstract":"During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer's disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the etiology. So, how can these changes be transmitted from one generation to the next? Answering this question would allow us to understand how the environment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the understanding of the relevance of heritability in neurodegenerative diseases. We highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. Additionally, we summarize evidence of how epigenetic marks inherited by experience and/or environmental stimuli contribute to cognitive status offspring since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Placenta as a Target of Epigenetic Alterations in Women with Gestational Diabetes Mellitus and Potential Implications for the Offspring. 胎盘作为妊娠期糖尿病妇女表观遗传改变的靶点及其对后代的潜在影响。

IF 2.5

Epigenomes Pub Date : 2021-05-10 DOI: 10.3390/epigenomes5020013

Dennise Lizárraga, Alejandra García-Gasca

{"title":"The Placenta as a Target of Epigenetic Alterations in Women with Gestational Diabetes Mellitus and Potential Implications for the Offspring.","authors":"Dennise Lizárraga, Alejandra García-Gasca","doi":"10.3390/epigenomes5020013","DOIUrl":"https://doi.org/10.3390/epigenomes5020013","url":null,"abstract":"Gestational diabetes mellitus (GDM) is a pregnancy complication first detected in the second or third trimester in women that did not show evident glucose intolerance or diabetes before gestation. In 2019, the International Diabetes Federation reported that 15.8% of live births were affected by hyperglycemia during pregnancy, of which 83.6% were due to gestational diabetes mellitus, 8.5% were due to diabetes first detected in pregnancy, and 7.9% were due to diabetes detected before pregnancy. GDM increases the susceptibility to developing chronic diseases for both the mother and the baby later in life. Under GDM conditions, the intrauterine environment becomes hyperglycemic, while also showing high concentrations of fatty acids and proinflammatory cytokines, producing morphological, structural, and molecular modifications in the placenta, affecting its function; these alterations may predispose the baby to disease in adult life. Molecular alterations include epigenetic mechanisms such as DNA and RNA methylation, chromatin remodeling, histone modifications, and expression of noncoding RNAs (ncRNAs). The placenta is a unique organ that originates only in pregnancy, and its main function is communication between the mother and the fetus, ensuring healthy development. Thus, this review provides up-to-date information regarding two of the best-documented (epigenetic) mechanisms (DNA methylation and miRNA expression) altered in the human placenta under GDM conditions, as well as potential implications for the offspring.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5020013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The EpiDiverse Plant Epigenome-Wide Association Studies (EWAS) Pipeline. EpiDiverse植物表观基因组关联研究(EWAS)管道。

IF 2.5

Epigenomes Pub Date : 2021-05-04 DOI: 10.3390/epigenomes5020012

Sultan Nilay Can, Adam Nunn, Dario Galanti, David Langenberger, Claude Becker, Katharina Volmer, Katrin Heer, Lars Opgenoorth, Noe Fernandez-Pozo, Stefan A Rensing

引用次数: 3

Firing up Cold Tumors-Targeting the Epigenetic Machinery to Enhance Cancer Immunotherapy. 激活冷肿瘤--针对表观遗传机制加强癌症免疫疗法。

IF 2.5

Epigenomes Pub Date : 2021-05-03 DOI: 10.3390/epigenomes5020011

Guan-Ling Lin, Leah H J Tsai, Peter J K Kuppen, Michael W Y Chan

引用次数: 0

Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage. 生命早期暴露于环境污染物会扰乱精子表观基因组，并通过父系谱系诱导三代阴性妊娠结局。

IF 2.5

Epigenomes Pub Date : 2021-05-01 DOI: 10.3390/epigenomes5020010

Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschênes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Côté, Ayelet Ziv-Gal, Jodi A Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L Bailey

{"title":"Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage.","authors":"Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschênes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Côté, Ayelet Ziv-Gal, Jodi A Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L Bailey","doi":"10.3390/epigenomes5020010","DOIUrl":"https://doi.org/10.3390/epigenomes5020010","url":null,"abstract":"Due to the grasshopper effect, the Arctic food chain in Canada is contaminated with persistent organic pollutants (POPs) of industrial origin, including polychlorinated biphenyls and organochlorine pesticides. Exposure to POPs may be a contributor to the greater incidence of poor fetal growth, placental abnormalities, stillbirths, congenital defects and shortened lifespan in the Inuit population compared to non-Aboriginal Canadians. Although maternal exposure to POPs is well established to harm pregnancy outcomes, paternal transmission of the effects of POPs is a possibility that has not been well investigated. We used a rat model to test the hypothesis that exposure to POPs during gestation and suckling leads to developmental defects that are transmitted to subsequent generations via the male lineage. Indeed, developmental exposure to an environmentally relevant Arctic POPs mixture impaired sperm quality and pregnancy outcomes across two subsequent, unexposed generations and altered sperm DNA methylation, some of which are also observed for two additional generations. Genes corresponding to the altered sperm methylome correspond to health problems encountered in the Inuit population. These findings demonstrate that the paternal methylome is sensitive to the environment and that some perturbations persist for at least two subsequent generations. In conclusion, although many factors influence health, paternal exposure to contaminants plays a heretofore-underappreciated role with sperm DNA methylation contributing to the molecular underpinnings involved.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5020010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A Pilot Study Investigating the Role of Gender in the Intergenerational Relationships between Gene Expression, Chronic Pain, and Adverse Childhood Experiences in a Clinical Sample of Youth with Chronic Pain. 一项初步研究调查性别在基因表达、慢性疼痛和不良童年经历之间的代际关系中的作用，在一个患有慢性疼痛的青少年临床样本中。

IF 2.5

Epigenomes Pub Date : 2021-04-15 DOI: 10.3390/epigenomes5020009

Jennaya Christensen, Jaimie K Beveridge, Melinda Wang, Serena L Orr, Melanie Noel, Richelle Mychasiuk

{"title":"A Pilot Study Investigating the Role of Gender in the Intergenerational Relationships between Gene Expression, Chronic Pain, and Adverse Childhood Experiences in a Clinical Sample of Youth with Chronic Pain.","authors":"Jennaya Christensen, Jaimie K Beveridge, Melinda Wang, Serena L Orr, Melanie Noel, Richelle Mychasiuk","doi":"10.3390/epigenomes5020009","DOIUrl":"https://doi.org/10.3390/epigenomes5020009","url":null,"abstract":"Chronic pain is a highly prevalent and costly issue that often emerges during childhood or adolescence and persists into adulthood. Adverse childhood experiences (ACEs) increase risk for several adverse health conditions, including chronic pain. Recent evidence suggests that parental trauma (ACEs, post-traumatic stress disorder (PTSD) symptoms) confers risk of poor health outcomes in their children. Intergenerational relationships between parental trauma and child chronic pain may be mediated by epigenetic mechanisms. A clinical sample of youth with chronic pain and their parents completed psychometrically sound questionnaires assessing ACEs, PTSD symptoms, and chronic pain, and provided a saliva sample. These were used to investigate the intergenerational relationships between four epigenetic biomarkers (COMT, DRD2, GR, and SERT), trauma, and chronic pain. The results indicated that the significant biomarkers were dependent upon the gender of the child, wherein parental ACEs significantly correlated with changes in DRD2 expression in female children and altered COMT expression in the parents of male children. Additionally, the nature of the ACE (maltreatment vs. household dysfunction) was associated with the specific epigenetic changes. There may be different pathways through which parental ACEs confer risk for poor outcomes for males and females, highlighting the importance of child gender in future investigations.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5020009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Cell-Free DNA Methylation as Blood-Based Biomarkers for Pancreatic Adenocarcinoma-A Literature Update. 无细胞DNA甲基化作为胰腺腺癌的血液生物标志物-文献更新。

IF 2.5

Epigenomes Pub Date : 2021-04-09 DOI: 10.3390/epigenomes5020008

Stine Dam Henriksen, Ole Thorlacius-Ussing

引用次数: 11

Enhancement of the Antileukemic Action of the Inhibitors of DNA and Histone Methylation: 5-Aza-2'-Deoxycytidine and 3-Deazaneplanocin-A by Vitamin C. 维生素 C 增强 DNA 和组蛋白甲基化抑制剂的抗白血病作用：维生素 C 对 5-Aza-2'-Deoxycytidine 和 3-Deazaneplanocin-A 抗白血病作用的增强。

IF 2.5

Epigenomes Pub Date : 2021-03-24 DOI: 10.3390/epigenomes5020007

Richard L Momparler, Sylvie Côté, Louise F Momparler

{"title":"Enhancement of the Antileukemic Action of the Inhibitors of DNA and Histone Methylation: 5-Aza-2'-Deoxycytidine and 3-Deazaneplanocin-A by Vitamin C.","authors":"Richard L Momparler, Sylvie Côté, Louise F Momparler","doi":"10.3390/epigenomes5020007","DOIUrl":"10.3390/epigenomes5020007","url":null,"abstract":"Epigenetic gene silencing by DNA methylation and histone methylation by EZH2 play an important role in the development of acute myeloid leukemia (AML). EZH2 catalyzes the trimethylation of histone H3-lysine 27-trimethylated (H3K27me3). These epigenetic alterations silence the expression of the genes that suppress leukemogenesis. Reversal of this gene silencing by 5-aza-2'-deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, and by 3-deazaneplanocin-A (DZNep), an inhibitor of EZH2, results in synergistic gene reactivation and antileukemic interaction. The objective of this study is to determine if the addition of another epigenetic agent could further enhance the antileukemic action of these inhibitors of DNA and histone methylation. Vitamin C (Vit C) is reported to enhance the antineoplastic action of 5-Aza-CdR on AML cells. The mechanism responsible for this action of Vit C is due to its function as a cofactor of alpha-ketoglutarate-dependent dioxygenases (α-KGDD). The enhancement by Vit C of the catalytic activity of α-KGDD of the ten eleven translocation (TET) pathway, as well as of the Jumonji C histone demethylases (JHDMs), is shown to result in demethylation of DNA and histones, leading to reactivation of tumor suppressor genes and an antineoplastic effect. This action of Vit C has the potential to complement the antileukemic action of 5-Aza-CdR and DZNep. We observe that Vit C remarkably increases the antineoplastic activity of 5-Aza-CdR and DZNep against myeloid leukemic cells. An important step to bring this novel epigenetic therapy to clinical trial in patients with AML is the determination of its optimal dose schedule.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the PRMT5-SND1 Axis in Hepatocellular Carcinoma. PRMT5-SND1轴在肝细胞癌中的作用

IF 2.5

Epigenomes Pub Date : 2021-03-01 Epub Date: 2021-01-05 DOI: 10.3390/epigenomes5010002

Tanner Wright, Yalong Wang, Mark T Bedford

{"title":"The Role of the PRMT5-SND1 Axis in Hepatocellular Carcinoma.","authors":"Tanner Wright, Yalong Wang, Mark T Bedford","doi":"10.3390/epigenomes5010002","DOIUrl":"https://doi.org/10.3390/epigenomes5010002","url":null,"abstract":"Arginine methylation is an essential post-translational modification (PTM) deposited by protein arginine methyltransferases (PRMTs) and recognized by Tudor domain-containing proteins. Of the nine mammalian PRMTs, PRMT5 is the primary enzyme responsible for the deposition of symmetric arginine methylation marks in cells. The staphylococcal nuclease and Tudor domain-containing 1 (SND1) effector protein is a key reader of the marks deposited by PRMT5. Both PRMT5 and SND1 are broadly expressed and their deregulation is reported to be associated with a range of disease phenotypes, including cancer. Hepatocellular carcinoma (HCC) is an example of a cancer type that often displays elevated PRMT5 and SND1 levels, and there is evidence that hyperactivation of this axis is oncogenic. Importantly, this pathway can be tempered with small-molecule inhibitors that target PRMT5, offering a therapeutic node for cancer, such as HCC, that display high PRMT5-SND1 axis activity. Here we summarize the known activities of this writer-reader pair, with a focus on their biological roles in HCC. This will help establish a foundation for treating HCC with PRMT5 inhibitors and also identify potential biomarkers that could predict sensitivity to this type of therapy.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5010002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25518214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6