Epigenomes最新文献_第10页

Clinical Utility of Epigenetic Changes in Pancreatic Adenocarcinoma. 胰腺癌表观遗传学改变的临床应用。

IF 2.5

Epigenomes Pub Date : 2021-09-27 DOI: 10.3390/epigenomes5040020

Joyce K Thompson, Filip Bednar

引用次数: 3

Evolution of CG Methylation Maintenance Machinery in Plants. 植物CG甲基化维持机制的进化。

IF 2.5

Epigenomes Pub Date : 2021-09-14 DOI: 10.3390/epigenomes5030019

Louis Tirot, Pauline E Jullien, Mathieu Ingouff

引用次数: 10

Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users. 可燃和非可燃尼古丁产品使用者酒精消费的表观遗传分析。

IF 2.5

Epigenomes Pub Date : 2021-09-01 DOI: 10.3390/epigenomes5030018

Kelsey Dawes, Luke Sampson, Rachel Reimer, Shelly Miller, Robert Philibert, Allan Andersen

{"title":"Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users.","authors":"Kelsey Dawes, Luke Sampson, Rachel Reimer, Shelly Miller, Robert Philibert, Allan Andersen","doi":"10.3390/epigenomes5030018","DOIUrl":"https://doi.org/10.3390/epigenomes5030018","url":null,"abstract":"Alcohol and tobacco use are highly comorbid and exacerbate the associated morbidity and mortality of either substance alone. However, the relationship of alcohol consumption to the various forms of nicotine-containing products is not well understood. To improve this understanding, we examined the relationship of alcohol consumption to nicotine product use using self-report, cotinine, and two epigenetic biomarkers specific for smoking (cg05575921) and drinking (Alcohol T Scores (ATS)) in n = 424 subjects. Cigarette users had significantly higher ATS values than the other groups (p < 2.2 × 10-16). Using the objective biomarkers, the intensity of nicotine and alcohol consumption was correlated in both the cigarette and smokeless users (R = -0.66, p = 3.1 × 10-14; R2 = 0.61, p = 1.97 × 10-4). Building upon this idea, we used the objective nicotine biomarkers and age to build and test a Balanced Random Forest classification model for heavy alcohol consumption (ATS > 2.35). The model performed well with an AUC of 0.962, 89.3% sensitivity, and 85% specificity. We conclude that those who use non-combustible nicotine products drink significantly less than smokers, and cigarette and smokeless users drink more with heavier nicotine use. These findings further highlight the lack of informativeness of self-reported alcohol consumption and suggest given the public and private health burden of alcoholism, further research into whether using non-combustible nicotine products as a mode of treatment for dual users should be considered.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering. 基于CRISPR/ dcas9的表观基因组工程解读植物染色质调控

IF 2.5

Epigenomes Pub Date : 2021-08-24 DOI: 10.3390/epigenomes5030017

Annick Dubois, François Roudier

{"title":"Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering.","authors":"Annick Dubois, François Roudier","doi":"10.3390/epigenomes5030017","DOIUrl":"https://doi.org/10.3390/epigenomes5030017","url":null,"abstract":"CRISPR-based epigenome editing uses dCas9 as a platform to recruit transcription or chromatin regulators at chosen loci. Despite recent and ongoing advances, the full potential of these approaches to studying chromatin functions in vivo remains challenging to exploit. In this review we discuss how recent progress in plants and animals provides new routes to investigate the function of chromatin regulators and address the complexity of associated regulations that are often interconnected. While efficient transcriptional engineering methodologies have been developed and can be used as tools to alter the chromatin state of a locus, examples of direct manipulation of chromatin regulators remain scarce in plants. These reports also reveal pitfalls and limitations of epigenome engineering approaches that are nevertheless informative as they are often associated with locus- and context-dependent features, which include DNA accessibility, initial chromatin and transcriptional state or cellular dynamics. Strategies implemented in different organisms to overcome and even take advantage of these limitations are highlighted, which will further improve our ability to establish the causality and hierarchy of chromatin dynamics on genome regulation.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance? 胎盘中的免疫抑制和表观基因组调控能否为癌症免疫逃避和免疫疗法抗性提供新的见解？

IF 2.5

Epigenomes Pub Date : 2021-07-25 DOI: 10.3390/epigenomes5030016

Sultana Mehbuba Hossain, Chiemi F Lynch-Sutherland, Aniruddha Chatterjee, Erin C Macaulay, Michael R Eccles

{"title":"Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?","authors":"Sultana Mehbuba Hossain, Chiemi F Lynch-Sutherland, Aniruddha Chatterjee, Erin C Macaulay, Michael R Eccles","doi":"10.3390/epigenomes5030016","DOIUrl":"10.3390/epigenomes5030016","url":null,"abstract":"Cancer is the second leading cause of mortality and morbidity in the developed world. Cancer progression involves genetic and epigenetic alterations, accompanied by aggressive changes, such as increased immune evasion, onset of metastasis, and drug resistance. Similar to cancer, DNA hypomethylation, immune suppression, and invasive cell behaviours are also observed in the human placenta. Mechanisms that lead to the acquisition of invasive behaviour, immune evasion, and drug and immunotherapy resistance are presently under intense investigations to improve patient outcomes. Here, we review current knowledge regarding the similarities between immune suppression and epigenome regulation, including the expression of repetitive elements (REs), endogenous retroviruses (ERVs) and transposable elements (TEs) in cells of the placenta and in cancer, which are associated with changes in immune regulation and invasiveness. We explore whether immune suppression and epigenome regulation in placenta offers novel insights into immunotherapy resistance in cancer, and we also discuss the implications and the knowledge gaps relevant to these findings, which are rapidly being accrued in these quite disparate research fields. Finally, we discuss potential linkages between TE, ERV and RE activation and expression, regarding mechanisms of immune regulation in placenta and cancer. A greater understanding of the role of immune suppression and associated epigenome regulation in placenta could help to elucidate some comparable mechanisms operating in cancer, and identify potential new therapeutic targets for treating cancer.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H3K4 Methylation in Aging and Metabolism. 衰老和代谢中的H3K4甲基化。

IF 2.5

Epigenomes Pub Date : 2021-06-18 DOI: 10.3390/epigenomes5020014

Chia-Ling Hsu, Yi-Chen Lo, Cheng-Fu Kao

{"title":"H3K4 Methylation in Aging and Metabolism.","authors":"Chia-Ling Hsu, Yi-Chen Lo, Cheng-Fu Kao","doi":"10.3390/epigenomes5020014","DOIUrl":"10.3390/epigenomes5020014","url":null,"abstract":"During the process of aging, extensive epigenetic alterations are made in response to both exogenous and endogenous stimuli. Here, we summarize the current state of knowledge regarding one such alteration, H3K4 methylation (H3K4me), as it relates to aging in different species. We especially highlight emerging evidence that links this modification with metabolic pathways, which may provide a mechanistic link to explain its role in aging. H3K4me is a widely recognized marker of active transcription, and it appears to play an evolutionarily conserved role in determining organism longevity, though its influence is context specific and requires further clarification. Interestingly, the modulation of H3K4me dynamics may occur as a result of nutritional status, such as methionine restriction. Methionine status appears to influence H3K4me via changes in the level of S-adenosyl methionine (SAM, the universal methyl donor) or the regulation of H3K4-modifying enzyme activities. Since methionine restriction is widely known to extend lifespan, the mechanistic link between methionine metabolic flux, the sensing of methionine concentrations and H3K4me status may provide a cogent explanation for several seemingly disparate observations in aging organisms, including age-dependent H3K4me dynamics, gene expression changes, and physiological aberrations. These connections are not yet entirely understood, especially at a molecular level, and will require further elucidation. To conclude, we discuss some potential H3K4me-mediated molecular mechanisms that may link metabolic status to the aging process.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5020014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease. 表观遗传过程对与年龄相关的认知能力衰退和阿尔茨海默病的影响。

IF 2.5

Epigenomes Pub Date : 2021-06-18 DOI: 10.3390/epigenomes5020015

Aina Bellver-Sanchis, Mercè Pallàs, Christian Griñán-Ferré

{"title":"The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease.","authors":"Aina Bellver-Sanchis, Mercè Pallàs, Christian Griñán-Ferré","doi":"10.3390/epigenomes5020015","DOIUrl":"10.3390/epigenomes5020015","url":null,"abstract":"During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer's disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the etiology. So, how can these changes be transmitted from one generation to the next? Answering this question would allow us to understand how the environment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the understanding of the relevance of heritability in neurodegenerative diseases. We highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. Additionally, we summarize evidence of how epigenetic marks inherited by experience and/or environmental stimuli contribute to cognitive status offspring since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Placenta as a Target of Epigenetic Alterations in Women with Gestational Diabetes Mellitus and Potential Implications for the Offspring. 胎盘作为妊娠期糖尿病妇女表观遗传改变的靶点及其对后代的潜在影响。

IF 2.5

Epigenomes Pub Date : 2021-05-10 DOI: 10.3390/epigenomes5020013

Dennise Lizárraga, Alejandra García-Gasca

{"title":"The Placenta as a Target of Epigenetic Alterations in Women with Gestational Diabetes Mellitus and Potential Implications for the Offspring.","authors":"Dennise Lizárraga, Alejandra García-Gasca","doi":"10.3390/epigenomes5020013","DOIUrl":"https://doi.org/10.3390/epigenomes5020013","url":null,"abstract":"Gestational diabetes mellitus (GDM) is a pregnancy complication first detected in the second or third trimester in women that did not show evident glucose intolerance or diabetes before gestation. In 2019, the International Diabetes Federation reported that 15.8% of live births were affected by hyperglycemia during pregnancy, of which 83.6% were due to gestational diabetes mellitus, 8.5% were due to diabetes first detected in pregnancy, and 7.9% were due to diabetes detected before pregnancy. GDM increases the susceptibility to developing chronic diseases for both the mother and the baby later in life. Under GDM conditions, the intrauterine environment becomes hyperglycemic, while also showing high concentrations of fatty acids and proinflammatory cytokines, producing morphological, structural, and molecular modifications in the placenta, affecting its function; these alterations may predispose the baby to disease in adult life. Molecular alterations include epigenetic mechanisms such as DNA and RNA methylation, chromatin remodeling, histone modifications, and expression of noncoding RNAs (ncRNAs). The placenta is a unique organ that originates only in pregnancy, and its main function is communication between the mother and the fetus, ensuring healthy development. Thus, this review provides up-to-date information regarding two of the best-documented (epigenetic) mechanisms (DNA methylation and miRNA expression) altered in the human placenta under GDM conditions, as well as potential implications for the offspring.","PeriodicalId":55768,"journal":{"name":"Epigenomes","volume":"5 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/epigenomes5020013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The EpiDiverse Plant Epigenome-Wide Association Studies (EWAS) Pipeline. EpiDiverse植物表观基因组关联研究(EWAS)管道。

IF 2.5

Epigenomes Pub Date : 2021-05-04 DOI: 10.3390/epigenomes5020012

Sultan Nilay Can, Adam Nunn, Dario Galanti, David Langenberger, Claude Becker, Katharina Volmer, Katrin Heer, Lars Opgenoorth, Noe Fernandez-Pozo, Stefan A Rensing

引用次数: 3

Firing up Cold Tumors-Targeting the Epigenetic Machinery to Enhance Cancer Immunotherapy. 激活冷肿瘤--针对表观遗传机制加强癌症免疫疗法。

IF 2.5

Epigenomes Pub Date : 2021-05-03 DOI: 10.3390/epigenomes5020011

Guan-Ling Lin, Leah H J Tsai, Peter J K Kuppen, Michael W Y Chan

引用次数: 0