ACS Applied Engineering Materials最新文献

{"title":"Self-Healing Liquid Metal Magnetic Composite Films for Wearable Sensors and Electromagnetic Shielding","authors":"Shuaike Li,&nbsp;Xiaoqin Guo*,&nbsp;Zhongyi Bai*,&nbsp;Mengxia Guo,&nbsp;Yumei Ren,&nbsp;Huicong Niu,&nbsp;Hao Zhang and Jiushuai Deng*,&nbsp;","doi":"10.1021/acsaenm.4c0058210.1021/acsaenm.4c00582","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00582https://doi.org/10.1021/acsaenm.4c00582","url":null,"abstract":"<p >Film materials exhibit excellent potential for intelligent wearable devices and flexible electronic components owing to their being lightweight, thin, and flexible. However, their application faces several challenges such as their poor mechanical and self-healing properties. Herein, a composite film comprising poly(vinyl alcohol) (PVA) as the matrix, a gallium-based liquid metal, and conductive magnetic nickel was fabricated. The film exhibits high conductivity, tensile strength, and self-healing ability as well as good electromagnetic interference (EMI) shielding performance. The excellent flexibility and overall EMI shielding performance of the PVA-based composite film are attributed to the introduction of liquid metals, containing abundant hydrogen bonding sites. This PVA-based composite film exhibits excellent mechanical characteristics (stress 28 MPa, strain 180%) owing to its superb flexibility. The composite film also has self-healing ability, allowing it to continue working after self-healing. In addition, the PVA-based composite film exhibits good EMI shielding performance through multiple loss mechanisms. The film (thickness 0.4 mm) exhibits an overall shielding performance of up to 26 dB in the X-band (8.2–12.4 GHz). The average total shielding effectiveness of the pure PVA film increased from 0.4 to 24.7 dB (a 6075% increase) after the introduction of nickel and liquid metals. This multifunctional magnetic composite film has excellent potential for intelligent wearable devices, flexible electronic components, and strain sensors.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2899–2909 2899–2909"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143126559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast-Acting and Skin-Compatible Antimicrobial Coating on Cotton Fabrics via In Situ Self-Assembly of Phosphine-Coordinated Copper Iodide Clusters","authors":"Adrielle Xianwen Chen,&nbsp;Devina Krystel Ravichandran Beins,&nbsp;Yue Wang,&nbsp;He-Kuan Luo*,&nbsp;Yi Yan Yang* and Ning Li*,&nbsp;","doi":"10.1021/acsaenm.4c0054810.1021/acsaenm.4c00548","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00548https://doi.org/10.1021/acsaenm.4c00548","url":null,"abstract":"<p >Cotton fabrics and textiles are ubiquitous in domestic, healthcare, and commercial settings, but they can harbor a multitude of disease-causing pathogens due to their lack of intrinsic antimicrobial properties. Here, we report a highly effective antiviral and antibacterial coating prepared <i>in situ</i> on commercial cotton fabrics by using phosphine-coordinated copper iodide clusters as the sole precursor. Self-assembled hexagonal nanodisks of [Cu₄I₄(TPP)₄] (TPP = triphenylphosphine) clusters formed a hydrophilic coating at only 0.36 wt % relative to the cotton substrate, but capable of eliminating &gt;99.9% of murine hepatitis coronaviruses (SARS-CoV surrogate) and clinical isolates of methicillin-resistant <i>Staphylococcus aureus</i> within 2 min. Direct surface contact was experimentally verified as the mechanism of action, whereby the coating induced the disruption of the bacterial cell membrane. More notably, the coating also exhibited other excellent properties, including colorless appearance, high durability to various post-treatments, excellent skin compatibility, and ease of industrial scale-up, making it a promising technology to prevent the spread of nosocomial infections and enhance our preparedness against global outbreaks of infectious diseases in the future.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2864–2874 2864–2874"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Biowaste into Nanocatalysts: Polyphenol-Engineered Core–Shell Silica Nanoparticles for Multifaceted Application","authors":"Madhan Kumar Meganathan,&nbsp;Vedavalli Rajasekar,&nbsp;Raman Arunachalam,&nbsp;Ganesan Ponesakki,&nbsp;Mythily Rajan and Sathya Ramalingam*,&nbsp;","doi":"10.1021/acsaenm.4c0047210.1021/acsaenm.4c00472","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00472https://doi.org/10.1021/acsaenm.4c00472","url":null,"abstract":"<p >The integration of cost-effective, nontoxic, and environmentally friendly core–shell nanomaterials using green waste is crucial for diverse industrial applications. Traditional metal-based nanoparticles and nanocomposites used in Beckmann rearrangement and dye degradation pose significant energy, environmental, and health challenges. In this work, we introduce nanoscale core–shell Polyphenol-functionalized silica nanoparticles (SP NPs) as a green nanocatalyst for Beckmann rearrangement and dye degradation, adhering to green chemistry principles. The SP NPs are prepared through a two-step process: creating an ester linkage between polyphenols and silica with a carboxyl terminal followed by hydrogen bonding of silica over the polyphenol surface. The resulting core–shell structure, with a 48 nm silica-polyphenol core and a 10 nm silica shell, was confirmed by HR-TEM and dynamic light scattering measurements. These stable nanoparticles serve as an efficient nanocatalyst for the room temperature conversion of oxime to amide with a simple purification strategy, achieving a conversion efficiency of 97.2% without acids or solvents, surpassing conventional methods. The environmental and economic viability of this material in the Beckmann rearrangement is validated by an Ecoscale score of 90.61 and favorable green metrics such as an E-factor of 0.0288 and reaction mass efficiency of 97.2%. Additionally, the hydrogen radical generation capability of SP NPs enables the reduction of industrial organic pollutants such as dyes without external light sources, achieving over 99% dye degradation. The synergistic behavior of the core–shell morphology provides an eco-friendly, reusable catalyst, offering a practical and sustainable solution to industrial and environmental challenges associated with the Beckmann rearrangement and dye degradation.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2827–2841 2827–2841"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Piezoelectric Nanogenerators with Sr-Doped Lanthanum Cobaltite (La1–xSrxCoO3) and Multiwalled Carbon Nanotubes for Energy Harvesting","authors":"S M Anyet Ullah Shohag,&nbsp;Luke Franco,&nbsp;Adhira Tippur,&nbsp;Swati Mohan,&nbsp;Md. Wasikur Rahman and Mohammed Jasim Uddin*,&nbsp;","doi":"10.1021/acsaenm.4c0050310.1021/acsaenm.4c00503","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00503https://doi.org/10.1021/acsaenm.4c00503","url":null,"abstract":"<p >Piezoelectric nanogenerators (PENGs) are an efficient source of energy, converting mechanical energy into electrical energy via the ferroelectric effect. To develop self-powered devices that require no external energy sources, a nanogenerator was fabricated, comprising Sr²⁺-doped lanthanum cobaltite (La_1–<i>x</i>Sr_<i>x</i>CoO₃ defined as LSCO) perovskite, polyvinylidene fluoride (PVDF), and multiwalled carbon nanotubes (MWCNT) as supplementary fillers. LSCO was synthesized by a simple molten-salt process, and piezoelectric composite films were prepared through sonication followed by poling and curing. The addition of LSCO to PVDF and further MWCNT in the LSCO/PVDF composite to form piezoelectric films was optimized, and then the composite films were placed between two copper electrodes to fabricate the PENG. Electrical performance of the PENG was investigated and resulted in the enhancement of dielectric, piezoelectric, and energy storage properties. Pristine LSCO-based PENGs produced open-circuit AC peak-to-peak outputs of 25.71 V, 40.3 nA, and 15.919 mW/m², while Sr doping in the composite showed a remarkable impact. DC voltage was found to be ∼8.2 V for the optimum LSCO/PVDF composite films, which was further improved by 20% due to MWCNT addition tested by a bridge rectifier in a series. At 105 BPM, the PENGs could charge a 3.3 μF capacitor to 1.14 V in about 75 s. Finally, the PENG was used as an energy harvesting device, smart weight sensor, and motion sensor to operate low-power electronic devices.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2842–2855 2842–2855"},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Thermally Conductive and Mechanically Strong Aramid Nanofiber Composite Film by a Single-Walled Carbon Nanotube and Ti3C2Tx MXene for Electromagnetic Shielding and Thermal Management","authors":"Lin Li,&nbsp;Zhenghong Zeng,&nbsp;Zefeng Yang,&nbsp;Shangang Zhou,&nbsp;Yuhan Zhang,&nbsp;Yao Wu,&nbsp;Junwen Ren,&nbsp;Ruichi Zeng and Wenfu Wei*,&nbsp;","doi":"10.1021/acsaenm.4c0065510.1021/acsaenm.4c00655","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00655https://doi.org/10.1021/acsaenm.4c00655","url":null,"abstract":"<p >Currently, the development of electromagnetic shielding materials with both mechanical strength and high thermal conductivity for next-generation electronic devices remains a challenge. In this study, we developed single-walled carbon nanotube (SWCNT)/MXene/aramid nanofiber (ANF) composite films, with a “brick-and-mortar” structure, by vacuum filtration and a hot-pressing method. This structure enables the composite film to enhance the mechanical and thermal performance while maintaining a satisfied electromagnetic shielding function. Particularly, the low-temperature plasma-treated SWCNTs were utilized to significantly overcome the interface resistance, where strong hydrogen bonds with ANFs have been confirmed. The results indicated that the composite film achieved a tensile strength of 281.2 MPa and an elongation at break of 17.6%. The combination of SWCNTs and Ti₃C₂T_<i>x</i> MXene forms a three-dimensional thermal conduction network, resulting in an exceptional thermal conductivity of 14.99 W/m·K for the SWCNT/MXene/ANF composite film, which is 571% higher than that of a pure ANF film. The “brick-and-mortar” structure results in continuous absorption and attenuation of electromagnetic waves, allowing the electromagnetic shielding effectiveness to reach around 31.9 dB. Overall, the strategy proposed in this work has shown positive potential multifunctional electromagnetic shielding materials with good mechanical and thermal performance.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 2","pages":"302–313 302–313"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupling Joule Heating with Vibration Ball Milling for Synthesizing Carbon-Supported Ni100–xFex Nanoparticles Achieving Efficient Oxygen Evolution and Alkaline Water Electrolysis","authors":"Li Zhang,&nbsp;Mengyuan Ma,&nbsp;Zhenya Hu,&nbsp;Hui Liu,&nbsp;Dong Chen,&nbsp;Shaonan Tian*,&nbsp;Lin Xu*,&nbsp;Guozhu Chen* and Jun Yang*,&nbsp;","doi":"10.1021/acsaenm.4c0059110.1021/acsaenm.4c00591","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00591https://doi.org/10.1021/acsaenm.4c00591","url":null,"abstract":"<p >Rapid and cost-effective synthesis of electrocatalysts for oxygen evolution reaction (OER) poses a significant technical challenge for the commercialization of water electrolysis. We, herein, report a facile strategy that couples quick Joule heating with mechanical ball milling for synthesizing well-defined Ni_{100–<i>x</i>}Fe_<i>x</i> (0 ≤ <i>x</i> ≤ 100) alloy nanoparticles on carbon substrate toward high-efficiency OER and water splitting. This synthetic strategy involves first simply mixing the precursors and carbon substrate through ball milling and subsequent Joule heating on an electrical device for fast forming carbon-supported alloy nanoparticles with fine sizes and uniform distribution. In particular, the single-component Ni/C nanoparticles (i.e., <i>x</i> = 0) synthesized by this way include both fcc and hcp crystal phases, with the highest proportion of hcp phase at 370 °C, which endows the Ni/C nanoparticles with better OER activity than that of Ni/C samples synthesized at other temperatures. In addition, the Ni_{100–<i>x</i>}Fe_<i>x</i>/C nanoparticles at an appropriate Ni/Fe ratio of 72/28 (Ni₇₂Fe₂₈/C) exhibit the best OER electrocatalysis, with a low overpotential of only 276 mV at a current density of 10 mA cm^–2, due to the optimal electronic interaction between Ni and Fe in the alloys. More importantly, under simulated industrial electrolysis conditions (30 wt % KOH at 60 °C), a two-electrode alkaline electrolyzer assembled with Ni₇₂Fe₂₈/C at the anode and commercial Pt/C at the cathode (Ni₇₂Fe₂₈/C||Pt/C) requires only 1.39 V to deliver the current density of 100 mA cm^–2, along with an excellent 120-h durability at the same current density.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2919–2932 2919–2932"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Way Additively Manufactured Shape Memory Alloy Wideband Reconfigurable Compound Antenna","authors":"Michael Sherburne*,&nbsp;Kyle Sibert,&nbsp;Mary Daffron,&nbsp;Andrew Lennon,&nbsp;Howard Feldmesser,&nbsp;Josh Furer,&nbsp;Katherine Wolff,&nbsp;Kevin Pionke,&nbsp;Paul Biermann,&nbsp;Louis Bettwy,&nbsp;Daniel Eby,&nbsp;Chuck Hebert,&nbsp;Samuel Gonzalez,&nbsp;David Grim,&nbsp;Steven Storck and Jennifer Hollenbeck,&nbsp;","doi":"10.1021/acsaenm.4c0048810.1021/acsaenm.4c00488","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00488https://doi.org/10.1021/acsaenm.4c00488","url":null,"abstract":"<p >A paradigm shifting antenna technology taking advantage of recent advancements in additive manufacturing is presented for the first time. Fine control over additive manufacturing has allowed fabrication of a two-way shape memory alloy antenna. A double spiral antenna capable of actuating through thermal response alone is able to actuate from a flat spiral antenna to an extended conical spiral antenna. Actuation control was achieved by measuring changes in electrical resistance caused by shape memory alloy phase changes. The prototype antenna was validated from 4 GHz to 11 GHz (S to X bands) with a gain of approximately 5 dBi. The measured trends in antenna gain as a function of frequency from the actuation agree with simulations.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 1","pages":"44–50 44–50"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsaenm.4c00488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Yield Exfoliated MXene Nanosheets through Vapor Energy-Driven Delamination","authors":"Feng Shi,&nbsp;Chenchen Han,&nbsp;Peng Liu,&nbsp;Enhui Liang,&nbsp;Lijin Zhang,&nbsp;Zhong Su* and Chao Lai*,&nbsp;","doi":"10.1021/acsaenm.4c0053210.1021/acsaenm.4c00532","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00532https://doi.org/10.1021/acsaenm.4c00532","url":null,"abstract":"<p >MXene is a two-dimensional nanosheet material with a structure akin to graphene and has drawn considerable attention for its unique large-scale layer architecture, exceptional electrical conductivity, and hydrophilic properties. At present, ultrasonic oscillation is utilized to exfoliate and produce high-quality MXene nanosheets. Nonetheless, this technique can lead to the fracture of the lamellar structure, and the yield of high-quality MXene is only up to 10–20%. Hence, this study proposed a simple exfoliation strategy that uses the energy generated by water vapor to exfoliate bulk MXene into thin high-quality MXene nanosheets. The entire process is easy and environmentally friendly, accompanied by a yield of up to 73%. Also, after exfoliation, the obtained MXene nanosheets demonstrate an exceptional conductivity of 5824 S/cm. When used as a conductive additive incorporated into the LTO anode, it showed a high and stable reversible cycling capacity of 143 mAh g^–1 after 400 cycles. Our work not only delivers a straightforward and safe technique for the synthesis of high-quality MXene nanosheets but also provides a reference for its application in specific fields.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2856–2863 2856–2863"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Removal of Anionic Pollutants Using Active Propulsion of Patchy ZIF-8 Microparticles in Electric Field","authors":"Ruchi Patel,&nbsp;Philip J. Brahana and Bhuvnesh Bharti*,&nbsp;","doi":"10.1021/acsaenm.4c0058010.1021/acsaenm.4c00580","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00580https://doi.org/10.1021/acsaenm.4c00580","url":null,"abstract":"<p >Active colloids are microparticles capable of self-propelling at low Reynolds numbers, presenting unique opportunities to enhance adsorption processes at the microscale. In this study, we develop patchy zeolitic imidazolate framework-8 (ZIF-8) microparticles with asymmetrically deposited gold patches as a class of active adsorbents for the removal of ionic pollutants from water. By applying an alternating current electric field, these patchy ZIF-8 particles propel via induced-charge electrophoresis, exhibiting linear and helical propulsion trajectories based on the geometric configuration of the patch. Our experiments demonstrate that this electric field-driven active propulsion significantly accelerates the adsorption kinetics of anions, including perchlorate, sulfide, and fluoride. Our study provides insights into the potential of active particles to overcome mass transport limitations in pollutant adsorption, highlighting a fuel-free approach for targeted water remediation. We present the design principles of patchy ZIF-8 particles, explore the influence of particle symmetry on propulsion dynamics, and demonstrate the practical implications of using active colloids for environmental remediation. These findings lay the groundwork for future research focused on optimizing particle design and expanding the applicability of active porous adsorbents to a broader range of pollutant removal challenges.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2777–2789 2777–2789"},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Mitochondrial Complex I in the Proinflammatory Response to Polylactide Implants","authors":"Chima V. Maduka*,&nbsp;Ashley V. Makela,&nbsp;Anthony Tundo,&nbsp;Evran Ural,&nbsp;Katlin B. Stivers,&nbsp;Mohammed Alhaj,&nbsp;Ramani Narayan,&nbsp;Stuart B. Goodman,&nbsp;Nureddin Ashammakhi,&nbsp;Jennifer H. Elisseeff,&nbsp;Kurt D. Hankenson and Christopher H. Contag*,&nbsp;","doi":"10.1021/acsaenm.4c0039310.1021/acsaenm.4c00393","DOIUrl":"https://doi.org/10.1021/acsaenm.4c00393https://doi.org/10.1021/acsaenm.4c00393","url":null,"abstract":"<p >During the foreign body response, immune cells are metabolically rewired after exposure to breakdown products of various biomaterials, including polylactide (PLA) and polyethylene. Particles of polyethylene interact with Toll-like receptor 4 on macrophages, resulting in increased oxygen consumption that forms reactive oxygen species at complex I of the mitochondrial electron transport chain (mETC). However, PLA degradation products bind to monocarboxylate transporters for downstream signaling with elevated oxygen consumption rates, whose functional implication is unclear and remains inferred from cellular responses to polyethylene biomaterials. By chemically probing the function of the mETC, we show that proinflammatory macrophages activated by exposure to amorphous PLA (aPLA) breakdown products rely on mitochondrial respiration for ATP production independent of oxygen consumption rates. In contrast, macrophages activated by semicrystalline PLA (cPLA) breakdown products exhibit a metabolic phenotype wherein ATP levels are unaffected by changing oxygen consumption rates. In subcutaneous implants, the incorporation of metformin in aPLA or cPLA to chemically inhibit complex I did not effectively modulate the proinflammatory response to biomaterials, suggesting that PLA degradation products elicit a distinct metabolic program, thus providing an alternative perspective on the role of mitochondrial respiration in the inflammatory response to biomaterials.</p>","PeriodicalId":55639,"journal":{"name":"ACS Applied Engineering Materials","volume":"2 12","pages":"2815–2826 2815–2826"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}