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Significance of Sulfated Glycans on Mucins in the Gut 硫酸甘聚糖对肠道黏蛋白的影响
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2219.1e
Hirohito Abo, Hiroto Kawashima
{"title":"Significance of Sulfated Glycans on Mucins in the Gut","authors":"Hirohito Abo, Hiroto Kawashima","doi":"10.4052/tigg.2219.1e","DOIUrl":"https://doi.org/10.4052/tigg.2219.1e","url":null,"abstract":"In the intestine, mucins function as a physical barrier separating the gut bacteria and the host. MUC2 mucin is a highly O-glycosylated glycoprotein, and its glycans are an essential post-translational modification for MUC2 function. In recent years, it has been discovered that specific structural units of the complex MUC2 glycans play distinct physiological functions. In particular, the sulfation of GlcNAc and Galactose in MUC2 glycans is essential for intestinal barrier function. Furthermore, gut bacteria utilize mucin sugar chains as a nutrient source by employing specific sulfatase enzymes, allowing them to colonize in the intestine. On the other hand, gut bacteria regulate host glycosylation through the induction of glycosyltransferase expression. In the light of recent studies on the structure and function of MUC2 glycans, mucins are not only functioning as a physical barrier but also as molecules that mediate complex interactions with gut microbiota. In this article, we discuss the function of MUC2 mucin and its glycosylation, with a particular focus on sulfated glycans.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a glycoRNA Detection Tool and Biological Roles of glycoRNA glycoRNA检测工具的开发及glycoRNA的生物学作用
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2326.6j
Haruhiko Fujihira
{"title":"Development of a glycoRNA Detection Tool and Biological Roles of glycoRNA","authors":"Haruhiko Fujihira","doi":"10.4052/tigg.2326.6j","DOIUrl":"https://doi.org/10.4052/tigg.2326.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
<i>Xenopus</i> Galectin: Molecular Function and Evolution & lt; i&gt Xenopus&lt; / i&gt;凝集素:分子功能和进化
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2224.1e
Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura
{"title":"&lt;i&gt;Xenopus&lt;/i&gt; Galectin: Molecular Function and Evolution","authors":"Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura","doi":"10.4052/tigg.2224.1e","DOIUrl":"https://doi.org/10.4052/tigg.2224.1e","url":null,"abstract":"Galectins are carbohydrate-binding proteins that do not require metals, and are widely distributed in vertebrates. The basic specificity of galectins for β-galactosides is conserved in their carbohydrate recognition domains (CRDs). Although galectins have been implicated in important biological functions, there is limited evidence that galectin-galactoside binding is directly linked to such functions. Extensive functional analysis of galectins in a large number of species is necessary to understand the broad range of evolutionarily conserved functions. Therefore, we focused on Xenopus galectins and identified and analyzed 12 species of Xenopus laevis galectins. The only non-mammalian vertebrate that has been comprehensively analyzed for galectins is the Xenopus laevis, which we use as a model for galectin research. In this review, we introduce the types of galectins and the functions of Xenopus galectins available to date.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ツメガエルガレクチン：分子の機能と進化 凝血凝集素:分子的功能和进化
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2224.1j
Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura
{"title":"ツメガエルガレクチン：分子の機能と進化","authors":"Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura","doi":"10.4052/tigg.2224.1j","DOIUrl":"https://doi.org/10.4052/tigg.2224.1j","url":null,"abstract":"ガレクチンは脊椎動物に広く分布する非金属要求性の糖結合タンパク質である。ガレクチンのβ-ガラクトシドに対する基本的な特異性は糖認識ドメイン（CRD）により保存されている。ガレクチンは重要な生命現象に関与していると考えられてきたが、ガレクチンと糖鎖の結合が直接機能に結び付くことを証明できた例は少ない。進化的に保存されたガレクチンの本来の機能を幅広く知るために、多くの種での網羅的な機能解析を行う必要がある。そこで我々はツメガエルのガレクチンに着目し、現在までに12種のアフリカツメガエルガレクチンを同定し、解析をおこなってきた。哺乳類以外の脊椎動物でガレクチンの包括的な解析がおこなわれているのは、我々がガレクチン研究のモデルとして用いているアフリカツメガエルのみである。このレビューでは現在までに得られているツメガエルガレクチンの種類や機能について紹介する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
多能性幹細胞におけるグリコサミノグライカンの機能 多能性干细胞中糖绦虫的功能
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2206.1j
Chika Ogura, Shoko Nishihara
{"title":"多能性幹細胞におけるグリコサミノグライカンの機能","authors":"Chika Ogura, Shoko Nishihara","doi":"10.4052/tigg.2206.1j","DOIUrl":"https://doi.org/10.4052/tigg.2206.1j","url":null,"abstract":"細胞表面や細胞外マトリックスに存在するグリコサミノグライカン（GAG）は、特徴的な二糖繰返し構造をもち、硫酸転移酵素により硫酸化修飾を受ける。この二糖繰返し構造と硫酸化パターンの組合せにより、GAGは特定のシグナルリガンドもしくは受容体と結合し、シグナル伝達の調節に寄与する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Functions of Glycosaminoglycan in Pluripotent Stem Cells 糖胺聚糖在多能干细胞中的作用
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2206.1e
Chika Ogura, Shoko Nishihara
{"title":"The Functions of Glycosaminoglycan in Pluripotent Stem Cells","authors":"Chika Ogura, Shoko Nishihara","doi":"10.4052/tigg.2206.1e","DOIUrl":"https://doi.org/10.4052/tigg.2206.1e","url":null,"abstract":"Glycosaminoglycans (GAGs) on the cell surface and in the extra cellular matrix have multiple biological roles, including cell signaling. They have a characteristic repeating disaccharide structure and are sulfated by sulfotransferases, the resulting combination of which governs which signal ligands bind to them.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Analysis of GPI-glycans from GPI-anchored Proteins by Mass Spectrometry 质谱法分析gpi锚定蛋白中gpi聚糖的结构
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2209.1j
Miyako Nakano
{"title":"Structural Analysis of GPI-glycans from GPI-anchored Proteins by Mass Spectrometry","authors":"Miyako Nakano","doi":"10.4052/tigg.2209.1j","DOIUrl":"https://doi.org/10.4052/tigg.2209.1j","url":null,"abstract":"グリコシルホスファチジルイノシトール（Glycosylphosphatidylinositol, GPI）アンカー型タンパク質（GPI-APs）とは、細胞膜上の糖脂質（GPI）によりアンカーされている一群のタンパク質であり、真核生物において広く存在している。GPI部分は、ホスファチジルイノシトール、グルコサミン、3つのマンノース、そしてエタノールアミンリン酸を基本構造とし、この基本構造と、それを介したタンパク質の膜へのアンカーの仕組みは、生物間でよく保存されている。発作性夜間ヘモグロビン尿症を初め、GPIアンカー欠損症が次々と見いだされている。これらの疾患を理解するためにも、GPIアンカーの生合成、つまり、糖鎖と脂質のリモデリング過程を知ることは大変重要である。本稿では、リモデリング過程を観察するために、リモデリングを触媒する酵素をコードする遺伝子をノックアウトした出芽酵母の変異株と、GPI-APsのモデル分子を用いて、GPIアンカー中の糖鎖の構造を液体クロマトグラフィー-エレクトロスプレーイオン化質量分析（LC-ESI MS）により分析・解析する方法を紹介する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"175 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LYSET is a New Factor Critical for Lysosomal Enzyme Transport and Viral Infection LYSET是溶酶体酶转运和病毒感染的新关键因子
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2317.6j
Yuko Tashima
{"title":"LYSET is a New Factor Critical for Lysosomal Enzyme Transport and Viral Infection","authors":"Yuko Tashima","doi":"10.4052/tigg.2317.6j","DOIUrl":"https://doi.org/10.4052/tigg.2317.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LYSET is a New Factor Critical for Lysosomal Enzyme Transport and Viral Infection LYSET是溶酶体酶转运和病毒感染的新关键因子
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2317.6e
Yuko Tashima
{"title":"LYSET is a New Factor Critical for Lysosomal Enzyme Transport and Viral Infection","authors":"Yuko Tashima","doi":"10.4052/tigg.2317.6e","DOIUrl":"https://doi.org/10.4052/tigg.2317.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of Sulfated Glycans on Mucins in the Gut 硫酸甘聚糖对肠道黏蛋白的影响
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2219.1j
Hirohito Abo, Hiroto Kawashima
{"title":"Significance of Sulfated Glycans on Mucins in the Gut","authors":"Hirohito Abo, Hiroto Kawashima","doi":"10.4052/tigg.2219.1j","DOIUrl":"https://doi.org/10.4052/tigg.2219.1j","url":null,"abstract":"腸管において、ムチンは腸内細菌と宿主を隔てる物理的バリアとして機能する。MUC2ムチンは、高度にO結合型糖鎖修飾を受けた糖タンパク質で、付加する糖鎖はムチンの機能発現に必須の翻訳後修飾である。近年、複雑な構造をもつMUC2糖鎖の特定の構造単位が特有の生理機能を果たすことが見出されつつある。特に、ムチン糖鎖におけるN-アセチルガラクトサミンとガラクトースの硫酸化は、腸管バリア機能に必須の糖鎖構造であることが示された。また、腸内細菌は特定の硫酸基分解酵素を用いることで、ムチン糖鎖を栄養源として利用し、腸へと生着する。一方、腸内細菌は糖転移酵素の発現誘導を介して、宿主の糖鎖修飾を制御する。このように、昨今のムチン糖鎖の構造と機能に関する研究から、ムチンは単に物理的バリアとして機能するのではなく、腸内細菌との複雑な相互作用を制御する分子であることが明らかにされつつある。本稿では、 MUC2ムチンおよびその糖鎖修飾の機能に触れながら、特にムチン糖鎖の硫酸化修飾について解説したい。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135770967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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