Immuno-Analyse & Biologie Specialisee最新文献

{"title":"Current Understanding of Novel Coronavirus: Molecular Pathogenesis, Diagnosis, and Treatment Approaches","authors":"N. Jha, Madhan Jeyaraman, gupta, S. Ojha, K. Dua, D. Chellappan, S. Muthu, Ankur Sharma, S. Jha, R. Jain, Naveen Jeyaraman, Prajwal Gs, Rohit Satyam, Fahad Khan, P. Pandey, Nandini Verma, S. Singh, S. Roychoudhury, S. Dholpuria, J. Ruokolainen, K. Kesari","doi":"10.3390/IMMUNO1010004","DOIUrl":"https://doi.org/10.3390/IMMUNO1010004","url":null,"abstract":"An outbreak of “Pneumonia of Unknown Etiology” occurred in Wuhan, China, in late December 2019. Later, the agent factor was identified and coined as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the disease was named coronavirus disease 2019 (COVID-19). In a shorter period, this newly emergent infection brought the world to a standstill. On 11 March 2020, the WHO declared COVID-19 as a pandemic. Researchers across the globe have joined their hands to investigate SARS-CoV-2 in terms of pathogenicity, transmissibility, and deduce therapeutics to subjugate this infection. The researchers and scholars practicing different arts of medicine are on an extensive quest to come up with safer ways to curb the pathological implications of this viral infection. A huge number of clinical trials are underway from the branch of allopathy and naturopathy. Besides, a paradigm shift on cellular therapy and nano-medicine protocols has to be optimized for better clinical and functional outcomes of COVID-19-affected individuals. This article unveils a comprehensive review of the pathogenesis mode of spread, and various treatment modalities to combat COVID-19 disease.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82363359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?","authors":"M. Kudelko, Tsz-fung Yip, G. C. T. Law, S. M. Lee","doi":"10.3390/IMMUNO1010003","DOIUrl":"https://doi.org/10.3390/IMMUNO1010003","url":null,"abstract":"Prevalent coagulopathy and thromboembolism are observed in severe COVID-19 patients with 40% of COVID-19 mortality being associated with cardiovascular complications. Abnormal coagulation parameters are related to poor prognosis in COVID-19 patients. Victims also displayed presence of extensive thrombosis in infected lungs. Vitamin K is well-known to play an essential role in the coagulation system. Latest study revealed an existing correlation between vitamin K deficiency and COVID-19 severity, highlighting a role of vitamin K, probably via coagulation modulation. In agreement, other recent studies also indicated that anti-coagulant treatments can reduce mortality in severe cases. Altogether, potential mechanisms linking COVID-19 with coagulopathy in which vitamin K may exert its modulating role in coagulation related with disease pathogenesis are established. In this review, we discuss the recent evidence supporting COVID-19 as a vascular disease and explore the potential benefits of using vitamin K against COVID-19 to improve disease outcomes.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86639808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immuno—A New Multidisciplinary Open Access Journal for Immunological Science and Medicine","authors":"T. Torigoe","doi":"10.3390/IMMUNO1010002","DOIUrl":"https://doi.org/10.3390/IMMUNO1010002","url":null,"abstract":"Welcome to Immuno [...]","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"129 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86384163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprogramming of Central Carbon Metabolism in Myeloid Cells upon Innate Immune Receptor Stimulation","authors":"L. Perrin-Cocon, Olivier Diaz, Anne Aublin-Gex, P. Vidalain, V. Lotteau","doi":"10.3390/IMMUNO1010001","DOIUrl":"https://doi.org/10.3390/IMMUNO1010001","url":null,"abstract":"Immunometabolism is a relatively new field of research that aims at understanding interconnections between the immune system and cellular metabolism. This is now well-documented for innate immune cells of the myeloid lineage such as macrophages and myeloid dendritic cells (DCs) when they engage their differentiation or activation programs. Several studies have shown that stimulation of DCs or macrophages by the binding of pathogen-associated molecular patterns (PAMPs) to pattern recognition receptors (PRRs) leads to increased glycolytic activity and rewiring of central carbon metabolism. These metabolic modulations are essential to support and settle immunological functions by providing energy and immunoregulatory metabolites. As the understanding of molecular mechanisms progressed, significant differences between cell types and species have also been discovered. Pathways leading to the regulation of central carbon metabolism in macrophages and DCs by PRR signaling and consequences on cellular functions are reviewed here.","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83558985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La carence maternelle en vitamine B12 : quelles conséquences pour le nouveau-né ? À propos d’un cas marocain","authors":"S. Elmachtani Idrissi ,&nbsp;N. El Omri ,&nbsp;R. El Jaoudi ,&nbsp;F. Chibani ,&nbsp;A. Biaze ,&nbsp;A. Dami ,&nbsp;S. Bouhsain ,&nbsp;Z. Ouzzif ,&nbsp;L. Chabraoui","doi":"10.1016/j.immbio.2013.06.002","DOIUrl":"10.1016/j.immbio.2013.06.002","url":null,"abstract":"<div><p>The stock of newborn vitamin B12 (VitB12) comes exclusively from placental transfer. After dietary diversification, the VitB12 is provided by foods of animal origin. The aim of this observation is to point out the serious consequences of maternal VitB12 deficiency for infants exclusively breastfed and the importance of early diagnosis of this pathology. This observation is a concrete feature of daily collaboration between clinician and biologist, which is an essential point of the ISO standard EN 15189 concerning laboratories accreditation.</p></div><div><p>Le stock en vitamine B12 (VitB12) du nouveau-né provient exclusivement du transfert placentaire. Après la diversification alimentaire, la VitB12 est apportée par les aliments d’origine animale. L’objectif de notre observation est de faire le point sur les conséquences gravissimes de la carence maternelle en VitB12 pour le nourrisson nourri exclusivement au sein ainsi que l’importance du diagnostic précoce de cette pathologie. Cette observation est un exemple concret de collaboration clinicien-biologiste, permettant le respect de la norme ISO EN 15189 sur l’accréditation des laboratoires.</p></div>","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"28 5","pages":"Pages 362-365"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.immbio.2013.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73252030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Les thrombopénies fœtales et néonatales alloimmunes","authors":"G. Bertrand,&nbsp;C. Kaplan","doi":"10.1016/j.immbio.2013.04.005","DOIUrl":"10.1016/j.immbio.2013.04.005","url":null,"abstract":"<div><p>Fetal and neonatal alloimmune thrombocytopenia may be regarded as the platelet counterpart of hemolytic disease of the fetus and newborn. The most feared complication of this syndrome is the occurrence of intracranial hemorrhage leading to death or neurological sequels. With advances in the diagnosis and management of the index case and of pregnancies at risk, the prognosis of affected infants has improved. Further research must focus on the mechanisms of maternal sensitization and development of specific therapy. Collaborative and large-scale studies are necessary.</p></div><div><p>Les thrombopénies fœtales et néonatales alloimmunes, équivalents plaquettaires de la maladie hémolytique du nouveau-né, ne sont pas des évènements rares. En cas de thrombopénie sévère, la survenue d’hémorragie intracrânienne altère le pronostic avec risque de décès ou séquelles neurologiques graves. La prise en charge thérapeutique du cas index et des grossesses futures dépend donc du diagnostic biologique amélioré par le développement de techniques de laboratoire de plus en plus sensibles et fiables. Des études collaboratives sont nécessaires afin de mieux comprendre la physiopathologie de l’immunisation maternelle et de mettre en œuvre un dépistage adéquat, un traitement spécifique, voire une éventuelle prévention.</p></div>","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"28 5","pages":"Pages 335-342"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.immbio.2013.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81807600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activité adénosine désaminase pleurale : un outil de choix pour le diagnostic des pleurésies tuberculeuses dans les pays à haute prévalence","authors":"H. Delacour ,&nbsp;C. Ficko ,&nbsp;A. Bousquet ,&nbsp;S. Bugier ,&nbsp;É. Fontan ,&nbsp;F. Ceppa","doi":"10.1016/j.immbio.2013.09.002","DOIUrl":"10.1016/j.immbio.2013.09.002","url":null,"abstract":"<div><p>Dans les zones de haute prévalence tuberculeuse, les pleurésies tuberculeuses constituent la première étiologie des pleurésies séro-fibrineuses. De nombreux biomarqueurs, dont la détermination de l’activité adénosine désaminase pleurale, ont été proposé pour aider au diagnostic de cette entité clinique et palier les limites des outils diagnostics classiques (examen direct, culture…). Bien que de nombreuses études aient démontré l’intérêt de la détermination de l’activité adénosine désaminase pleurale, ce marqueur reste assez méconnu. L’objectif de cet article est de rappeler son intérêt en axant notre propos sur les pays à forte prévalence tuberculeuse.</p></div><div><p>Tuberculous pleurisy (TP) is one of the most common aetiologies of lymphocytic predominant pleural effusion in tuberculous endemic areas. Its definitive diagnosis depends on isolation of <em>Mycobacterium tuberculosis</em> in the pleural effusion or pleural tissue, but mycobacterial culture requires weeks to obtain the results and exhibits poor performances. Also various biomarkers, including pleural adenosine deaminase activity (ADA), have been proposed to assist the diagnosis of TP. Many studies have investigated the usefulness of this biomarker for the early diagnosis of TP. Measurement of ADA in pleural effusion is thus likely to be a useful diagnosis tool for TP.</p></div>","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"28 5","pages":"Pages 353-357"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.immbio.2013.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80129473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the mutagenic potential of a combinational prophylactic transdermal patch by Ames test","authors":"S. Banerjee ,&nbsp;S. Singh ,&nbsp;R. Policegoudra ,&nbsp;P. Chattopadhyay ,&nbsp;A. Ghosh ,&nbsp;V. Veer","doi":"10.1016/j.immbio.2013.07.004","DOIUrl":"10.1016/j.immbio.2013.07.004","url":null,"abstract":"<div><h3>Aims</h3><p>The Ames <em>Salmonella</em>/microsome mutagenicity assay is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of that chemical substances which can produce genetic damage that leads to gene mutations.</p></div><div><h3>Methods</h3><p><span>In this study, we evaluated the mutagenic potential of prophylactic transdermal patches containing eserine and pralidoxime chloride (2-PAM) and its placebo patches using TA98, TA100, TA1535 and TA1538 strains of </span><span><em>Salmonella typhimurium</em></span> by Ames test<em>.</em> Characterization of the patches was done before the initiation of the study. The assays were performed according to the plate incorporation procedure described by Organization for Economic Cooperation and Development (OECD) recommendations and Ames and Whitfield spot test procedure.</p></div><div><h3>Results</h3><p>Both eserine and 2-PAM drugs impregnated patches along with drug unimpregnated patches were not found to be mutagenic.</p></div><div><h3>Conclusion</h3><p>This investigation reflects that the patches are non-mutagenic and safe for human use.</p></div><div><h3>Objectifs</h3><p><span><span>Le test Ames de mutagénicité à partir de </span>microsomes de </span><em>Salmonella</em> est un réactif capable de mettre en évidence à court terme la reversion d’une souche auxotrophe, ce qui permet d’étudier une grande variété de composés chimiques susceptibles de provoquer des mutations géniques.</p></div><div><h3>Méthodes</h3><p>Dans cette étude, nous avons évalué à l’aide du test Ames le potentiel mutagénique de patchs transdermiques prophylactiques sur différentes souches de <em>Salmonella typhimurium</em> (TA98, TA100, TA1535 et TA1538). Ces patchs contenaient de l’ésérine, du chlorure de pralidoxime (2-PAM) et des placebos. L’analyse des patchs a été réalisée avant le début des expérimentations. La technique de l’incorporation aux plaques de culture est celle décrite dans les recommandations de l’OCDE (Organisation de coopération et de développement économiques), de la Société Ames et du spot test de Whitfield.</p></div><div><h3>Résultats</h3><p>Les patchs imprégnés d’ésérine et de 2-PAM, de même que les patchs placebo, ne se sont pas révélés mutagènes.</p></div><div><h3>Conclusion</h3><p>Nos travaux montrent que les patchs analysés sont non mutagènes et donc utilisables pour un emploi chez l’Homme.</p></div>","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"28 5","pages":"Pages 322-326"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.immbio.2013.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86105126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leucémie aiguë néonatale révélée par Blueberry Muffin syndrome (à propos d’un cas)","authors":"I. Tlamçani,&nbsp;S. Benjelloun,&nbsp;G. Yahyaoui,&nbsp;N. Benseddik,&nbsp;M.H. Amrani","doi":"10.1016/j.immbio.2013.04.009","DOIUrl":"10.1016/j.immbio.2013.04.009","url":null,"abstract":"<div><p>Acute leukemia is uncommon in neonates and has a much poorer prognosis than in older children. We report a case of acute myeloblastic leukemia observed in a neonate who had skin lesions (Blueberry Muffin syndrome), bleeding and hepatosplenomegaly at birth, which justified intensive care since the first postnatal week. The patient died 13<!--> <!-->days after. We present here physical and laboratory findings, which indicate a grim prognosis. These criteria should be considered carefully in order to ensure realistic information for the parents and appropriate decision.</p></div><div><p>La leucémie aiguë est une maladie exceptionnelle en période néonatale et son pronostic est sévère, bien moins bon que chez les enfants plus âgés. Le Blueberry Muffin syndrome se manifeste par des lésions cutanées sous forme de papulonodules violacées disséminées sur tout le corps, présent dès la naissance et doit faire rechercher la présence d’éventuelles infections congénitales, d’incompatibilités fœto-maternelles ou de pathologies tumorales. Nous rapportons un cas de leucémie aiguë myéloblastique néonatale qui s’est manifestée par un Blueberry Muffin syndrome ainsi qu’un syndrome hémorragique et tumoral présents dès la naissance ce qui a justifié une prise en charge en réanimation dès la première semaine de vie. L’évolution a été fatale après 13<!--> <!-->jours de vie.</p></div>","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"28 5","pages":"Pages 366-369"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.immbio.2013.04.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82790475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caractéristiques immuno-analytiques de la copeptine","authors":"C. Desbene,&nbsp;O. Gaillard","doi":"10.1016/j.immbio.2013.09.001","DOIUrl":"10.1016/j.immbio.2013.09.001","url":null,"abstract":"<div><p>Besides structural and physiological data of copeptin, this paper points out the optimal conditions for sampling, assays and interpretation of results.</p></div><div><p>Après les caractéristiques structurales et physiologiques de la copeptine, les données pré, per et post analytiques de son dosage sont abordées pour l’interprétation des résultats.</p></div>","PeriodicalId":55599,"journal":{"name":"Immuno-Analyse & Biologie Specialisee","volume":"28 5","pages":"Pages 386-392"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.immbio.2013.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79116615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}