Aging-Us最新文献

{"title":"Correction for: 1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway.","authors":"Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, Ikuro Maruyama","doi":"10.18632/aging.206208","DOIUrl":"10.18632/aging.206208","url":null,"abstract":"","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 2","pages":"607"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pan-cancer analysis of Methyltransferase-like 16 (METTL16) and validated in colorectal cancer.","authors":"Ling Liu, Siying Wang, Xuyu Chen, Qian Luo, Zhaoxia Wang, Juan Li","doi":"10.18632/aging.206210","DOIUrl":"10.18632/aging.206210","url":null,"abstract":"<p><p>Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative studies of the relevance of METTL16 across diverse tumors remain sparse. We comprehensively investigated the effect of METTL16 expression on tumor prognosis across human malignancies by analyzing multiple cancer-related databases like Tumor Immune Estimation Resource (TIMER) and human protein atlas (HPA). Bioinformatics data indicated that METTL16 was overexpressed in most of these human malignancies and was significantly associated with the prognosis of patients with cancer, especially in colorectal cancer (CRC). Subsequently, <i>In vitro</i> experiments, the utility of METTL16 that downregulation of its expression could result in reduced proliferation and migration of CRC cells. Our findings reveal novel insights into METTL16 expression and its biological functions in diverse cancer types, indicating that METTL16 could serve as a prognostic biomarker and plays an important role in colorectal cancer.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"588-606"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in radiotherapy outcomes across cancer types: a comparative study of glioblastoma multiforme and low-grade gliomas.","authors":"Alexander Veviorskiy, Garik V Mkrtchyan, Andreyan N Osipov, Evgeny Izumchenko, Ivan V Ozerov, Alex Aliper, Alex Zhavoronkov, Morten Scheibye-Knudsen","doi":"10.18632/aging.206212","DOIUrl":"10.18632/aging.206212","url":null,"abstract":"<p><p>Radiotherapy is a crucial treatment option for various cancers. However, the results of radiotherapy can vary widely across different cancer types and even among patients with the same type of cancer. This variability presents a major challenge in optimizing treatment strategies and improving patient survival. Here, we collected radiotherapy phenotype and expression data from 32 TCGA cancer datasets and performed overall survival analysis for 32 cancer types. Additionally, we conducted a signaling pathway enrichment analysis to identify key pathways involved in radiotherapy resistance and sensitivity. Our findings show that radiotherapy improves survival outcomes in certain cancer types, such as glioblasoma multiforme (GBM), while worsening outcomes in others, such as low-grade glioma (LGG). Next, we focused on exploring the differences in radiotherapy outcomes between GBM and LGG, focusing on the molecular mechanisms contributing to these variations. We identify differential regulation of pathways related to programmed cell death, DNA repair, telomere maintenance, chromosome condensation, antiviral responses, and interferon signaling between GBM and LGG patients perhaps explaining radiotherapy efficacy. A genetic analysis confirmed the importance of immune response and radiotherapy outcome for LGG patients. These insights underscore the importance of personalized treatment approaches and the need for further research to improve radiotherapy outcomes in cancer patients.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"550-562"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model.","authors":"Hoang Van M Nguyen, Eleana Cabello, David Dyer, Chloe Fender, Manuel Garcia-Jaramillo, Norman G Hord, Steven Austad, Arlan Richardson, Archana Unnikrishnan","doi":"10.18632/aging.206211","DOIUrl":"10.18632/aging.206211","url":null,"abstract":"<p><p>We evaluated the impact of sex and mitochondrial-haplotype on the age-related changes in the fecal gut microbiome of the genetically heterogeneous rodent model, the OKC-HET^B/W rat. The age-related changes in the microbiome differed markedly between male and female rats. Five microbial species changed significantly with age in male rats compared to nine microbial species in female rats. Only three of these microbes changed with age in both male and female rats. The mitochondrial-haplotype of the rats also affected how aging altered the microbiome. Interestingly, most of the microbial species that changed significantly with age were mitochondrial-haplotype and sex specific, i.e., changing in one sex and not the other. We also discovered that sex and mitochondrial-haplotype significantly affected the age-related variations in content of fecal short-chain fatty acids and plasma metabolites that influence or are regulated by the microbiome, e.g., tryptophan derived metabolites and bile acids. This study demonstrates that the host's sex plays a significant role in how the gut microbiome evolves with age, even within a genetically diverse background. Importantly, this is the first study to show that the mitochondrial-haplotype of a host impacts the age-related changes in the microbiome.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"524-549"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cut-off values for the muscle mass indices determined using DXA in healthy Polish adults - a comparison to EWGSOP2 recommendation.","authors":"Aleksandra Radecka, Waldemar Pluta, Tomasz Miazgowski, Anna Lubkowska","doi":"10.18632/aging.206206","DOIUrl":"10.18632/aging.206206","url":null,"abstract":"<p><strong>Background: </strong>Muscle mass measurements are vital for predicting health outcomes and diagnosing muscle disorders. This study provides reference data for appendicular lean mass (ALM) and total lean mass (TLM) in healthy Polish adults with normal muscle strength and physical performance as per EWGSOP2 guidelines.</p><p><strong>Methods: </strong>The study included healthy volunteers with normal muscle strength and functional status. Lean mass was measured using Hologic Horizon DXA. Mean values of TLM, ALM, fat-free mass (FFM), and indices (TLMI, ALMI, FFMI) were calculated for seven age groups (by decade). Cut-off points equivalent to T-scores of -1 and -2 standard deviations (SDs) below the young adult reference mean (ages 20-39) were determined.</p><p><strong>Results: </strong>Data from 1,111 participants (328 men, 46.3 ± 20 years; 783 women, 43.7 ± 23 years) were analyzed. In young adults, mean ALM was 28.1 kg (men) and 17.2 kg (women), and ALMI was 8.6 kg/m² (men) and 6.1 kg/m² (women). Low muscle mass cut-off points (2 SDs below) were 18 kg and 10.9 kg (ALM) and 6 kg/m² and 4.3 kg/m² (ALMI) for men and women, respectively. Men exhibited significantly greater lean mass than women across all age groups (P < 0.001). Lean mass declined with age in both genders, following a nonlinear pattern, except for ALMI in men.</p><p><strong>Conclusions: </strong>This study provides the first population-based reference values for ALM and TLM in healthy Polish adults aged 20-89 years, integrating criteria for normal muscle strength and physical performance.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"482-496"},"PeriodicalIF":3.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and genetic determination of measures of peripheral vascular health in the Long Life Family Study.","authors":"Deidra R Fricke, Ryan K Cvejkus, Emma Barinas-Mitchell, Mary F Feitosa, Joanne M Murabito, Sandeep Acharya, Michael R Brent, E Warwick Daw, Ryan L Minster, Joseph M Zmuda, Allison L Kuipers","doi":"10.18632/aging.206204","DOIUrl":"10.18632/aging.206204","url":null,"abstract":"<p><p>Peripheral artery disease (PAD) is a major contributor to morbidity in older adults. We aimed to determine genetic and non-genetic determinants of PAD and ankle-brachial index (ABI) in the Long Life Family Study (LLFS). 3006 individuals had ABI assessment, including 1090 probands (mean age 89), 1554 offspring (mean age 60) and 362 spousal controls (mean age 61). Outcomes include minimum of right and left ABIs and PAD (ABI <0.9). Stepwise regression determined independent significant non-genetic correlates of ABI and PAD. Genomewide association and linkage analyses were adjusted for age, sex, study center, significant principal components, and independent predictors. All analyses accounted for familial relatedness. Median ABI was 1.16 and 7.4% had PAD (18.2% probands, 1.0% offspring, 1.9% controls). Correlates of PAD and lower ABI included age, SBP, and creatinine (ABI only); BMI (ABI only), HDL (ABI only) and DBP (PAD only); and antihypertensive use, current smoking, female sex (ABI only), and high school noncompletion (ABI only). Genomewide linkage identified 1 region (15q12-q13) and association identified 3 single nucleotide polymorphisms (rs780213, rs12512857, rs79644420) of interest. In these families, PAD prevalence was low compared to other studies of older adults. We identified four genomic sites that may harbor variants associated with protection from PAD.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"464-481"},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of senescence rejuvenation mechanism of <i>Magnolia officinalis</i> extract including honokiol as a core ingredient.","authors":"Yun Haeng Lee, Eun Young Jeong, Ye Hyang Kim, Ji Ho Park, Jee Hee Yoon, Yoo Jin Lee, So Hun Lee, Yeon Kyung Nam, So Yoon Cha, Jin Seong Park, So Yeon Kim, Youngjoo Byun, Song Seok Shin, Joon Tae Park","doi":"10.18632/aging.206207","DOIUrl":"10.18632/aging.206207","url":null,"abstract":"<p><p>Reactive oxygen species (ROS) contribute to aging by mainly damaging cellular organelles and DNA. Although strategies to reduce ROS production have been proposed as important components of anti-aging therapy, effective mechanisms to lower ROS levels have not yet been identified. Here, we screened natural compounds frequently used as cosmetic ingredients to find substances that reduce ROS levels. <i>Magnolia officinalis</i> (<i>M. officinalis</i>) extract significantly lowered the levels of ROS in senescent fibroblasts. A novel mechanism by which <i>M. officinalis</i> extract restores mitochondrial function to reduce ROS, a byproduct of inefficient electron transport, was discovered. The reduction of ROS by <i>M. officinalis</i> extracts reversed senescence-associated phenotypes and skin aging. Then, honokiol was demonstrated as a core ingredient of <i>M. officinalis</i> extract that exhibits antioxidant effects. Honokiol functions as an oxygen radical scavenger through redox processes, also significantly reduced ROS levels by restoring mitochondrial function. In summary, our study identified a novel mechanism by which <i>M. officinalis</i> extract reverses aging and skin aging by reducing ROS through restoring mitochondrial function. These new findings will not only expand our understanding of aging and associated diseases, but also provide new approaches to anti-aging treatments.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"497-523"},"PeriodicalIF":3.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the use of black phosphorus quantum dots in the treatment of atherosclerosis.","authors":"Shengwei Zhang, Yiran Ji, Bingxuan Xu, Die Hu, Xue Zhang, Yujian Song, Keke Chen, Yilin Wen, Xiaoxin He, Yun Chen, Tingting Zheng","doi":"10.18632/aging.206205","DOIUrl":"10.18632/aging.206205","url":null,"abstract":"<p><p>Atherosclerosis is the pathological basis of cardiovascular disease, and there are no clinical drugs that can safely and efficiently remove atherosclerotic plaques. In this study, black phosphorus quantum dots (BPQDs) were applied to the treatment of atherosclerosis in high fat diet ApoE^-/- model mice that BPQDs were given every other day for 3 weeks without changing the high-fat diet. 45.3% atherosclerotic plaque was cleared efficiently within 3 weeks in BPQDs intravenous administration way every other day. The treatment was more effective than traditional statins. The findings suggest that BPQDs have great potential to be applied for clinical prevention and treatment of AS that does not require dietary changes.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"17 ","pages":"563-587"},"PeriodicalIF":3.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice.","authors":"Duraipandy Natarajan, Shoba Ekambaram, Stefano Tarantini, Raghavendra Y Nagaraja, Andriy Yabluchanskiy, Andria F Hedrick, Vibhudutta Awasthi, Madhan Subramanian, Anna Csiszar, Priya Balasubramanian","doi":"10.18632/aging.206203","DOIUrl":"10.18632/aging.206203","url":null,"abstract":"<p><p>Microvascular endothelial dysfunction, characterized by impaired neurovascular coupling, reduced glucose uptake, blood-brain barrier disruption, and microvascular rarefaction, plays a critical role in the pathogenesis of age-related vascular cognitive impairment (VCI). Emerging evidence points to non-cell autonomous mechanisms mediated by adverse circulating milieu (an increased ratio of pro-geronic to anti-geronic circulating factors) in the pathogenesis of endothelial dysfunction leading to impaired cerebral blood flow and cognitive decline in the aging population. In particular, age-related adipose dysfunction contributes, at least in part, to an unfavorable systemic milieu characterized by chronic hyperglycemia, hyperinsulinemia, dyslipidemia, and altered adipokine profile, which together contribute to microvascular endothelial dysfunction. Hence, in the present study, we aimed to test whether thermogenic stimulation, an intervention known to improve adipose and systemic metabolism by increasing cellular energy expenditure, could mitigate brain endothelial dysfunction and improve cognition in the aging population. Eighteen-month-old C57BL/6J mice were treated with saline or β3-adrenergic agonist (CL 316, 243, CL) for 6 weeks followed by functional analysis to assess endothelial function and cognition. CL treatment improved neurovascular coupling responses and rescued brain glucose uptake in aged animals. In addition, CL treatment also attenuated blood-brain barrier leakage and associated neuroinflammation in the cortex and increased microvascular density in the hippocampus of aged mice. More importantly, these beneficial changes in microvascular function translated to improved cognitive performance in aged mice. Our results suggest that β3-adrenergic agonist treatment improves multiple aspects of cerebromicrovascular function and can be potentially repurposed for treating age-associated cognitive decline.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"448-463"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP).","authors":"Leah M Roberts, Nola Herlihy, Andres Reig, Shiny Titus, Rolando Garcia-Milian, James Knight, Raziye Melike Yildirim, Cheri K Margolis, Yigit Cakiroglu, Bulent Tiras, Christine V Whitehead, Marie D Werner, Emre Seli","doi":"10.18632/aging.206202","DOIUrl":"10.18632/aging.206202","url":null,"abstract":"<p><p>Intraovarian injection of autologous platelet-rich plasma (PRP) has recently been investigated as a potential treatment for patients with diminished ovarian reserve. In the current study, differential gene expression in cumulus cells obtained from patients treated with PRP was compared to controls. RNA sequencing libraries were constructed from the cumulus cells, and differential expression analysis was performed with a false discovery rate threshold of <i>p</i>-value ≤0.05 and Log2 fold change ≥0.584. RNA sequencing of cumulus cells revealed significant differences in gene expression when comparing those treated with PRP and resulted in a live birth (<i>n</i> = 5) to controls with live birth (<i>n</i> = 5), or to controls with failed implantation (<i>n</i> = 5). Similarly, when all samples treated with PRP (those that resulted in live birth or arrested embryos (<i>n</i> = 10)) were compared to all samples from controls (those that resulted in live birth, no pregnancy, or arrested embryos (<i>n</i> = 13)), gene expression was significantly different. Several pathways were consistently affected by PRP treatment through multiple comparisons, including carbohydrate metabolism, cell death and survival, cell growth and proliferation, and cell-to-cell signaling, all of which have been implicated in human causes of infertility.</p>","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"431-447"},"PeriodicalIF":3.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}