Aging-Us最新文献_第7页

Brown adipose tissue enhances exercise performance and healthful longevity. 褐色脂肪组织提高运动表现和健康长寿。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-18 DOI: 10.18632/aging.206179

Dorothy E Vatner, Jie Zhang, Stephen F Vatner

{"title":"Brown adipose tissue enhances exercise performance and healthful longevity.","authors":"Dorothy E Vatner, Jie Zhang, Stephen F Vatner","doi":"10.18632/aging.206179","DOIUrl":"10.18632/aging.206179","url":null,"abstract":"Brown adipose tissue (BAT), a major subtypes of adipose tissues, is known for thermogenesis and promoting healthful longevity. Our hypothesis is that BAT protects against impaired healthful longevity, i.e., obesity, diabetes, cardiovascular disorders, cancer, Alzheimer's disease, and reduced exercise tolerance. While most prior studies have shown that exercise regulates BAT activation and improves BAT density, relatively few have shown that BAT increases exercise performance. In contrast, our recent studies with the regulator of G protein signaling 14 (RGS14) knockout (KO) model of extended longevity showed that it enhances exercise performance, mediated by its more potent BAT, compared with BAT from wild type mice. For example, when the BAT from RGS14 KO mice is transplanted to WT mice, their exercise capacity is enhanced at 3 days after BAT transplantation, whereas BAT transplantation from WT to WT mice increased exercise performance, but only at 8 weeks after transplantation. The goal of this research perspective is to review the role of BAT in mediating healthful longevity, specifically exercise capacity. In view of the ability of BAT to mediate healthful longevity and enhance exercise performance, it is likely that a pharmaceutical analog of BAT will become a novel therapeutic modality.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"undefined ","pages":"13442-13451"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arginase-II gene deficiency reduces skeletal muscle aging in mice. 精氨酸酶ii基因缺乏可减少小鼠骨骼肌衰老。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-12 DOI: 10.18632/aging.206173

Matteo Caretti, Duilio Michele Potenza, Guillaume Ajalbert, Urs Albrecht, Xiu-Fen Ming, Andrea Brenna, Zhihong Yang

{"title":"Arginase-II gene deficiency reduces skeletal muscle aging in mice.","authors":"Matteo Caretti, Duilio Michele Potenza, Guillaume Ajalbert, Urs Albrecht, Xiu-Fen Ming, Andrea Brenna, Zhihong Yang","doi":"10.18632/aging.206173","DOIUrl":"10.18632/aging.206173","url":null,"abstract":"Age-associated sarcopenia decreases mobility and is promoted by cell senescence, inflammation, and fibrosis. The mitochondrial enzyme arginase-II (Arg-II) plays a causal role in aging and age-associated diseases. Therefore, we aim to explore the role of Arg-II in age-associated decline of physical activity and skeletal muscle aging in a mouse model. Young (4-6 months) and old (20-24 months) wild-type (wt) mice and mice deficient in arg-ii (arg-ii-/-) of both sexes are investigated. We demonstrate a decreased physical performance of old wt mice, which is partially prevented in arg-ii-/- animals, particularly in males. The improved phenotype of arg-ii-/- mice in aging is associated with reduced sarcopenia, cellular senescence, inflammation, and fibrosis, whereas age-associated decline of microvascular endothelial cell density, satellite cell numbers, and muscle fiber types in skeletal muscle is prevented in arg-ii-/- mice. Finally, we demonstrate an increased arg-ii gene expression level in aging skeletal muscle and found Arg-II protein expression in endothelial cells and fibroblasts, but not in skeletal muscle fibers, macrophages, and satellite cells. Our results suggest that increased Arg-II in non-skeletal muscle cells promotes age-associated sarcopenia, particularly in male mice.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"13563-13587"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ISarcoPRM algorithm for global operationalization of sarcopenia diagnosis. 肌少症诊断全局操作化的ISarcoPRM算法。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-11 DOI: 10.18632/aging.206174

Pelin Analay, Murat Kara, Levent Özçakar

引用次数: 0

Gender-specification lifestyle factors associated with mild cognitive impairment among young-old adults in Taiwan. 台湾中青年轻度认知障碍之性别生活型态因素。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-10 DOI: 10.18632/aging.206172

Su-Wen Chuang, Ching-Wen Chen, Meng-Chang Lee, Yu-Hsuan Chen, Wen Su, Cheng-Jung Chen, Wei-Teing Chen, Po-Jen Hsiao, Chih-Chien Chiu, Sui-Lung Su

{"title":"Gender-specification lifestyle factors associated with mild cognitive impairment among young-old adults in Taiwan.","authors":"Su-Wen Chuang, Ching-Wen Chen, Meng-Chang Lee, Yu-Hsuan Chen, Wen Su, Cheng-Jung Chen, Wei-Teing Chen, Po-Jen Hsiao, Chih-Chien Chiu, Sui-Lung Su","doi":"10.18632/aging.206172","DOIUrl":"10.18632/aging.206172","url":null,"abstract":"Background: The prevalence of mild cognitive impairment (MCI) exhibits a positive correlation with age, particularly evident in the old-old female population. Lifestyle factors have been identified as crucial risk determinants for MCI. However, there is a scarcity of research focusing on lifestyle factors among young-old population.Objective: This study aimed to explore the lifestyle factors associated with MCI in young-old male and female.Methods: This study employed a cross-sectional design and utilized demographic and lifestyle data obtained from participants enrolled in the Taiwan Biobank (TWB) between 2008 and 2021, with 32,897 individuals aged 60 to 70 years old. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), with a total score ranging from 0 to 30 points. The cut-off of MCI scores was ≤18, ≤21, and ≤25 according to the education level, respectively. Logistic regression analysis was employed to assess the association between lifestyles and cognitive function.Results: 3,878 individuals (11.78%) suffered from MCI. Upon gender stratification, high exercise metabolic equivalents in male (OR = 0.8, 95% CI: 0.70 - 0.92) and moderate exercise in female serve as protective factors for MCI (OR = 0.78, 95% CI: 0.70 - 0.87). Additionally, diversified dietary preferences among female (OR = 0.80, 95% CI: 0.66 - 0.97) also emerge as protective factors for cognitive function.Conclusions: It is worth noting that male is advised to target a higher exercise metabolic equivalent, while female can attain cognitive benefits with moderate exercise and diversified dietary.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"16 ","pages":"13662-13675"},"PeriodicalIF":3.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear lipid droplets: a novel regulator of nuclear homeostasis and ageing. 核脂滴：核稳态和衰老的新调节器。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-09 DOI: 10.18632/aging.206175

Konstantinos Palikaras, Nektarios Tavernarakis

{"title":"Nuclear lipid droplets: a novel regulator of nuclear homeostasis and ageing.","authors":"Konstantinos Palikaras, Nektarios Tavernarakis","doi":"10.18632/aging.206175","DOIUrl":"10.18632/aging.206175","url":null,"abstract":"Aging is a fundamental driver of numerous life-threatening diseases, significantly compromising cellular structures and functions, including the integrity of the nucleus. A consistent feature of aging across diverse species is the progressive accumulation of lipid droplets (nLDs) within the nuclear compartment, which disrupts nuclear architecture and functionality. Notably, aging is accompanied by a marked increase in nLD accumulation at the nuclear envelope. Interventions known to extend lifespan, such as caloric restriction and reduced insulin signaling, significantly reduce both the rate of accumulation and the size of nLDs. The triglyceride lipase ATGL-1, which localizes to the nuclear envelope, plays a critical role in limiting nLD buildup and maintaining nuclear lipid balance, especially in long-lived mutant worms. These findings establish excessive nuclear lipid deposition as a key hallmark of aging, with profound implications for nuclear processes such as chromatin organization, DNA repair, and gene regulation. In addition, ATGL-1 emerges as a promising therapeutic target for preserving nuclear health, extending organismal healthspan, and combating age-related disorders driven by lipid dysregulation.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"undefined ","pages":"13436-13441"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of Huangqi formula (Eefooton) in chronic kidney disease: clinical research and narrative literature review. 黄芪方治疗慢性肾脏病的临床研究及文献综述。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-07 DOI: 10.18632/aging.206170

Kuo-Cheng Lu, San-Chiang Wu, Tsuo-Cheng Lu, I-Shang Tzeng, Chun-En Kuo, Yu-Chiang Hung, Szu-Ying Wu, Te-Chuan Chen, Ming-Kai Tsai, Chih-Kuang Chuang, Wen-Long Hu

{"title":"Therapeutic effects of Huangqi formula (Eefooton) in chronic kidney disease: clinical research and narrative literature review.","authors":"Kuo-Cheng Lu, San-Chiang Wu, Tsuo-Cheng Lu, I-Shang Tzeng, Chun-En Kuo, Yu-Chiang Hung, Szu-Ying Wu, Te-Chuan Chen, Ming-Kai Tsai, Chih-Kuang Chuang, Wen-Long Hu","doi":"10.18632/aging.206170","DOIUrl":"10.18632/aging.206170","url":null,"abstract":"Objective: The study aimed to assess the clinical effects of employing the Huangqi formula (Eefooton; EFT) for chronic kidney disease (CKD) treatment. A narrative literature review was undertaken to elucidate the specific ingredients of EFT and their potential impact on renal health.Methods: A retrospective observational study investigated EFT treatment in outpatients with stable CKD (stages 3B to 5) from March 2019 to March 2021. Patients received 20 mL of EFT thrice daily for 6 months, along with standard treatment. Control groups were matched to the EFT cohort. Regular assessments of renal, liver functions, and lipid profiles were conducted.Results: Serum creatinine (Cr) and eGFR levels consistently improved in stage 3B CKD patients at each follow-up visit. At 6 months, improvement in Cr and eGFR was observed for stage 4 and 5 CKD. Stage 3B CKD patients exhibited notable reductions in systolic blood pressure after 3 and 6 months of EFT treatment. Remarkably, a substantial decrease in HbA1C was noted in stage 4 CKD individuals after three months of therapy. Additionally, stage 4 CKD patients saw a significant reduction in LDL levels after both 3 and 6 months of EFT treatment. A literature review on EFT ingredients indicated that the positive effects of EFT might be associated with its anti-inflammatory, antioxidant, and anti-fibrotic properties.Conclusions: This research demonstrated that incorporating EFT alongside standard treatment enhanced renal function in individuals with CKD. EFT is proposed as a feasible complementary treatment for CKD patients, emphasizing the importance of early intervention.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"16 ","pages":"13627-13647"},"PeriodicalIF":3.9,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid beta biomarker for dementia detection by hyperspectral ophthalmoscope images. 高光谱检眼镜图像检测痴呆的β淀粉样蛋白生物标志物。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-06 DOI: 10.18632/aging.206171

Yu-Bun Ng, Sheng-Feng Sung, Hong-Thai Nguyen, Shih-Wun Liang, Yu-Ming Tsao, Yi-Hui Kao, Wen-Shou Lin, Hsiang-Chen Wang

{"title":"Amyloid beta biomarker for dementia detection by hyperspectral ophthalmoscope images.","authors":"Yu-Bun Ng, Sheng-Feng Sung, Hong-Thai Nguyen, Shih-Wun Liang, Yu-Ming Tsao, Yi-Hui Kao, Wen-Shou Lin, Hsiang-Chen Wang","doi":"10.18632/aging.206171","DOIUrl":"10.18632/aging.206171","url":null,"abstract":"The escalating prevalence and economic burden of dementia underscore the urgency for innovative detection methods. This study investigates the potential of hyperspectral imaging (HSI) to detect dementia by analyzing retinal changes associated with amyloid beta (Aβ) formations. Leveraging a dataset of 3,256 ophthalmoscopic images from 137 participants aged 60 to 85 years, categorized into dementia and non-dementia groups via the Mini-Mental State Examination (MMSE), we extracted features from five key regions of interest (ROIs) identified for their pronounced changes in Aβ biomarkers. The analysis revealed that gender does not significantly influence dementia levels, and no substantial spectral differences were observed within the 380 nm to 600 nm wavelength range. However, significant variations in spectral reflection intensity were noted between 600 nm and 780 nm across both genders, suggesting a potential avenue for distinguishing stages of dementia. Despite the impact of diabetes on the vascular system, its stages did not significantly influence dementia development. This research highlights the utility of HSI in identifying dementia-related retinal changes and calls for further exploration into its effectiveness as a diagnostic tool, potentially offering a non-invasive method for early detection of dementia.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"16 ","pages":"13648-13661"},"PeriodicalIF":3.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility. 血液中dna甲基化年龄和加速表观遗传衰老作为预测乳腺癌易感性的肿瘤标志物。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-05 DOI: 10.18632/aging.206169

Su Yon Jung, Herbert Yu, Youping Deng, Matteo Pellegrini

{"title":"DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility.","authors":"Su Yon Jung, Herbert Yu, Youping Deng, Matteo Pellegrini","doi":"10.18632/aging.206169","DOIUrl":"10.18632/aging.206169","url":null,"abstract":"Background: DNA methylation (DNAm)-based marker of aging, referred to as 'epigenetic age' or 'DNAm age' is a highly accurate multi-tissue biomarker for aging, associated with age-related disease risk, including cancer. Breast cancer (BC), an age-associated disease, is associated with older DNAm age and epigenetic age acceleration (age accel) at tissue levels. But this raises a question on the predictability of DNAm age/age accel in BC development, emphasizing the importance of studying DNAm age in pre-diagnostic peripheral blood (PB) in BC etiology and prevention.Methods: We included postmenopausal women from the largest study cohort and prospectively investigated BC development with their pre-diagnostic DNAm in PB leukocytes (PBLs). We estimated Horvath's pan-tissue DNAm age and investigated whether DNAm age/age accel highly correlates with risk for developing subtype-specific BC and to what degree the risk is modified by hormones and lifestyle factors.Results: DNAm age in PBLs was tightly correlated with age in this age range, and older DNAm age and epigenetic age accel were significantly associated with risk for developing overall BC and luminal subtypes. Of note, in women with bilateral oophorectomy before natural menopause experiencing shorter lifetime estrogen exposure than those with natural menopause, epigenetic age accel substantially influenced BC development, independent of obesity status and exogeneous estrogen use.Conclusions: Our findings contribute to better understanding of biologic aging processes that mediate BC carcinogenesis, detecting a non-invasive epigenetic aging marker that better reflects BC development, and ultimately identifying the elderly with high risk who can benefit from epigenetically targeted preventive interventions.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"16 ","pages":"13534-13562"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis. 通过综合分析揭示KLHL23作为肝细胞癌的关键免疫调节因子。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-04 DOI: 10.18632/aging.206167

Liangliang Xu, Bo Li, Yuchen Liu, Zhengming Hu, Qing Dan, Bingxuan Xu, Hongjin Xiang, Yun Chen, Tingting Zheng, Desheng Sun, Li Liu

{"title":"Unveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis.","authors":"Liangliang Xu, Bo Li, Yuchen Liu, Zhengming Hu, Qing Dan, Bingxuan Xu, Hongjin Xiang, Yun Chen, Tingting Zheng, Desheng Sun, Li Liu","doi":"10.18632/aging.206167","DOIUrl":"10.18632/aging.206167","url":null,"abstract":"Age-related cancers are characterized by impaired protein homeostasis, where Kelch protein superfamily members have showed accumulating clues as critical regulators. In this paper, the cancerous role of Kelch-like family member 23 (KLHL23) was comprehensively analyzed with TCGA and single cell GEO database across overall 33 cancer types. By multi-omics analysis upon the transcriptomic, genomic, and methylation data, the current study explored the association of KLHL23 with patient survival, gene ontology, tumor-infiltrating lymphocytes, and drug responses. The correlation of copy number variations and methylation with dysregulated expression of KLHL23 were also addressed. Notably, KLHL23 levels correlated with survival in cancers such as hepatocellular carcinoma and low-grade glioma. The study also highlighted how reduced KLHL23 expression is linked to increased immune activity and sensitivity to chemotherapy, suggesting its potential as a biomarker for cancer prognosis and treatment responsiveness.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"null ","pages":"13608-13626"},"PeriodicalIF":3.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing. 局部ABT-263治疗可减少皮肤老化，改善随后的伤口愈合。

IF 3.9 3区医学

Aging-Us Pub Date : 2024-12-03 DOI: 10.18632/aging.206165

Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Joy Ha, Jannat Dhillon, Grace H Shin, Jack Crouch, Adam C Gower, Sami Gritli, Daniel S Roh

{"title":"Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing.","authors":"Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Joy Ha, Jannat Dhillon, Grace H Shin, Jack Crouch, Adam C Gower, Sami Gritli, Daniel S Roh","doi":"10.18632/aging.206165","DOIUrl":"10.18632/aging.206165","url":null,"abstract":"Senescent cells accumulate in aging tissues, impairing their ability to undergo repair and regeneration following injury. Previous research has demonstrated that targeting tissue senescence with senolytics can enhance tissue regeneration and repair by selectively eliminating SnCs in specific aged tissues. In this study, we focused on eliminating senescent skin cells in aged mice to assess the effects on subsequent wound healing. We applied ABT-263 directly to the skin of 24-month-old mice over a 5-day period. Following topical ABT-263, aged skin demonstrated decreased gene expression of senescence markers p16 and p21, accompanied by reductions in SA-β-gal- and p21-positive cells compared to DMSO controls. However, ABT-263 also triggered a temporary inflammatory response and macrophage infiltration in the skin. Bulk RNA sequencing of ABT-263-treated skin revealed prompt upregulation of genes associated with wound healing pathways, including hemostasis, inflammation, cell proliferation, angiogenesis, collagen synthesis, and extracellular matrix organization. Aged mice skin pre-treated with topical ABT-263 exhibited accelerated wound closure. In conclusion, topical ABT-263 effectively reduced several senescence markers in aged skin, thereby priming the skin for improved subsequent wound healing. This enhancement may be attributed to ABT-263-induced senolysis which in turn stimulates the expression of genes involved in extracellular matrix remodeling and wound repair pathways.","PeriodicalId":55547,"journal":{"name":"Aging-Us","volume":"16 ","pages":"16-32"},"PeriodicalIF":3.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0