黑磷量子点治疗动脉粥样硬化的研究。

IF 3.9 3区医学 Q2 CELL BIOLOGY

Aging-Us Pub Date : 2025-02-20 DOI:10.18632/aging.206205

Shengwei Zhang, Yiran Ji, Bingxuan Xu, Die Hu, Xue Zhang, Yujian Song, Keke Chen, Yilin Wen, Xiaoxin He, Yun Chen, Tingting Zheng

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引用次数: 0

摘要

动脉粥样硬化是心血管疾病的病理基础，临床上还没有一种药物能够安全有效地清除动脉粥样硬化斑块。本研究将黑磷量子点（BPQDs）应用于高脂饮食ApoE-/-模型小鼠的动脉粥样硬化治疗，在不改变高脂饮食的情况下，每隔一天给予BPQDs 3周。BPQDs隔日静脉给药3周内有效清除45.3%的动脉粥样硬化斑块。这种治疗方法比传统的他汀类药物更有效。研究结果表明，BPQDs在不需要改变饮食习惯的情况下，有很大的潜力应用于临床预防和治疗AS。

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Study on the use of black phosphorus quantum dots in the treatment of atherosclerosis.

Atherosclerosis is the pathological basis of cardiovascular disease, and there are no clinical drugs that can safely and efficiently remove atherosclerotic plaques. In this study, black phosphorus quantum dots (BPQDs) were applied to the treatment of atherosclerosis in high fat diet ApoE^-/- model mice that BPQDs were given every other day for 3 weeks without changing the high-fat diet. 45.3% atherosclerotic plaque was cleared efficiently within 3 weeks in BPQDs intravenous administration way every other day. The treatment was more effective than traditional statins. The findings suggest that BPQDs have great potential to be applied for clinical prevention and treatment of AS that does not require dietary changes.

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