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Anatomical Society Research Studentships 2025/26
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-05-13 DOI: 10.1111/acel.70102
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引用次数: 0
Correction to “Form Follows Function: Nuclear Morphology as a Quantifiable Predictor of Cellular Senescence”
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-04-16 DOI: 10.1111/acel.70076
{"title":"Correction to “Form Follows Function: Nuclear Morphology as a Quantifiable Predictor of Cellular Senescence”","authors":"","doi":"10.1111/acel.70076","DOIUrl":"https://doi.org/10.1111/acel.70076","url":null,"abstract":"<p>Belhadj J, Surina S, Hengstschläger M, Lomakin AJ. Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence. <i>Aging Cell</i>. 2023 Dec;22(12):e14012.</p><p>The “OPEN RESEARCH” section of the article did not include information regarding the RNA-seq data and its availability to the wider community. We would like to correct this omission by updating the “DATA AVAILABILITY STATEMENT” in the “OPEN RESEARCH” section with the following:</p><p>“The raw data for the RNA-seq analysis used in this study have been deposited in the NCBI GEO public database under accession number GSE293637 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293637).”</p><p>We apologize for this omission.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 5","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additional Cover 额外的封面
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-04-10 DOI: 10.1111/acel.70073
Hyunho Lee, Matteo Massaro, Nourhan Abdelfattah, Gherardo Baudo, Haoran Liu, Kyuson Yun, Elvin Blanco
{"title":"Additional Cover","authors":"Hyunho Lee,&nbsp;Matteo Massaro,&nbsp;Nourhan Abdelfattah,&nbsp;Gherardo Baudo,&nbsp;Haoran Liu,&nbsp;Kyuson Yun,&nbsp;Elvin Blanco","doi":"10.1111/acel.70073","DOIUrl":"https://doi.org/10.1111/acel.70073","url":null,"abstract":"<p>The cover image is based on the article <i>Nuclear respiratory factor-1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells</i> by Hyunho Lee et al., https://doi.org/10.1111/acel.14446.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 4","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical Society Research Studentships 2025/26 解剖学会研究奖学金2025/26
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-04-10 DOI: 10.1111/acel.70074
{"title":"Anatomical Society Research Studentships 2025/26","authors":"","doi":"10.1111/acel.70074","DOIUrl":"https://doi.org/10.1111/acel.70074","url":null,"abstract":"","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 4","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Featured Cover 了封面
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-04-10 DOI: 10.1111/acel.70072
Zhidi Lin, Guangyu Xu, Xiao Lu, Hongli Wang, Feizhou Lu, Xinlei Xia, Jian Song, Jianyuan Jiang, Xiaosheng Ma, Fei Zou
{"title":"Featured Cover","authors":"Zhidi Lin,&nbsp;Guangyu Xu,&nbsp;Xiao Lu,&nbsp;Hongli Wang,&nbsp;Feizhou Lu,&nbsp;Xinlei Xia,&nbsp;Jian Song,&nbsp;Jianyuan Jiang,&nbsp;Xiaosheng Ma,&nbsp;Fei Zou","doi":"10.1111/acel.70072","DOIUrl":"https://doi.org/10.1111/acel.70072","url":null,"abstract":"<p>The cover image is based on the article <i>Piezo1 exacerbates inflammation-induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca2+/CaMKII/Drp1 axis</i> by Zhidi Lin et al., https://doi.org/10.1111/acel.14440.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 4","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence” 修正“脑内皮细胞衰老介导衰老血脑屏障功能障碍”。
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-04-07 DOI: 10.1111/acel.70067
{"title":"Correction to “Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence”","authors":"","doi":"10.1111/acel.70067","DOIUrl":"10.1111/acel.70067","url":null,"abstract":"<p>\u0000 <span>Novo, J. P.</span>, <span>Gee, L.</span>, <span>Caetano, C. A.</span>, <span>Tomé, I.</span>, <span>Vilaça, A.</span>, <span>Zglinicki, T.</span>, <span>Moreira, I. S.</span>, <span>Jurk, D.</span>, <span>Rosa, S.</span>, &amp; <span>Ferreira, L.</span> (<span>2024</span>). <span>Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence</span>. <i>Aging Cell</i>, <span>23</span>, e14270. https://doi.org/10.1111/acel.14270\u0000 </p><p>In the published version of the above article, we noticed a few typographical errors in Figure 1a(III) and in Figure 2.</p><p>The corrected figures are shown below:</p><p>We apologize for this error.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 5","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy 利用免疫返老还童：克服T细胞衰老和衰竭在癌症免疫治疗中的进展。
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-04-03 DOI: 10.1111/acel.70055
Tesfahun Dessale Admasu, John S. Yu
{"title":"Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy","authors":"Tesfahun Dessale Admasu,&nbsp;John S. Yu","doi":"10.1111/acel.70055","DOIUrl":"10.1111/acel.70055","url":null,"abstract":"<p>Immunotherapy has transformed the landscape of cancer treatment, with T cell-based strategies at the forefront of this revolution. However, the durability of these responses is frequently undermined by two intertwined phenomena: T cell exhaustion and senescence. While exhaustion is driven by chronic antigen exposure in the immunosuppressive tumor microenvironment, leading to a reversible state of diminished functionality, senescence reflects a more permanent, age- or stress-induced arrest in cellular proliferation and effector capacity. Together, these processes represent formidable barriers to sustained anti-tumor immunity. In this review, we dissect the molecular underpinnings of T cell exhaustion and senescence, revealing how these dysfunctions synergistically contribute to immune evasion and resistance across a range of solid tumors. We explore cutting-edge therapeutic approaches aimed at rewiring the exhausted and senescent T cell phenotypes. These include advances in immune checkpoint blockade, the engineering of “armored” CAR-T cells, senolytic therapies that selectively eliminate senescent cells, and novel interventions that reinvigorate the immune system's capacity for tumor eradication. By spotlighting emerging strategies that target both exhaustion and senescence, we provide a forward-looking perspective on the potential to harness immune rejuvenation. This comprehensive review outlines the next frontier in cancer immunotherapy: unlocking durable responses by overcoming the immune system's intrinsic aging and exhaustion, ultimately paving the way for transformative therapeutic breakthroughs.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 5","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-Based Lifespan Extension in Mice Strongly Affects Lipids Across Six Organs 药物延长小鼠寿命对六个器官的脂质有强烈影响。
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-03-24 DOI: 10.1111/acel.14465
Sara Greenfield, Nathaniel C. Stevens, Lauren Bishop, Zachary Rabow, Daniela C. Soto, Abdali Omar Abdullah, Richard A. Miller, Oliver Fiehn
{"title":"Drug-Based Lifespan Extension in Mice Strongly Affects Lipids Across Six Organs","authors":"Sara Greenfield,&nbsp;Nathaniel C. Stevens,&nbsp;Lauren Bishop,&nbsp;Zachary Rabow,&nbsp;Daniela C. Soto,&nbsp;Abdali Omar Abdullah,&nbsp;Richard A. Miller,&nbsp;Oliver Fiehn","doi":"10.1111/acel.14465","DOIUrl":"10.1111/acel.14465","url":null,"abstract":"<p>Caloric restriction is associated with slow aging in model organisms. Additionally, some drugs have also been shown to slow aging in rodents. To better understand metabolic mechanisms that are involved in increased lifespan, we analyzed metabolomic differences in six organs of 12-month-old mice using five interventions leading to extended longevity, specifically caloric restriction, 17-α estradiol, and caloric restriction mimetics rapamycin, canagliflozin, and acarbose. These interventions generally have a stronger effect in males than in females. Using Jonckheere's trend test to associate increased average lifespans with metabolic changes for each sex, we found sexual dimorphism in metabolism of plasma, liver, gastrocnemius muscle, kidney, and inguinal fat. Plasma showed the strongest trend of differentially expressed compounds, highlighting potential benefits of plasma in tracking healthy aging. Using chemical set enrichment analysis, we found that the majority of these affected compounds were lipids, particularly in male tissues, in addition to significant differences in trends for amino acids, which were particularly apparent in the kidney. We also found strong metabolomic effects in adipose tissues. Inguinal fat exhibited surprising increases in neutral lipids with polyunsaturated side chains in male mice. In female mice, gonadal fat showed trends proportional to lifespan extension effect across multiple lipid classes, particularly phospholipids. Interestingly, for most tissues, we found similar changes induced by lifespan-extending interventions to metabolomic differences between untreated 12-month-old mice and 4-month-old mice. This finding implies that lifespan-extending treatments tend to reverse metabolic phenotypes to a biologically younger stage.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 5","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Featured Cover 了封面
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-03-11 DOI: 10.1111/acel.70045
Akash Kumar Singh, Ila Joshi, Neeharika M. N. Reddy, Sushmitha S. Purushotham, M. Eswaramoorthy, Madavan Vasudevan, Sourav Banerjee, James P. Clement, Tapas K. Kundu
{"title":"Featured Cover","authors":"Akash Kumar Singh,&nbsp;Ila Joshi,&nbsp;Neeharika M. N. Reddy,&nbsp;Sushmitha S. Purushotham,&nbsp;M. Eswaramoorthy,&nbsp;Madavan Vasudevan,&nbsp;Sourav Banerjee,&nbsp;James P. Clement,&nbsp;Tapas K. Kundu","doi":"10.1111/acel.70045","DOIUrl":"https://doi.org/10.1111/acel.70045","url":null,"abstract":"<p>The cover image is based on the article <i>Epigenetic modulation rescues neurodevelopmental deficits in Syngap1+/−; mice</i> by Akash Kumar Singh et al.,https://doi.org/10.1111/acel.14408<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 3","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additional Cover 额外的封面
IF 7.8 1区 医学
Aging Cell Pub Date : 2025-03-11 DOI: 10.1111/acel.70046
Akash Kumar Singh, Ila Joshi, Neeharika M. N. Reddy, Sushmitha S. Purushotham, M. Eswaramoorthy, Madavan Vasudevan, Sourav Banerjee, James P. Clement, Tapas K. Kundu, Tamunotonye Omoluabi, Zia Hasan, Jessie E. Piche, Abeni R. S. Flynn, Jules J. E. Doré, Susan G. Walling, Andrew C. W. Weeks, Touati Benoukraf, Qi Yuan
{"title":"Additional Cover","authors":"Akash Kumar Singh,&nbsp;Ila Joshi,&nbsp;Neeharika M. N. Reddy,&nbsp;Sushmitha S. Purushotham,&nbsp;M. Eswaramoorthy,&nbsp;Madavan Vasudevan,&nbsp;Sourav Banerjee,&nbsp;James P. Clement,&nbsp;Tapas K. Kundu,&nbsp;Tamunotonye Omoluabi,&nbsp;Zia Hasan,&nbsp;Jessie E. Piche,&nbsp;Abeni R. S. Flynn,&nbsp;Jules J. E. Doré,&nbsp;Susan G. Walling,&nbsp;Andrew C. W. Weeks,&nbsp;Touati Benoukraf,&nbsp;Qi Yuan","doi":"10.1111/acel.70046","DOIUrl":"https://doi.org/10.1111/acel.70046","url":null,"abstract":"<p>The cover image is based on the article <i>Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model</i> by Tamunotonye Omoluabi et al., https://doi.org/10.1111/acel.14405<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 3","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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