Aging Cell最新文献

{"title":"Additional Cover","authors":"Yuichiro Ukon,&nbsp;Takashi Kaito,&nbsp;Hiromasa Hirai,&nbsp;Takayuki Kitahara,&nbsp;Masayuki Bun,&nbsp;Joe Kodama,&nbsp;Daisuke Tateiwa,&nbsp;Shinichi Nakagawa,&nbsp;Masato Ikuta,&nbsp;Takuya Furuichi,&nbsp;Yuya Kanie,&nbsp;Takahito Fujimori,&nbsp;Shota Takenaka,&nbsp;Tadashi Yamamuro,&nbsp;Satoru Otsuru,&nbsp;Seiji Okada,&nbsp;Masakatsu Yamashita,&nbsp;Takeshi Imamura","doi":"10.1111/acel.14381","DOIUrl":"https://doi.org/10.1111/acel.14381","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis</i> by Yuichiro Ukon et al.,\u0000https://doi.org/10.1111/acel.14254\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"Kangkang Yu,&nbsp;Feifei Li,&nbsp;Ling Ye,&nbsp;Fanyuan Yu","doi":"10.1111/acel.14379","DOIUrl":"https://doi.org/10.1111/acel.14379","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Accumulation of DNA G-quadruplex in mitochondrial genome hallmarks mesenchymal senescence</i> by Kangkang Yu et al.,\u0000https://doi.org/10.1111/acel.14265\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Florencia Herbstein,&nbsp;Melanie Sapochnik,&nbsp;Alejandra Attorresi,&nbsp;Cora Pollak,&nbsp;Sergio Senin,&nbsp;David Gonilski-Pacin,&nbsp;Nicolas Ciancio del Giudice,&nbsp;Manuel Fiz,&nbsp;Belén Elguero,&nbsp;Mariana Fuertes,&nbsp;Lara Müller,&nbsp;Marily Theodoropoulou,&nbsp;Lucas B. Pontel,&nbsp;Eduardo Arzt","doi":"10.1111/acel.14378","DOIUrl":"https://doi.org/10.1111/acel.14378","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent\u0000noncanonical pathway</i> by Florencia Herbstein et al., https://doi.org/10.1111/acel.14258<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"Sachin Kumar,&nbsp;Jeffrey D. Vassallo,&nbsp;Kalpana J. Nattamai,&nbsp;Aishlin Hassan,&nbsp;Angelika Vollmer,&nbsp;Rebekah Karns,&nbsp;Mehmet Sacma,&nbsp;Travis Nemkov,&nbsp;Angelo D'Alessandro,&nbsp;Hartmut Geiger","doi":"10.1111/acel.14380","DOIUrl":"https://doi.org/10.1111/acel.14380","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment</i> by Sachin Kumar et al.,\u0000https://doi.org/10.1111/acel.14324\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro immuno-prevention of nitration/dysfunction of myogenic stem cell activator HGF, towards developing a strategy for age-related muscle atrophy","authors":"Sakiho Tanaka,&nbsp;Alaa Elgaabari,&nbsp;Miyumi Seki,&nbsp;So Kuwakado,&nbsp;Kahona Zushi,&nbsp;Junri Miyamoto,&nbsp;Shoko Sawano,&nbsp;Wataru Mizunoya,&nbsp;Kenshiro Ehara,&nbsp;Naruha Watanabe,&nbsp;Yohei Ogawa,&nbsp;Hikaru Imakyure,&nbsp;Reina Fujimaru,&nbsp;Rika Osaki,&nbsp;Kazuki Shitamitsu,&nbsp;Kaoru Mizoguchi,&nbsp;Tomoki Ushijima,&nbsp;Takahiro Maeno,&nbsp;Takashi Nakashima,&nbsp;Takahiro Suzuki,&nbsp;Mako Nakamura,&nbsp;Judy E. Anderson,&nbsp;Ryuichi Tatsumi","doi":"10.1111/acel.14337","DOIUrl":"10.1111/acel.14337","url":null,"abstract":"<p>In response to peroxynitrite (ONOO⁻) generation, myogenic stem satellite cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198 and Y250) predominantly on fast IIa and IIx myofibers to lose its binding to the signaling receptor c-met, thereby disturbing muscle homeostasis during aging. Here we show that rat anti-HGF monoclonal antibody (mAb) 1H41C10, which was raised in-house against a synthetic peptide FTSNPEVR_nitroY₁₉₈EV, a site well-conserved in mammals, functions to confer resistance to nitration dysfunction on HGF. 1H41C10 was characterized by recognizing both nitrated and non-nitrated HGF with different affinities as revealed by Western blotting, indicating that the paratope of 1H41C10 may bind to the immediate vicinity of Y198. Subsequent experiments showed that 1H41C10-bound HGF resists peroxynitrite-induced nitration of Y198. A companion mAb-1H42F4 presented similar immuno-reactivity, but did not protect Y198 nitration, and thus served as the control. Importantly, 1H41C10-HGF also withstood Y250 nitration to retain c-met binding and satellite cell activation functions in culture. The Fab region of 1H41C10 exerts resistivity to Y250 nitration possibly due to its localization in the immediate vicinity to Y250, as supported by an additional set of experiments showing that the 1H41C10-Fab confers Y250-nitration resistance which the Fc segment does not. Findings highlight the in vitro preventive impact of 1H41C10 on HGF nitration-dysfunction that strongly impairs myogenic stem cell dynamics, potentially pioneering cogent strategies for counteracting or treating age-related muscle atrophy with fibrosis (including sarcopenia and frailty) and the therapeutic application of investigational HGF drugs.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142250032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Xiao Lu,&nbsp;Dachuan Li,&nbsp;Zhidi Lin,&nbsp;Tian Gao,&nbsp;Zhaoyang Gong,&nbsp;Yuxuan Zhang,&nbsp;Hongli Wang,&nbsp;Xinlei Xia,&nbsp;Feizhou Lu,&nbsp;Jian Song,&nbsp;Guangyu Xu,&nbsp;Jianyuan Jiang,&nbsp;Xiaosheng Ma,&nbsp;Fei Zou","doi":"10.1111/acel.14346","DOIUrl":"https://doi.org/10.1111/acel.14346","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>HIF-1α-induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation</i> by Xiao Lu et al., https://doi.org/10.1111/acel.14210<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"Kerriann K. Badal,&nbsp;Abhishek Sadhu,&nbsp;Bindu L. Raveendra,&nbsp;Carrie McCracken,&nbsp;Sebastian Lozano-Villada,&nbsp;Amol C. Shetty,&nbsp;Phillip Gillette,&nbsp;Yibo Zhao,&nbsp;Dustin Stommes,&nbsp;Lynne A. Fieber,&nbsp;Michael C. Schmale,&nbsp;Anup Mahurkar,&nbsp;Robert D. Hawkins,&nbsp;Sathyanarayanan V. Puthanveettil","doi":"10.1111/acel.14347","DOIUrl":"https://doi.org/10.1111/acel.14347","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity</i> by Kerriann K. Badal et al., https://doi.org/10.1111/acel.14228 Image Credit: Phillip Gillette and Lynne Fieber\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment","authors":"Sachin Kumar,&nbsp;Jeffrey D. Vassallo,&nbsp;Kalpana J. Nattamai,&nbsp;Aishlin Hassan,&nbsp;Angelika Vollmer,&nbsp;Rebekah Karns,&nbsp;Mehmet Sacma,&nbsp;Travis Nemkov,&nbsp;Angelo D'Alessandro,&nbsp;Hartmut Geiger","doi":"10.1111/acel.14324","DOIUrl":"10.1111/acel.14324","url":null,"abstract":"<p>Aged hematopoietic stem cells (HSCs) show reduced reconstitution potential, limiting their use in transplantation settings in the clinic. We demonstrate here that exposure of aged HSCs ex vivo to a pH of 6.9 instead of the commonly used pH of 7.4 results in enhanced HSCs potential that is consistent with rejuvenation, including attenuation of the myeloid bias of aged HSC and restoration of a youthful frequency of epigenetic polarity. Rejuvenation of aged HSCs by pH 6.9 is, at least in part, due to alterations in the polyamine/methionine pathway within pH 6.9 HSCs, and consequently, attenuation of the production of spermidine also attenuated aging of HSCs. Exposure of aged HSCs to pH 6.9, or pharmacological targeting of the polyamine pathway, might thus extend the use of HSCs from aged donors for therapeutic applications.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Marcus Dittrich,&nbsp;Laura Bernhardt,&nbsp;Christopher A. Penfold,&nbsp;Thorsten E. Boroviak,&nbsp;Charis Drummer,&nbsp;Rüdiger Behr,&nbsp;Tobias Müller,&nbsp;Thomas Haaf","doi":"10.1111/acel.14331","DOIUrl":"https://doi.org/10.1111/acel.14331","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Age-related and species-specific methylation changes in the protein-coding marmoset sperm epigenome</i> by Marcus Dittrich et al., https://doi.org/10.1111/acel.14200.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice","authors":"Inés Muela-Zarzuela,&nbsp;Juan Miguel Suarez-Rivero,&nbsp;Daniel Boy-Ruiz,&nbsp;Juan López-Pérez,&nbsp;Marta Sotelo-Montoro,&nbsp;Maria del Mar Navarrete-Alonso,&nbsp;Isidro G. Collado,&nbsp;José Manuel Botubol-Ares,&nbsp;Alberto Sanz,&nbsp;Mario D. Cordero","doi":"10.1111/acel.14272","DOIUrl":"10.1111/acel.14272","url":null,"abstract":"<p>The role of the inflammasomes in aging and progeroid syndromes remain understudied. Recently, MCC950, a NLRP3 inhibitor, was used in Zmpste24^−/− mice to ameliorate the phenotypes. However, the safety of MCC950 was questioned due to liver toxicity observed in humans. Nevertheless, inhibition of the inflammasomes would be a beneficial therapy for progeria. Here, we show that OLT1177 (dapansutrile), other NLRP3 inhibitor, improved cellular and animal phenotypes using progeroid fibroblasts and a Lmna^G609G/G609G mouse model. In both cases dapansutrile reduced progerin accumulation, NLRP3-inflammasome activation and secretory phenotype of senescence, extended the lifespan of progeroid animals, preserved bodyweight, and reduced kyphosis, inflammation, and senescence. Interestingly, dapansutrile further improved the effect of lonafarnib, the only FDA-approved drug for the progeria. The combination of both drugs reduced the inflammation and senescence, extended survival and ameliorated various progeroid defects both in vitro and in vivo, compared with treatment using lonafarnib alone. These findings and the safety of dapansutrile demonstrated in several clinical trials proposes it as a possible co-adjuvant treatment with lonafarnid in HGPS.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}