Aging Cell最新文献

{"title":"Featured Cover","authors":"Hansol Lee,&nbsp;Hong-Hsi Lee,&nbsp;Yixin Ma,&nbsp;Laleh Eskandarian,&nbsp;Kyla Gaudet,&nbsp;Qiyuan Tian,&nbsp;Eva A. Krijnen,&nbsp;Andrew W. Russo,&nbsp;David H. Salat,&nbsp;Eric C. Klawiter,&nbsp;Susie Y. Huang","doi":"10.1111/acel.14417","DOIUrl":"https://doi.org/10.1111/acel.14417","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Age-related alterations in human cortical microstructure across the lifespan: Insights from high-gradient diffusion MRI</i> by Hansol Lee et al., https://doi.org/10.1111/acel.14267\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 11","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single-cell analysis’","authors":"","doi":"10.1111/acel.14364","DOIUrl":"10.1111/acel.14364","url":null,"abstract":"&lt;p&gt;Castillo-Fernandez, J., Herrera-Puerta, E., Demond, H., Clark, S.J., Hanna, C.W., Hemberger, M. and Kelsey, G. (2020), Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single-cell analysis. &lt;i&gt;Aging Cell&lt;/i&gt;, 19: e13278. https://doi.org/10.1111/acel.13278.&lt;/p&gt;&lt;p&gt;In the assignment of individual GV oocytes as having NSN or SN chromatin configuration based on scRNA-Seq profiles, we used a published gene list, in which we now believe NSN and SN samples may have been mis-assigned. We have now generated our own scRNA-Seq datasets of NSN and SN oocytes (https://doi.org/10.21203/rs.3.rs-4901993/v1), which now enables us to correctly reassign NSN and SN status of GV oocytes in this paper. This necessitates the following corrections:&lt;/p&gt;&lt;p&gt;In the Results sections 2.1, 2.2, 2.4, 2.5: the terms NSN and SN were used incorrectly as a result of the mis-assignment. The corrected sentences are provided below:&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Section 2.1&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;“To assign chromatin configuration states in our data set, we classified the 87 oocytes according to the level of expression of genes reported to show at least a two-fold overexpression in NSN oocytes compared to SN oocytes (data reanalysed from Ma et al., 2013). Twenty oocytes were found to express these transcripts at a higher level and were classified transcriptionally as NSN (Figure 1d).”&lt;/p&gt;&lt;p&gt;“Out of the 20 NSN oocytes, twelve corresponded to the young group and eight to the aged one.”&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Section 2.2&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;“Clusters 1 and 2 comprised only SN aged oocytes; Cluster 3 mainly comprised young SN oocytes plus a small number of NSN oocytes; and Cluster 4 purely NSN oocytes regardless of age, which were closer to young SN oocytes (Cluster 3) than to aged SN oocytes (Clusters 1 and 2).”&lt;/p&gt;&lt;p&gt;“Following this assumption, differential expression was tested using cluster number as a continuous variable to identify transcripts that change in abundance from old transcriptionally like SN oocytes to young transcriptionally like SN oocytes and, lastly, to NSN oocytes (both young and aged).”&lt;/p&gt;&lt;p&gt;“To exclude that the observed differences in transcript abundance of maternal effect genes were an effect solely of chromatin configuration, the analysis was repeated using only the subset of oocytes assigned as SN and the enrichment for maternal effect genes was also observed (Figure S1).”&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Section 2.4&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;“Interestingly, all of the predicted NSN aged oocytes were also defined as young-like oocytes, although the young-like group also contained some aged oocytes assigned as SN (Figure 2e).”&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;Section 2.5&lt;/b&gt;\u0000 &lt;/p&gt;&lt;p&gt;“However, when examining differences between assigned chromatin configurations, lower CpG methylation was observed in NSN-classified oocytes both globally (Wilcoxon test; &lt;i&gt;p&lt;/i&gt; = 1.4 × 10&lt;sup&gt;−5&lt;/sup&gt;) and in all three categories","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 11","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling","authors":"","doi":"10.1111/acel.14383","DOIUrl":"10.1111/acel.14383","url":null,"abstract":"<p><b>RETRACTION</b>: Chen, L., Yang, R., Qiao, W., Zhang, W., Chen, J., Mao, L., Goltzman, D., Miao, D. (2019). 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling. <i>Aging Cell</i>, 18(3), e12951. https://doi.org/10.1111/acel.12951</p><p>The above article, published online on 24 March 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between; the journal Editor-in-Chief, Monty Montano; The Anatomical Society; and John Wiley &amp; Sons Ltd. The retraction has been agreed due to duplications observed between elements of Figures 1h and 1j; 5d and 5f; 3a and 6j; and Supplemental Figures 4c and 4e.</p><p>The authors acknowledged their errors in figure management, which led to the duplications observed between Figures 3a and 6j, as well as between S4c and S4e. They also admitted to copying and pasting small areas from figure S4e into the same image for aesthetic purposes. Additionally, they admitted to editing Figure 4d (ChIP gel image) to reduce noise and enhance the clarity of the bands shown. The authors provided some data and an explanation for the similarities observed between Figures 1h and 1j; and Figures 5d and 5f. However, their explanation was not sufficient. Due to the extent of the identified issues, the editors have lost confidence in the data presented. The authors disagree with the retraction.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 11","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"Yuichiro Ukon,&nbsp;Takashi Kaito,&nbsp;Hiromasa Hirai,&nbsp;Takayuki Kitahara,&nbsp;Masayuki Bun,&nbsp;Joe Kodama,&nbsp;Daisuke Tateiwa,&nbsp;Shinichi Nakagawa,&nbsp;Masato Ikuta,&nbsp;Takuya Furuichi,&nbsp;Yuya Kanie,&nbsp;Takahito Fujimori,&nbsp;Shota Takenaka,&nbsp;Tadashi Yamamuro,&nbsp;Satoru Otsuru,&nbsp;Seiji Okada,&nbsp;Masakatsu Yamashita,&nbsp;Takeshi Imamura","doi":"10.1111/acel.14381","DOIUrl":"https://doi.org/10.1111/acel.14381","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis</i> by Yuichiro Ukon et al.,\u0000https://doi.org/10.1111/acel.14254\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 10","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"Kangkang Yu,&nbsp;Feifei Li,&nbsp;Ling Ye,&nbsp;Fanyuan Yu","doi":"10.1111/acel.14379","DOIUrl":"https://doi.org/10.1111/acel.14379","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Accumulation of DNA G-quadruplex in mitochondrial genome hallmarks mesenchymal senescence</i> by Kangkang Yu et al.,\u0000https://doi.org/10.1111/acel.14265\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 10","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Florencia Herbstein,&nbsp;Melanie Sapochnik,&nbsp;Alejandra Attorresi,&nbsp;Cora Pollak,&nbsp;Sergio Senin,&nbsp;David Gonilski-Pacin,&nbsp;Nicolas Ciancio del Giudice,&nbsp;Manuel Fiz,&nbsp;Belén Elguero,&nbsp;Mariana Fuertes,&nbsp;Lara Müller,&nbsp;Marily Theodoropoulou,&nbsp;Lucas B. Pontel,&nbsp;Eduardo Arzt","doi":"10.1111/acel.14378","DOIUrl":"https://doi.org/10.1111/acel.14378","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent\u0000noncanonical pathway</i> by Florencia Herbstein et al., https://doi.org/10.1111/acel.14258<figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 10","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"Sachin Kumar,&nbsp;Jeffrey D. Vassallo,&nbsp;Kalpana J. Nattamai,&nbsp;Aishlin Hassan,&nbsp;Angelika Vollmer,&nbsp;Rebekah Karns,&nbsp;Mehmet Sacma,&nbsp;Travis Nemkov,&nbsp;Angelo D'Alessandro,&nbsp;Hartmut Geiger","doi":"10.1111/acel.14380","DOIUrl":"https://doi.org/10.1111/acel.14380","url":null,"abstract":"<p>Cover legend: The cover image is based on the Article <i>Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment</i> by Sachin Kumar et al.,\u0000https://doi.org/10.1111/acel.14324\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 10","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging”","authors":"","doi":"10.1111/acel.14363","DOIUrl":"10.1111/acel.14363","url":null,"abstract":"<p>Melendez, J., Sung, Y.J., Orr, M., Yoo, A., Schindler, S., Cruchaga, C., Bateman, R. <i>Aging Cell</i>, 2024. https://doi.org/10.1111/acel.14230</p><p>In the published version of Melendez et al. (2024), an incorrect version of Table 1 was shown.</p><p>The correct table is shown below.\u0000 </p><p>We apologize for this error.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 11","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-inflammatory cytokine 11 plays a pivotal role in inflammaging-associated pathologies","authors":"José M. Izquierdo","doi":"10.1111/acel.14360","DOIUrl":"10.1111/acel.14360","url":null,"abstract":"<p>Chronic sterile inflammation contributes to aging-associated pathologies/malignancies like cancer and autoimmune disorders. In their recent Nature article, Widjaja et al. established the pro-inflammatory, pro-fibrotic cytokine 11 (IL11) as a regulatory driver/hub of aging-associated inflammation (inflammaging) in mice. Genetic and pharmacological IL11 blockade reduces inflammaging, improving healthspan, lifespan, and longevity in male and female mice, highlighting IL11 as a new inflammatory aging clock and a potential molecular target in inflammaging-associated human degenerative diseases.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 11","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19","authors":"Xuetao Qi,&nbsp;Shulu Yuan,&nbsp;Jiuyang Ding,&nbsp;Weiqi Sun,&nbsp;Yajiao Shi,&nbsp;Yuanwei Xing,&nbsp;Zilong Liu,&nbsp;Yun Yao,&nbsp;Su Fu,&nbsp;Baofei Sun,&nbsp;Xiaolan Qi,&nbsp;Bing Xia,&nbsp;Fengyu Liu,&nbsp;Ming Yi,&nbsp;Jian Mao,&nbsp;You Wan,&nbsp;Jie Zheng","doi":"10.1111/acel.14352","DOIUrl":"10.1111/acel.14352","url":null,"abstract":"<p>Coronavirus disease 2019 (COVID-19) has been suggested to increase the risk of memory decline and Alzheimer's disease (AD), the main cause of dementia in the elderly. However, direct evidence about whether COVID-19 induces AD-like neuropathological changes in the brain, especially post recovery from acute infection, is still lacking. Here, using postmortem human brain samples, we found abnormal accumulation of hyperphosphorylated tau protein in the hippocampus and medial entorhinal cortex within 4–13 months post clinically recovery from acute COVID-19, together with prolonged activation of glia cells and increases in inflammatory factors, even though no SARS-COV-2 invasion was detected in these regions. By contrast, COVID-19 did not change beta-amyloid deposition and hippocampal neuron number, and had limited effects on AD-related pathological phenotypes in olfactory circuits including olfactory bulb, anterior olfactory nucleus, olfactory tubercle, piriform cortex and lateral entorhinal cortex. These results provide neuropathological evidences linking COVID-19 with prognostic increase of risk for AD.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"23 11","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}