Aging CellPub Date : 2025-07-16DOI: 10.1111/acel.70170
Estevão Scudese, Andrea G. Marshall, Zer Vue, Vernat Exil, Benjamin I. Rodriguez, Mert Demirci, Larry Vang, Edgar Garza López, Kit Neikirk, Bryanna Shao, Han Le, Dominique Stephens, Duane D. Hall, Rahmati Rostami, Taylor Rodman, Kinuthia Kabugi, Jian-qiang Shao, Margaret Mungai, Salma T. AshShareef, Innes Hicsasmaz, Sasha Manus, Celestine N. Wanjalla, Aaron Whiteside, Revathi Dasari, Clintoria R. Williams, Steven M. Damo, Jennifer A. Gaddy, Brian Glancy, Estélio Henrique Martin Dantas, André Kinder, Ashlesha Kadam, Dhanendra Tomar, Fabiana Scartoni, Matheus Baffi, Melanie R. McReynolds, Mark A. Phillips, Anthonya Cooper, Sandra A. Murray, Anita M. Quintana, Nelson Wandira, Okwute M. Ochayi, Magdalene Ameka, Annet Kirabo, Sepiso K. Masenga, Chanel Harris, Ashton Oliver, Pamela Martin, Amadou Gaye, Olga Korolkova, Vineeta Sharma, Bret C. Mobley, Prasanna Katti, Antentor Hinton
{"title":"Featured Cover","authors":"Estevão Scudese, Andrea G. Marshall, Zer Vue, Vernat Exil, Benjamin I. Rodriguez, Mert Demirci, Larry Vang, Edgar Garza López, Kit Neikirk, Bryanna Shao, Han Le, Dominique Stephens, Duane D. Hall, Rahmati Rostami, Taylor Rodman, Kinuthia Kabugi, Jian-qiang Shao, Margaret Mungai, Salma T. AshShareef, Innes Hicsasmaz, Sasha Manus, Celestine N. Wanjalla, Aaron Whiteside, Revathi Dasari, Clintoria R. Williams, Steven M. Damo, Jennifer A. Gaddy, Brian Glancy, Estélio Henrique Martin Dantas, André Kinder, Ashlesha Kadam, Dhanendra Tomar, Fabiana Scartoni, Matheus Baffi, Melanie R. McReynolds, Mark A. Phillips, Anthonya Cooper, Sandra A. Murray, Anita M. Quintana, Nelson Wandira, Okwute M. Ochayi, Magdalene Ameka, Annet Kirabo, Sepiso K. Masenga, Chanel Harris, Ashton Oliver, Pamela Martin, Amadou Gaye, Olga Korolkova, Vineeta Sharma, Bret C. Mobley, Prasanna Katti, Antentor Hinton","doi":"10.1111/acel.70170","DOIUrl":"https://doi.org/10.1111/acel.70170","url":null,"abstract":"<p>Cover legend: The cover image is based on the article <i>3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes</i> by Estevão Scudese et al.,\u0000https://doi.org/10.1111/acel.70054\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-07-16DOI: 10.1111/acel.70178
{"title":"Anatomical Society Research Studentships 2025/26","authors":"","doi":"10.1111/acel.70178","DOIUrl":"https://doi.org/10.1111/acel.70178","url":null,"abstract":"","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-07-16DOI: 10.1111/acel.70173
Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins
{"title":"Additional Cover","authors":"Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins","doi":"10.1111/acel.70173","DOIUrl":"https://doi.org/10.1111/acel.70173","url":null,"abstract":"<p>Cover legend: The cover image is based on the article <i>Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles</i> by Tianpeng\u0000Zhang et al., https://doi.org/10.1111/acel.70071.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-07-16DOI: 10.1111/acel.70172
Muthu Saravanan Manoharan, Grace C. Lee, Nathan Harper, Justin A. Meunier, Marcos I. Restrepo, Fabio Jimenez, Sreenath Karekatt, Anne P. Branum, Alvaro A. Gaitan, Kian Andampour, Alisha M. Smith, Michael Mader, Michelle Noronha, Devjit Tripathy, Nu Zhang, Alvaro G. Moreira, Lavanya Pandranki, South Texas Veterans Health Care System (STVHCS) COVID-19 Clinical team, STVHCS COVID-19 Vaccine team, STVHCS COVID-19 Convalescent care team, STVHCS Center for Personalized Medicine, Sandra Sanchez-Reilly, Hanh D. Trinh, Clea Barnett, Luis Angel, Leopoldo N. Segal, Susannah Nicholson, Robert A. Clark, Weijing He, Jason F. Okulicz, Sunil K. Ahuja
{"title":"Additional Cover","authors":"Muthu Saravanan Manoharan, Grace C. Lee, Nathan Harper, Justin A. Meunier, Marcos I. Restrepo, Fabio Jimenez, Sreenath Karekatt, Anne P. Branum, Alvaro A. Gaitan, Kian Andampour, Alisha M. Smith, Michael Mader, Michelle Noronha, Devjit Tripathy, Nu Zhang, Alvaro G. Moreira, Lavanya Pandranki, South Texas Veterans Health Care System (STVHCS) COVID-19 Clinical team, STVHCS COVID-19 Vaccine team, STVHCS COVID-19 Convalescent care team, STVHCS Center for Personalized Medicine, Sandra Sanchez-Reilly, Hanh D. Trinh, Clea Barnett, Luis Angel, Leopoldo N. Segal, Susannah Nicholson, Robert A. Clark, Weijing He, Jason F. Okulicz, Sunil K. Ahuja","doi":"10.1111/acel.70172","DOIUrl":"https://doi.org/10.1111/acel.70172","url":null,"abstract":"<p>Cover legend: The cover image is based on the article <i>The 15-Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging</i>\u0000by Muthu Saravanan Manoharan et al., https://doi.org/10.1111/acel.70063.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-07-08DOI: 10.1111/acel.70158
{"title":"RETRACTION: Aggravation of Alzheimer's Disease due to the COX-2-Mediated Reciprocal Regulation of IL-1β and Aβ Between Glial and Neuron Cells","authors":"","doi":"10.1111/acel.70158","DOIUrl":"10.1111/acel.70158","url":null,"abstract":"<p><b>RETRACTION</b>: P. Wang, P.-P. Guan, T. Wang, X. Yu, J.-J. Guo and Z.-Y. Wang, “Aggravation of Alzheimer's Disease due to the COX-2-Mediated Reciprocal Regulation of IL-1β and Aβ Between Glial and Neuron Cells,” <i>Aging Cell</i> 13, no. 4 (2014): 605-615, https://doi.org/10.1111/acel.12209.</p><p>The above article, published online on 13 March 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Monty Montano; the Anatomical Society; and John Wiley & Sons Ltd. The retraction has been agreed upon following an investigation based on concerns raised by a third party. Duplications were uncovered between the NF-κB bands presented in Figure 2C and the β-actin bands in Figure 4K. Further duplication between the β-actin bands in Figures 4E and 5B, 4I and 5A, and between 4J and 5A were also observed. The authors collaborated with our investigation, but due to the time that has elapsed since publication, they were unable to produce any original data. As a result, the editors have lost confidence in the results and conclusions presented in this study. The authors did not confirm agreement with the final wording of the retraction.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-06-19DOI: 10.1111/acel.70136
Ricardo Afonso-Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega
{"title":"Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?","authors":"Ricardo Afonso-Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega","doi":"10.1111/acel.70136","DOIUrl":"10.1111/acel.70136","url":null,"abstract":"<p>Cockayne Syndrome (CS) is an autosomal recessive disorder arising from mutations in either of two disease-associated genes, <i>ERCC6 or ERCC8</i>. CS patients exhibit cutaneous photosensitivity, neuropathological abnormalities, severe growth retardation, a distinctive facial appearance with pronounced sunken eyes, musculoskeletal anomalies, sensory impairment, and dental decay. Approximately 70% of all CS cases carry <i>ERCC6</i> mutations; therefore, this review will focus solely on Cockayne Syndrome complementation group B (CS-B). CS-B exhibits several hallmarks of aging, including genomic instability, epigenetic modifications, loss of proteostasis, and mitochondrial failure. CS-B is proposed to result from the accumulation of DNA damage and the resulting transcription impairment. However, the main pathophysiological mechanisms underlying the severe cellular impairments observed in CS-B remain unclear. Here, we review the current literature to elucidate ERCC6-related mechanisms, highlighting the key and emerging pathological mechanisms underlying CS-B, as well as their putative interactions. Considering the mechanisms that heavily rely on ERCC6, we propose that CS-B pathogenesis arises from a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction. Furthermore, we argue that these molecular features influence each other, rather than acting as isolated mechanisms. This suggests that the crosstalk between mechanisms is a key factor for CS-B pathogenesis. Although efforts have been made to unveil CS-B pathogenesis, research is still lacking, hindering progress in understanding this deadly disease. Future work will prove crucial to determine the main contributor to CS-B pathogenesis and identify new interactions between CS-B-affected mechanisms.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-06-17DOI: 10.1111/acel.70124
Chiara Herzog, Jesse R. Poganik, Nir Barzilai, Nathan Basisty, Isabel Beerman, Daniel W. Belsky, Rafael de Cabo, Julián Candia, Faraz Faghri, Steve Horvath, Andrea B. Maier, Viviana Perez, Payel Sen, Mahdi Moqri, Vadim N. Gladyshev, Luigi Ferrucci
{"title":"Biomarkers of Aging–NIA Joint Symposium 2024: New Insights Into Aging Biomarkers","authors":"Chiara Herzog, Jesse R. Poganik, Nir Barzilai, Nathan Basisty, Isabel Beerman, Daniel W. Belsky, Rafael de Cabo, Julián Candia, Faraz Faghri, Steve Horvath, Andrea B. Maier, Viviana Perez, Payel Sen, Mahdi Moqri, Vadim N. Gladyshev, Luigi Ferrucci","doi":"10.1111/acel.70124","DOIUrl":"10.1111/acel.70124","url":null,"abstract":"<p>The second Biomarkers of Aging Symposium, jointly hosted by the National Institute on Aging (NIA) Intramural Research Program and the Biomarkers of Aging Consortium (BAC) on September 12, 2024, in Baltimore, MD, convened leading researchers, clinicians, and stakeholders in the aging field to share new developments and discuss roadmaps to advance biomarkers of aging. This meeting report summarizes the highlights of this symposium and underscores the urgent need to understand longitudinal, complex, and heterogeneous processes of aging to unlock the full potential of aging biomarkers.</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-06-10DOI: 10.1111/acel.70128
Kangsan Roh, Haobo Li, Rebecca Nicole Freeman, Luca Zazzeron, Ahlim Lee, Charles Zhou, Siman Shen, Peng Xia, Justin Ralph Baldovino Guerra, Cedric Sheffield, Timothy P. Padera, Yirong Zhou, Sekeun Kim, Aaron Aguirre, Nicolas Houstis, Jason D. Roh, Fumito Ichinose, Rajeev Malhotra, Anthony Rosenzweig, James Rhee
{"title":"Featured Cover","authors":"Kangsan Roh, Haobo Li, Rebecca Nicole Freeman, Luca Zazzeron, Ahlim Lee, Charles Zhou, Siman Shen, Peng Xia, Justin Ralph Baldovino Guerra, Cedric Sheffield, Timothy P. Padera, Yirong Zhou, Sekeun Kim, Aaron Aguirre, Nicolas Houstis, Jason D. Roh, Fumito Ichinose, Rajeev Malhotra, Anthony Rosenzweig, James Rhee","doi":"10.1111/acel.70128","DOIUrl":"https://doi.org/10.1111/acel.70128","url":null,"abstract":"<p>Cover legend: The cover image is based on the article <i>Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart</i> by Kangsan Roh et al., https://doi.org/10.1111/acel.70043.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 6","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aging CellPub Date : 2025-06-10DOI: 10.1111/acel.70134
{"title":"Correction to “Defective Dimerization of FoF1-ATP Synthase Secondary to Glycation Favors Mitochondrial Energy Deficiency in Cardiomyocytes During Aging”","authors":"","doi":"10.1111/acel.70134","DOIUrl":"10.1111/acel.70134","url":null,"abstract":"<p>Bou-Teen, D., Fernandez-Sanz, C., Miro-Casas, E., Nichtova, Z., Bonzon-Kulichenko, E., Casós, K., Inserte, J., Rodriguez-Sinovas, A., Benito, B., Sheu, S.-S., Vázquez, J., Ferreira-González, I., & Ruiz-Meana, M. (2022). Defective dimerization of FoF1-ATP synthase secondary to glycation favors mitochondrial energy deficiency in cardiomyocytes during aging. <i>Aging Cell</i>, 21, e13564. https://doi.org/10.1111/acel.13564</p><p>In Funding Information, the text “This work was supported by the Instituto de Salud Carlos III of the Spanish Ministry of Health (FIS-PI19-01196) and a grant from the Sociedad Española de Cardiología (SEC/FEC-INV-BAS 217003)” was insufficient.</p><p>This should have read</p><p>This work was funded by the Instituto de Salud Carlos III of the Spanish Ministry of Health (FIS-PI19/01196) and co-funded by the European Union (FEDER) and a grant from the Sociedad Española de Cardiología (SEC/FEC-INV-BAS 217003).</p>","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":"24 7","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.70134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
