Aging Cell最新文献_第2页

Mitochondrial heterogeneity and crosstalk in aging: Time for a paradigm shift? 衰老过程中的线粒体异质性和串扰：范式转变的时机已到？

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-26 DOI: 10.1111/acel.14296

Antentor O. Hinton Jr., Zer Vue, Estevão Scudese, Kit Neikirk, Annet Kirabo, Monty Montano

引用次数: 0

Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging-related diseases 通过调节 CD4+T 细胞延缓免疫衰老：有望成为衰老相关疾病的治疗靶点

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-18 DOI: 10.1111/acel.14317

Tingting Xia, Ying Zhou, Jiayao An, Zhi Cui, Xinqin Zhong, Tianyi Cui, Bin Lv, Xin Zhao, Xiumei Gao

{"title":"Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging-related diseases","authors":"Tingting Xia, Ying Zhou, Jiayao An, Zhi Cui, Xinqin Zhong, Tianyi Cui, Bin Lv, Xin Zhao, Xiumei Gao","doi":"10.1111/acel.14317","DOIUrl":"10.1111/acel.14317","url":null,"abstract":"CD4+T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4+T cells results in a series of changes in the CD4+T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4+T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions. However, the underlying mechanism of CD4+T cells senescence and its intricate association with diseases remains to be elucidated and comprehensively understood. By summarizing the immunosenescent progress and network of CD4+T cell subsets, we reveal the crucial role of CD4+T cells in the occurrence and development of age-related diseases. Furthermore, we provide new insights and theoretical foundations for diseases targeting CD4+T cell subsets aging as a treatment focus, offering novel approaches for therapy, especially in infections, cancers, autoimmune diseases, and other diseases in the elderly.","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review 衰老、细胞衰老与肠道微生物组改变之间的联系：综述。

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-15 DOI: 10.1111/acel.14315

Dong-Hyun Jang, Ji-Won Shin, Eunha Shim, Naoko Ohtani, Ok Hee Jeon

{"title":"The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review","authors":"Dong-Hyun Jang, Ji-Won Shin, Eunha Shim, Naoko Ohtani, Ok Hee Jeon","doi":"10.1111/acel.14315","DOIUrl":"10.1111/acel.14315","url":null,"abstract":"The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, and predisposition to age-associated diseases. Cellular senescence, characterized by a cessation of cell division in response to various stressors, induces morphological and functional changes within tissues. The complexity and heterogeneity of senescent cells, alongside the secretion of senescence-associated secretory phenotype, exacerbate the aging process through pro-inflammatory pathways and influence the microenvironment and immune system. Concurrently, aging-associated changes in gut microbiome diversity and composition contribute to dysbiosis, further exacerbating systemic inflammation and undermining the integrity of various bodily functions. This review encapsulates the burgeoning research on the reciprocal relationship between cellular senescence and gut dysbiosis, highlighting their collective impact on age-related musculoskeletal diseases, including osteoporosis, sarcopenia, and osteoarthritis. It also explores the potential of modulating the gut microbiome and targeting cellular senescence as innovative strategies for healthy aging and mitigating the progression of aging-related conditions. By exploring targeted interventions, including the development of senotherapeutic drugs and probiotic therapies, this review aims to shed light on novel therapeutic avenues. These strategies leverage the connection between cellular senescence and gut microbiome alterations to advance aging research and development of interventions aimed at extending health span and improving the quality of life in the older population.","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence 衰老导致的血脑屏障功能障碍由脑内皮衰老介导。

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-15 DOI: 10.1111/acel.14270

João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira

引用次数: 0

Anatomical Society Research Studentships 2024/25 解剖学会 2024/25 年度研究奖学金

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-13 DOI: 10.1111/acel.14307

引用次数: 0

Aging-associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms 与衰老相关的心房颤动：以潜在机制为重点的全面综述。

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-12 DOI: 10.1111/acel.14309

Meng-Fei Wang, Can Hou, Fang Jia, Cheng-Hao Zhong, Cong Xue, Jian-Jun Li

{"title":"Aging-associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms","authors":"Meng-Fei Wang, Can Hou, Fang Jia, Cheng-Hao Zhong, Cong Xue, Jian-Jun Li","doi":"10.1111/acel.14309","DOIUrl":"10.1111/acel.14309","url":null,"abstract":"Atrial fibrillation (AF) has been receiving a lot of attention from scientists and clinicians because it is an extremely common clinical condition. Due to its special hemodynamic changes, AF has a high rate of disability and mortality. So far, although AF has some therapeutic means, it is still an incurable disease because of its complex risk factors and pathophysiologic mechanisms, which is a difficult problem for global public health. Age is an important independent risk factor for AF, and the incidence of AF increases with age. To date, there is no comprehensive review on aging-associated AF. In this review, we systematically discuss the pathophysiologic evidence for aging-associated AF, and in particular explore the pathophysiologic mechanisms of mitochondrial dysfunction, telomere attrition, cellular senescence, disabled macroautophagy, and gut dysbiosis involved in recent studies with aging-associated AF. We hope that by exploring the various dimensions of aging-associated AF, we can better understand the specific relationship between age and AF, which may be crucial for innovative treatments of aging-associated AF.","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are immunosenescent T cells really senescent? 免疫衰老的 T 细胞真的衰老了吗？

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-07 DOI: 10.1111/acel.14300

Helena Slaets, Naomi Veeningen, Peter L. J. de Keizer, Niels Hellings, Sven Hendrix

{"title":"Are immunosenescent T cells really senescent?","authors":"Helena Slaets, Naomi Veeningen, Peter L. J. de Keizer, Niels Hellings, Sven Hendrix","doi":"10.1111/acel.14300","DOIUrl":"10.1111/acel.14300","url":null,"abstract":"Loss of proper T-cell functioning is a feature of aging that increases the risk of developing chronic diseases. In aged individuals, highly differentiated T cells arise with a reduced expression of CD28 and CD27 and an increased expression of KLRG-1 or CD57. These cells are often referred to as immunosenescent T cells but may still be highly active and contribute to autoimmunity. Another population of T cells known as exhausted T cells arises after chronic antigen stimulation and loses its effector functions, leading to a failure to combat malignancies and viral infections. A process called cellular senescence also increases during aging, and targeting this process has proven to be fruitful against a range of age-related pathologies in animal models. Cellular senescence occurs in cells that are irreparably damaged, limiting their proliferation and typically leading to chronic secretion of pro-inflammatory factors. To develop therapies against pathologies caused by defective T-cell function, it is important to understand the differences and similarities between immunosenescence and cellular senescence. Here, we review the hallmarks of cellular senescence versus senescent and exhausted T cells and provide considerations for the development of specific therapies against age-related diseases.","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements 逆龄：一种独特的衰老表观遗传生物标记，由逆转录子的 DNA 甲基化状态捕获。

IF 7.8 1区医学

Aging Cell Pub Date : 2024-08-02 DOI: 10.1111/acel.14288

Lishomwa C. Ndhlovu, Matthew L. Bendall, Varun Dwaraka, Alina P. S. Pang, Nicholas Dopkins, Natalia Carreras, Ryan Smith, Douglas F. Nixon, Michael J. Corley

{"title":"Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements","authors":"Lishomwa C. Ndhlovu, Matthew L. Bendall, Varun Dwaraka, Alina P. S. Pang, Nicholas Dopkins, Natalia Carreras, Ryan Smith, Douglas F. Nixon, Michael J. Corley","doi":"10.1111/acel.14288","DOIUrl":"10.1111/acel.14288","url":null,"abstract":"Reactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that locus-specific retroelement DNA methylation can be used to create retroelement-based epigenetic clocks that accurately measure chronological age in the immune system, across human tissues, and pan-mammalian species. We also developed a highly accurate retroelement epigenetic clock compatible with EPICv.2.0 data that was constructed from CpGs that did not overlap with existing first- and second-generation epigenetic clocks, suggesting a unique signal for epigenetic clocks not previously captured. We found retroelement-based epigenetic clocks were reversed during transient epigenetic reprogramming, accelerated in people living with HIV-1, and responsive to antiretroviral therapy. Our findings highlight the utility of retroelement-based biomarkers of aging and support a renewed emphasis on the role of retroelements in geroscience.","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiological processes underlying hidden hearing loss revealed in Kcnt1/2 double knockout mice 揭示 Kcnt1/2 双基因敲除小鼠隐性听力损失的病理生理过程。

IF 7.8 1区医学

Aging Cell Pub Date : 2024-07-24 DOI: 10.1111/acel.14243

Nick M. A. Schubert, Daniël O. J. Reijntjes, Marcel van Tuinen, Sarath Vijayakumar, Timothy A. Jones, Sherri M. Jones, Sonja J. Pyott

{"title":"Pathophysiological processes underlying hidden hearing loss revealed in Kcnt1/2 double knockout mice","authors":"Nick M. A. Schubert, Daniël O. J. Reijntjes, Marcel van Tuinen, Sarath Vijayakumar, Timothy A. Jones, Sherri M. Jones, Sonja J. Pyott","doi":"10.1111/acel.14243","DOIUrl":"10.1111/acel.14243","url":null,"abstract":"Presbycusis is a prevalent condition in older adults characterized by the progressive loss of hearing due to age-related changes in the cochlea, the auditory portion of the inner ear. Many adults also struggle with understanding speech in noise despite having normal auditory thresholds, a condition termed “hidden” hearing loss because it evades standard audiological assessments. Examination of animal models and postmortem human tissue suggests that hidden hearing loss is also associated with age-related changes in the cochlea and may, therefore, precede overt age-related hearing loss. Nevertheless, the pathological mechanisms underlying hidden hearing loss are not understood, which hinders the development of diagnostic biomarkers and effective treatments for age-related hearing loss. To fill these gaps in knowledge, we leveraged a combination of tools, including transcriptomic profiling and morphological and functional assessments, to identify these processes and examine the transition from hidden to overt hearing loss. As a novel approach, we took advantage of a recently characterized model of hidden hearing loss: Kcnt1/2 double knockout mice. Using this model, we find that even before observable morphological pathology, hidden hearing loss is associated with significant alteration in several processes, notably proteostasis, in the cochlear sensorineural structures, and increased susceptibility to overt hearing loss in response to noise exposure and aging. Our findings provide the first insight into the pathophysiology associated with the earliest and, therefore, most treatable stages of hearing loss and provide critical insight directing future investigation of pharmaceutical strategies to slow and possibly prevent overt age-related hearing loss.","PeriodicalId":55543,"journal":{"name":"Aging Cell","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acel.14243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141755875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age- and disease-related autophagy impairment in Huntington disease: New insights from direct neuronal reprogramming 亨廷顿病中与年龄和疾病相关的自噬损伤：直接神经元重编程的新发现

IF 7.8 1区医学

Aging Cell Pub Date : 2024-07-23 DOI: 10.1111/acel.14285

Chuyang Luo, Junsheng Yang

引用次数: 0