American Journal of the Medical Sciences最新文献

{"title":"81 Cocaine induced transient third-degree heart block","authors":"CH Hood, S Kancharla, WS Rose, JD Pollard","doi":"10.1016/S0002-9629(25)00090-4","DOIUrl":"10.1016/S0002-9629(25)00090-4","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 ","pages":"Page S55"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3 Cardiovascular outcomes in graves' disease patients treated with antithyroid medication versus total thyroidectomy: a retrospective cohort study","authors":"TE Ahmad, H Malik, T Sikka, H Pirzadah, M Hussein, A Abdelmaksoud, E Toraih","doi":"10.1016/S0002-9629(25)00012-6","DOIUrl":"10.1016/S0002-9629(25)00012-6","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 ","pages":"Pages S2-S3"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2 Cardiovascular outcomes of GLP-1 receptor agonists in patients with coronary artery disease and heart failure: a meta-analysis","authors":"SN Notta, N Notta, A Jagadish, M Jbara, V Ramu","doi":"10.1016/S0002-9629(25)00011-4","DOIUrl":"10.1016/S0002-9629(25)00011-4","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 ","pages":"Pages S1-S2"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"88 Dolichoarteriopathies: a spectrum of arterial abnormalities and their clinical implications","authors":"R Ksayer, B Gonzalez Perez, K Zakharia, F Tirado Polo, G Ali","doi":"10.1016/S0002-9629(25)00097-7","DOIUrl":"10.1016/S0002-9629(25)00097-7","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 ","pages":"Pages S59-S60"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"66 Rare pediatric case of diabetic ketoacidosis in cystic fibrosis","authors":"S Rein, M Rossi, A Savant","doi":"10.1016/S0002-9629(25)00075-8","DOIUrl":"10.1016/S0002-9629(25)00075-8","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 ","pages":"Page S45"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated triglyceride-glucose index as a predictor of carotid plaque incidence: Insights from a comprehensive meta-analysis","authors":"Arankesh Mahadevan MBBS ,&nbsp;Bhavin A. Patel MD ,&nbsp;Sashwath Srikanth MD ,&nbsp;Raja Godasi MBBS ,&nbsp;Rupak Desai MBBS","doi":"10.1016/j.amjms.2024.08.013","DOIUrl":"10.1016/j.amjms.2024.08.013","url":null,"abstract":"<div><h3>Background</h3><div>Early detection of carotid plaque (CP) can help reduce the burden of ASCVD in the general population. CP and triglyceride-glucose index (TyGi) are associated with insulin resistance.</div></div><div><h3>Objectives</h3><div>We performed a meta-analysis exploring the association of TyGi levels with the incidence of CP.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Scopus, and Google Scholar till September 2023 reporting TyGi and CP identified 67 studies, of which 13 met our study criteria. TyGi was assessed both categorically and continuously. Binary random-effects models used for pooled odds ratios (OR) with 95% confidence intervals (CI) and I² statistic for heterogeneity.</div></div><div><h3>Results</h3><div>Analyzed data from 163,792 patients with a mean age of 53 ± 8.9 years, primarily female (51.5%). Common comorbidities were hypertension (42.4%) followed by dyslipidemia (24.3%). Multivariable analysis showed that high vs. low TyGi quartile was associated with a higher risk of CP with unadjusted OR (1.82, 95% CI [1.5 - 2.21], <em>p</em> &lt; 0.01; I² = 95.77, <em>p</em> &lt; 0.01) and adjusted OR (1.3, 95% CI [1.16 - 1.46], <em>p</em> &lt; 0.01; I² = 79.71, <em>p</em> &lt; 0.01). Increasing TyGi also had a higher risk of CP with unadjusted OR (1.53, 95% CI [1.15 - 2.03], <em>p</em> &lt; 0.01; I² = 98.48, <em>p</em> &lt; 0.01) and adjusted OR (1.23, 95% CI [1.11 - 1.35], <em>p</em> &lt; 0.01; I² = 89.82, <em>p</em> &lt; 0.01). The association was validated by sensitivity analysis.</div></div><div><h3>Conclusion</h3><div>Our study indicates a higher risk of CP in patients with higher TyGi scores, underscoring its significance as a predictor for carotid atherosclerosis.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 197-207"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single nucleotide polymorphisms of GEMIN3 modify the risk of primary Sjögren's syndrome in female patients","authors":"Dong Wang PhD ,&nbsp;Jingjing Zhang MD ,&nbsp;Yufei Zhao MD ,&nbsp;Ruijie Cao MD ,&nbsp;Yingnan Wang MD ,&nbsp;Iren Guo Student ,&nbsp;Chenxing Peng PhD ,&nbsp;Yanrong Song MD ,&nbsp;Shasha Zhang MD","doi":"10.1016/j.amjms.2024.07.001","DOIUrl":"10.1016/j.amjms.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>MicroRNA (miRNA)-processing machinery may modify the risk of primary Sjögren's syndrome (pSS) by altering miRNA expression profiles. Inflammatory cytokines and reactive oxygen species (ROS) are also involved in pSS; however, the role of altered miRNAs expression in its pathogenesis is still unclear. We aimed to evaluate the relationship between single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes, including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), and the risk of pSS in female patients. The potential associations of cytokines and ROS with pSS-susceptible SNPs were also evaluated.</div></div><div><h3>Materials and Methods</h3><div>The SNPs confirmed by polymerase chain reaction ligase detection reaction were genotyped in 74 female patients with pSS and 77 controls. The relationship was analyzed by Student's t-test, Wilcoxon rank-sum test, chi-square test, Pearson's correlation test, and binary logistic regression analysis.</div></div><div><h3>Results</h3><div>For rs197412 of the GEMIN3 gene, the genotype TT carrier was associated with a 2.172-fold increased risk for pSS when compared with that of CT+CC carrier (odds ratio: 2.172, 95% CI, 1.133–4.166, <em>p</em>=0.019). Simultaneously, the pSS-susceptible TT carriers were associated with increased interferon-γ (IFN-γ) (<em>P</em> &lt; 0.001) and tumor necrosis factor-α (TNF-α) (<em>P</em> = 0.003) levels when compared with that of CT+CC genotype carriers in female patients with pSS. The subsequent analysis also showed a weak positive correlation between IFN-γ and TNF-α levels (r=0.271, <em>P</em> = 0.019).</div></div><div><h3>Conclusion</h3><div>The predictors of GEMIN3 SNPs might modify pSS development in females by mediating the expression of miRNAs and therefore regulate the levels of IFN-γ and TNF-α.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 137-144"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble RAGE attenuates myocardial I/R injury by suppressing interleukin-6","authors":"Jie Zhang MD ,&nbsp;Jian Liu MD ,&nbsp;Jiming Yin MD ,&nbsp;Xue Jiang MD ,&nbsp;Lu Chen MD ,&nbsp;Xiangjun Zeng PhD ,&nbsp;Caixia Guo MD, PhD","doi":"10.1016/j.amjms.2024.08.001","DOIUrl":"10.1016/j.amjms.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory responses play a central role in myocardial ischemia/reperfusion (I/R) injury. Previous studies have demonstrated that the receptor for advanced glycation end-products (RAGE) is involved in the pro-inflammatory process of myocardial I/R injury by binding to diverse ligands. Thus, the inhibitory effects of soluble receptor for advanced glycation end-products (sRAGE), a decoy receptor for RAGE, on myocardial I/R injury may be associated with a reduced inflammatory state.</div></div><div><h3>Methods</h3><div>In this study, plasma levels of several inflammatory mediators were measured in patients with acute myocardial infarction (AMI) and I/R-treated cardiomyocyte-specific sRAGE knock-in (sRAGE-CKI) mice. Cardiac function, infarct size, and macrophage phenotypes were examined and documented in mouse hearts.</div></div><div><h3>Results</h3><div>We enrolled 38 patients diagnosed with myocardial infarction (AMI) [mean age, 58.81 ± 10.40 years] and 26 control with negative coronary arteriographic findings [mean age, 61.84 ± 8.57 years]. The results showed that sRAGE levels were significantly elevated in the AMI patient group compared with the control group (1905.00 [1462.50, 2332.5] vs 1570.00 [1335.00, 1800.00] pg/mL, <em>p</em> &lt; 0.05), which were negatively correlated with interleukin (IL)-1, IL-6, and IL-8 levels. Cardiac-specific overexpression of sRAGE dramatically improved cardiac function and reduced infarct size during myocardial I/R. Furthermore, sRAGE overexpression decreased the plasma IL-6 levels and pro-inflammatory iNOS⁺ M1-macrophages, and increased CD206⁺ M2-macrophages in the mouse hearts.</div></div><div><h3>Conclusions</h3><div>Our findings suggested that sRAGE protects the heart from myocardial I/R injury by inhibiting the infiltration of pro-inflammatory M1-macrophages, and subsequently decreasing IL-6 secretion.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 228-237"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute urticaria and cardiovascular diseases","authors":"Eli Magen MD ,&nbsp;Eugene Merzon MD ,&nbsp;Ilan Green MD ,&nbsp;Israel Magen MD ,&nbsp;Avivit Golan-Cohen MD ,&nbsp;Shlomo Vinker MD ,&nbsp;Ariel Israel MD, PhD","doi":"10.1016/j.amjms.2024.08.004","DOIUrl":"10.1016/j.amjms.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><div>Acute urticaria (AU), characterized by sudden skin wheals, has been associated with various triggers. While chronic urticaria's cardiovascular comorbidities have been studied, AU's associations remain largely unexplored.</div></div><div><h3>Objective</h3><div>This study aimed to identify prevalent cardiovascular comorbidities in AU patients and assess their clinical significance.</div></div><div><h3>Methods</h3><div>A retrospective cohort study used data from Leumit Health Services, matching AU patients with controls. Demographic, clinical, and laboratory data were analyzed. Statistical analyses included Fisher's Exact Test and Mann-Whitney U test.</div></div><div><h3>Results</h3><div>The AU group (72,851 individuals) showed no sex/ethnic distribution differences from controls (291,404 individuals). Systolic blood pressure, weight, BMI, glucose, hemoglobin A1c, C-reactive protein, eosinophil counts, total IgE levels were higher in AU (p &lt; 0.001). Several cardiovascular comorbidities showed significant associations with AU, including valvular heart diseases (aortic regurgitation, mitral regurgitation, and pulmonary valve stenosis), cardiac arrhythmias (atrial fibrillation and others), deep vein thrombosis, diseases of capillaries, peripheral artery disease, cerebrovascular disease, coronary artery disease, and inflammatory heart diseases (pericarditis, heart failure, and hypertension) (p &lt; 0.05). Medications, including antihistamines and glucocorticoids, were more prevalent in the AU group (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>This study's findings underscore the importance of recognizing cardiovascular comorbidities in AU patients and considering their implications for management. The observed associations provide insight into potential shared mechanisms between AU and cardiovascular diseases, though further research is needed to validate and expand upon these findings.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 160-165"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of primary biliary cirrhosis - idiopathic inflammatory myopathy overlap syndrome: A single center study","authors":"Juan Wu MD ,&nbsp;Yue Yin MD, PhD ,&nbsp;Xinxin Han MD, PhD ,&nbsp;Hong Di MD, PhD ,&nbsp;Yingdong Han MD, PhD ,&nbsp;Min Shen MD, PhD ,&nbsp;Yun Zhang MD ,&nbsp;Xuejun Zeng MD, PhD","doi":"10.1016/j.amjms.2024.08.005","DOIUrl":"10.1016/j.amjms.2024.08.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Primary biliary cirrhosis–idiopathic inflammatory myopathy (PBC-IIM) overlap syndrome (OS) is a rare condition in which cardiac involvement is observed. We aimed to characterize the clinical features and associated factors of PBC-IIM OS patients with cardiac involvement.</div></div><div><h3>Methods</h3><div>Patients with PBC-IIM OS that visited our hospital from January 1983 to December 2021 were enrolled. Clinical presentations and laboratory and imaging data were recorded. The clinical data of patients with and without cardiac involvement were compared. According to the first instance of a disease flare, prognostic factors were also studied.</div></div><div><h3>Results</h3><div>Thirty-four patients with PBC-IIM OS were enrolled. A total of 58.8% of patients presented with muscle weakness at disease onset, which primarily involved skeletal muscle (85.3%). Slight liver dysfunction was discovered in this OS cohort. In patients with cardiac involvement, palpitation (63.6%) and dyspnea (36.4%) were the most common onset symptoms. Arrhythmia was a vital manifestation in OS patients, in which half of OS patients had nonsustained ventricular tachycardia (50.0%, 11/22). Compared with noncardiac involvement, myalgia (4.5%, <em>P</em> = 0.004) and fever (0.0%, <em>P</em> = 0.011) were reported relatively rarely at disease onset in the group with cardiac involvement. The prognosis analysis showed that positivity for anti-Ro52 (HR=0.00, <em>P</em> = 0.034) negatively correlated with relapse in OS patients.</div></div><div><h3>Conclusion</h3><div>PBC-IIM OS has unique features. Typical clinical manifestations and early worsening cardiac indicators can be used to identify cardiac involvement and predict prognosis. Anti-Ro52 may have prognostic value for PBC-IIM OS.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 166-175"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}