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COPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD COPET研究发现,生物量暴露作为COPD病因型的临床相关性。
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-07-09 DOI: 10.1016/j.amjms.2025.07.001
Esra Ertan Yazar MD, PhD , Nilgün Demirci MD, PhD , Burcu Arpınar Yiğitbaş MD, PhD , Mukadder Çalıkoğlu MD, PhD , Gazi Gülbaş MD, PhD , Muzaffer Onur Turan MD, PhD , Hülya Şahin MD, PhD , Nurhan Sarıoğlu MD, PhD , Nevin Taci Hoca MD, PhD , Fulsen Bozkuş MD, PhD , Seda Tural MD, PhD , Nihal Arzu Mirici MD, PhD , Nalan Ogan MD, PhD , Burcu Yormaz MD, PhD , Ayperi Öztürk MD, PhD , Filiz Koşar MD, PhD , Evrim Eylem Akpınar MD, PhD , Gülşah Günlüoğlu MD, PhD , Burak Mete MD, PhD , Can Öztürk MD, PhD , Mecit Süerdem MD, PhD
{"title":"COPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD","authors":"Esra Ertan Yazar MD, PhD ,&nbsp;Nilgün Demirci MD, PhD ,&nbsp;Burcu Arpınar Yiğitbaş MD, PhD ,&nbsp;Mukadder Çalıkoğlu MD, PhD ,&nbsp;Gazi Gülbaş MD, PhD ,&nbsp;Muzaffer Onur Turan MD, PhD ,&nbsp;Hülya Şahin MD, PhD ,&nbsp;Nurhan Sarıoğlu MD, PhD ,&nbsp;Nevin Taci Hoca MD, PhD ,&nbsp;Fulsen Bozkuş MD, PhD ,&nbsp;Seda Tural MD, PhD ,&nbsp;Nihal Arzu Mirici MD, PhD ,&nbsp;Nalan Ogan MD, PhD ,&nbsp;Burcu Yormaz MD, PhD ,&nbsp;Ayperi Öztürk MD, PhD ,&nbsp;Filiz Koşar MD, PhD ,&nbsp;Evrim Eylem Akpınar MD, PhD ,&nbsp;Gülşah Günlüoğlu MD, PhD ,&nbsp;Burak Mete MD, PhD ,&nbsp;Can Öztürk MD, PhD ,&nbsp;Mecit Süerdem MD, PhD","doi":"10.1016/j.amjms.2025.07.001","DOIUrl":"10.1016/j.amjms.2025.07.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The finding that COPD can also develop in non-smokers has led to further investigations of etiologic causes other than smoking. This study evaluated the relationship between tobacco smoking and/or biomass-burning smoke exposure (BBS) and the demographic, clinical, and prognostic characteristics of individuals with COPD.</div></div><div><h3>Methods</h3><div>A total of 1129 stable COPD patients from the COPET study were retrospectively analyzed. The patients were divided into three groups: the COPD-B group (<em>n</em> = 52), which included patients who were solely BBS; the COPD-C group (<em>n</em> = 634), which included patients who exclusively tobacco smoking; and the COPD-BC group (<em>n</em> = 443), which included patients with both BBS and tobacco smoking.</div></div><div><h3>Results</h3><div>The average age of the patients was 65.8 ± 9.1 years, and 87.4 % of them were men. In the COPD-B group, the following factors were significantly greater compared to the COPD-C and COPD-BC groups: age (<em>p</em> = 0.001), BMI (<em>p</em> = 0.001), percentage of female patients (<em>p</em> &lt; 0.001), FEV<sub>1</sub>/FVC ratio (<em>p</em> = 0.014), eosinophil count (<em>p</em> &lt; 0.001), ADO score (<em>p</em> &lt; 0.001), and the proportion of patients with frequent exacerbations (<em>p</em> = 0.013). Thorax CT scans showed that the COPD-BC group had a greater incidence of bronchiectasis and emphysema than the COPD-B and COPD-C groups (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This study highlights significant clinical and radiological differences among COPD patients based on tobacco smoking and BBS, which may substantially impact COPD outcomes, including exacerbations and prognosis.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 4","pages":"Pages 365-370"},"PeriodicalIF":1.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intranasal administration of stem cell therapy: A promising approach for early Alzheimer’s disease intervention 鼻内给药干细胞治疗:早期阿尔茨海默病干预的一种有希望的方法。
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-07-08 DOI: 10.1016/j.amjms.2025.07.002
Eeshal Fatima MBBS , Anoushey Fatima MBBS
{"title":"Intranasal administration of stem cell therapy: A promising approach for early Alzheimer’s disease intervention","authors":"Eeshal Fatima MBBS ,&nbsp;Anoushey Fatima MBBS","doi":"10.1016/j.amjms.2025.07.002","DOIUrl":"10.1016/j.amjms.2025.07.002","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 4","pages":"Pages 405-406"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost analysis of mechanical thrombectomy vs catheter-directed thrombolysis vs anticoagulation alone for pulmonary embolism 机械取栓、导管溶栓和单独抗凝治疗肺栓塞的成本分析
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-07-05 DOI: 10.1016/j.amjms.2025.06.011
Zein Kattih MD , Simon Meredith DO , Vincent Dong DO , Victoria Roselli MS , Daniel Mina , Dimitre Stefanov PhD , Shankar Thampi MD , Arber Kodra MD , Chad Kliger MD , Bushra Mina MD , The Lenox Hill Hospital Pulmonary Embolism Response Team (PERT)
{"title":"Cost analysis of mechanical thrombectomy vs catheter-directed thrombolysis vs anticoagulation alone for pulmonary embolism","authors":"Zein Kattih MD ,&nbsp;Simon Meredith DO ,&nbsp;Vincent Dong DO ,&nbsp;Victoria Roselli MS ,&nbsp;Daniel Mina ,&nbsp;Dimitre Stefanov PhD ,&nbsp;Shankar Thampi MD ,&nbsp;Arber Kodra MD ,&nbsp;Chad Kliger MD ,&nbsp;Bushra Mina MD ,&nbsp;The Lenox Hill Hospital Pulmonary Embolism Response Team (PERT)","doi":"10.1016/j.amjms.2025.06.011","DOIUrl":"10.1016/j.amjms.2025.06.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Pulmonary embolism is the third most common cause of cardiovascular death in the US with a high financial burden. Data on cost-analysis is limited in comparing advanced treatment modalities.</div></div><div><h3>Methods</h3><div>A cohort of patients were selected from a PERT registry database from cases at a tertiary center in a metropolitan area between 2016 and 2023. Patients were treated with either anticoagulation alone, CDT, or MT. The primary outcome was revenue-per-case.</div></div><div><h3>Results</h3><div>MT had the highest revenue-per-case, with a median (IQR) of $59,058 ($42,827-$86,950) (<em>p</em> &lt; 0.0001). CDT had a median (IQR) revenue-per-case of $19,007 ($14,062-$34,651). Anticoagulation alone had a median (IQR) revenue-per-case of $16,171 ($12,666-$31,473). Margin-per-case closely paralleled the primary outcome. While hospital length of stay, survival at discharge, and 90-day readmission were not different among the groups, ICU utilization was 20 % in anticoagulation patients, 100 % in CDT patients, and 24 % in MT patients (<em>p</em> &lt; 0.0001). CTEPH was identified in 12 % of the anticoagulation group, 12 % of the CDT patients, and none of the MT patients (<em>p</em> = 0.04).</div></div><div><h3>Discussion</h3><div>MT has a significantly higher revenue-per-case compared with anticoagulation alone and CDT. ICU utilization of mechanical thrombectomy was lower than catheter-directed thrombolysis and near the ICU utilization with anticoagulation alone. Institution policies and device choice may impact these outcomes, which may vary by center.</div></div><div><h3>Conclusions</h3><div>Advanced therapies that can prevent the downstream sequalae of PE have higher cost but may be more advantageous, and further research is required to evaluate long term benefits.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 4","pages":"Pages 328-332"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An analysis of studies comparing myocarditis and pericarditis in COVID-19 vaccinated and SARS-CoV-2 infected individuals COVID-19疫苗接种者与SARS-CoV-2感染者心肌炎和心包炎比较研究分析
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-07-05 DOI: 10.1016/j.amjms.2025.06.012
Whitney Bowyer BS , Alyson Haslam PhD , Vinay Prasad MD, MPH
{"title":"An analysis of studies comparing myocarditis and pericarditis in COVID-19 vaccinated and SARS-CoV-2 infected individuals","authors":"Whitney Bowyer BS ,&nbsp;Alyson Haslam PhD ,&nbsp;Vinay Prasad MD, MPH","doi":"10.1016/j.amjms.2025.06.012","DOIUrl":"10.1016/j.amjms.2025.06.012","url":null,"abstract":"<div><div><span>We sought to identify studies that examined myocarditis<span> and pericarditis after both COVID-19 </span></span>vaccination<span> and SARS-CoV-2 infection. A literature search was conducted, and retrospective cohort studies<span><span> examining incidence rates for myocarditis and </span>pericarditis<span> after both COVID-19 vaccination and SARS-CoV-2 infection were included. The methodologies and conclusions of each study was assessed, and a risk of bias was determined. We found 6 articles that utilized cohorts of both vaccinated and infected populations. Of the included articles, all of them had risk of bias concerns, with 50 % having a poor-quality rating and 50 % having a fair quality rating. Methodological biases, including reliance on electronic health record data, inadequate observational periods, and failure to account for baseline characteristics between the two cohorts, were observed across studies. Ultimately, these methodological limitations lead to hyperinflated myocarditis rates in the infection cohorts and a lack of meaningful comparisons between the infection and vaccination cohorts.</span></span></span></div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 4","pages":"Pages 392-399"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of genetic liability to migraines on spontaneous coronary artery dissection and fibromuscular dysplasia 偏头痛遗传易感性对自发性冠状动脉剥离和纤维肌肉发育不良的影响。
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-06-16 DOI: 10.1016/j.amjms.2025.06.007
Yun-Hu Chen MS , Fang Yan MB
{"title":"Effect of genetic liability to migraines on spontaneous coronary artery dissection and fibromuscular dysplasia","authors":"Yun-Hu Chen MS ,&nbsp;Fang Yan MB","doi":"10.1016/j.amjms.2025.06.007","DOIUrl":"10.1016/j.amjms.2025.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Associations among migraines, spontaneous coronary artery dissection<span> (SCAD), and fibromuscular dysplasia (FMD) have been reported; however, their causality is inconclusive.</span></div></div><div><h3>Methods</h3><div>We inferred a causal relation between exposure (migraines) and outcomes (SCAD and FMD) using two-sample MR<span> analysis. Mediation analysis was performed using reverse and multivariate MR analysis methods. Finally, using two-sample MR analysis, we explored whether the currently perceived potential risk factors for SCAD and FMD mediate the aforementioned causal association.</span></div></div><div><h3>Results</h3><div>Inverse Variance Weighted (IVW) analysis showed that migraines increased the risk of developing SCAD and FMD. SCAD increases the risk of developing FMD. Reverse causality or pleiotropy was not observed. Multivariate random IVW analysis showed that the effect of migraine on FMD was no longer significant in the multivariate model, whereas the effect of SCAD remained significant. SCAD mediated the causal association between migraine and FMD, with a mediating effect of 0.119 and a proportion of 18.30 %. IVW analyses did not find direct evidence that these associations were consistently related to other potential pathogenic factors of SCAD or FMD.</div></div><div><h3>Conclusions</h3><div>Migraines are a risk factor for both SCAD and FMD, whereas SCAD is an incomplete mediator of the causal relation between migraine and FMD. However, mechanistic studies are warranted to investigate this link.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 4","pages":"Pages 383-391"},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic efficacy of scopoletin on oxidative stress and cardiac dysfunction in streptozotocin-induced diabetic rats 东莨菪碱对链脲佐菌素诱导的糖尿病大鼠氧化应激和心功能障碍的治疗作用。
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-06-13 DOI: 10.1016/j.amjms.2025.06.010
Abdelrahim Alqudah PhD , Esam Qnais PhD , Omar Gammoh PhD , Yousra Bseiso MSc , Mohammed Wedyan PhD , Sireen Abdul Rahim Shilbayeh PhD , Rawan Abudalo PhD , Muna Oqal PhD , Alaa A.A. Aljabali PhD
{"title":"Therapeutic efficacy of scopoletin on oxidative stress and cardiac dysfunction in streptozotocin-induced diabetic rats","authors":"Abdelrahim Alqudah PhD ,&nbsp;Esam Qnais PhD ,&nbsp;Omar Gammoh PhD ,&nbsp;Yousra Bseiso MSc ,&nbsp;Mohammed Wedyan PhD ,&nbsp;Sireen Abdul Rahim Shilbayeh PhD ,&nbsp;Rawan Abudalo PhD ,&nbsp;Muna Oqal PhD ,&nbsp;Alaa A.A. Aljabali PhD","doi":"10.1016/j.amjms.2025.06.010","DOIUrl":"10.1016/j.amjms.2025.06.010","url":null,"abstract":"<div><h3>Background</h3><div><span><span><span>Cardiac dysfunction associated with diabetes often arises as a serious condition, primarily driven by persistent oxidative imbalance and chronic inflammation. There are few treatments for such complication and therefore, there is considerable interest in </span>natural compounds<span> such as scopoletin<span> has antioxidative and anti-inflammatory activities. This study investigates how scopoletin may influence disease progression in a rat model of </span></span></span>diabetic cardiomyopathy induced by </span>streptozotocin (STZ).</div></div><div><h3>Methods</h3><div><span><span>Thirty-two male Wistar rats were evenly distributed into four study groups using a randomization protocol: a non-diabetic control, an untreated diabetic group, a diabetic group administered scopoletin, and a diabetic group treated with </span>metformin (Glucophage) as a reference therapy. Post-diabetes induction by streptozotocin, treatments were administered for three weeks, subsequently, </span>malondialdehyde<span> (MDA) concentrations were measured along with, the enzymatic activities of key cardiac antioxidants—superoxide dismutase (SOD), catalase<span> (CAT), and glutathione peroxidase<span> (GPx)—were evaluated to assess oxidative defense status. ATPase activities, gene expression (p53 and VCAM-1), and histopathological examinations of heart tissues.</span></span></span></div></div><div><h3>Results</h3><div>Scopoletin treatment significantly reduced MDA levels by up to 35 %, with <em>p</em><span> &lt; 0.01 compared to the diabetic control. Antioxidant enzyme activities were notably enhanced, with increases in SOD, CAT, and GPx activities by approximately 50 % (</span><em>p</em> &lt; 0.01). Cardiac ATPase activities showed marked improvement (<em>p</em> &lt; 0.05), and the expression of p53 and VCAM-1 was effectively downregulated (<em>p</em><span> &lt; 0.01). Histopathological analysis revealed substantial reductions in myocardial damage, vacuolation, and tissue congestion in scopoletin-treated groups, with the high-dose effects comparable to those observed with metformin (Glucophage).</span></div></div><div><h3>Conclusions</h3><div>Scopoletin demonstrates significant potential in treating diabetic cardiomyopathy. These results encourage further clinical trials to explore scopoletin as a complementary therapy for cardiac complications in diabetic patients.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 5","pages":"Pages 496-504"},"PeriodicalIF":1.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of hepatitis B virus infection and helicobacter pylori co-infection with gastric disorders and cancer 乙型肝炎病毒感染和幽门螺杆菌合并感染与胃疾病和胃癌的关系:一项在中国人群中的研究
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-06-13 DOI: 10.1016/j.amjms.2025.06.009
Xiaoying Wu M.Med, Jianhua Yu MBBS, Xi Luo M.Med, Yuntong Lan MBBS
{"title":"Association of hepatitis B virus infection and helicobacter pylori co-infection with gastric disorders and cancer","authors":"Xiaoying Wu M.Med,&nbsp;Jianhua Yu MBBS,&nbsp;Xi Luo M.Med,&nbsp;Yuntong Lan MBBS","doi":"10.1016/j.amjms.2025.06.009","DOIUrl":"10.1016/j.amjms.2025.06.009","url":null,"abstract":"<div><h3>Background and aims</h3><div><span>The relationship between hepatitis B virus (HBV) and </span>gastric disorders<span> remains elusive. This study aimed to assess the associations between HBV infection and three gastric disorders. To our knowledge, this is among the first studies to report a synergistic association between HBV and HP co-infection and gastric cancer risk.</span></div></div><div><h3>Methods</h3><div>HBV-positive patients (<em>n</em> = 352) and HBV-negative controls (<em>n</em><span><span><span> = 520) were recruited from June 2018 to May 2020 at the People’s Hospital of Qijiang District. All patients were examined with gastroscopy<span> and histopathological analysis was performed on gastric specimens. HBV DNA and hepatitis B virus </span></span>surface antigen (HBsAg) were detected by qPCR and the enzyme-linked immunosorbent assay (ELISA), respectively. The relationship of HBV infection with gastric disorders was evaluated by </span>logistic regression analysis<span>. Survival and relapse rates of HBV gastric cancer (GC) cases were estimated using the Kaplan-Meier survival curve and Cox proportional hazard regression model.</span></span></div></div><div><h3>Results</h3><div>Gastric mucosal lesions were more serious in the HBV-positive group than in the HBV- negative groups (<em>P &lt;</em><span><span> 0.05). HBV DNA and HBsAg levels were strongly correlated with the manifestation of gastritis, </span>gastric ulcer, and GC, and were the highest in GC patients. HBV and </span><em>Helicobacter Pylori</em> (HP) infections were identified as risk factors for GC (<em>P</em><span> &lt; 0.05). HBV was significantly associated with gastric ulcer (OR = 10.51, 95 % CI = 5.66–19.52, </span><em>p</em> &lt; 0.01) and gastric cancer (OR = 2.21, 95 % CI = 1.21–3.47, <em>p</em><span> = 0.037), while co-infection with HP further increased GC risk (OR = 3.39, 95 % CI = 1.71–6.12, </span><em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>HBV infection was correlated with some gastric lesions. HBV infection alone might be a risk factor of GC. HBV infection potently increases the risk of GC in HP-positive patients.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 3","pages":"Pages 251-258"},"PeriodicalIF":1.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of inhaler treatments on respiratory functions and exacerbation frequency in non-cystic fibrosis bronchiectasis 吸入器治疗对非囊性纤维化支气管扩张呼吸功能和加重频率的影响。
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-06-13 DOI: 10.1016/j.amjms.2025.06.008
Uğur Fidan MD, PhD , Deniz Kızılırmak MD, PhD , Ayşın Şakar Coşkun MD, PhD
{"title":"Impact of inhaler treatments on respiratory functions and exacerbation frequency in non-cystic fibrosis bronchiectasis","authors":"Uğur Fidan MD, PhD ,&nbsp;Deniz Kızılırmak MD, PhD ,&nbsp;Ayşın Şakar Coşkun MD, PhD","doi":"10.1016/j.amjms.2025.06.008","DOIUrl":"10.1016/j.amjms.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div><span>Bronchiectasis<span> is a chronic airway disease caused by abnormal and permanent dilation of the airways. This study aimed to evaluate the effects of inhaler therapy use on </span></span>respiratory functions and clinical outcomes in patients with non-cystic fibrosis bronchiectasis.</div></div><div><h3>Methods</h3><div>One hundred forty-six patients with non-cystic fibrosis bronchiectasis aged over 18 years, diagnosed using high-resolution computed tomography, were included in the study. Age, sex, body mass index<span><span><span>, smoking status, additional diseases, known etiologic factors, and vaccination status of the patients included in the retrospectively designed study were recorded as sociodemographic data. Respiratory functions, disease severity, and clinical outcomes of patients with bronchiectasis who did and did not receive inhaled </span>anticholinergic and </span>steroid treatments were compared.</span></div></div><div><h3>Results</h3><div>Ninety (61.6 %) of the 146 patients included in the study were women. The mean age was 56.14 ± 16.22 years. The etiology of bronchiectasis was unknown in 78 (53.4 %) patients. The most prevalent comorbidity was asthma. According to modified Reiff scoring, 91 (62.3 %) patients were classified as having mild bronchiectasis. Twenty-six (17.8 %) patients had airway obstruction. There were 93 (63.7 %) patients using inhaled corticosteroids and 32 (21.9 %) using inhaled anticholinergics.</div></div><div><h3>Conclusions</h3><div>It was determined that patients using inhaler anticholinergics or inhaled steroids were in the more severe group. However, inhaler anticholinergic<span> and inhaler steroid treatments had no effect on hospital admissions and exacerbation frequency in patients with bronchiectasis. Hospitalizations were more frequent among patients with bronchiectasis using inhaled steroids.</span></div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 4","pages":"Pages 347-352"},"PeriodicalIF":1.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased prevalence, ER visits, and hospitalizations in medicare systemic lupus erythematosus patients living in socially vulnerable counties: A cross-sectional study 生活在社会脆弱县的医保系统性红斑狼疮患者患病率、急诊就诊和住院率增加:一项横断面研究。
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-06-12 DOI: 10.1016/j.amjms.2025.05.009
Emily R. Cosentino MD , James C. Oates (Jim) MD
{"title":"Increased prevalence, ER visits, and hospitalizations in medicare systemic lupus erythematosus patients living in socially vulnerable counties: A cross-sectional study","authors":"Emily R. Cosentino MD ,&nbsp;James C. Oates (Jim) MD","doi":"10.1016/j.amjms.2025.05.009","DOIUrl":"10.1016/j.amjms.2025.05.009","url":null,"abstract":"<div><h3>Background</h3><div>Systemic Lupus Erythematosus (SLE) disproportionately affects women, minorities, and individuals with low socioeconomic status. We hypothesized that counties with a higher percentage of disadvantaged individuals have a higher prevalence of SLE and increased acute hospital events, including emergency room (ER) visits and hospitalizations, among Medicare patients with SLE.</div></div><div><h3>Methods</h3><div><span>This cross-sectional study used the Centers for Disease Control and Prevention’s </span>Social Vulnerability Index (SVI) and Lupus Research Alliance’s Lupus Index Medicare data. SLE was identified through Medicare fee-for-service administrative records from 2016 containing two or more ICD-10 codes for SLE. We examined SLE prevalence, acute hospital events, and their association with county-level SVI rankings.</div></div><div><h3>Results</h3><div>The study population was 89 % female and 69 % White, with 22 % Black. SVI ranking (<em>r</em> = 0.508) and its subthemes correlated with SLE prevalence, with socioeconomic status and household composition showing the strongest associations (<em>R</em> = 0.431 and <em>R</em> = 0.365, respectively). Similar but weaker correlations were seen between SVI and acute healthcare events, including ER visits and hospitalizations.</div><div>Limitations include the cross-sectional design preventing longitudinal analysis, reliance on administrative data potentially introducing bias, and exclusion of counties with fewer than 10 SLE patients.</div></div><div><h3>Conclusions</h3><div>This is the first study linking county-level vulnerability to SLE prevalence and healthcare events in a Medicare SLE population. Findings suggest that social and environmental factors<span><span> influence SLE risk and healthcare utilization, much like other </span>chronic diseases. The modest association between location and hospital/ER events suggests that structural factors may act as barriers to optimal care and outcomes.</span></div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 3","pages":"Pages 237-244"},"PeriodicalIF":1.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased susceptibility to vibrio vulnificus infection in patients with MASLD, cirrhosis, and chronic liver diseases 肝病、肝硬化和慢性肝病患者对创伤弧菌感染的易感性增加
IF 1.8 4区 医学
American Journal of the Medical Sciences Pub Date : 2025-06-05 DOI: 10.1016/j.amjms.2025.06.002
Mohammad Aldiabat MD MPH , Yassine Kilani MD , Mahmoud Y. Madi MD , Punnag Saha PhD , Subhajit Roy PhD , Don C. Rockey MD , Saurabh Chatterjee MS, PhD , Wing-Kin Syn MD PhD
{"title":"Increased susceptibility to vibrio vulnificus infection in patients with MASLD, cirrhosis, and chronic liver diseases","authors":"Mohammad Aldiabat MD MPH ,&nbsp;Yassine Kilani MD ,&nbsp;Mahmoud Y. Madi MD ,&nbsp;Punnag Saha PhD ,&nbsp;Subhajit Roy PhD ,&nbsp;Don C. Rockey MD ,&nbsp;Saurabh Chatterjee MS, PhD ,&nbsp;Wing-Kin Syn MD PhD","doi":"10.1016/j.amjms.2025.06.002","DOIUrl":"10.1016/j.amjms.2025.06.002","url":null,"abstract":"","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"370 3","pages":"Pages 305-307"},"PeriodicalIF":1.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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