American Journal of the Medical Sciences最新文献_第3页

45 A case of neonatal gestational alloimmune liver disease masked by volvulus

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00054-0

C DeVette, M Robbins

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83 Harlequin syndrome and right ventricular failure: a complex case following mitral valve replacement

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00092-8

G Loyola, N Qadir, A Karan, MC O'Brien, J Sousou, J Williams, P Reddy

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9 Treatment-induced diabetic neuralgia leading to diabetic thoracic polyradiculopathy

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00018-7

FA Vazquez, B Carman, M Quarton, A Burkenstock, K Bateman

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Visceral adipose tissue area predicts major adverse kidney events in patients with acute necrotizing pancreatitis 内脏脂肪组织面积可预测急性坏死性胰腺炎患者的主要肾脏不良事件。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.08.003

Xihong Zhang MD , Wenjian Mao MD , Lu Ke PhD , Tiejun Wu MD , Minyi Xu MPH , Yunze Tan MD , Yu Liu MD , Luyu Liu MSc , Gang Li MD , Jing Zhou MD , Jingzhu Zhang MSc , Bo Ye MD , Zhihui Tong MD , Jianqiang Guo MD , Weiqin Li MD

{"title":"Visceral adipose tissue area predicts major adverse kidney events in patients with acute necrotizing pancreatitis","authors":"Xihong Zhang MD , Wenjian Mao MD , Lu Ke PhD , Tiejun Wu MD , Minyi Xu MPH , Yunze Tan MD , Yu Liu MD , Luyu Liu MSc , Gang Li MD , Jing Zhou MD , Jingzhu Zhang MSc , Bo Ye MD , Zhihui Tong MD , Jianqiang Guo MD , Weiqin Li MD","doi":"10.1016/j.amjms.2024.08.003","DOIUrl":"10.1016/j.amjms.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><div>Given the previously reported harmful effects of abdominal fat burden on kidney function, we aim to investigate the relationship between major adverse kidney events within 30 days (MAKE30) and abdominal obesity in acute necrotizing pancreatitis (ANP) patients and explore the underlying risk factors.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of all patients admitted within 72 h after the first episode of ANP to a tertiary center between June 2015 and June 2019 was conducted. Automatic image analysis software was used to calculate the area of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and skeletal muscle from computed tomography scans at the umbilical level. The potential risk factors of MAKE30 were analyzed by logistic regression.</div></div><div><h3>Results</h3><div>A total of 208 eligible ANP patients were enrolled, with an incidence of 23% for MAKE30. VAT area was more closely associated with the development of MAKE30, with an area under the ROC curve of 0.69 (cutoff value 200 cm<sup>2</sup>, 63.8% sensitivity and 66.7% specificity). Multivariate logistic regression analysis demonstrated that VAT area [OR 1.01 (1.01–1.02); p < 0.001] was an independent risk factor in predicting MAKE30. Patients with a VAT area > 200 cm<sup>2</sup> had more requirements of renal replacement therapy (32% vs. 12%, <em>P</em> < 0.001), and a significantly higher incidence of other poor clinical outcomes (all <em>p</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>Early assessment of the VAT area may help identify ANP patients at high risk of MAKE30, suggesting that it could be a potential indicator for adverse kidney events.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 152-159"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Winkia neuii (Actinomyces neuii) vertebral osteomyelitis and review of the literature 一例神经放线菌（Winkia neuii）椎骨骨髓炎病例及文献综述。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.08.007

Nicholas Richwagen MD , Destinee Morris MD , Rita Paulis MD , Daniel Murphy MD , Matthew Perkins MD, MTM&H , Edwin Kamau PhD, D(ABMM)

引用次数: 0

FOXO4 suppresses cisplatin resistance of triple-negative breast cancer by inhibiting autophagy FOXO4 通过抑制自噬抑制三阴性乳腺癌的顺铂耐药性

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.08.012

Yating Zhu MM , Chenguang Zhang PhD , Qiuyu Yin MM , Wenting Xu PhD , Yulou Luo MB , Jianghua Ou PhD

{"title":"FOXO4 suppresses cisplatin resistance of triple-negative breast cancer by inhibiting autophagy","authors":"Yating Zhu MM , Chenguang Zhang PhD , Qiuyu Yin MM , Wenting Xu PhD , Yulou Luo MB , Jianghua Ou PhD","doi":"10.1016/j.amjms.2024.08.012","DOIUrl":"10.1016/j.amjms.2024.08.012","url":null,"abstract":"<div><h3>Background</h3><div>Resistance to chemotherapy containing cisplatin (DDP) is a main challenge in the treatment of triple-negative breast cancer (TNBC). Forkhead box O4 (FOXO4) is frequently downregulated in DDP-resistant cells. However, it is unclear whether FOXO4 down-regulation is related to DDP resistance. Here, we investigated the relationship between FOXO4 and DDP resistance in TNBC.</div></div><div><h3>Methods</h3><div>We established the DDP-resistant cell lines MDA-MB-231/DDP and BT-549/DDP through in vitro selection. CCK-8 and colony formation assays analyzed cell growth. The resistance index was calculated. Cell autophagy was evaluated. Western blotting and qRT-PCR measured protein and gene expression. The binding between FOXO4 and TGF-β1 was determined by the dual-luciferase reporter assay.</div></div><div><h3>Results</h3><div>FOXO4 expression was significantly lower in MDA-MB-231/DDP and BT-549/DDP cells. FOXO4 overexpression increased the sensitivity of TNBC cells to DDP. The PI3K class Ⅲ and Beclin-1 levels and LC3-II/LC3-I ratio elevated significantly in DDP-resistant cells. Moreover, the autophagic flux was enhanced in DDP-resistant cells. 3-MA enhanced the sensitivity of TNBC cells to DDP by inhibiting autophagy. Overexpression of FOXO4, treatment with 3-MA, and their combination significantly reduced the drug resistance index. FOXO4 directly targeted TGF-β1. Additionally, TGF-β1 knockdown inhibited autophagy and restored the sensitivity of DDP-resistant cells to DDP. Mechanistically, FOXO4 affected TNBC resistance to DDP by regulating autophagy and TGF-β1.</div></div><div><h3>Conclusion</h3><div>FOXO4 overexpression, in combination with autophagy inhibitors, can significantly improve the sensitivity of TNBC-resistant cells to DDP. These findings reveal the role and mechanism of FOXO4 in DDP sensitivity and may provide evidence for the development of TNBC therapies.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 252-263"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of spontaneous hemoperitoneum in a bone marrow transplant recipient on VV-ECMO 骨髓移植受者在使用 VV-ECMO 时发生自发性腹腔积血的罕见病例。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.08.017

Patrick Donabedian MD , Amir M. Emtiazjoo MD, MSc , Mindaugus Rackauskas MD, PhD , Philip Efron MD, FCCM , Cynthia Gries MD, MSc , Melissa Burger MD , Letitia Bible MD , Victoria Reams PharmD, BCTXP , Marc O. Maybauer MD, PhD , Biplab K. Saha MD

{"title":"A rare case of spontaneous hemoperitoneum in a bone marrow transplant recipient on VV-ECMO","authors":"Patrick Donabedian MD , Amir M. Emtiazjoo MD, MSc , Mindaugus Rackauskas MD, PhD , Philip Efron MD, FCCM , Cynthia Gries MD, MSc , Melissa Burger MD , Letitia Bible MD , Victoria Reams PharmD, BCTXP , Marc O. Maybauer MD, PhD , Biplab K. Saha MD","doi":"10.1016/j.amjms.2024.08.017","DOIUrl":"10.1016/j.amjms.2024.08.017","url":null,"abstract":"<div><div>A 53-year-old man with acute myeloid leukemia received an allogeneic hematopoietic cell transplant (HCT) from a matched unrelated donor. One month after his transplantation, he developed ARDS requiring initiation of VV-ECMO. He suffered from pancytopenia, managed with frequent transfusions, granulocyte-colony stimulating factor (G-CSF) and weekly thrombopoietin receptor agonist. On ECMO day 17, the patient developed severe hypotension after insertion of a chest tube for a large right-sided pneumothorax. CT angiography of the abdomen showed hemoperitoneum. Exploratory laparotomy revealed approximately 4 L of blood and a ruptured splenic hilum. A splenectomy was performed. Unfortunately, the patient continued to require multiple daily blood products and his condition continued to decline despite two reoperations. His family chose to discontinue ECMO and he passed away peacefully. Spontaneous splenic rupture after GM-CSF has never been reported in patients on VV-ECMO. This manuscript reviews the literature regarding the pathophysiology and clinical manifestation of this rare occurrence.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 296-300"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-IgLON5 disease: A case with intestinal obstruction and peripheral neuropathy 抗 IgLON5 病：一个伴有肠梗阻和周围神经病变的病例。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.07.035

Yunwen Qi MMS, Yongling Zheng MMS, Zhiyou Cai MD, Xiaogang Zhang MD

{"title":"Anti-IgLON5 disease: A case with intestinal obstruction and peripheral neuropathy","authors":"Yunwen Qi MMS, Yongling Zheng MMS, Zhiyou Cai MD, Xiaogang Zhang MD","doi":"10.1016/j.amjms.2024.07.035","DOIUrl":"10.1016/j.amjms.2024.07.035","url":null,"abstract":"<div><div>IgLON5 autoimmunity is a novel antibody-mediated disorder characterized by serum and/or cerebrospinal fluid (CSF) positivity for IgLON5 antibody. Anti-IgLON5 disease mainly manifests as sleep disturbances, movement disorders and brainstem syndromes. In this study, we report the case of a patient with anti-IgLON5 disease who presented with abdominal distension, abdominal pain, intermittent dysuria and constipation, and intermittent lightning pain in the extremities, which are atypical of anti-IgLON5 disease and could easily lead to misdiagnosis. After performing autoantibody screening, we considered anti-IgLON5 disease. The patient was started on a course of immunotherapy with intravenous dexamethasone, intravenous immunoglobulin (IVIG) and oral azathioprine (Imuran). Following treatment, the manifestations nearly resolved. The clinical manifestations of anti-IgLON5 disease are diverse and may present in different combinations, which can easily lead to misdiagnosis. Early recognition and treatment of this autoimmune disease with immunosuppressive agents may lead to better outcomes.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 264-267"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

26 Stepping into trouble: a case of pseudomonas mendocina bacteremia

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00035-7

N Arceneaux, A Lapointe, B Edwards, S Sanne, S Kamboj

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46 Glucose-6-phosphate dehydrogenase deficiency presenting with prolonged direct hyperbilirubinemia in a full-term neonate: a case report

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00055-2

M Shokrolahi, F Bhatti

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