新的代谢综合征预测因子：主动脉旁脂肪组织。

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences Pub Date : 2025-04-01 DOI:10.1016/j.amjms.2024.11.008

Fahri Çakan MD , Adem Adar MD , Sinan Akıncı MD , Uğur Köktürk MD , Ertan Akbay MD , Orhan Önalan MD

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引用次数: 0

摘要

背景：代谢综合征（MetS）是心血管疾病的独立危险因素。血管周围脂肪库不仅具有能量储存功能，还具有内分泌功能。主动脉旁脂肪组织（PAT）是一种血管周围的局部脂肪组织，已被认为在肥胖介导的血管疾病中发挥作用，并与MetS成分和冠状动脉和腹主动脉钙化的措施有关。以前曾用断层扫描和磁共振成像技术描述和检查过PAT。本研究旨在描述超声心动图测量的MetS患者主动脉旁脂肪组织的特征。方法：根据患者的MetS情况分为两组。升主动脉前的低回声空间在胸骨旁长轴位上被认为是PAT。使用DAGitty图确定回归分析的可能协变量。结果：共纳入494例患者。在MetS组中，PAT明显更高[9.6 (6.1/10.6)vs. 6.1 (0.9/9) mm]，结论：基于使用这种新描述的经胸超声心动图获得的测量结果，确定了其与MetS的关系。这些结果可以指导临床医生对肿瘤的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Novel predictor for metabolic syndrome: Para-aortic adipose tissue

Background

Metabolic Syndrome (MetS) is an independent risk factor for cardiovascular disease. Perivascular fat depots not only serve as energy storage but also function as endocrine organs. Para-aortic adipose tissue (PAT), a perivascular local adipose tissue, has been suggested to play a role in obesity-mediated vascular disease, and has been associated with MetS components and measures of coronary and abdominal aortic calcification. PAT was previously described and examined using tomography and magnetic resonance imaging. This study aimed to describe the features of para-aortic adipose tissue measured echocardiographically in individuals with MetS.

Methods

Patients were divided into two groups according to their MetS status. The hypoechoic space in front of the ascending aorta was considered a PAT on the parasternal long-axis view. Possible covariates for the regression analysis were determined using the DAGitty diagram.

Results

A total of 494 patients were enrolled in this study. The PAT was significantly higher in the MetS group [9.6 (6.1/10.6) vs. 6.1 (0.9/9) mm, p < 0.001]. Logistic regression analysis revealed that PAT (OR=2,15, p = 0,003) was significantly associated with MetS. 7.55 mm of PAT has a sensitivity of 65 % and specificity of 65 % [AUC = 0.675, p < 0.001, 95 % CI (0.623–0.726)] in predicting the presence of MetS.

Conclusions

Based on the measurements obtained using this newly described modality in transthoracic echocardiography, its relationship with MetS was determined. These results can guide clinicians in diagnosing MetS.

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.