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Archives of Disease in Childhood-Education and Practice Edition最新文献

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Challenging case of hypernatraemia in infancy. 婴儿高钠血症疑难病例。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-08-28 DOI: 10.1136/archdischild-2024-327310
Katherine Hawton, Louise Galloway, Matthew Harmer, Anitha Kumaran, Mira Kharbanda, Caroline Platt, Toby Candler
{"title":"Challenging case of hypernatraemia in infancy.","authors":"Katherine Hawton, Louise Galloway, Matthew Harmer, Anitha Kumaran, Mira Kharbanda, Caroline Platt, Toby Candler","doi":"10.1136/archdischild-2024-327310","DOIUrl":"https://doi.org/10.1136/archdischild-2024-327310","url":null,"abstract":"<p><p>A 1-month-old male infant presented unwell with a fever and shock. Blood tests showed hypernatraemia, hyperchloraemia and raised urea and creatinine. Initially, he was treated for dehydration secondary to sepsis. However, high urine output combined with low urine osmolality and high plasma osmolality was suggestive of a disorder of arginine vasopressin (AVP), previously called diabetes insipidus (DI). On further endocrine testing, thyroxine (T4) level was low with an inappropriately normal thyroid-stimulating hormone level with no other anterior pituitary hormone abnormalities, a normal MRI head and ophthalmological assessment. Desmopressin, a synthetic form of AVP, was commenced, however, there was an inadequate response despite dose escalation, leading to a diagnosis of AVP resistance (previously nephrogenic DI) rather than AVP deficiency (previously cranial DI). Copeptin, an AVP precursor peptide and surrogate marker, was significantly elevated. A renal tubulopathy genetic screen demonstrated a likely pathogenic hemizygous variant in the AVP receptor 2 gene, which has previously been associated with X-linked vasopressin resistance. This case demonstrates the challenge of differentiating between AVP deficiency and resistance in infancy and the value of copeptin and genetic testing in confirming diagnosis. We outline an approach to fluid management in AVP disorders.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weak femoral pulses post procedure. 术后股动脉搏动减弱。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2023-326725
Ian Scott Kendall, Rachel Bates, Steven Karyiannas, Andrew J Sands, Damien Kenny
{"title":"Weak femoral pulses post procedure.","authors":"Ian Scott Kendall, Rachel Bates, Steven Karyiannas, Andrew J Sands, Damien Kenny","doi":"10.1136/archdischild-2023-326725","DOIUrl":"10.1136/archdischild-2023-326725","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"202-204"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What are CAR T-cells? 什么是 CAR T 细胞？
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2023-326081
Eleni Syrimi, Shivani Bailey
{"title":"What are CAR T-cells?","authors":"Eleni Syrimi, Shivani Bailey","doi":"10.1136/archdischild-2023-326081","DOIUrl":"10.1136/archdischild-2023-326081","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"191-195"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Term neonate with neck and supraclavicular swelling at birth. 足月新生儿出生时颈部和锁骨上肿胀。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2022-325142
Shavindra Chellen, Shaveta Mulla
{"title":"Term neonate with neck and supraclavicular swelling at birth.","authors":"Shavindra Chellen, Shaveta Mulla","doi":"10.1136/archdischild-2022-325142","DOIUrl":"10.1136/archdischild-2022-325142","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"201-208"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epistle. 书信
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2024-327600
Neelam Gupta
{"title":"Epistle.","authors":"Neelam Gupta","doi":"10.1136/archdischild-2024-327600","DOIUrl":"10.1136/archdischild-2024-327600","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":"109 4","pages":"151"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fifteen-minute consultation: How to approach the initial discussions of dysmorphism with parents. 十五分钟咨询：如何与家长初步讨论畸形问题。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2023-325658
Kate Frances Parmenter, Sharon English, Jennifer Campbell
{"title":"Fifteen-minute consultation: How to approach the initial discussions of dysmorphism with parents.","authors":"Kate Frances Parmenter, Sharon English, Jennifer Campbell","doi":"10.1136/archdischild-2023-325658","DOIUrl":"10.1136/archdischild-2023-325658","url":null,"abstract":"<p><p>Approaching discussions and introducing the idea of dysmorphology to parents and families can be perceived as difficult and even daunting by health professionals resulting in uneasiness in how best to initiate important dialogues sensitively and accessibly.Here, we offer a structured approach to the assessment of, and subsequent initial discussion around, dysmorphism and potential syndromic features in babies and children.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"174-178"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10203983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidisciplinary training initiative for postnatal clinical environments to increase staff's confidence in managing babies requiring neonatal transitional care. 针对产后临床环境的多学科培训倡议，以增强员工管理需要新生儿过渡护理婴儿的信心。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2023-325860
Claire Elizabeth Stewart, Ross Holloway, Patience Pounds, Rosemary Ofasi, Yury Petrunin, Luciana Gotea, Jessica Collier, Lisa Cole, Cynthia Henry, Veena Wadhwani, Ioana Gozar, Sunit Vinod Godambe
{"title":"Multidisciplinary training initiative for postnatal clinical environments to increase staff's confidence in managing babies requiring neonatal transitional care.","authors":"Claire Elizabeth Stewart, Ross Holloway, Patience Pounds, Rosemary Ofasi, Yury Petrunin, Luciana Gotea, Jessica Collier, Lisa Cole, Cynthia Henry, Veena Wadhwani, Ioana Gozar, Sunit Vinod Godambe","doi":"10.1136/archdischild-2023-325860","DOIUrl":"10.1136/archdischild-2023-325860","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"179-183"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139503218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applied pharmacokinetics to improve pharmacotherapy in neonatal and paediatric intensive care units: focus on correct dose selection. 应用药物动力学改进儿科重症监护室的药物治疗：重点是正确选择剂量。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2023-326325
Dotan Shaniv, Karel Allegaert
{"title":"Applied pharmacokinetics to improve pharmacotherapy in neonatal and paediatric intensive care units: focus on correct dose selection.","authors":"Dotan Shaniv, Karel Allegaert","doi":"10.1136/archdischild-2023-326325","DOIUrl":"10.1136/archdischild-2023-326325","url":null,"abstract":"<p><p>Drug dosing and exposure throughout childhood are constantly affected by maturational changes like weight, age or body surface area. In neonatal and paediatric intensive care units (NICU and PICU, respectively), drug dosing and exposure are further impacted by non-maturational changes. These changes are related to factors such as sepsis, cardiac failure, acute kidney injury, extracorporeal circuits or drug-drug interactions (DDIs) resulting from polypharmacy.This potentially complex situation may alter drug pharmacokinetics to result in greater-than-usual intrapatient and interpatient drug exposure variability. These effects may call for individual dosage adjustments. Dosage adjustments may apply to both loading doses or maintenance doses, which should be used as appropriate, depending on the specific characteristics of a given drug. Phenobarbital and vancomycin dosing are hereby used as illustrations.To optimise dose selection in NICU/PICU settings, we suggest to consider therapeutic drug monitoring integrated in model-informed precision dosing, and to familiarise oneself with existing paediatric drug formularies as well as DDI databases/search engines. Paediatric clinical pharmacologists and pharmacists can hereby guide clinicians with no prior experience on how to properly apply these data sources to day-to-day practice in individual patients or specific subpopulations of NICU or PICU patients.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"184-190"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adolescent with an abrupt onset of muscle pain and fever. 突然出现肌肉疼痛和发烧的青少年。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-07-18 DOI: 10.1136/archdischild-2024-326878
Riccardo Barberini, Antonella Luglio, Alessandro De Fanti, Lorenzo Iughetti, Andrea Trombetta
{"title":"Adolescent with an abrupt onset of muscle pain and fever.","authors":"Riccardo Barberini, Antonella Luglio, Alessandro De Fanti, Lorenzo Iughetti, Andrea Trombetta","doi":"10.1136/archdischild-2024-326878","DOIUrl":"10.1136/archdischild-2024-326878","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"205-207"},"PeriodicalIF":1.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practical approach to managing metabolic bone disease of prematurity in the neonatal unit. 管理新生儿单位早产儿代谢性骨病的实用方法。
IF 1.1 4区 医学
Archives of Disease in Childhood-Education and Practice Edition Pub Date : 2024-05-17 DOI: 10.1136/archdischild-2023-326100
Chris Forster, Shazia Hoodbhoy, Catriona Macdougall, Karen King, Nigel Gooding, Kimberly Mak, Talat Mushtaq
{"title":"Practical approach to managing metabolic bone disease of prematurity in the neonatal unit.","authors":"Chris Forster, Shazia Hoodbhoy, Catriona Macdougall, Karen King, Nigel Gooding, Kimberly Mak, Talat Mushtaq","doi":"10.1136/archdischild-2023-326100","DOIUrl":"10.1136/archdischild-2023-326100","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"143-146"},"PeriodicalIF":1.1,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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