{"title":"Mysterious chronic skin lesions.","authors":"Hortense Petat, Billal Tedbirt, Abdeljallil Zeggay, Isabelle Michelet, Claire Morin, Christophe Marguet","doi":"10.1136/archdischild-2023-325412","DOIUrl":"10.1136/archdischild-2023-325412","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"361-362"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9313954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Four months of tuberculosis (TB) treatment is non-inferior to the current 6-month treatment in drug-susceptible paediatric TB.","authors":"Graciaa Singhal, Amanda Jane Friend","doi":"10.1136/archdischild-2022-324395","DOIUrl":"https://doi.org/10.1136/archdischild-2022-324395","url":null,"abstract":"Study design Design: An openlabel, noninferiority, randomised controlled trial. Allocation: 1:1 allocation, stratified by age, HIV status, treating centre and ethambutol use. Blinding: Single blinding of diagnosis and endpoint tuberculosis (TB) review committees. Study question Setting: Uganda, Zambia, South Africa and India. Patients: 1204 children (aged <16 years) with symptomatic, nonsevere, smearnegative TB due to the start of firstline treatment. Intervention: 8 weeks of standard treatment as per local guidelines, followed by isoniazid/rifampicin for 16 weeks in the control arm, and 8 weeks in the intervention arm. Primary outcomes: ’Unfavourable’ status by 72 weeks, including treatment failure, loss to followup or death. A modified intentiontotreat analyses was carried out. Secondary outcomes: Adverse event of grade ≥3 and economic analyses to estimate costs and health outcomes. Followup: 72 weeks (18 months) from the start of treatment. Main results The % of participants that had a primaryoutcome event was 3% in both treatment groups (adjusted difference, −0.4 percentage points; 95% confidence interval, −2.2 to 1.5). The noninferiority of 4 months treatment was consistent across every subgroup analysis.","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":"108 5","pages":"373"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epistle.","authors":"Neelam Gupta","doi":"10.1136/archdischild-2023-326271","DOIUrl":"https://doi.org/10.1136/archdischild-2023-326271","url":null,"abstract":"","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":"108 5","pages":"313"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huria Metezai, Amar Wahid, Ceri Jones, Jordan Evans
{"title":"Fifteen-minute consultation: Rectal bleeding in children.","authors":"Huria Metezai, Amar Wahid, Ceri Jones, Jordan Evans","doi":"10.1136/archdischild-2022-324626","DOIUrl":"10.1136/archdischild-2022-324626","url":null,"abstract":"<p><p>Bleeding per rectum in children is an infrequent presentation associated with a wide range of differential diagnoses, from benign to life-threatening. Irrespective of the underlying aetiology, it is typically a worrisome symptom for caregivers. Published data are limited, particularly for the UK population, from which to provide clear evidence-based guidance for assessment and management of infants, children and young people presenting with bleeding per rectum. In this Fifteen-Minute Consultation, we therefore explore the common aetiologies and combine opinions from acute paediatrics, paediatric gastroenterology and paediatric surgery to offer a structure for a diagnostic approach and initial management of lower gastrointestinal bleeding in infants, children and young people.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"320-325"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10428321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Thomas Neame, Kathrin Cresswell, Ian Sinha, Daniel B Hawcutt
{"title":"Developing and assessing health information technologies: opportunities and challenges.","authors":"Matthew Thomas Neame, Kathrin Cresswell, Ian Sinha, Daniel B Hawcutt","doi":"10.1136/archdischild-2022-324521","DOIUrl":"10.1136/archdischild-2022-324521","url":null,"abstract":"Department of General Paediatrics, Alder Hey Children’s Hospital, Liverpool, UK The University of Edinburgh, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK Department of Paediatric Respiratory Medicine, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK National Institute for Health Research (NIHR) Clinical Research Facility, Alder Hey Children’s Hospital, Liverpool, UK Department of Women’s and Children’s Health, University of Liverpool, Liverpool, UK","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"369-372"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10599090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two-year-old boy with sparse hair.","authors":"Hager Barakizou","doi":"10.1136/archdischild-2023-325315","DOIUrl":"10.1136/archdischild-2023-325315","url":null,"abstract":"Our patient was born full term and with no complications from nonconsanguineous healthy parents. He was referred to the paediatrics department at 2 years of age for sparse hair. He had a history of recurrent and unexplained fever since he was 3 months old. He was unable to sweat and had dry skin. The maternal uncle of the proband, aged 20 years has the same complaint. On examination, the growth and the mental development were normal. He had skin, hair (figure 1) and teeth (figure 2) abnormalities. His temperature was 38.3°C. The rest of the examination was unremarkable. Screening for sepsis was negative.","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"359-360"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9214300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathon Aa Holland, Jonathan P Funnell, Rhea Mittal, Deepa Krishnakumar
{"title":"How to use lumbar puncture manometry in children.","authors":"Jonathon Aa Holland, Jonathan P Funnell, Rhea Mittal, Deepa Krishnakumar","doi":"10.1136/archdischild-2022-324881","DOIUrl":"10.1136/archdischild-2022-324881","url":null,"abstract":"<p><p>Measurement of cerebrospinal fluid pressure through lumbar puncture (LP) manometry is an essential practical skill all paediatricians should possess competency in. The ability to perform manometry is crucial in the diagnosis of idiopathic intracranial hypertension and can provide critical information on raised (or lowered) intracranial pressure in other clinical scenarios. Practitioners should be familiar with the procedure and in particular with equipment available to them locally. In this article, we will describe an approach to LP manometry. The online supplemental material includes an instructional video as well as supporting practical information.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"340-346"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/bb/edpract-2022-324881.PMC10511985.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10598893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fifteen-minute consultation: Management of constipation in childhood.","authors":"Sian Copley, Maureen Lawson, David Anthony King","doi":"10.1136/archdischild-2023-325375","DOIUrl":"10.1136/archdischild-2023-325375","url":null,"abstract":"<p><p>Constipation is common in childhood. It is a frequent presentation to primary care and common reason for referral to secondary and tertiary care. In the majority of cases, childhood constipation is idiopathic, with no significant underlying cause, but still presents a significant issue to patients, families and healthcare providers. We consider a case of idiopathic constipation, review the current evidence base for investigations and treatment and suggest practical management strategies.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"314-319"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9220052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diarrhoea, vomiting and reduced wet nappies - a familiar story with unexpected twists.","authors":"Elena Jones, JongEun Song, Shouja Alam","doi":"10.1136/archdischild-2023-325682","DOIUrl":"10.1136/archdischild-2023-325682","url":null,"abstract":"<p><p>Vomiting and diarrhoea is a common presenting complaint in paediatrics. Most often it is due to a benign and self-limiting infectious illness. Here, we explore the diagnostic journey of a 7-month-old infant with these symptoms presenting in a secondary care hospital and the overnight clinical problem solving involved in tackling the unexpected complexities.</p>","PeriodicalId":55471,"journal":{"name":"Archives of Disease in Childhood-Education and Practice Edition","volume":" ","pages":"385-390"},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9723022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}