Biocybernetics and Biomedical Engineering最新文献

{"title":"Modelling the dynamics of microbubble undergoing stable and inertial cavitation: Delineating the effects of ultrasound and microbubble parameters on sonothrombolysis","authors":"Zhi Qi Tan ,&nbsp;Ean Hin Ooi ,&nbsp;Yeong Shiong Chiew ,&nbsp;Ji Jinn Foo ,&nbsp;Yin Kwee Ng ,&nbsp;Ean Tat Ooi","doi":"10.1016/j.bbe.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.04.003","url":null,"abstract":"<div><p>Sonothrombolysis induces clot breakdown using ultrasound waves to excite microbubbles. Despite the great potential, selecting optimal ultrasound (frequency and pressure) and microbubble (radius) parameters remains a challenge. To address this, a computational model was developed to investigate the bubble behaviour during sonothrombolysis. The blood and clot were assumed to be non-Newtonian and porous, respectively. The effects of ultrasound and microbubble parameters on flow-induced shear stress on the clot surface during stable and inertial cavitation were investigated. It was found that microbubble translation towards the clot and the shear stress on the clot surface during stable cavitation were significant when the bubble was about to undergo inertial cavitation. While insonation of large microbubble (radius of <span><math><mrow><mn>1</mn><mo>.</mo><mn>65</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span>) at low frequency (0.50 MHz) produced the highest shear stress during stable cavitation, selection of these parameters is not as intuitive for inertial cavitation due to the strong competing effect between jet velocity and translational distance. An increase in jet velocity is always accompanied by a decrease in the translational distance and vice versa. Therefore, a right balance between the jet velocity and the translational distance is critical to maximise the shear stress on the clot surface. A jet velocity of 303 m/s and a distance travelled of <span><math><mrow><mn>5</mn><mo>.</mo><mn>12</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span> at an initial bubble-clot separation of <span><math><mrow><mn>10</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span> produced the greatest clot surface shear stress. This is achievable by insonating a <span><math><mrow><mn>0</mn><mo>.</mo><mn>55</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span> microbubble using 0.50 MHz and 600 kPa ultrasound.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000275/pdfft?md5=3e30ca360dcd5e3cc5a1a52cc4cf81df&pid=1-s2.0-S0208521624000275-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140823902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium feature-based brain tumor diagnosis platform using random forest model","authors":"","doi":"10.1016/j.bbe.2024.07.002","DOIUrl":"10.1016/j.bbe.2024.07.002","url":null,"abstract":"<div><p><span>Calcium flux<span> has been successfully verified to play an important role in the malignant proliferation and progression of brain tumors, which can serve as an important diagnosis guide. However, clinical diagnosis based on calcium information remains challenging because of the highly complex and heterogeneous features in calcium signals. Here we propose a calcium feature-based tumor diagnosis and treatment guidance platform (CA-TDT-GP) using random forest analysis framework for the efficient prediction of complex tumor behaviors for clinical therapy guidance. Multiple important features associated with brain tumor biological malignancy were screened out through comprehensive feature importance analysis. It provided useful guidance for understanding the </span></span>biological process and the selection of drugs of brain tumors. Further clinical validation confirmed the accurate prediction of tumor biological characteristics by the model, with a coefficient of determination of over 0.86 in the same cohort of patients and over 0.77 for the new cohort of patients. We further verified the clinical malignant assessment by this model, which performed a 100% prediction match with diagnosed WHO grades, indicating great potential of the platform for clinical guidance. This promising model provides a new diagnostic and therapeutic tool for brain tumor research and preclinical treatment.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gabor-net with multi-scale hierarchical fusion of features for fundus retinal blood vessel segmentation","authors":"Tao Fang ,&nbsp;Zhefei Cai ,&nbsp;Yingle Fan","doi":"10.1016/j.bbe.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.05.004","url":null,"abstract":"<div><p>This paper proposes a fundus retinal blood vessel segmentation model based on a deep convolutional network structure and biological visual feature extraction mechanism. It aims to solve the multi-scale problem of blood vessels in the fundus retinal blood vessel segmentation task in the field of medical image processing on the basis of increasing the biological interpretability of the model. First, the subject feature information of the retinal blood vessel image is obtained by using the non-subsampled Residual Bolck convolution main channel. Secondly, combined with the study of biological vision mechanisms, an information processing model of the Retina-Exogenius-Primary visual cortex (V1) ventral visual pathway was established. Gabor functions of different scales are used to simulate the structure of different levels of the visual pathway, and the scale information at different levels is integrated into the corresponding hierarchical stages of the convolutional main pathway network to enrich the information of small blood vessels and enhance the semantic information of the overall blood vessels. Finally, considering the imbalance of the ratio of vessel and nonvessel pixels, an adaptive optimization scheme using hybrid loss function weights is proposed to enhance the priority of blood vessel pixels in the calculation of the loss function. According to the experimental results on the STARE, DRIVE and CHASE_DB1 data sets, the model still achieves superior performance evaluation indicators overall compared with the existing optimal methods in the fundus retinal blood vessel segmentation task. This research is of great significance to the field of medical image processing and can provide more accurate auxiliary diagnostic information for clinical diagnosis and treatment.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical aspects of modeling flow through the cerebral artery system with multiple small perforators","authors":"Michał Tomaszewski ,&nbsp;Michał Kucewicz ,&nbsp;Radosław Rzepliński ,&nbsp;Jerzy Małachowski ,&nbsp;Bogdan Ciszek","doi":"10.1016/j.bbe.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.04.002","url":null,"abstract":"<div><p>This study investigates the flow and hemodynamics of small perforator blood vessels that branch from the basilar artery (BA) in the brain. Using advanced imaging techniques and computational fluid dynamics (CFD) simulations, detailed 3D geometries of the perforators were acquired through barium contrast injection, micro-CT scans, and data processing. The hybrid geometry, combining micro-CT scans and mesh extraction algorithms, provided accurate vessel models. The influence of different types of finite volume on the analysis was examined, with polyhedral elements showing the most efficient ratio of the analysis time to convergence level. Additionally, the effect of boundary conditions on hemodynamic parameters was studied. Simulations using 0.0 mmHg pressure conditions at the outlets directed flow mainly through the BA, neglecting the perforator branches. In contrast, non-zero outlet pressure conditions significantly increased the flow in the perforators, leading to non-physiological flow velocities and overestimation of hemodynamic parameters. The assumption of pressure conditions of 0 mmHg at outlets was found to be valid for simple single vessel geometries, but not for more complex vascular systems. This research contributes valuable information on the complex flow patterns and hemodynamics of small perforator blood vessels in the brain and emphasizes the importance of accurately modeling geometry and boundary conditions in such studies.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the insulin therapy for diabetic patients using optimal impulsive disturbance rejection: Continuous time approach","authors":"Martin Dodek,&nbsp;Eva Miklovičová,&nbsp;Miroslav Halás","doi":"10.1016/j.bbe.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.05.003","url":null,"abstract":"<div><p>The paper proposes a new model-based optimization approach to improve the clinical efficiency of compensatory insulin bolus treatment in diabetic patients, aiming to mitigate the consequences of diabetes. The most important contribution of this paper is a novel methodology for determining the optimal parameters of insulin treatment, namely the size and timing of insulin boluses, to effectively compensate for carbohydrate intake. This concept can be seen as the so-called optimal model-based bolus calculator. The presented theoretical framework deals with the problem of optimal disturbance rejection in impulsive systems by minimizing an integral quadratic cost function. The methodology considers a personalized empirical transfer function model with static gains and time constants as the only parameters assumed to be known, making the bolus calculator more straightforward to implement in clinical practice. Contrary to other techniques, the proposed methodology considers impulsive insulin administration in the form of boluses, which is more feasible than continuous infusion. In contrast to the conventional bolus calculator, the proposed algorithm allows for maximizing therapy performance by optimizing the relative time of insulin bolus administration with respect to carbohydrate intake. Another feature to highlight is that the solution of the optimization problem can be obtained analytically, hence no numerical iterative solvers are required. Additionally, the continuous-time domain approach allows for a much finer adjustments of the insulin administration timing compared to discrete-time models. The proposed approach was validated in an in-silico study, which demonstrated the importance of systematically determined insulin–carbohydrate ratio and the relative delay between disturbance and its compensation. The results showed that the proposed optimal bolus calculator outperforms the traditional suboptimal formula.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative features pyramid network for medical image segmentation","authors":"Xiwang Xie ,&nbsp;Lijie Xie ,&nbsp;Guanyu Li ,&nbsp;Hao Guo ,&nbsp;Weidong Zhang ,&nbsp;Feng Shao ,&nbsp;Wenyi Zhao ,&nbsp;Ling Tong ,&nbsp;Xipeng Pan ,&nbsp;Jubai An","doi":"10.1016/j.bbe.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.04.001","url":null,"abstract":"<div><p>The diverse shapes and scales, complicated backgrounds, blurred boundaries, and similar appearances challenge the current organ segmentation methods in medical scene images. It is difficult to acquire satisfactory performance to directly extend the object segmentation methods in the natural scene images to the medical scene images. In this paper, we propose a discriminant feature pyramid (DFPNet) network for organ segmentation in the original medical images, which consists of two sub-networks: the feature steered network and the border network. To be specific, the feature steered network takes a top-down step-wise manner to extract abundant context information, which is conducive to suppressing the cluttered background and perceiving the scale variation of objects. The border network utilizes a bottom-up step-wise manner to optimize the boundary feature map, which aims at distinguishing adjacent edge features with similar appearances but diverse labels. A series of experiments were conducted on three publicly available medical datasets ( i.e., LUNA 16, RIM-ONE-R1, and VNC datasets) to evaluate the validity and generalization of the proposed DFPNet. Experimental results indicate that our network achieves superior performance in terms of the receiver operating characteristic (ROC) curve, F-Score, Jaccard index, and Hausdorff distance. The code will be available at: <span>https://github.com/Xie-Xiwang/DFPNet</span><svg><path></path></svg>.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140605225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A linear-attention-combined convolutional neural network for EEG-based visual stimulus recognition","authors":"Junjie Huang,&nbsp;Wanzhong Chen,&nbsp;Tao Zhang","doi":"10.1016/j.bbe.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.05.001","url":null,"abstract":"<div><p>The recognition task of visual stimuli based on EEG (Electroencephalogram) has become a major and important topic in the field of Brain–Computer Interfaces (BCI) research. Although the underlying spatial features of EEG can effectively represent visual stimulus information, it still remains a highly challenging task to explore the local–global information of the underlying EEG to achieve better decoding performance. Therefore, in this paper we propose a deep learning architecture called Linear-Attention-combined Convolutional Neural Network (LACNN) for visual stimuli EEG-based classification task. The proposed architecture combines the modules of Convolutional Neural Networks (CNN) and Linear Attention, effectively extracting local and global features of EEG for decoding while maintaining low computational complexity and model parameters. We conducted extensive experiments on a public EEG dataset from the Stanford Digital Repository. The experimental results demonstrate that LACNN achieves an average decoding accuracy of 54.13% and 29.83% in 6-category and 72-exemplar classification tasks respectively, outperforming the state-of-the-art methods, which indicates that our method can effectively decode visual stimuli from EEG. Further analysis of LACNN shows that the Linear Attention module improves the separability between different category features and localizes key brain region information that aligns with the paradigm principles.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of coronary bypass implants: Experimental and fluid-structure interaction analysis","authors":"Shirin Changizi ,&nbsp;Nima Afrasiabian ,&nbsp;Aisa Rassoli ,&nbsp;Nasser Fatouraee ,&nbsp;Seyed Hossein Ahmadi Tafti","doi":"10.1016/j.bbe.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.05.002","url":null,"abstract":"<div><p>Bypass surgery is a commonly employed method for treating coronary artery diseases, involving the use of grafts to bypass occluded arteries. However, graft occlusion remains a concern due to mechanical disparities between the grafts and native arteries. This study aims to compare the mechanical properties of three frequently used grafts in coronary bypass surgeries: human saphenous veins, mammary arteries, and radial arteries. Stress-relaxation tests were conducted on samples obtained from these vessels, and their mechanical properties were characterized. The stress–strain curves of each sample were fitted using the quasi-linear viscoelastic (QLV) model, with MATLAB software used to extract the model's constants. Additionally, fluid–structure simulations were performed employing the extracted viscoelastic mechanical properties of the vessels. The analysis revealed that the saphenous vein exhibited the highest elastic coefficient (0.5247) and non-linearity coefficient (0.8135) among the studied grafts. The mammary artery demonstrated nearly seven times greater viscoelasticity compared to the other graft options. Furthermore, the examination of shear stress distribution indicated lower shear stress regions in the radial and mammary artery specimens compared to the saphenous specimens. Notably, the lower wall of the host artery exhibited the greatest oscillatory shear index (OSI), with the radial specimen displaying the highest oscillation in this region compared to the other two specimens. The mechanical characterization results presented in this study hold potential applications in pathogenic and clinical investigations of heart diseases, aiding in the development of appropriate treatment approaches.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of entropy rate measures for the evaluation of time series complexity: Simulations and application to heart rate and respiratory variability","authors":"Chiara Barà ,&nbsp;Riccardo Pernice ,&nbsp;Cristina Angela Catania ,&nbsp;Mirvana Hilal ,&nbsp;Alberto Porta ,&nbsp;Anne Humeau-Heurtier ,&nbsp;Luca Faes","doi":"10.1016/j.bbe.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.04.004","url":null,"abstract":"<div><p>Most real-world systems are characterised by dynamics and correlations emerging at multiple time scales, and are therefore referred to as complex systems. In this work, the complexity of time series produced by complex systems was investigated in the frame of information theory computing the entropy rate via the conditional entropy (CE) measure. A comparative investigation of several CE estimators, based on linear parametric and non-linear model-free representations of the process dynamics, was performed considering simulated linear autoregressive (AR) and mixed non-linear deterministic and linear stochastic dynamics processes, as well as physiological time series reflecting short-term cardiorespiratory dynamics. In simulations, the estimated CE values decreased when reducing the system complexity through an increase in the pole radius of the AR process or with the predominance of the deterministic behaviour in the mixed dynamics. In the application to cardiorespiratory dynamics, a reduction in physiological complexity was observed resulting from a regularization of the time series of heart rate and respiratory volume when decreasing the breathing rate. Our results evidence how simple and fast approaches based on linear parametric or permutation-based model-free estimators allow efficient discrimination of complexity changes in the short-term evolution of complex dynamic systems. However, in the presence of non-linear dynamics, the superiority of the more general but computationally expensive nearest-neighbour method is highlighted. These findings have implications for the assessment of complex dynamics both in clinical settings and in physiological monitoring.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000287/pdfft?md5=7f496472fa37f0bb2608dbfe903fcbcf&pid=1-s2.0-S0208521624000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of central nervous system oxygen toxicity symptoms using electrodermal activity and machine learning","authors":"Md-Billal Hossain ,&nbsp;Kia Golzari ,&nbsp;Youngsun Kong ,&nbsp;Bruce J. Derrick ,&nbsp;Richard E. Moon ,&nbsp;Michael J. Natoli ,&nbsp;M. Claire Ellis ,&nbsp;Christopher Winstead-Derlega ,&nbsp;Sara I. Gonzalez ,&nbsp;Christopher M. Allen ,&nbsp;Mathew S. Makowski ,&nbsp;Brian M. Keuski ,&nbsp;John J. Freiberger ,&nbsp;Hugo F. Posada-Quintero ,&nbsp;Ki H. Chon","doi":"10.1016/j.bbe.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.03.004","url":null,"abstract":"<div><h3>Objective</h3><p>Breathing elevated oxygen partial pressures (PO₂) prior to SCUBA diving increases the risk of developing central nervous system oxygen toxicity (CNS-OT), which could impair performance or result in seizure and subsequent drowning. We aimed to study the dynamics of electrodermal activity (EDA) while breathing elevated PO₂ in the hyperbaric environment (HBO₂) as a possible means to predict impending CNS-OT. To this end, we used machine learning to automatically detect and predict the onset of symptoms associated with CNS-OT in humans by using features derived from EDA in both time and frequency domains.</p></div><div><h3>Methods</h3><p>We collected electrodermal activity (EDA) data from forty-nine exposures to HBO₂ while subjects were undergoing cognitive load and exercise in a hyperbaric oxygen chamber. Four independent experts were present during the experiment to monitor and classify any symptoms associated with hyperbaric oxygen toxicity. We computed a highly sensitive time varying spectral EDA index, named TVSymp, and extracted informative features from skin conductance responses (SCRs). Machine learning algorithms were trained and validated for classifying features from SCRs and TVSymp as CNS-OT related or non-CNS-OT related. Machine learning models were validated using a subject-independent leave one subject out (LOSO) validation scheme.</p></div><div><h3>Results</h3><p>Our machine learning model was able to classify EDA dynamics related to CNS-OT with 100 % sensitivity and 84 % specificity via LOSO validation. Moreover, the median prediction time for CNS-OT symptoms was ∼ 250 s preceding the occurrence of actual symptoms.</p></div><div><h3>Significance</h3><p>This study shows that EDA can potentially be used for early prediction of CNS-OT in divers with a high sensitivity and sufficient prediction time for countermeasures. While the study results are promising, independent validation datasets are warranted to confirm the findings. However, the current results are well corroborated in an animal study, which consistently showed seizure prediction time of 2 min prior to seizure.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":6.4,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000226/pdfft?md5=6ad239b693b9abf97054efb9220f787c&pid=1-s2.0-S0208521624000226-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}