Biocybernetics and Biomedical Engineering最新文献

筛选
英文 中文
Validation of a body sensor network for cardiorespiratory monitoring during dynamic activities 验证用于动态活动期间心肺监测的人体传感器网络
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-09-23 DOI: 10.1016/j.bbe.2024.09.002
Alessandra Angelucci , Federica Camuncoli , Federica Dotti , Filippo Bertozzi , Manuela Galli , Marco Tarabini , Andrea Aliverti
{"title":"Validation of a body sensor network for cardiorespiratory monitoring during dynamic activities","authors":"Alessandra Angelucci ,&nbsp;Federica Camuncoli ,&nbsp;Federica Dotti ,&nbsp;Filippo Bertozzi ,&nbsp;Manuela Galli ,&nbsp;Marco Tarabini ,&nbsp;Andrea Aliverti","doi":"10.1016/j.bbe.2024.09.002","DOIUrl":"10.1016/j.bbe.2024.09.002","url":null,"abstract":"<div><div>One of the major challenges in the field of wearable devices is to accurately measure physiological parameters during dynamic activities. The aim of this work is to present a completely wearable Wireless Body Sensor Network (WBSN) for cardio-respiratory monitoring during dynamic activities and a validation of the devices composing the WBSN against reference measurement systems. The WBSN is composed of three inertial measurement units (IMUs) to detect the respiratory rate (RR), and of a fourth unit to detect the pulse rate (PR). 30 healthy volunteers (17 men, mean age 25.9 ± 6.0 years, mean weight 68.7 ± 9.7 kg, mean height 170.9 ± 9.5 cm) were enrolled in a validation protocol consisting in walking, running, and cycling. The participants had to simultaneously wear the devices of the WBSN and reference instruments. The IMU-based system proved to be particularly effective in monitoring RR during cycling, with a RMSE of 3.77 bpm for the complete cohort, and during running. The respiratory signal during walking exhibited a frequency content like the stride, making it difficult to properly filter the desired signal content. PR showed good agreement with the reference heart rate monitor. The system exploits information regarding motion to improve RR estimation during dynamic activities thanks to an ad hoc signal processing algorithm.</div></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 4","pages":"Pages 794-803"},"PeriodicalIF":5.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000676/pdfft?md5=7b1f1f42608cbb77aef909206d34b316&pid=1-s2.0-S0208521624000676-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative evaluation of the effect of circle of willis structures on cerebral hyperperfusion: A multi-scale model analysis 威利斯圈结构对脑过度灌注影响的定量评估多尺度模型分析
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-09-20 DOI: 10.1016/j.bbe.2024.08.005
Suqin Huang , Bao Li , Jincheng Liu , Liyuan Zhang , Hao Sun , Huanmei Guo , Yanping Zhang , Fuyou Liang , Yanjun Gong , Youjun Liu
{"title":"Quantitative evaluation of the effect of circle of willis structures on cerebral hyperperfusion: A multi-scale model analysis","authors":"Suqin Huang ,&nbsp;Bao Li ,&nbsp;Jincheng Liu ,&nbsp;Liyuan Zhang ,&nbsp;Hao Sun ,&nbsp;Huanmei Guo ,&nbsp;Yanping Zhang ,&nbsp;Fuyou Liang ,&nbsp;Yanjun Gong ,&nbsp;Youjun Liu","doi":"10.1016/j.bbe.2024.08.005","DOIUrl":"10.1016/j.bbe.2024.08.005","url":null,"abstract":"<div><p>Cerebral hyperperfusion occurs in some patients after superficial temporal artery–middle cerebral artery bypass surgery. However, there is uncertainty about cerebral hyperperfusion after bypass for patients with different Circle of Willis (CoW) structures.</p><p>This study established a lumped parameter model coupled with one–dimensional model (0–1D), whilst a deep learning model for predicting pressure drop (DLM–PD) caused by stenosis and a cerebral autoregulation model (CAM) were introduced into the model. Based on this model, 9 CoW structural models before and after bypass was constructed, to investigate the effects of different CoW structures on cerebral hyperperfusion after bypass. The model and the results were further verified by clinical data.</p><p>The MSE of mean flow rates from 0–1D model calculation and from clinically measurement was 1.4%. The patients exhibited hyperperfusion in three CoW structures after bypass: missing right anterior segment of anterior cerebral artery (mRACA1) (13.96% hyperperfusion), mRACA1 and foetal-type right anterior segment of posterior cerebral artery (12.81%), and missing anterior communicating artery and missing left posterior communicating artery (112.41%). The error between the average flow ratio from the model calculations and fromclinical measurement was less than 5%.</p><p>This study demonstrated that the CoW structure had a significant impact on hyperperfusion after bypass. The general 0–1D model coupled with DLM–PD and CAM proposed in this study, could accurately simulate the hemodynamic environment of different CoW structures before and after bypass, which might help physicians identify high–risk patients with hyperperfusion before surgery, and promote the development of non-invasive diagnosis and treatment of cerebrovascular diseases.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 4","pages":"Pages 782-793"},"PeriodicalIF":5.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inference-enabled tracking of acute mental stress via multi-modal wearable physiological sensing: A proof-of-concept study 通过多模态可穿戴生理传感技术对急性精神压力进行推理追踪:概念验证研究
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-09-19 DOI: 10.1016/j.bbe.2024.09.004
Yuanyuan Zhou , Azin S. Mousavi , Yekanth R. Chalumuri , Jesse D. Parreira , Mihir Modak , Jesus Antonio Sanchez-Perez , Asim H. Gazi , Omer T. Inan , Jin-Oh Hahn
{"title":"Inference-enabled tracking of acute mental stress via multi-modal wearable physiological sensing: A proof-of-concept study","authors":"Yuanyuan Zhou ,&nbsp;Azin S. Mousavi ,&nbsp;Yekanth R. Chalumuri ,&nbsp;Jesse D. Parreira ,&nbsp;Mihir Modak ,&nbsp;Jesus Antonio Sanchez-Perez ,&nbsp;Asim H. Gazi ,&nbsp;Omer T. Inan ,&nbsp;Jin-Oh Hahn","doi":"10.1016/j.bbe.2024.09.004","DOIUrl":"10.1016/j.bbe.2024.09.004","url":null,"abstract":"<div><h3>Objective</h3><p>To develop a novel algorithm for tracking acute mental stress which can infer acute mental stress state from multi-modal digital signatures of physiological parameters compatible with wearable-enabled sensing.</p></div><div><h3>Methods</h3><p>We derived prominent digital signatures of physiological responses to mental stress using cross-integration of multi-modal physiological signals including the electrocardiogram (ECG), photoplethysmogram (PPG), seismocardiogram (SCG), ballistocardiogram (BCG), electrodermal activity (EDA), and respiratory effort. Then, we developed an algorithm for tracking acute mental stress that can continuously classify stress vs no stress states by computing an aggregated likelihood computed with respect to a priori probability density distributions associated with the digital signatures of mental stress under stress and no stress states.</p></div><div><h3>Results</h3><p>Our algorithm could adequately infer mental stress state (average classification accuracy: 0.85, sensitivity: 0.85, specificity: 0.86) using a small number of prominent digital signatures derived from cross-integration of multi-modal physiological signals. The digital signatures in our work significantly outperformed the digital signatures employed in the state-of-the-art in tracking acute mental stress. Its exploitation of collective inference allowed for improved inference of mental stress state relative to naïve data mining techniques.</p></div><div><h3>Conclusion</h3><p>Our algorithm for tracking acute mental stress has the potential to make a leap in continuous, high-accuracy, and high-confidence inference of mental stress via convenient wearable-enabled physiological sensing. <u>Significance</u>: The ability to continuously monitor and track mental stress can collectively improve human wellbeing.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 4","pages":"Pages 771-781"},"PeriodicalIF":5.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An in-vitro cell culture system for accurately reproducing the coupled hemodynamic signals at the artery endothelium 准确再现动脉内皮耦合血液动力学信号的体外细胞培养系统
IF 6.4 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-08-22 DOI: 10.1016/j.bbe.2024.08.001
Lixue Liang, Xueying Wang, Dong Chen, Yanxia Wang, Xiaoyue Luo, Bo Liu, Yu Wang, Kai-rong Qin
{"title":"An in-vitro cell culture system for accurately reproducing the coupled hemodynamic signals at the artery endothelium","authors":"Lixue Liang, Xueying Wang, Dong Chen, Yanxia Wang, Xiaoyue Luo, Bo Liu, Yu Wang, Kai-rong Qin","doi":"10.1016/j.bbe.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.bbe.2024.08.001","url":null,"abstract":"Microfluidics has been an effective technology to reconstruct the in-vivo physiological hemodynamic microenvironment, which is significantly important for preventing and curing circulatory system-related diseases. However, these existing microfluidic systems have failed to accurately reproduce the arterial blood pressure, shear stress, circumferential strain, as well as their coupling relationship, and have not taken into account whether the cells at various locations in the culture chamber are subjected to consistent mechanical stimulation. To solve the above shortcomings, this study developed an in-vitro endothelial cell culture system (ECCS) containing a microfluidic chip and afterload components based on the hemodynamic principles to reappear the desired hemodynamic signals and their coupling relationship accurately, while a relatively uniform area of stress and strain distribution was selected in the microfluidic chip for a more reliable cell mechanobiology study. The sensitivity of global hemodynamic behaviors of the ECCS was analyzed, and numerical simulation and in-vitro experiments were implemented to verify the performance of the proposed ECCS. Finally, the cellular hemodynamic response was tested using human umbilical vein endothelial cells, demonstrating that the proposed in-vitro ECCS has better biological effectiveness. In general, the proposed ECCS in this study provided a more accurate and reliable tool for reproducing the in-vivo hemodynamic microenvironment and showed good potential in the mechanobiology study.","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"7 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142186969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlations between vascular properties and mental dysfunctions in long-COVID-19 support the vascular depression hypothesis 长COVID-19中血管特性与精神功能障碍之间的相关性支持血管抑郁假说
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1016/j.bbe.2024.07.001
Tomasz Gólczewski , Katarzyna Plewka , Marcin Michnikowski , Andrzej Chciałowski
{"title":"Correlations between vascular properties and mental dysfunctions in long-COVID-19 support the vascular depression hypothesis","authors":"Tomasz Gólczewski ,&nbsp;Katarzyna Plewka ,&nbsp;Marcin Michnikowski ,&nbsp;Andrzej Chciałowski","doi":"10.1016/j.bbe.2024.07.001","DOIUrl":"10.1016/j.bbe.2024.07.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Vascular depression hypothesis (VDH) bases on co-occurrence of vascular and mental dysfunctions in advanced age; however, there may be still a controversy about whether there is some direct association between vascular and mental properties or the co-occurrence is only a statistical artifact caused by commonness of these dysfunctions in the elderly. COVID-19 gave opportunity to test VDH under conditions different from aging.</p></div><div><h3>Methods</h3><p>25 patients were examined 3–6 month after SARS-CoV-2 infection. Subjective worsening of mental functions, presumably caused by the disease, was quantified with three psychometric tests. Blood flow waveforms were obtained for the left brachial and common carotid arteries. The waveform shape changes continuously with age; therefore, an individual shape can be characterized by the index WA being the calendar age (CA) of the average healthy rested subject having the most similar shape (consequently, in healthy rested subjects WA-CA = 0, in average). The mathematical functional analysis was used to calculate WA.</p></div><div><h3>Results</h3><p>Brachial WA-CA = 13 yrs, in average (p &lt; 0.00005; Cohen’s d = 0.99), and was correlated with tests scores (r = 0.55, 0.65, 0.46). Mean carotid WA-CA were smaller (7.2 and 1.6) but they were also correlated with the scores (right: r = 0.44, 0.55, 0.32; left: r = 0.49, 0.51, 0.38). Scores of two tests were inversely correlated with the systolic (r = -0.54, −0.58) and diastolic (r = -0.46, −0.56) pressures.</p></div><div><h3>Conclusions</h3><p>Since neither vascular nor mental problems are common after COVID-19, these relatively high correlations indicate that vascular and mental properties are not independent, i.e., they support VDH. Note that this not only concerns cerebral vasculature.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 461-469"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000482/pdfft?md5=977e303aaf5ed949204aeb13fb38c49b&pid=1-s2.0-S0208521624000482-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141941432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parallel collaboration and closed-loop control of a cursor using multimodal physiological signals 利用多模态生理信号对光标进行并行协作和闭环控制
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1016/j.bbe.2024.07.004
Zeqi Ye , Yang Yu , Yiyun Zhang , Yingxin Liu , Jianxiang Sun , Zongtan Zhou , Ling-Li Zeng
{"title":"Parallel collaboration and closed-loop control of a cursor using multimodal physiological signals","authors":"Zeqi Ye ,&nbsp;Yang Yu ,&nbsp;Yiyun Zhang ,&nbsp;Yingxin Liu ,&nbsp;Jianxiang Sun ,&nbsp;Zongtan Zhou ,&nbsp;Ling-Li Zeng","doi":"10.1016/j.bbe.2024.07.004","DOIUrl":"10.1016/j.bbe.2024.07.004","url":null,"abstract":"<div><p>This paper explores the parallel collaboration of multimodal physiological signals, combining eye tracker output signals, motor imagery, and error-related potentials to control a computer mouse. Specifically, a parallel working mechanism is implemented in the decision layer, where the eye tracker manages cursor movements, and motor imagery manages click functions. Meanwhile, the eye tracker output signals are integrated with electroencephalography data to detect the idle state for asynchronous control. Additionally, error-related potentials evoked by visual feedback, are detected to reduce the cost of error corrections. To efficiently collect data and provide continuous evaluations, we performed offline training and online testing in the designed paradigm. To further validate the practicability, we conducted online experiments on the real-world computer, focusing on a scenario of opening and closing files. The experiments involved seventeen subjects. The results showed that the stability of the eye tracker was optimized from 67.6% to 95.2% by the designed filter, providing the support for parallel control. The accuracy of motor imagery conducted simultaneously with fixations reached 93.41 ± 2.91%, proving the feasibility of parallel control. Furthermore, the real-world experiments took 45.86 ± 14.94 s to complete three movements and clicks, and showed a significant improvement compared to the baseline experiment without automatic error correction, validating the practicability of the system and the efficacy of error-related potentials detection. Moreover, this system freed users from the stimulus paradigm, enabling a more natural interaction. To sum up, the parallel collaboration of multimodal physiological signals is novel and feasible, the designed mouse is practical and promising.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 470-480"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000512/pdfft?md5=330cd4fbe5c5491b0301fa371de3d879&pid=1-s2.0-S0208521624000512-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141941466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing blood glucose prediction with neural architecture search and deep reinforcement learning for type 1 diabetics 利用神经架构搜索和深度强化学习推进 1 型糖尿病患者的血糖预测
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1016/j.bbe.2024.07.006
Peter Domanski , Aritra Ray , Kyle Lafata , Farshad Firouzi , Krishnendu Chakrabarty , Dirk Pflüger
{"title":"Advancing blood glucose prediction with neural architecture search and deep reinforcement learning for type 1 diabetics","authors":"Peter Domanski ,&nbsp;Aritra Ray ,&nbsp;Kyle Lafata ,&nbsp;Farshad Firouzi ,&nbsp;Krishnendu Chakrabarty ,&nbsp;Dirk Pflüger","doi":"10.1016/j.bbe.2024.07.006","DOIUrl":"10.1016/j.bbe.2024.07.006","url":null,"abstract":"<div><p>For individuals with Type-1 diabetes mellitus, accurate prediction of future blood glucose values is crucial to aid its regulation with insulin administration, tailored to the individual’s specific needs. The authors propose a novel approach for the integration of a neural architecture search framework with deep reinforcement learning to autonomously generate and train architectures, optimized for each subject over model size and analytical prediction performance, for the blood glucose prediction task in individuals with Type-1 diabetes. The authors evaluate the proposed approach on the OhioT1DM dataset, which includes blood glucose monitoring records at 5-min intervals over 8 weeks for 12 patients with Type-1 diabetes mellitus. Prior work focused on predicting blood glucose levels in 30 and 45-min prediction horizons, equivalent to 6 and 9 data points, respectively. Compared to the previously achieved best error, the proposed method demonstrates improvements of 18.4 % and 22.5 % on average for mean absolute error in the 30-min and 45-min prediction horizons, respectively, through the proposed deep reinforcement learning framework. Using the deep reinforcement learning framework, the best-case and worst-case analytical performance measured over root mean square error and mean absolute error was obtained for subject ID 570 and subject ID 584, respectively. Models optimized for performance on the prediction task and model size were obtained after implementing neural architecture search in conjunction with deep reinforcement learning on these two extreme cases. The authors demonstrate improvements of 4.8 % using Long Short Term Memory-based architectures and 5.7 % with Gated Recurrent Units-based architectures for patient ID 570 on the analytical prediction performance by integrating neural architecture search with deep reinforcement learning framework. The patient with the lowest performance (ID 584) on the deep reinforcement learning method had an even greater performance boost, with improvements of 10.0 % and 12.6 % observed for the Long Short-Term Memory and Gated Recurrent Units, respectively. The subject-specific optimized models over performance and model size from the neural architecture search in conjunction with deep reinforcement learning had a reduction in model size which ranged from 20 to 150 times compared to the model obtained using only the deep reinforcement learning method. The smaller size, indicating a reduction in model complexity in terms of the number of trainable network parameters, was achieved without a loss in the prediction performance.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 481-500"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000536/pdfft?md5=93b6aff09e56179150aed20a868b9e84&pid=1-s2.0-S0208521624000536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clustering and machine learning framework for medical time series classification 用于医学时间序列分类的聚类和机器学习框架
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1016/j.bbe.2024.07.005
Samuel Ruipérez-Campillo , Michael Reiss , Elisa Ramírez , Antonio Cebrián , José Millet , Francisco Castells
{"title":"Clustering and machine learning framework for medical time series classification","authors":"Samuel Ruipérez-Campillo ,&nbsp;Michael Reiss ,&nbsp;Elisa Ramírez ,&nbsp;Antonio Cebrián ,&nbsp;José Millet ,&nbsp;Francisco Castells","doi":"10.1016/j.bbe.2024.07.005","DOIUrl":"10.1016/j.bbe.2024.07.005","url":null,"abstract":"<div><h3>Background and motivation:</h3><p>The application of artificial intelligence in medical research, particularly unsupervised learning techniques, has shown promising potential. Medical time series data poses a unique challenge for analysis due to its complexity. Existing unsupervised learning methods often fail to effectively classify these variations, highlighting a gap in current approaches. We introduce a methodological clustering classification framework designed to accurately handle such data, aiming for improved classification tasks in biomedical signals.</p></div><div><h3>Methods:</h3><p>To address these challenges, we introduce a novel approach for the analysis and classification of medical time series data. Our method integrates agglomerative hierarchical clustering with Hilbert vector space representations of medical signals and biological sequences. We rigorously define the mathematical principles and conduct evaluations using simulations of cardiac signals, real-world neural signal datasets, open-source protein sequences, and the MNIST dataset for illustrative purposes.</p></div><div><h3>Results:</h3><p>The proposed method exhibited a 96% success rate in classifying protein sequences by function and effectively identifying families within a large protein set. In cardiac signal analysis, it retained 0.996 variance in a condensed 6-dimensional space, accurately classifying 87.4% of simulated atrial flutter groups and 99.91% of main groups when excluding conduction direction. For neural signals, it demonstrated near-perfect tracking accuracy of neural activity in mouse brain recordings, as confirmed by expert evaluations.</p></div><div><h3>Conclusion:</h3><p>Our proposed method offers a novel, translational approach for the treatment and classification of medical and biological time series, addressing some of the prevalent challenges in the field and paving the way for more reliable and effective biomedical signal analysis.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 521-533"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of timing of umbilical cord clamping and birth on fetal to neonatal transition: OpenModelica-based virtual simulator-based approach 夹断脐带和分娩时间对胎儿到新生儿转变的影响:基于 OpenModelica 虚拟模拟器的方法
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1016/j.bbe.2024.08.008
Edgar Hernando Sepúlveda-Oviedo , Leonardo Enrique Bermeo Clavijo , Luis Carlos Méndez-Córdoba
{"title":"Effect of timing of umbilical cord clamping and birth on fetal to neonatal transition: OpenModelica-based virtual simulator-based approach","authors":"Edgar Hernando Sepúlveda-Oviedo ,&nbsp;Leonardo Enrique Bermeo Clavijo ,&nbsp;Luis Carlos Méndez-Córdoba","doi":"10.1016/j.bbe.2024.08.008","DOIUrl":"10.1016/j.bbe.2024.08.008","url":null,"abstract":"<div><p>The transition from fetal to newborn condition involves complex physiological adaptations for extrauterine life. A crucial event in this process is <em>the clamping of the umbilical cord</em>, which can be categorized as immediate or delayed. The type of clamping significantly influences the hemodynamics of the newborn. In this study, we developed a simulator based on existing cardiovascular models to better understand this practice. The simulator covers the period from late gestation to 24 h after birth and faithfully reproduces flow patterns observed in real-life situations (as evaluated by clinical specialists), considering factors such as the timing of cord clamping and the altitude of the birth location. It also reproduces blood pressure values reported in clinical data. Under similar conditions, the simulation results indicate that delayed cord clamping leads to increased oxygen concentration and improved blood volume compared to immediate cord clamping. Delayed cord clamping also had a positive impact on sustained placental respiration. Furthermore, this study provides further evidence that umbilical cord clamping should be based on physiological criteria rather than predefined time intervals.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 716-730"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000615/pdfft?md5=e5a6695a259ebc59fa93e072a4230232&pid=1-s2.0-S0208521624000615-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A lightweight spatially-aware classification model for breast cancer pathology images 乳腺癌病理图像的轻量级空间感知分类模型
IF 5.3 2区 医学
Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1016/j.bbe.2024.08.011
Liang Jiang, Cheng Zhang, Huan Zhang, Hui Cao
{"title":"A lightweight spatially-aware classification model for breast cancer pathology images","authors":"Liang Jiang,&nbsp;Cheng Zhang,&nbsp;Huan Zhang,&nbsp;Hui Cao","doi":"10.1016/j.bbe.2024.08.011","DOIUrl":"10.1016/j.bbe.2024.08.011","url":null,"abstract":"<div><p>Breast cancer is a prevalent malignant tumour with high global incidence. Its diagnosis relies primarily on the analysis of pathological breast images. Owing to the complex organisation of the tumour microenvironment, neural network models are essential as efficient classification tools in the field of pathological image analysis. This study introduced spatially-aware attention swift parallel convolution network (SPA-SPCNet), a lightweight and low-latency model for classifying breast pathologies. A novel module for multi-scale feature extraction was constructed using a depthwise separable convolution method. It focuses on the multi-scale features of pathological images to alleviate recognition problems caused by similar local features in breast cancer tissues. The module concatenates the convolutions of different kernels from three branches. Second, a lightweight dynamic spatially-aware attention module was introduced to integrate the visual graph convolutional architecture in a branch. This allowed the model to capture the spatial structure and relationships in image, enabling better handling of the unique spatial distribution relationship between breast cancer tissue structures. The other branch utilises a self-attention mechanism in the transformer. The module can dynamically adjust the attention of the model to different regions in the image, allowing it to focus on the key features of the complex spatial distribution of breast cancer tissue. This feature fusion method enabled the model to capture both global semantics and local details. Compared with existing lightweight models, the proposed model has advantages in terms of tissue structure classification accuracy, parameter quantity, floating-point operations, and real-time inference speed, providing a powerful tool for computer-aided breast pathological image classification.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 586-608"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信