Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie最新文献

{"title":"Integrating Mental Health in Perioperative Care: Addressing the Overlooked Impact of Chronic Stress and Depression on Surgical Outcomes.","authors":"Haider Asadullah, Sabahat Ul Ain Munir Abbasi, Rayyan Nabi","doi":"10.1177/07067437251340667","DOIUrl":"10.1177/07067437251340667","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251340667"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Non-Suicidal Self-Injuring Youth Who Do Not Endorse Suicidal Ideation: Prévalence et corrélation de l'automutilation non suicidaire chez des jeunes qui n'ont pas d'idées suicidaires.","authors":"Khrista Boylan, Laura Duncan, Li Wang, Ian Manion, Kathryn Bennett, Ian Colman, Katholiki Georgiades","doi":"10.1177/07067437251337609","DOIUrl":"10.1177/07067437251337609","url":null,"abstract":"<p><p>ObjectivesNon-suicidal self-injury (NSSI) is a common behaviour in youth with mental disorder and in the general population. While NSSI is an important predictor of suicide attempts, not all youth with NSSI experience this outcome. The objective of this study is to report on the overlap between NSSI and suicidal ideation or attempt among Canadian youth self-reporting these behaviours in the general population to define a group of youth who engage in NSSI alone. This group of youth may represent a unique clinical phenotype.MethodsWe used data from 14-17 year olds (<i>N</i> = 2,576) from the 2014 Ontario Child Health Study, a province-wide, cross-sectional, epidemiologic study of child health and mental disorder. Based on their responses to questions about past year experiences of suicidal thoughts and behaviours including NSSI, 6 mutually exclusive groups were created reflecting their differing profiles of suicidal thoughts and behaviours. These groups were compared to each other on socio-demographic and symptom characteristics.ResultsA total of 9.2% of youth reported NSSI, and half of these youth endorsed NSSI alone (without suicidal ideation or attempts). Both groups had significantly more females. Compared to other groups of youth endorsing suicidal thoughts and behaviours, the NSSI alone group had lower symptoms of mental disorder in all domains except for social anxiety symptoms. They also had the lowest perceived need for help of all groups.ConclusionsAbout half of youth who self-harm do so without suicidal intent, and some for as long as 1 year during adolescence. Further prospective study of youth with NSSI alone is needed, to determine symptom stability as well as incident more risky suicidal behaviour before recommendations regarding the appropriateness of minimal medical or psychological intervention for youth who engage in this behaviour can be considered. There also are important sex differences in NSSI that deserve additional prospective study.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337609"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Studies on the Effectiveness of Community Treatment Orders: An Updated Systematic Review of Quantitative Data: Études canadiennes sur l'efficacité des ordonnances de traitement en milieu communautaire : mise à jour d'un examen systématique des données quantitatives.","authors":"Steve Kisely, Mike Trott, Ravi Iyer","doi":"10.1177/07067437251339215","DOIUrl":"10.1177/07067437251339215","url":null,"abstract":"<p><p>ObjectivesCommunity treatment orders (CTOs) for people with severe mental illnesses are used across most of Canada. Our previous systematic review of 10 years ago found that the evidence-base was limited to small studies, with only one including controls. This review updates the evidence using studies conducted in Canada over the last decade.MethodsA systematic search of PubMed/Medline, Embase, CINAHL, and PsycINFO for any Canadian study of outcomes following CTO placement from March 2015 to January 2025.ResultsWe identified four articles from three studies. Adding these studies to the previous search gave a total of nine articles from seven studies. None could be included in a meta-analysis. There were reductions in readmission rates and bed-days following CTO placement, while psychiatric symptom, outpatient attendance, treatment adherence participation in psychiatric services and housing all improved. In one study, perceived coercion was no greater in the CTO cases than the controls and being on an order preferable to being in hospital. However, many of the studies were small and only two included controls, of which solely one adjusted for potential confounders using either matching or adjusted analyses. The certainty of evidence was therefore rated as very low.ConclusionsThe evidence-base for the use of CTOs in Canada remains limited. This research gap contrasts with other countries that have conducted large studies using randomized or matched controls and adjusted analyses. There is a need for larger studies with more standardized reporting methods to allow for the pooling of results.Protocol Registration NumberProspectively registered with PROSPERO registration number CRD42024615480.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251339215"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Healthcare for Drug or Alcohol Use Among Pregnant Women with Disabilities in Ontario Canada.","authors":"Andi Camden, Yona Lunsky, Astrid Guttmann, Simone N Vigod, Isobel Sharpe, Hong Lu, Hilary K Brown","doi":"10.1177/07067437251339794","DOIUrl":"10.1177/07067437251339794","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251339794"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Acceptability of Online Culturally Adapted Cognitive Behavioural Therapy for Depression and Anxiety in Canadians of South Asian Origin: A Randomized Controlled Trial: Faisabilité et acceptabilité de la thérapie cognitivo-comportementale en ligne adaptée à la culture pour traiter la dépression et l'anxiété chez les Canadiens d'origine sud-asiatique : Essai contrôlé à répartition aléatoire.","authors":"Farooq Naeem, Muhammad Ishrat Husain, Muhammad Omair Husain, Baldev Mutta, Gary Thandi, Azaad Kassam, Maureen Abbott, Marcos Sanches, Helen-Maria Vasiliadis, Saeed Farooq, Kwame McKenzie","doi":"10.1177/07067437251337644","DOIUrl":"10.1177/07067437251337644","url":null,"abstract":"<p><p>BackgroundThis paper reports a pilot trial of culturally adapted CBT (CaCBT) for Canadian South Asians. The primary objective of this study was to assess the feasibility and acceptability of online CaCBT to treat anxiety and depression in Canadian South Asian individuals. The secondary objective was to measure changes in depression, anxiety, and disability.MethodsAn assessor-blind randomized clinical trial was conducted at 3 sites in Canada (Greater Toronto Area, Ottawa, and Vancouver). One hundred forty-six participants were randomly allocated to 1 of 2 groups: Ca-CBT (experimental group) or standard cognitive behavioural therapy (CBT) (control group) in a 1:1 ratio. The primary outcome, feasibility, was measured through engagement, recruitment, and participant retention. Acceptability was measured through the Verona Service Satisfaction Scale. Working Alliance Inventory was used to measure therapeutic engagement. Secondary outcomes included depression (Hospital Anxiety and Depression Scale-HADS), somatic symptoms (Bradford Somatic Inventory-BSI), and disability (WHO Disability Assessment Schedule 2.0 (WHODAS). Assessments were carried out at baseline, at the end of therapy (12 weeks from baseline), and at follow-up (36 weeks from baseline).ResultsWe were able to recruit participants within the given timeframe with excellent retention rates in both arms. Most participants in the intervention group, 56 (74.7%), attended ≥ 8 sessions, and 11 (14.7%) attended 5 to 7 sessions. Eight (10.7%) participants from the intervention group and 9 (12.0%) from the control group dropped out of therapy (<5 sessions). Participants in the intervention group reported higher levels of satisfaction (<i>P</i> = 0.001) and therapeutic engagement (<i>P</i> < 0.001) compared with the control group. Participants in both groups benefited from CBT.ConclusionsThis is the first report of online CaCBT for depression and anxiety for Canadian South Asians. The intervention is acceptable and feasible. Culturally adapted CBT is as effective as standard CBT in reducing the symptoms of depression and anxiety.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337644"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Symptoms of Psychosis and International Classification of Diseases 11th Revision (ICD-11) Complex Post-traumatic Stress Disorder: A Network Analysis in a Canadian Sample from Montreal: Symptômes positifs de psychose et trouble de stress post-traumatique complexe (CIM-11): Une analyse de réseau dans un échantillon canadien de Montréal.","authors":"Yafit Levin, Amelie Mazza, Philip Hyland, Thanos Karatzias, Mark Shevlin, Grainne McGinty, Yaakov Hoffman, Eric Lis, Menachem Ben-Ezra, Bachem Rahel","doi":"10.1177/07067437251337645","DOIUrl":"10.1177/07067437251337645","url":null,"abstract":"<p><p>ObjectivesTraumatic experiences constitute a risk factor for developing different psychopathologies, such as post-traumatic stress disorder (PTSD), complex PTSD (CPTSD), and positive symptoms of psychosis. However, on the symptom level, it is still unclear how CPTSD and positive symptoms of psychosis associate with each other. The present study aimed to shed light on these dynamics by investigating the symptoms network of CPTSD and positive symptoms of psychosis.MethodsA network analysis was performed on CPTSD and psychosis symptoms among a Canadian community sample with a history of traumatic life events (<i>n</i> = 747). Measures included the international trauma questionnaire and the mPRIME screen.ResultsIn total, 4.8% of the sample reached the criteria of probable PTSD and 7% fulfilled the criteria of probable CPTSD. PTSD and CPTSD groups had a significantly higher severity of positive symptoms of psychosis compared to the no-disorder group. Network analysis revealed 3 distinct communities of symptoms of PTSD, disturbances in self-organization, and psychosis. Affective dysregulation served as the bridging symptom between the communities. Hearing one's own thoughts aloud was the most central symptom in the network.ConclusionsFindings show that positive symptoms of psychosis can be considered trauma-related responses. Furthermore, interventions targeting affective dysregulation as well as the experience and distress associated with hearing one's own thoughts aloud may contribute to symptom reduction and improved functioning.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337645"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involuntary Treatment for Severe Substance Use Disorders - Issues, Evidence and Considerations for its Use.","authors":"Benedikt Fischer, Wayne Hall, Didier Jutras-Aswad, Bernard Le Foll","doi":"10.1177/07067437251338553","DOIUrl":"https://doi.org/10.1177/07067437251338553","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251338553"},"PeriodicalIF":3.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l'angiogenèse et cognition chez les personnes âgées à risque de démence.","authors":"Bing Xin Song, Erica Vieira, Damien Gallagher, Breno S Diniz, Corinne E Fischer, Alastair J Flint, Nathan Herrmann, Linda Mah, Benoit H Mulsant, Tarek K Rajji, Clement Ma, Krista L Lanctôt","doi":"10.1177/07067437251337627","DOIUrl":"https://doi.org/10.1177/07067437251337627","url":null,"abstract":"<p><p>ObjectiveChanges in angiogenesis have been shown to contribute to cognitive decline and dementia. We aimed to identify angiogenesis blood markers associated with cognitive performance in older adults with mild cognitive impairment (MCI), remitted major depressive disorder (rMDD), or both (rMDD + MCI) who are at risk for dementia.MethodWe analyzed data from participants with MCI, rMDD, or rMDD + MCI in the Prevention of Alzheimer's Dementia with Cognitive Remediation plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression study. Elastic net regression was used to select variables associated with cognitive performance among 19 angiogenesis markers and 6 covariates. Linear regressions were used to determine which of the selected angiogenesis markers were associated with cognitive performance, controlling for the selected covariates. Significant angiogenesis markers were independently analyzed without other angiogenesis markers, controlling for covariates, with subgroup analyses in those with and without rMDD.ResultsAngiogenin was the only selected marker associated with cognitive performance (<i>β</i> = 0.28, <i>P</i>_adj = 0.03, <i>f</i>² = .02) when controlling for other selected markers (endothelial cell-specific molecule 1, e-selectin, interleukin-33 [IL-33], oncostatin M, platelet-derived growth factor-AB, IL-33 receptor, and tissue inhibitor of metalloproteinases-1) and selected covariates (age, education, apolipoprotein E ε4 status, diagnosis, and cardiovascular risk factors). When independently analyzed, angiogenin remained positively associated with cognitive performance (<i>β</i> = 0.21, <i>P</i> = 0.01, <i>f</i>² =.02), controlling for the covariates. In subgroup analyses, angiogenin was also associated with cognition in rMDD and rMDD + MCI participants (<i>β</i> =0.50, SE = 0.14, <i>P</i> < 0.001, <i>f</i>² = 0.08) and in MCI-only participants (<i>β</i>= 0.20, SE = 0.09<i>,</i> <i>P</i> = 0.02, <i>f</i>² = 0.02).ConclusionThe association of angiogenin with cognitive performance highlights a potentially novel biological pathway that could influence cognition in older adults at risk for dementia. Angiogenin may protect against cognitive decline, opening new avenues for innovative preventive, or therapeutic interventions.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337627"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Geospatial Analysis of Early Psychosis Intervention Programs in Toronto, Canada: Une analyse géospatiale des programmes d'intervention précoce en cas de psychose à Toronto, au Canada.","authors":"Martin Rotenberg, Justin Graffi, Kelly Anderson, Paul Kurdyak, Nicole Kozloff, George Foussias","doi":"10.1177/07067437251337807","DOIUrl":"https://doi.org/10.1177/07067437251337807","url":null,"abstract":"<p><p>ObjectivesEarly psychosis intervention (EPI) programs play a crucial role in detecting and treating psychosis early, yet disparities in access persist. This study aimed to assess the spatial accessibility of EPI programs in Toronto, Canada, and to explore the association between access and indicators of neighbourhood-level marginalization.MethodsWe conducted a geospatial analysis using floating catchment area and two-step floating catchment area methods, examining EPI program locations, census population estimates for the 158 Toronto neighbourhoods, and area-level marginalization data. Spatial regression models were used to estimate the association between marginalization factors and spatial accessibility.ResultsOn average, the closest EPI program is 4 km away from the centre of any given neighbourhood (range 0.8-11 km), with variability across the city. Clustering is observed in some neighbourhoods, indicating better spatial accessibility, whereas other neighbourhoods face lower access. A full spatial regression model showed increasing levels of housing and dwelling marginalization, as well as material resource marginalization, to be associated with better access.ConclusionWe identified neighbourhoods that have poorer spatial accessibility to EPI services. Some neighbourhood-level marginalization indicators previously found to be associated with psychosis risk are also associated with better spatial accessibility. It is notable that EPI services in Toronto may be located where they are most needed the most. The study underscores the importance of geospatial analyses to identify and address geographic distance as a potential source of disparity in access.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337807"},"PeriodicalIF":3.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study: Prédire la rechute d'épisodes dépressifs pendant le traitement d'entretien : Une étude de suivi du bien-être dans les troubles dépressifs majeurs du Réseau canadien d'intégration des biomarqueurs pour la dépression (CAN-BIND).","authors":"Raymond W Lam, Katerina Rnic, John-Jose Nunez, Keith Ho, Joelle LeMoult, Abraham Nunes, Trisha Chakrabarty, Jane A Foster, Benicio N Frey, Kate L Harkness, Stefanie Hassel, Sidney H Kennedy, Qingqin S Li, Roumen V Milev, Lena C Quilty, Susan Rotzinger, Claudio N Soares, Valerie H Taylor, Gustavo Turecki, Rudolf Uher","doi":"10.1177/07067437251337603","DOIUrl":"https://doi.org/10.1177/07067437251337603","url":null,"abstract":"<p><p>BackgroundRelapse rates in major depressive disorder (MDD) remain high even after treatment to remission. Identifying predictors of relapse is, therefore, crucial for improving maintenance strategies and preventing future episodes. Remote data collection and sensing technologies may allow for more comprehensive and longitudinal assessment of potential predictors.MethodsThe Canadian Biomarker Integration Network in Depression Wellness Monitoring for MDD (CBN-WELL) study was a prospective, multicentre observational study with an aim to identify biomarkers associated with relapse in patients on maintenance treatment for MDD. Participants had a DSM-5-TR diagnosis of MDD in remission and a Montgomery-Åsberg Depression Rating Scale (MADRS) score ≤14. Participants remained on their baseline medication regimens and were followed bimonthly for up to 2 years. Relapse criteria included MADRS > 22 for 2 consecutive weeks, suicidality or hospitalization, and initiation or change in medication for worsening symptoms. Data collection included clinical assessments, self-report questionnaires, and remote monitoring using wrist-worn actigraphs and smartphones.ResultsA total of 96 participants had follow-up data. Of these, 28.9% experienced a depressive relapse during the study period, with an average time to relapse of 211 days. Baseline depressive severity, as measured by MADRS, was higher in participants who relapsed compared to those who did not, but few other baseline clinical measures differentiated these groups.ConclusionsIndividuals with MDD in remission continued to have high relapse rates despite maintenance treatment. The paucity of clinical factors that predict relapse underscores the need for biomarkers. The CBN-WELL database can be used for future research to integrate multiple predictive factors and to identify objective measures to predict relapse in individuals.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337603"},"PeriodicalIF":3.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}